scholarly journals Comparative evaluation of interleukin-6 in the liver tissues, bile duct, blood serum and urine in patients with obstructive jaundice of benign etiology

2017 ◽  
Vol 9 (1) ◽  
pp. 33
Author(s):  
Jabbar Metulla ogly Hajiyev ◽  
Elman Gulu oglu Taghiyev ◽  
Novruz Jabbar oglu Hajiyev
Keyword(s):  
Bile Duct ◽  
Obstructive Jaundice ◽  
Blood Serum ◽  
Interleukin 6 ◽  
Comparative Evaluation ◽  
Serum And Urine ◽  
Liver Tissues

Цель исследования – сравнительное изучение содержания IL-6 в ткани печени, протоковой желчи, сыворотке крови и мочеу больных с ОЖ доброкачественного генеза, в зависимости от степени печеночной дисфункции.Материалы и методы. В статье в сравнительной оценке анализируются содержание IL-6 в ткани печени, сывороткекрови и протоковой желчи в динамике при хирургическом лечении 67 больных с обтурационной желтухой доброкачествен-ного генеза. У всех больных причиной обтурационной желтухи был холедохолитиаз. Степень печеночной дисфункции опре-деляли с учетом маркеров холестаза и цитолиза гепатоцитов в крови. Печеночная дисфункция I степени наблюдалась – у21 больного, печеночная дисфункция II степени – у 14, печеночная дисфункция III степени – у 10, печеночная дисфункция IV– у 9 больных. У 13 больного на фоне обтурационной желтухи был гнойный холангит. Концентрацию IL-6 в ткани печени(ТП), при заборе во время операции у 42 больных, в протоковой желчи сразу – в первой порции у 42 больных, на 3-и и 7-есутки после наружной декомпрессии желчных путей у 37 больных, в сыворотке крови и моче до операции, на 3-и и 7-е суткипосле операции определяли с помощью иммуноферментного анализа с использованием реактивов Dender Medsistems (USA).Результаты и их обсуждения. Сопоставление показателей IL-6 в ТП, протоковой желчи, сыворотке крови и моче у боль-ных различной степенью ПД показало, что сыворотка крови характеризовала более низким их уровнем содержания данно-го показателя, чем в ТП, желчи и моче, а больше всего данного цитокина определилось в желчи. При наличии ГХ наблюда-ется наибольшее накопление IL-6 в ТП, желчи и в моче по сравнению с сыворотке крови.Вывод Локальный и системный уровни IL-6 могут служить в качестве маркеров для оценки тяжести патологическогопроцесса, планирования консервативной терапии, мониторинга эффективности проводимого лечения и клинического те-чения.Ключевые слова: механическая желтуха, холедохолитиаз, интерлейкин – 6, печеночная дисфункция

Impaired Fibrinolysis in Obstructive Jaundice - Evidence from Clinical and Experimental Studies

1988 ◽  
Vol 60 (01) ◽  
pp. 025-029 ◽  
Author(s):  
M Colucci ◽  
D F Altomare ◽  
G Chetta ◽  
R Triggiani ◽  
L G Cavallo ◽  
...  
Keyword(s):  
Renal Failure ◽  
Bile Duct ◽  
Obstructive Jaundice ◽  
Plasminogen Activator ◽  
Fibrinolytic Activity ◽  
Experimental Studies ◽  
Plasminogen Activator Inhibitor ◽  
Venous Stasis ◽  
Microvascular Thrombosis ◽  
Duct Ligation

SummaryMicrovascular thrombosis is considered an important pathogenetic factor in renal failure associated with obstructive jaundice but the mechanisms leading to fibrin deposition are still unknown. The plasma levels of plasminogen activator inhibitor (PAI) in 29 patients with obstructive jaundice were found significantly increased as compared to 20 nonjaundiced patients. Fibrin autography of plasma supplemented with tissue plasminogen activator (t-PA) revealed that in icteric samples most of the added activator migrated with an apparent Mr of 100 kDa, corresponding to t-PA-PAI complex, whereas in control samples virtually all t-PA migrated as free enzyme. PAI activity detected in icteric samples is similar to the endothelial type PAI since it is neutralized by a monoclonal antibody against PAI-1.Venous stasis in jaundiced patients was neither associated with an increase in blood fibrinolytic activity nor with a decrease in PAI activity. Immunologic assay showed that t-PA release was impaired in 3 out of 4 patients. In controls, venous occlusion induced an increase in both fibrinolytic activity and t-PA antigen and a reduction in PAI activity. Bile duct recanalization in jaundiced patients subjected to surgery was accompanied by a decrease in plasma PAI activity which paralleled the decrease in serum bilirubin levels. In nonjaundiced patients, surgical treatment did not cause significant changes in either parameter. Rabbits made icteric by bile duct ligation showed an early and progressive increase in plasma PAI activity indicating that obstructive jaundice itself causes the elevation of circulating PAI. It is concluded that obstructive jaundice is associated with a severe impairment of fibrinolysis which might contribute to microvascular thrombosis and renal failure.

scholarly journals Obstructive Jaundice Following Transarterial Chemoembolization for Hepatocellular Carcinoma with Bile Duct Invasion

2021 ◽  
Vol 5 (02) ◽  
pp. 127-130
Author(s):  
Kazuki Matsushita ◽  
Ken Kageyama ◽  
Natsuhiko Kameda ◽  
Yurina Koizumi ◽  
Akira Yamamoto
Keyword(s):  
Hepatocellular Carcinoma ◽  
Bile Duct ◽  
Obstructive Jaundice ◽  
Transarterial Chemoembolization ◽  
Tumor Invasion ◽  
Endoscopic Sphincterotomy ◽  
Biliary Obstruction ◽  
Intraductal Tumor ◽  
Bile Duct Invasion ◽  
The Common

AbstractHepatocellular carcinoma (HCC) with bile duct invasion is considered rare. A case in which a fragment of intraductal tumor dropped into the common bile duct after transarterial chemoembolization (TACE) and caused abdominal pain, and obstructive jaundice secondary to biliary obstruction is presented. This case was successfully managed by emergent endoscopic sphincterotomy. Physicians should recognize one of the complications due to TACE for HCC with intraductal tumor invasion.

scholarly journals Liver in ulcerative colitis: obstructive jaundice due to bile duct carcinoma.

Gut ◽  
1966 ◽  
Vol 7 (5) ◽  
pp. 433-437 ◽  
Author(s):  
J G Rankin ◽  
A P Skyring ◽  
S J Goulston
Keyword(s):  
Ulcerative Colitis ◽  
Bile Duct ◽  
Obstructive Jaundice ◽  
Bile Duct Carcinoma ◽  
Duct Carcinoma

scholarly journals Impairment of Bilirubin Clearance and Intestinal Interleukin-6 Expression in Bile Duct-Ligated Vitamin D Receptor Null Mice

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e51664 ◽  
Author(s):  
Michiyasu Ishizawa ◽  
Michitaka Ogura ◽  
Shigeaki Kato ◽  
Makoto Makishima
Keyword(s):  
Vitamin D ◽  
Bile Duct ◽  
Vitamin D Receptor ◽  
Interleukin 6

Obstructive jaundice caused by circumscript papillomatosis of the common bile duct

2000 ◽  
Vol 32 (2) ◽  
pp. 88-89
Author(s):  
P. Ondrejka ◽  
A. Zabo ◽  
E. Siket ◽  
I. Sugar ◽  
B. Forgacs ◽  
...  
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Obstructive Jaundice ◽  
The Common

scholarly journals Analysis of the RNA content of the exosomes derived from blood serum and urine and its potential as biomarkers

2014 ◽  
Vol 369 (1652) ◽  
pp. 20130502 ◽  
Author(s):  
Mu Li ◽  
Emily Zeringer ◽  
Timothy Barta ◽  
Jeoffrey Schageman ◽  
Angie Cheng ◽  
...  
Keyword(s):  
Blood Serum ◽  
Cell Communication ◽  
Cell Culture Model ◽  
Culture Model ◽  
Wide Range ◽  
Abnormal Cells ◽  
A Cell ◽  
Invasive Diagnostics ◽  
Serum And Urine

Exosomes are tiny vesicles (30–150 nm) constantly secreted by all healthy and abnormal cells, and found in abundance in all body fluids. These vesicles, loaded with unique RNA and protein cargo, have a wide range of biological functions, including cell-to-cell communication and signalling. As such, exosomes hold tremendous potential as biomarkers and could lead to the development of minimally invasive diagnostics and next generation therapies within the next few years. Here, we describe the strategies for isolation of exosomes from human blood serum and urine, characterization of their RNA cargo by sequencing, and present the initial data on exosome labelling and uptake tracing in a cell culture model. The value of exosomes for clinical applications is discussed with an emphasis on their potential for diagnosing and treating neurodegenerative diseases and brain cancer.

Obstructive Jaundice doesn’t Change the Population Pharmacokinetics of Etomidate in Patients who Underwent Bile Duct Surgery

2021 ◽  
Vol 18 ◽  
Author(s):  
Jin-Chao Song ◽  
Xiao-Yan Meng ◽  
Hua Yang ◽  
Hao Gao ◽  
Mei-Hua Cai ◽  
...  
Keyword(s):  
Bile Duct ◽  
Obstructive Jaundice ◽  
Body Mass ◽  
High Performance ◽  
Anesthesia Induction ◽  
Forward Selection ◽  
Mixed Effects Modeling ◽  
Arterial Blood ◽  
Liquid Chromatography Tandem Mass ◽  
Parameter Values

Background: Etomidate is commonly used in the induction of anesthesia. We have previously confirmed that etomidate requirements are significantly reduced in patients with obstructive jaundice and that etomidate anesthesia during endoscopic retrograde cholangiopancreatography (ERCP) results in more stable hemodynamics when compared with propofol. The aim of the present study is to investigate whether obstructive jaundice affects the pharmacokinetics of etomidate in patients who underwent bile duct surgery. Methods: 18 patients with obstructive jaundice and 12 non-jaundiced patients scheduled for bile duct surgery were enrolled in the study. Etomidate 0.333 mg/kg was administered by IV bolus for anesthetic induction. Arterial blood samples were drawn before, during, and up to 300 minutes after the bolus. Plasma etomidate concentrations were determined using a validated high-performance liquid chromatography-tandem mass spectrometry assay. A population nonlinear mixed-effects modeling approach was used to characterize etomidate pharmacokinetics. The covariates of age, gender, height, weight, body surface area (BSA), body mass index (BMI), lean body mass (LBM), total bilirubin (TBL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bile acid (TBA), creatinine (CR), blood urea nitrogen (BUN) were tested for significant effects on parameters using a multiple forward selection approach. Covariate effects were judged based on changes in the objective function value (OFV). Results: A three-compartment disposition model adequately described the pharmacokinetics of etomidate. The model was further improved when height was a covariate of total clearance [Cl1=1.30+0.0232(HT-162), ΔOFV=−7.33; P<0.01)]. The introduction of any other covariates, including bilirubin and total bile acids, did not improve the model significantly (P>0.01). For the height of 162cm, the final pharmacokinetic parameter values were as follows: V1=1.42 (95% CI, 1.01-1.83, L), V2=5.52 (95% CI, 4.07-6.97, L), V3=63.9 (95% CI, 41.95-85.85, L), Cl1= 1.30 (95% CI, 1.19-1.41, L/min), Cl2= 1.21 (95%CI, 0.95-1.47, L/min), and Cl3=0.584 (95%CI, 0.95-1.21, L/min), respectively. Conclusion: A 3-compartment open model might best describe the concentration profile of etomidate after bolus infusion for anesthesia induction. The pharmacokinetics of etomidate were not changed by the presence of obstructive jaundice.

PERCUTANEOUS TRANSHEPATIC CHOLANGIOGRAPHY IN THE DIAGNOSTICS OF COMMON BILE DUCT DISEASES COMPLICATED BY OBSTRUCTIVE JAUNDICE*

2021 ◽  
Vol 8 (2) ◽  
pp. 62-67
Author(s):  
Valeriy V. Boyko ◽  
Yuriy V. Avdosyev ◽  
Anastasiia L. Sochnieva ◽  
Denys O. Yevtushenko ◽  
Dmitro V. Minukhin
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Obstructive Jaundice ◽  
Biliary Tract ◽  
Percutaneous Transhepatic Cholangiography ◽  
Biliary Decompression ◽  
Biliodigestive Anastomosis ◽  
Bile Duct Diseases

Aim: Evaluation of the effectiveness of percutaneous transhepatic cholangiography in the diagnostics of bile duct diseases complicated by obstructive jaundice. Material and methods: This article presents the experience of using percutaneous transhepatic cholangiography in 88 patients with benign and malignant common bile duct diseases complicated by obstructive jaundice. Results: Methods of direct contrasting of the biliary tract make it possible to visualize choledocholithiasis with 86.5% accuracy, with 84.1% common bile duct strictures, with 87.8% stricture of biliodigestive anastomosis and with 97.5% accuracy of cholangiocarcinomas. Conclusions: Direct antegrade bile duct enhancement should be used if ERCPG has low explanatory value. PTCG in case of “endoscopically complicated forms” of choledocholithiasis, CBD and BDA strictures and cholangiocarcinomas enhances all bile duct sections and helps assess the level and completeness of biliary blockade. Following PTCG, measures can be taken to achieve biliary decompression regardless of OJ genesis.

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