Indicators of endogenous intoxication and lipid peroxidation in the dynamics of treatment with α-lipoic acid in men with diabetic nephropathy at the stage of microalbuminuria

Nephrology ◽  
2021 ◽  
Vol 3_2021 ◽  
pp. 38-43
Author(s):  
M.A. Darenskaya Darenskaya ◽  
E.V. Chugunova Chugunova ◽  
S.I. Kolesnikov Kolesnikov ◽  
L.A. Grebenkina Grebenkina ◽  
N.V. Semenova Semenova ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Diabetic Nephropathy ◽  
Lipoic Acid ◽  
Endogenous Intoxication

N2L, a novel lipoic acid-niacin dimer, attenuates ferroptosis and decreases lipid peroxidation in HT22 cells

2021 ◽  
Author(s):  
Weijia Peng ◽  
Zeyu Zhu ◽  
Yang Yang ◽  
Jiawei Hou ◽  
Junfeng Lu ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Lipoic Acid ◽  
Ht22 Cells

scholarly journals Protective effect of alpha lipoic acid on diabetic nephropathy in rats

2019 ◽  
Vol 20 (3) ◽  
pp. 19-23
Author(s):  
Samar Yabes ◽  
Mohamed EL-Adl ◽  
Mohamed Hamed ◽  
Gehad El-Sayed
Keyword(s):  
Diabetic Nephropathy ◽  
Lipoic Acid ◽  
Nitrosative Stress ◽  
Acid Group ◽  
Controlled Study ◽  
Alpha Lipoic Acid ◽  
Sprague Dawley ◽  
Glycemic Status ◽  
Oxidative And Nitrosative Stress ◽  
Tissue Samples

Objective: To evaluate the protective role of alpha lipoic acid in rats affected with experimentally-induced diabetes and secondarily complicated with nephropathy. Design: Randomized controlled study. Animals: Forty-eight Sprague Dawley rats. Procedures: Rats were allocated randomly into four groups (12 each); Control rats (Group 1); alpha lipoic acid (ALA) supplemented rats (Group 2); rats with induced diabetic nephropathy (Group 3), and rats with diabetic nephropathy and supplemented with alpha lipoic acid (Group 4). After one month of experimental induction, serum, plasma and renal tissue samples were harvested to determine glycemic status, renal damage markers, antioxidant status, oxidative and nitrosative stress markers, apoptotic marker and histopathology of kidney tissues. Results: In comparison with non-supplemented diabetic rats, alpha lipoic acid reduced renal malondialdehyde (5.74± 0.26 vs 11.3± 1.96 nmol/g. tissue) and renal nitric oxide (30.06± 2.07 vs 36.6± 1.07 nmol/g. tissue). ALA significantly improved the antioxidant enzyme activity (catalase and reduced glutathione), glycemic status, and decreased caspase 3 concentration (P<0.05). Conclusion and clinical relevance: Alpha lipoic acid may be an alternative intervention to alleviate nephropathy as a complication of diabetes. Further studies need to be done in naturally occurring cases.

Behavioral and neurochemical effects of alpha lipoic acid associated with omega-3 in tardive dyskinesia induced by chronic haloperidol in rats

2017 ◽  
Vol 95 (7) ◽  
pp. 837-843 ◽  
Author(s):  
Dayane Pessoa de Araújo ◽  
Thaisa Gracielle Martins Camboim ◽  
Ana Patrícia Magalhães Silva ◽  
Caio da Fonseca Silva ◽  
Rebeca Canuto de Sousa ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Tardive Dyskinesia ◽  
Open Field ◽  
Field Test ◽  
Lipoic Acid ◽  
Open Field Test ◽  
Male Rats ◽  
Omega 3 ◽  
Orofacial Dyskinesia ◽  
Chronic Use

Tardive dyskinesia (TD) is characterized by involuntary movements of the lower portion of the face being related to typical antipsychotic therapy. TD is associated with the oxidative imbalance in the basal ganglia. Lipoic acid (LA) and omega-3 (ω-3) are antioxidants acting as enzyme cofactors, regenerating antioxidant enzymes. This study aimed to investigate behavioral and neurochemical effects of supplementation with LA (100 mg/kg) and ω-3 (1 g/kg) in the treatment of TD induced by chronic use of haloperidol (HAL) (1 mg/kg) in rats. Wistar male rats were used, weighing between 180–200 g. The animals were treated chronically (31 days) with LA alone or associated with HAL or ω-3. Motor behavior was assessed by open-field test, the catalepsy test, and evaluation of orofacial dyskinesia. Oxidative stress was accessed by determination of lipid peroxidation and concentration of nitrite. LA and ω-3 alone or associated caused an improvement in motor performance by increasing locomotor activity in the open-field test and decreased the permanence time on the bar in the catalepsy test and decreased the orofacial dyskinesia. LA and ω-3 showed antioxidant effects, decreasing lipid peroxidation and nitrite levels. Thus, the use of LA associated with ω-3 reduced the extrapyramidal effects produced by chronic use of HAL.

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