Role of Serum C-Reactive Protein Levels in Diagnosis of Acute Appendicitis

Background. The new coronavirus SARS-CoV-2, responsible for the Covid-19 pandemic, uses the angiotensin converting enzyme type 2 (ACE2), a physiological inhibitor of the renin angiotensin aldosterone system (RAAS), as a cellular receptor to infect cells. Since the RAAS can induce and modulate pro-inflammatory responses, it could play a key role in the pathophysiology of Covid-19. Thus, we aimed to determine the levels of plasma renin and aldosterone as indicators of RAAS activation in a series of consecutively admitted patients for Covid-19 in our clinic. Methods. Plasma renin and aldosterone levels were measured, among the miscellaneous investigations needed for Covid-19 management, early after admission in our clinic. Disease severity was assessed using a seven-category ordinal scale. Primary outcome of interest was the severity of patients’ clinical courses. Results. Forty-four patients were included. At inclusion, 12 patients had mild clinical status, 25 moderate clinical status and 7 severe clinical status. In univariate analyses, aldosterone and C-reactive protein (CRP) levels at inclusion were significantly higher in patients with severe clinical course as compared to those with mild or moderate course (p < 0.01 and p = 0.03, respectively). In multivariate analyses, only aldosterone and CRP levels remained positively associated with severity. We also observed a positive significant correlation between aldosterone and CRP levels among patients with an aldosterone level greater than 102.5 pmol/L. Conclusions. Both plasmatic aldosterone and CRP levels at inclusion are associated with the clinical course of Covid-19. Our findings may open new perspectives in the understanding of the possible role of RAAS for Covid-19 outcome.

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The role of high-sensitivity C-reactive protein levels in functional outcomes in patients with large-artery atherosclerosis and small-artery occlusion

Neurological Research ◽

10.1080/01616412.2017.1358937 ◽

2017 ◽

Vol 39 (11) ◽

pp. 981-987 ◽

Cited By ~ 8

Author(s):

Dongzhe Hou ◽

Ji Liu ◽

Ren Feng ◽

Yuan Gao ◽

Yajing Wang ◽

...

Keyword(s):

Functional Outcomes ◽

High Sensitivity ◽

Artery Occlusion ◽

Large Artery ◽

C Reactive Protein ◽

Small Artery ◽

Protein Levels ◽

Reactive Protein ◽

Small Artery Occlusion

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Role Of Total Leukocyte Count, Neutrophil Percentage, C-Reactive Protein And Ultrasonography In The Diagnosis Of Acute Appendicitis.

The Internet Journal of Surgery ◽

10.5580/18b ◽

2010 ◽

Vol 24 (1) ◽

Cited By ~ 1

Keyword(s):

Acute Appendicitis ◽

Leukocyte Count ◽

Total Leukocyte Count ◽

C Reactive Protein ◽

Reactive Protein ◽

Neutrophil Percentage

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Role of Plasma Presepsin, Procalcitonin and C-reactive Protein Levels in Determining the Severity and Mortality of Community-Acquired Pneumonia in the Emergency Department

10.22514/sv.2020.16.0034 ◽

2020 ◽

Keyword(s):

Emergency Department ◽

Community Acquired Pneumonia ◽

C Reactive Protein ◽

Pneumonia Severity ◽

Protein Levels ◽

Reactive Protein ◽

Imaging Results ◽

Severity Scores ◽

Significant Difference

Objective: In this study, we aimed to explore the role of the plasma presepsin level in patients with community-acquired pneumonia during admission to the emergency department in assessing the diagnosis, severity, and prognosis of the disease. In addition, we wanted to investigate the relationship of presepsinin with procalcitonin, C-reactive protein and pneumonia severity scores. Methods: One hundred twenty-three patients over the age of 18 who presented with a diagnosis of pneumonia to the emergency department were included in the study. The vital signs, symptoms, examination findings, background information, laboratory results, and radiological imaging results of the patients were recorded. The 30-day mortality rates of the patients were determined. Results: A statistically significant difference was found between the presepsin levels of the patients diagnosed with pneumonia and those of healthy subjects (p < 0.05). The plasma presepsin levels of the patients who died (8.63 ± 6.46) were significantly higher than those of the patients who lived (5.82 ± 5.97) (p < 0.05). The plasma procalcitonin and C-reactive protein levels of the dead patients were significantly higher than those living (p < 0.05). A presepsin cut-off value of 3.3 ng/mL for 30-day mortality was established (AUROC, 0.65; specificity, 45%; sensitivity, 82%). Procalcitonin is the most successful biomarker in the determination of mortality (AUROC, 0.70). A significant correlation was available between presepsin and lactate, C-reactive protein and procalcitonin (p < 0.05). There was a significant correlation between the Pneumonia Severity Index values and presepsin levels (p < 0.001, r = 0.311). Conclusion: The plasma presepsin level can be utilized for diagnosing community-acquired pneumonia. Plasma presepsin, procalcitonin and C-reactive protein levels can be used to predict the severity and mortality of community-acquired pneumonia.

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Role Of C-Reactive Protein in Diagnosis of Acute Appendicitis

Journal of Islamabad Medical & Dental College ◽

10.35787/jimdc.v10i4.660 ◽

2021 ◽

Vol 10 (4) ◽

pp. 210-214

Author(s):

Mirza Tassawar Hussain ◽

Muhammad Kashif Khan ◽

Syed Shamsuddin ◽

Aabid Ali ◽

Erum Khan ◽

...

Keyword(s):

Acute Appendicitis ◽

Correct Diagnosis ◽

C Reactive Protein ◽

Diagnostic Dilemma ◽

Senior Registrar ◽

Predictive Values ◽

Reactive Protein ◽

Highly Sensitive ◽

Sensitivity Specificity

Background: Appendicitis is a common surgical emergency and diagnostic dilemma. Making the correct diagnosis is often difficult as the clinical presentation varies according to the age of the patient and the position of appendix. The objective of this study was to identify clinical applicability of C- reactive protein, as a diagnostic test for appendicitis. Methods: This prospective study was carried out in Federal government Polyclinic hospital, Islamabad from January to July 2019, 114 patients underwent appendectomy for clinically diagnosed acute appendicitis. The decision to operate the patient was given by senior registrar. The blood samples for C-reactive protein were drawn before taking the patient to the operating theatre. Removed appendices were sent for histopathological confirmation of diagnosis. The C-reactive protein was then compared with the results of histopathology to determine its validity. The data was entered and analysed in SPSS 23. Results: The sensitivity, specificity, positive and negative predictive values of C-reactive protein in patients with clinical diagnosis of acute appendicitis were found to be 94%, 78%, 93% and 74 % respectively. Conclusion: CRP is helpful in making diagnosis of acute appendicitis. It is highly sensitive but has a relatively low specificity.

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