scholarly journals The Role of Low Energy Electrons in Radiobiology and Cancer Treatment

2021 ◽  
Author(s):  
Sasan Esmaili ◽  
Farzaneh Allaveisi
Keyword(s):  
Cancer Treatment ◽  
Anticancer Agents ◽  
High Energy ◽  
Low Energy ◽  
New Drugs ◽  
Particle Radiation ◽  
Energy Radiation ◽  
Regulatory Pathways ◽  
High Energy Electrons ◽  
Low Energy Electrons

Low energy radiation can be produced by all types of high energy radiation. Studies of low energy particle radiation help us to understand the chemistry induced by high energy radiations. Low energy electrons are capable of chemical selectivity in contrast to high energy electrons due to the large number of open dissociative channels in the former case and their resonant nature. Among different types of radiation, low energy electrons have a higher cross-section to DNA damage and they have an important role in the synergistic effect between radiation and chemotherapy anticancer agents in cancer treatment. Analysis of these combined records helps assign function of cells, identify metabolic and regulatory pathways and suggest targets for diagnostics and therapeutics identify animal models to develop new drugs, among other goals of biomedical interest.

scholarly journals Symmetric and triangle-shaped variability of blazars

2014 ◽  
Vol 10 (S313) ◽  
pp. 97-98
Author(s):  
Kenji Yoshida
Keyword(s):  
Gamma Ray ◽  
High Energy ◽  
Low Energy ◽  
Light Curves ◽  
X Ray ◽  
High Energy Electrons ◽  
Flux Variability ◽  
Low Energy Electrons ◽  
Flux Increase ◽  
Rise Phase

AbstractSymmetric and triangle-shaped flux variability in X-ray and gamma-ray light curves is observed from many blazars. We derived the X-ray spectrum changing in time by using a kinetic equation of high energy electrons. Giving linearly changing the injection of low energy electrons into accelerating and emitting region, we obtained the preliminary results that represent the characteristic X-ray variability of the linear flux increase with hardening in the rise phase and the linear decrease with softening in the decay phase.

On Lensless Imaging of Organics with Neutrons, X-Rays, Helium Atoms and Low Energy Electrons: Damage and Iterative Phase Retrieval

2001 ◽  
Vol 7 (S2) ◽  
pp. 268-269
Author(s):  
J.C.H. Spence ◽  
U. Weierstall ◽  
J. Fries
Keyword(s):  
Phase Retrieval ◽  
Iterative Algorithms ◽  
High Energy ◽  
Low Energy ◽  
X Rays ◽  
Noise Sources ◽  
Helium Atoms ◽  
High Energy Electrons ◽  
Elastic Event ◽  
Low Energy Electrons

Recent experiments with X-rays and high energy electrons have shown that image recovery from diffracted intensities is possible for non-periodic objects using iterative algorithms. Application of these methods to biological molecules raises the crucial problem of radiation damage, which may be quantified by Q = ΔE σi/σe, the amount of energy deposited by inelastic events per elastic event. Neutrons, helium atoms and low energy electrons below most ionization thresholds produce the smallest values of Q (see for TMV imaged at 60 eV). For neutrons (λ = 10-2Å, and deuterated, 15N-abelled molecules) Q is ∼3000 times smaller (∼50 times for λ = 1.8Å) than for electrons (80- 500keV) and about 4x 106 times smaller than for soft X-rays (1.5Å). Since σe for neutrons is about 105 times smaller than for electrons (and about 10 times smaller than for soft X-rays), a 105 times higher neutron dose is required to obtain the same S/N in a phase contrast image compared with electrons, if other noise sources are absent.

The Exploitation of Low-Energy Electrons in Cancer Treatment

2017 ◽  
Vol 188 (2) ◽  
pp. 123-143 ◽  
Author(s):  
Mohammad Rezaee ◽  
Richard P. Hill ◽  
David A. Jaffray
Keyword(s):  
Cancer Treatment ◽  
Low Energy ◽  
Low Energy Electrons

Deformation of cube-textured aluminum studied using laser-induced photoelectron emission

2007 ◽  
Vol 22 (9) ◽  
pp. 2582-2589 ◽  
Author(s):  
M. Cai ◽  
S.C. Langford ◽  
J.T. Dickinson ◽  
L.E. Levine
Keyword(s):  
Kinetic Energy ◽  
Energy Distribution ◽  
Tensile Deformation ◽  
High Energy ◽  
Field Energy ◽  
Electron Backscattered Diffraction ◽  
Grain Rotation ◽  
High Energy Electrons ◽  
Low Energy Electrons ◽  
Major Surface

The evolution of the kinetic energy distribution of photoelectrons from a cube-oriented aluminum sample during tensile deformation was probed with a retarding field energy analyzer. Because of the anisotropy of the aluminum work function, the electron-energy distribution is altered as the area fractions of the major surface planes change during deformation. In cube-textured aluminum, deformation reduces the {100} area fraction and the relatively low energy electrons from these surfaces. Conversely, the {110} and {111} area fractions and the relatively high energy electrons from these surfaces both increase. These changes are quantitatively consistent with texture analysis by electron backscattered diffraction (EBSD). They reflect deformation-induced production of {111} surfaces by slip and the exposure of {110} surfaces by grain rotation. Photoelectron kinetic energy measurements supplement EBSD measurements and are readily acquired in real-time.

The role of low-energy electrons in the high-energy radiolysis of condensed CF3I

2010 ◽  
Vol 22 (8) ◽  
pp. 084006 ◽  
Author(s):  
Mahesh Rajappan ◽  
Lin L Zhu ◽  
Jizhou Wang ◽  
Graeme Gardner ◽  
Kevin Bu ◽  
...  
Keyword(s):  
High Energy ◽  
Low Energy ◽  
Low Energy Electrons

scholarly journals Can Low-Energy Electrons Affect High-Energy Physics Accelerators?

2004 ◽  
Vol 93 (1) ◽  
Author(s):  
R. Cimino ◽  
I. R. Collins ◽  
M. A. Furman ◽  
M. Pivi ◽  
F. Ruggiero ◽  
...  
Keyword(s):  
High Energy Physics ◽  
High Energy ◽  
Low Energy ◽  
Low Energy Electrons ◽  
Energy Physics

scholarly journals The Role of Low-Energy Electron Interactions in cis-Pt(CO)2Br2 Fragmentation

2021 ◽  
Vol 22 (16) ◽  
pp. 8984
Author(s):  
Maicol Cipriani ◽  
Styrmir Svavarsson ◽  
Filipe Ferreira da Silva ◽  
Hang Lu ◽  
Lisa McElwee-White ◽  
...  
Keyword(s):  
Coordination Compound ◽  
Electron Attachment ◽  
High Energy ◽  
Low Energy ◽  
Carbonyl Complexes ◽  
Secondary Electrons ◽  
High Energy Radiation ◽  
Low Energy Electrons ◽  
In Cis

Platinum coordination complexes have found wide applications as chemotherapeutic anticancer drugs in synchronous combination with radiation (chemoradiation) as well as precursors in focused electron beam induced deposition (FEBID) for nano-scale fabrication. In both applications, low-energy electrons (LEE) play an important role with regard to the fragmentation pathways. In the former case, the high-energy radiation applied creates an abundance of reactive photo- and secondary electrons that determine the reaction paths of the respective radiation sensitizers. In the latter case, low-energy secondary electrons determine the deposition chemistry. In this contribution, we present a combined experimental and theoretical study on the role of LEE interactions in the fragmentation of the Pt(II) coordination compound cis-PtBr2(CO)2. We discuss our results in conjunction with the widely used cancer therapeutic Pt(II) coordination compound cis-Pt(NH3)2Cl2 (cisplatin) and the carbonyl analog Pt(CO)2Cl2, and we show that efficient CO loss through dissociative electron attachment dominates the reactivity of these carbonyl complexes with low-energy electrons, while halogen loss through DEA dominates the reactivity of cis-Pt(NH3)2Cl2.

An Overview of Privileged Scaffold: Quinolines and Isoquinolines in Medicinal Chemistry as Anticancer Agents

2020 ◽  
Vol 20 (28) ◽  
pp. 2599-2633
Author(s):  
Yanna Mao ◽  
Kunjal Soni ◽  
Chetan Sangani ◽  
Yongfang Yao
Keyword(s):  
Cancer Treatment ◽  
Anticancer Agents ◽  
Causes Of Death ◽  
Antitumor Agents ◽  
Antitumor Agent ◽  
New Drugs ◽  
Current Scenario ◽  
Anticancer Treatment ◽  
Privileged Scaffold ◽  
Isoquinoline Derivatives

: Cancer is one of the most difficult diseases and causes of death for many decades. Many pieces of research are continuously going on to get a solution for cancer. Quinoline and isoquinoline derivatives have shown their possibilities to work as an antitumor agent in anticancer treatment. The members of this privileged scaffold quinoline and isoquinoline have shown their controlling impacts on cancer treatment through various modes. In particular, this review suggests the current scenario of quinoline and isoquinoline derivatives as antitumor agents and refine the path of these derivatives to find and develop new drugs against an evil known as cancer.

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