Introduction. Melkersson-Rosenthal syndrome is a rare disease of unknown
etiology. Histopathologically, it presents as granulomatous cheilitis. From
laboratory aspect, it is a nonspecific, differential diagnostically and
therapeutically complex condition. Case Report. This is a report of six cases
treated at the Department of Allergology and Immunology of the Clinical
Center of Serbia, who had presented with the referral diagnosis of recurring
or persistent lip edema, and who were diagnosed with Melkersson-Rosenthal
syndrome upon detailed evaluation. Three patients had complete triad of
symptoms, two had the oligosymptomatic form and one manifested the
monosymptomatic form of the disease. Histopathological findings of the oral
mucosa specimens verified the presence of non-necrotic epithelioid granulomas
in all patients. The patients were treated with the H1 and H2 antihistamines,
corticosteroids, followed by anabolic drugs and antibiotics, resulting in
transient and unfavorable effects. Conclusion. In differential diagnosis,
Melkersson-Rosenthal syndrome diagnosis primarily refers to conditions of
angioneurotic edema and hereditary angioedema, as well as granulomatous
diseases such as sarcoidosis, tuberculosis and Chron?s disease. It is
necessary to follow-up these patients in view of monitoring the effects of
the therapy and possible development of systemic granulomatous diseases.
Chondroid syringoma of the upper lip: a rare entity
