scholarly journals Nephrolepis exaltata - Hibiscus rosa-sinensis combination herbal mask decreases levels of reactive oxygen species in nasal wash

2020 ◽  
Vol 39 (3) ◽  
pp. 184
Author(s):  
Awal Prasetyo ◽  
Resti Ariani ◽  
Arlita Leniseptaria Antari ◽  
Udadi Sadhana ◽  
Ika Pawitra Miranti ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Textile Industry ◽  
Controlled Trial ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Nasal Wash ◽  
Hibiscus Rosa Sinensis ◽  
Surgical Masks ◽  
Post Test ◽  
Superoxide Dismutase 3

<strong>Background</strong><br />Poor air and mask quality in the work environment increase the risks of inflammation, reactive oxygen species (ROS) production, ongoing oxidative stress, and superoxide dismutase 3 (SOD3) levels in the airways. The study aimed to investigate the effect of the Nephrolepis exaltata - Hibiscus rosa-sinensis (NE-HRS) combination herbal mask on the airways, as measured by ROS and SOD3 levels in the nasal wash of textile industry workers.<br /><br /><strong>Methods</strong><br />This was a pre- and post-test randomized controlled trial, consisting of 30 subjects with ³5-year working time, conducted for eight weeks and monitored every ten days. Subjects were randomized into 3 groups, regular surgical mask group (n=10), NE-HRS combination herbal mask group (n=10) and factory mask group (n=10). SOD3 and ROS levels were determined using ELISA. Data were analyzed with One-way ANOVA and multiple comparison tests.<br /><br /><strong>Results</strong> <br />ROS levels decreased significantly in all groups (p=0.004). Regular surgical masks decreased ROS levels by 67.90 ± 50.66 pg/mL, NE-HRS combination herbal masks by 49.91 ± 45.06 pg/mL, and factory masks by 193.96 ± 128.36 pg/ml. SOD3 levels also decreased but not significantly (p=0.053). Differences in ROS levels between surgical mask and NE-HRS combination herbal mask was not significant (p=0.796). <br /><br /><strong>Conclusion</strong><br />Herbal masks laminated with NE-HRS combination significantly reduced ROS levels among textile industry workers. NE-HRS combination herbal masks have a similar protective effect to the regular surgical mask.

scholarly journals Trend Analysis of Superoxide Dismutase 3 (SOD3) and Reactive Oxygen Species (ROS) levels on BioSmart and Safe Bus Passengers

2021 ◽  
Vol 14 (34) ◽  
pp. 2751-2760
Author(s):  
A R Hairul Asri ◽  
◽  
Awal Prasetyo ◽  
Udadi Sadhana ◽  
Arlita Leniseptaria Antari ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Superoxide Dismutase ◽  
Trend Analysis ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Superoxide Dismutase 3

A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility*†

1995 ◽  
Vol 64 (4) ◽  
pp. 825-831 ◽  
Author(s):  
Efrossini Kessopoulou ◽  
Hillary J. Powers ◽  
Khawam K. Sharma ◽  
Michael J. Pearson ◽  
Jean M. Russell ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Vitamin E ◽  
Male Infertility ◽  
Controlled Trial ◽  
Reactive Oxygen ◽  
Antioxidant Vitamin ◽  
Oxygen Species ◽  
Double Blind

scholarly journals Pengaruh Tomat (Solanum lycopersicum) terhadap Diameter Tubulus Seminiferus Tikus Putih (Rattus norvegicus) Galur Sprague dawley yang Diinduksi Gentamisin

2019 ◽  
Vol 5 (01) ◽  
pp. 38-42
Author(s):  
Fahmi Ikhtiar
Keyword(s):  
Reactive Oxygen Species ◽  
Solanum Lycopersicum ◽  
Rattus Norvegicus ◽  
Reactive Oxygen ◽  
Control Group ◽  
Oxygen Species ◽  
Sprague Dawley ◽  
Control Group Design ◽  
Group Design ◽  
Post Test

Gentamisin adalah salah satu antibiotik golongan aminoglikosida yang efektif melawan bakteri gram negatif. Gentamisin memiliki efek samping terhadap testis. Gentamisin dapat meningkatkan jumlah Reactive Oxygen Species (ROS) yaitu suatu radikal bebas yang dapat memicu stres oksidatif dalam testis. Hal ini berbahaya bagi kesuburan pria dan meningkatkan risiko infertilitas. Kadar ROS yang tinggi dapat dinetralkan menggunakan antioksidan. Salah satu antioksidan tersebut adalah likopen yang banyak terkandung didalam tomat. Tujuan penelitian ini untuk mengetahui pengaruh tomat terhadap diameter tubulus seminiferus tikus putih Rattus norvegicus yang diinduksi gentamisin. Jenis penelitian ini adalah eksperimental dengan desain post test only control group design. Penelitian menggunakan 25 ekor tikus putih yang dibagi dalam 5 kelompok dengan lima kali pengulangan. Kelompok terdiri dari kelompok K(-) yang tidak diberikan apapun, kelompok K(+) yang diberikan gentamisin 20 mg/kgBB, dan kelompok P1, P2, P3 yang diberikan gentamisin 20 mg/kgBB dan jus tomat masing-masing persentasi 25%, 50%, dan 100%. Penelitian dilakukan selama 24 hari. Berdasarkan hasil penelitian, terjadi peningkatan diameter tubulus seminiferus setelah diberikan jus tomat selama 24 hari.

scholarly journals Multivitamin and Mineral Supplementation Containing Phytonutrients Scavenges Reactive Oxygen Species in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Trial

Nutrients ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 101 ◽  
Author(s):  
Seunghee Kang ◽  
Yeni Lim ◽  
You Jin Kim ◽  
Eun Sung Jung ◽  
Dong Ho Suh ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Dna Damage ◽  
Fruits And Vegetables ◽  
Controlled Trial ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Ros Scavenging ◽  
Double Blind ◽  
Mineral Supplementation ◽  
Endogenous Antioxidant

Phytonutrients and vitamin and mineral supplementation have been reported to provide increased antioxidant capacity in humans; however, there is still controversy. In the current clinical trial, we examined the antioxidant and DNA protection capacity of a plant-based, multi-vitamin/mineral, and phytonutrient (PMP) supplementation in healthy adults who were habitually low in the consumption of fruits and vegetables. This study was an eight-week, double-blind, randomized, parallel-arm, and placebo-controlled trial. PMP supplementation for eight weeks reduced reactive oxygen species (ROS) and prevented DNA damage without altering endogenous antioxidant system. Plasma vitamins and phytonutrients were significantly correlated with ROS scavenging and DNA damage. In addition, gene expression analysis in PBMC showed subtle changes in superoxide metabolic processes. In this study, we showed that supplementation with a PMP significantly improved ROS scavenging activity and prevented DNA damage. However, additional research is still needed to further identify mechanisms of actions and the role of circulating phytonutrient metabolites.

scholarly journals PEMBERIAN EKSTRAK RUMPUT KEBAR (Biophytum petersianum Klotszch) TERHADAP VIABILITAS SPERMATOZOA MENCIT (Mus musculus) DIABETES MELITUS

2021 ◽  
Vol 4 (1) ◽  
pp. 26
Author(s):  
Prima Arundani ◽  
Reny I'tishom ◽  
Bambang Purwanto
Keyword(s):  
Diabetes Mellitus ◽  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Control Group ◽  
Oxygen Species ◽  
Control Group Design ◽  
Group Design ◽  
Biophytum Petersianum ◽  
Post Test ◽  
Diabetes Melitus

<p>Diabetes mellitus yang tidak ditangani dengan baik akan mengakibatkan infertilitas yang disebabkan oleh adanya kerusakan salah satu organ reproduksi yaitu testis. Hiperglikemia atau tingginya kadar gula dalam darah berperan dalam kerusakan sel dengan cara peningkatan <em>reactive oxygen spescies</em> (ROS) sehingga terjadi stres oksidatif jaringan yang mengakibatkan radikal hidroksil. Peningkatan <em>Reactive Oxygen Species </em>(ROS) menyebabkan cedera sel melalui mekanisme peroksidasi lipid dan kerusakan oksidatif protein serta DNA. Proses lipid periksidase pada akhirnya merusak membran spermatozoa dan mitokondria DNA sehingga menyebabkan penurunan kualitas spermatozoa.</p><p><strong>          </strong>Penelitian ini bertujuan mengetahui efek ekstrak rumput kebar terhadap viabilitas spermatozoa mencit jantan (<em>Musmusculus) </em>model diabetes melitus<em>. </em>Penelitian ini merupakan penelitian eksperimental dengan rancangan <em>post test only control group design</em>. Ekstrak rumput kebar menggunakan metode maserasi dengan pelarut etanol 96%. Sebanyak 30 ekor mencit yang dibagi ke dalam 5 kelompok, yaitu kelompok kontrol negatif yaitu mencit diabates mellitus yang di sonde cmc na, kelompok kontrol positif yaitu mencit diabetes mellitus yang di sonde metformin, kelompok I, II, dan III yang di sonde ekstrak rumput kebar dengan dosis 67,5; 130; dan 270 mg/kg BB. Viabilitas spermatozoa dianalisis dengan mengambil sampel spermatozoa dari kauda epididimis.</p><p>Hasil uji Kruskal Wallis menunjukkan hasil yang signifikan p = 0,005 (p ˂ 0,05) pada viabilitas spermatozoa mencit diabetes mellitus dan perbedaan yang bermakna pada kelompok kontrol negatif  mencit dengan diabetes mellitus dengan kelompok perlakuan 3 yang diberi metformin dan ekstrak rumput kebar dosis 270 mg/kg BB. viabilitas spermatozoa pada kelompok kontrol negatif memiliki persentase terendah sedangkan pada kelompok perlakuan 3 memiliki persentase tertinggi. Simpulan penelitian ini adalah ekstrak rumput kebar (<em>Biophytum petersianum </em>Klotzsch) meningkatkan viabilitas spermatozoa mencit (<em>Mus </em>musculus) model diabetes melitus.</p><p> </p>

Mitochondria as a source of reactive oxygen species

2009 ◽  
pp. c3 ◽  
Author(s):  
Helena M. Cochemé ◽  
Michael P. Murphy
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species

Clinical aspects of reactive oxygen and nitrogen species

2004 ◽  
Vol 71 ◽  
pp. 121-133 ◽  
Author(s):  
Ascan Warnholtz ◽  
Maria Wendt ◽  
Michael August ◽  
Thomas Münzel
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Risk Factor ◽  
Endothelial Dysfunction ◽  
Vascular Tissue ◽  
Rapid Development ◽  
Reactive Oxygen ◽  
Clinical Aspects ◽  
No Production ◽  
Oxygen Species

Endothelial dysfunction in the setting of cardiovascular risk factors, such as hypercholesterolaemia, hypertension, diabetes mellitus and chronic smoking, as well as in the setting of heart failure, has been shown to be at least partly dependent on the production of reactive oxygen species in endothelial and/or smooth muscle cells and the adventitia, and the subsequent decrease in vascular bioavailability of NO. Superoxide-producing enzymes involved in increased oxidative stress within vascular tissue include NAD(P)H-oxidase, xanthine oxidase and endothelial nitric oxide synthase in an uncoupled state. Recent studies indicate that endothelial dysfunction of peripheral and coronary resistance and conductance vessels represents a strong and independent risk factor for future cardiovascular events. Ways to reduce endothelial dysfunction include risk-factor modification and treatment with substances that have been shown to reduce oxidative stress and, simultaneously, to stimulate endothelial NO production, such as inhibitors of angiotensin-converting enzyme or the statins. In contrast, in conditions where increased production of reactive oxygen species, such as superoxide, in vascular tissue is established, treatment with NO, e.g. via administration of nitroglycerin, results in a rapid development of endothelial dysfunction, which may worsen the prognosis in patients with established coronary artery disease.

Fas ligand expression in rat kupffer cells in response to lipopolysaccharide is mediated by reactive oxygen species

2001 ◽  
Vol 120 (5) ◽  
pp. A361-A361
Author(s):  
K UCHIKURA ◽  
T WADA ◽  
Z SUN ◽  
S HOSHINO ◽  
G BULKLEY ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Kupffer Cells ◽  
Fas Ligand ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Ligand Expression
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