scholarly journals Effect of Natural Polyphenols on Reactive Oxygen Species in Patients with Myocardial Infarction: A Double Blind Placebo Controlled Trial

Author(s):  
Dr Rahul Goyal ◽  
1995 ◽  
Vol 64 (4) ◽  
pp. 825-831 ◽  
Author(s):  
Efrossini Kessopoulou ◽  
Hillary J. Powers ◽  
Khawam K. Sharma ◽  
Michael J. Pearson ◽  
Jean M. Russell ◽  
...  

Nutrients ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 101 ◽  
Author(s):  
Seunghee Kang ◽  
Yeni Lim ◽  
You Jin Kim ◽  
Eun Sung Jung ◽  
Dong Ho Suh ◽  
...  

Phytonutrients and vitamin and mineral supplementation have been reported to provide increased antioxidant capacity in humans; however, there is still controversy. In the current clinical trial, we examined the antioxidant and DNA protection capacity of a plant-based, multi-vitamin/mineral, and phytonutrient (PMP) supplementation in healthy adults who were habitually low in the consumption of fruits and vegetables. This study was an eight-week, double-blind, randomized, parallel-arm, and placebo-controlled trial. PMP supplementation for eight weeks reduced reactive oxygen species (ROS) and prevented DNA damage without altering endogenous antioxidant system. Plasma vitamins and phytonutrients were significantly correlated with ROS scavenging and DNA damage. In addition, gene expression analysis in PBMC showed subtle changes in superoxide metabolic processes. In this study, we showed that supplementation with a PMP significantly improved ROS scavenging activity and prevented DNA damage. However, additional research is still needed to further identify mechanisms of actions and the role of circulating phytonutrient metabolites.


Author(s):  
Awal Prasetyo ◽  
Resti Ariani ◽  
Arlita Leniseptaria Antari ◽  
Udadi Sadhana ◽  
Ika Pawitra Miranti ◽  
...  

<strong>Background</strong><br />Poor air and mask quality in the work environment increase the risks of inflammation, reactive oxygen species (ROS) production, ongoing oxidative stress, and superoxide dismutase 3 (SOD3) levels in the airways. The study aimed to investigate the effect of the Nephrolepis exaltata - Hibiscus rosa-sinensis (NE-HRS) combination herbal mask on the airways, as measured by ROS and SOD3 levels in the nasal wash of textile industry workers.<br /><br /><strong>Methods</strong><br />This was a pre- and post-test randomized controlled trial, consisting of 30 subjects with ³5-year working time, conducted for eight weeks and monitored every ten days. Subjects were randomized into 3 groups, regular surgical mask group (n=10), NE-HRS combination herbal mask group (n=10) and factory mask group (n=10). SOD3 and ROS levels were determined using ELISA. Data were analyzed with One-way ANOVA and multiple comparison tests.<br /><br /><strong>Results</strong> <br />ROS levels decreased significantly in all groups (p=0.004). Regular surgical masks decreased ROS levels by 67.90 ± 50.66 pg/mL, NE-HRS combination herbal masks by 49.91 ± 45.06 pg/mL, and factory masks by 193.96 ± 128.36 pg/ml. SOD3 levels also decreased but not significantly (p=0.053). Differences in ROS levels between surgical mask and NE-HRS combination herbal mask was not significant (p=0.796). <br /><br /><strong>Conclusion</strong><br />Herbal masks laminated with NE-HRS combination significantly reduced ROS levels among textile industry workers. NE-HRS combination herbal masks have a similar protective effect to the regular surgical mask.


2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Maria C Rubio ◽  
Susana Puntarulo ◽  
Paula Gonzalez ◽  
Cecilia Ramos ◽  
Pablo Lewin ◽  
...  

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