CLINICAL MANIFESTATIONS OF ORAL MUCOSAL LESIONS IN VERIOUS DERMATOSIS

Subject. This review presents a modern literature review on the clinical manifestations of severe autoimmune disease — pemphigus vulgaris, chronic genetic determinate dermatosis — by the example of epidermolysis bullosa, dermatosis — lichen planus, acute immuno-mediated disease — multiforme exudative erythema. The goal is to conduct a systematic analysis of modern domestic and foreign literature to determine some features of the clinical manifestations of chronic dermatoses with lesions of the oral mucosa. Methodology. A review of the studies allows us to consider the etiology and pathogenesis of the development of these nosologies, approaches to modern classification, as well as an analysis of their clinical features with an emphasis on differential diagnosis. Results. It was noted that with combined damage to the skin and oral mucosa, the diagnosis of these dermatoses in patients does not present any particular difficulties. However, the significance of determining pathognomonic signs of damage to the oral mucosa with a particular dermatosis increases significantly with an isolated lesion of the oral mucosa, and when it is the primary and only manifestation of skin disease. Conclusions. Undoubtedly, the principle of continuity of the interested specialties among which are undoubted - dermatovenerologists, dentists, gastroenterologists, gynecologists, neuropsychiatrists, has great prospects in both diagnosis and complex treatment. Nevertheless, for their widespread use, the local and general treatment of these patients needs to be verified, solving urgent problems of introducing and adapting modern technologies for rapid prototyping them into practical healthcare, which together will allow significant progress in their diagnosis and prevention.

Download Full-text

Prevalence of Oral Mucosal Lesions in a Tertiary Care Dental Hospital of Kathmandu

Journal of Nepal Medical Association ◽

10.31729/jnma.3283 ◽

2017 ◽

Vol 56 (207) ◽

pp. 362-366

Author(s):

Dipshikha Bajracharya ◽

Sujaya Gupta ◽

Bidhata Ojha ◽

Radha Baral

Keyword(s):

Squamous Cell Carcinoma ◽

Retrospective Study ◽

Oral Cavity ◽

Cell Carcinoma ◽

Oral Mucosa ◽

Buccal Mucosa ◽

Tertiary Care ◽

Oral Mucosal Lesions ◽

Dental Hospital ◽

Mucosal Lesions

Introduction: Oral mucosa can be affected by a variety of soft tissue lesions and conditions. Benign as well as malignant lesions of oral cavity are common. Squamous cell carcinoma is one of the commonest malignancies. The present retrospective study was undertaken to study the prevalence of various oral mucosal lesions in a tertiary care dental hospital of Kathmandu. Methods: This retrospective study was carried out in the Department of Oral and Maxillofacial Pathology at Kantipur Dental College and Teaching hospital from January 2015 to January 2017. The study included biopsy specimen from the oral cavity. The parameters included in the study were age, gender, site of the lesion and histopathological diagnosis. The data collected was statistically analyzed. Results: A total of 111 biopsy cases were included in the present study. Out of which, there was 16 (14.4%) cases of non neoplastic and 16 (14.4%) cases of benign pathology. The oral cavity lesions were commonly seen in age range between 6-74 years where males 59 (53.2%) were mostly affected. The most common site for oral lesion was buccal mucosa 23 (20.7%) and anterior gingiva 23 (20.7%). 15 (13.5%) cases of oral squamous cell carcinoma were seen as the predominant malignancy affecting in the vestibular region 8 (7.2%). Conclusions: The present study shows benign as well as the non neoplastic lesions were more prevalent in oral mucosa with the buccal mucosa and anterior gingiva as the commonest site of occurrence. Keywords: Benign; Malignant; Non neoplastic; Oral mucosal lesion.

Download Full-text

Analysis of clinical and diagnostic features and criteria for the effectiveness of treatment of autoimmune bullous dermatoses pemphigus group

Ukrainian Journal of Dermatology Venerology Cosmetology ◽

10.30978/ujdvk2021-1-51 ◽

2021 ◽

pp. 51-57

Author(s):

М.Е. Zapolsky ◽

М.М. Lebediuk ◽

N.B. Prokofyeva ◽

V.V. Goncharenko ◽

S.V. Nerubashchenko

Keyword(s):

Immunofluorescence Microscopy ◽

Clinical Manifestations ◽

Diagnostic Algorithm ◽

Pemphigus Vulgaris ◽

Diagnostic Features ◽

Iga Pemphigus ◽

Modern Classification ◽

Pemphigus Erythematosus ◽

Pemphigus Vegetans

The modern classification of autoimmune bullous dermatoses is represented by three groups of diseases that have not only clinical, but also histomorphological, histochemical and immunogenetic similarities. Autoimmune bullous dermatoses are a group of heterogeneous diseases accompanied by the formation of blisters and erosions on the skin and/or mucous membranes under the influence of specific autoimmune complexes. The main clinical manifestations and diagnostic markers of autoimmune bullous dermatoses (ABD) belonging to the pemphigus group are considered.Objective — to analyze the prevalence of clinical forms of pemphigus in the southern region of Ukraine for the period from 2010 to 2020.Materials and methods. The observation group consisted of 88 patients aged 21 to 75 years. The features of clinical manifestations of typical and atypical forms of pemphigus have been studied, a diagnostic algorithm and criteria for the effectiveness of treatment in the early stages of the disease have been developed.Results and discussion. Pemphigus vulgaris was found in 61 (69.3 %), pemphigus vegetans — in 7 (7.9 %), pemphigus erythematosus — in 6 (6.8 %), herpetiform pemphigus — in 4 (4.5 %), IgA pemphigus — in 3 (3.4 %), paraneoplastic pemphigus — in 3 (3.4 %) patients.Conclusions. Modern clinical diagnostic features of ABD (pemphigus group) require the inclusion of immunofluorescence microscopy, direct and indirect enzyme immunoassay in laboratory screening. Not only positive clinical dynamics, but also the rate of disappearance of autoantibodies that induce the diseases (desmoglein, desmoplakin, periplakin, etc.) should be considered the criteria of the effectiveness of treatment of patients with ABD. At the same time, knowledge of the clinical features of ABD and the diseases that mimic them remains an important aspect.

Download Full-text

Amalgam associated mercury accumulations in normal oral mucosa, oral mucosal lesions of lichen planus and contact lesions associated with amalgam

Journal of Oral Pathology and Medicine ◽

10.1111/j.1600-0714.1990.tb00779.x ◽

1990 ◽

Vol 19 (1) ◽

pp. 39-42 ◽

Cited By ~ 69

Author(s):

J. Bolewska ◽

P. Holmstrup ◽

B. Moller-Madsen ◽

B. Kenrad ◽

G. Danscher

Keyword(s):

Lichen Planus ◽

Oral Mucosa ◽

Normal Oral Mucosa ◽

Oral Mucosal Lesions ◽

Mucosal Lesions

Download Full-text

Oral mucosal lesions in patients with pemphigus and pemphigoid skin diseases: a cross sectional study from southern India.

Dentistry 3000 ◽

10.5195/d3000.2017.59 ◽

2017 ◽

Vol 5 (1) ◽

Cited By ~ 1

Author(s):

Arvind Babu Rajendra Santosh ◽

Venkat Ramana Reddy Baddam ◽

Chigurupati Anuradha ◽

Chandrashekar Poosarla

Keyword(s):

Skin Diseases ◽

Disease Process ◽

Pemphigus Vulgaris ◽

Diagnostic Procedures ◽

Cross Sectional Study ◽

Southern India ◽

Cross Sectional ◽

Autoimmune Blistering Disease ◽

Oral Mucosal Lesions ◽

Mucosal Lesions

Objective:To assess the prevalence of oral mucosal lesions in patients with pemphigus and pemphigoid diseases from Southern India. Design and Methods: A cross-sectional hospital based study was conducted from August 2010 to July 2011. Patients with confirmed pemphigus and pemphigoid skin disease were selected and informed to participate in the study. Oral examination of all participants were done to document site and type of oral manifestation and diagnostic procedures such as histopathological and Immunofluorescence methods were performed to confirm the diagnosis. Demographic details such as age, gender and occupation were also documented. The results of the study were analyzed by SPSS software version 19.0 (Armonk, NY) and presented as descriptive statistics. Results: Sixty percent of the patients exhibited oral mucosal manifestations. A higher female (86.66%) predilection of autoimmune blistering disease was observed in the study. A slightly higher number of pemphigoid patients (53.33%, 16 out of 30) were reported than pemphigus (46.66%, 14 out of 30 cases). The most common subtypes of pemphigus is Pemphigus vulgaris 71% (10 out of 14) among pemphigus, and bullous pemphigoid 87.5%(14 out of 16) among pemphigoid. Buccal mucosa (92.85%) is the most common site in pemphigus patients, where as hard palate (12.5%) is mostly commonly reported site in pemphigoid patients. Initial involvement of oral tissue in disease process was observed in 78.57% of pemphigus, and 12.5% of pemphigoid patients. Conclusion: Oral mucosal lesions are more frequently associated in pemphigus patients. Oral mucosal lesions are the initial site of disease process in pemphigus patients. The significance of diagnosis of oral lesions at earlier stage of disease, specifically pemphigus may help in early intervention of disease and help to reduce the morbidity and mortality state. The study emphasizes multidisciplinary approach in diagnosis and management of both pemphigus and pemphigoid.

Download Full-text

Presence of Candida albicans in potentially malignant oral mucosal lesions

Archive of oncology ◽

10.2298/aoo0401051v ◽

2004 ◽

Vol 12 (1) ◽

pp. 51-54 ◽

Cited By ~ 13

Author(s):

Nada Vuckovic ◽

Marija Bokor-Bratic ◽

Dejan Vuckovic ◽

Ivana Picuric

Keyword(s):

Candida Albicans ◽

Lichen Planus ◽

Oral Mucosa ◽

Viral Infections ◽

Oral Candidiasis ◽

Candida Infection ◽

Lower Lip ◽

Oral Mucosal Lesions ◽

Potentially Malignant ◽

Mucosal Lesions

Recently, an interest in the study of oral candidiasis has markedly increased mainly because of its association with viral infections due to human immunodeficiency, but also because of its relation with potentially malignant lesions of oral mucosa. These lesions belong to the wide group of leukoplakia. Leukoplakia is a clinical term used to describe a range of nonspecific white lesions, whose appearance does not generally correlate well with histopathologic changes; therefore, biopsy should be performed in all cases to determine which are precancerous or potentially malignant ones. In order to study the association of Candida albicans and the types of mucosal lesions, we took 30 consecutive biopsies of oral mucosa and the smears for microbiologic examination from the changed surface of mucosa and from the rest of oral cavity. The study group consisted of 30 patients, 21 women and 9 men, with the average age of 50.23 years (range, 25-77 years). In 6 cases Candida was diagnosed in mucosal biopsy. In the smear from the lesion, it was present in 3 cases, and 2 cases were found in the smear from an unchanged oral mucosa. In 9/30 cases (30%) Candida was positive regardless of the smear area or mode of diagnosis. The most common lesion is leukoplakia, diagnosed in 12/30 cases (40%), in 6 female and 6 male patients. The average age of those patients was 52.42 years. The lesions were located as follows: cheek mucosa - 5 cases; gingival mucosa - 2; lower lip - 2; floor of the mouth - 2; soft palate - 1; Candida was present in 3/12 cases. The lesion with the second highest incidence is lichen planus (9 cases), with positive Candida infection in 4/9 (44.44%). Epithelial dysplasia, although diagnosed in a very small number of cases (1/30 or 3.3%) with leukoplakia, was associated with a Candida infection. Generally, Candida is present in potentially malignant oral mucosal lesions (in 3/12 or 25% of leukoplakia cases, in 4/9 or 44.44% of lichen planus cases, and 1/1 squamous papilloma), with an increasing incidence in lesions with serious dysplastic epithelial changes.

Download Full-text

Comment on: “Trichloroacetic acid as a treatment for persistent oral mucosal lesions in pemphigus vulgaris”

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2019.05.107 ◽

2019 ◽

Vol 81 (5) ◽

pp. e139 ◽

Cited By ~ 1

Author(s):

Roberto Bueno-Filho ◽

Helena Barbosa Lugão ◽

Ana Maria Roselino

Keyword(s):

Trichloroacetic Acid ◽

Pemphigus Vulgaris ◽

Oral Mucosal Lesions ◽

Mucosal Lesions

Download Full-text

Resistant oral mucosal lesions in pemphigus vulgaris responsive to double filtration plasmapheresis: First case report from Turkey

Transfusion and Apheresis Science ◽

10.1016/j.transci.2013.01.008 ◽

2013 ◽

Vol 48 (2) ◽

pp. 273-275 ◽

Cited By ~ 4

Author(s):

E. Şavk ◽

M. Uslu ◽

I. Yavaşoğlu ◽

G. Kadıköylü ◽

N. Şendur ◽

...

Keyword(s):

Case Report ◽

Pemphigus Vulgaris ◽

Double Filtration Plasmapheresis ◽

First Case ◽

Oral Mucosal Lesions ◽

Mucosal Lesions ◽

Double Filtration

Download Full-text

THE IMPORTANT ROLE OF ORAL MEDICINE SPECIALIST IN MANAGEMENT OF STEVENS-JOHNSON SYNDROME PATIENT

Dentino : Jurnal Kedokteran Gigi ◽

10.20527/dentino.v5i2.8969 ◽

2020 ◽

Vol 5 (2) ◽

pp. 165

Author(s):

Nuri Fitriasari ◽

Eko Rotary Nurtito ◽

Nanan Nur’aeny ◽

Indah Suasani Wahyuni

Keyword(s):

Case Report ◽

Oral Mucosa ◽

Electrolyte Imbalance ◽

Stevens Johnson Syndrome ◽

Oral Medicine ◽

Johnson Syndrome ◽

Mucosal Involvement ◽

Oral Mucosal Lesions ◽

Mucosal Lesions

ABSTRACTIntroduction: Stevens-Johnson Syndrome (SJS) is an acute hypersensitivity reaction that manifests on the skin, oral mucosa, ocular, gastrointestinal, genital and anal area. It is also potentially life-threatening in concern of dehydration and infection. Oral mucosal lesions due to SJS resulted in a significant decrease of patient’s quality of life. When the oral mucosa involved, the intake of nutrients and fluids is disrupted contributing to electrolyte imbalance that aggravates dehydration. Moreover, oral mucosal lesions have become an entry point for infection. Purpose: This case report describes the important role of oral medicine specialists in the management of oral mucosal lesions in SJS patient. Review: A 26-year-old female patient was referred from the Department of Dermatology and Venereology with a diagnosis of SJS et causa suspected paracetamol and/or amoxycillin. The complaints comprised of pain on the lips and oral cavity, difficulty in mouth opening, and pain when swallowing. The management for oral lesions included: history taking, external and intra oral examinations, dexamethasone mouthwash, nystatin oral suspension, and sodium chloride (NaCl) 0.9% solution. The patient showed improvement in oral mucosal lesions within 3 weeks of treatment that was provided by oral medicine specialist and medical team collaboration. Conclusion: Based on this case report, the role of oral medicine specialist is very important as part of the management team for SJS patient. Oral medicine specialist can reduce morbidity that results from oral mucosal involvement. Collaboration with oral medicine specialist since the beginning of treatment is the key to success in SJS management. Keywords: Oral medicine specialist, Oral mucosal lesion, Stevens-Johnson Syndrome.

Download Full-text