scholarly journals The Correlation of Serum Total Testosterone, Sex Hormone Binding Globulin and Free Androgen Index with Athens Insomnia Scale Score in Polycystic Ovary Syndrome

2018 ◽  
Vol 10 (1) ◽  
pp. 46
Author(s):  
Hartanto Bayuaji ◽  
Heda Melinda Nazaruddin Nataprawira ◽  
Herri Suhari Sastramihardja
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Sleep Disturbance ◽  
Testosterone Level ◽  
Polycystic Ovary ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Hormone Binding ◽  
Ovary Syndrome ◽  
Free Androgen Index ◽  
Athens Insomnia Scale

BACKGROUND: Polycystic ovary syndrome (PCOS), a common reproductive endocrinologic disorder in woman, was considered to be related to sleep disturbance. This study is aimed to analyze the correlation between excess androgen markers and Athens Insomnia Scale (AIS) in PCOS.METHODS: This observational, cross-sectional study of PCOS was conducted to 31 subjects to evaluate the correlation between serum total testosterone, sex hormone binding globulin (SHBG) and free androgen index with the incidence of sleep disturbance using AIS. Sleep disturbance was present if the score ≥6. The correlation between excess androgen markers and sleep disturbance was analyzed using Pearson’s coefficient of correlation or Spearman’s rho test. Correlation coefficient more than 0.5 with p<0.05 was considered significant.RESULTS: Out of 31 PCOS subjects aged 20-40 years, 39% subjects had AIS score ≥6. Mean serum testosterone in AIS score >6 group was higher than AIS score <6 group but not statistically significant (46.68 vs. 28.49 ng/mL, p>0.05). No significant correlation was found between serum total testosterone, SHBG and free androgen index with AIS score. After adjusting for AIS score, there was the moderate positive correlation between serum total testosterone level although not statistically significant (r=0.54, p=0.07).CONCLUSION: The serum total testosterone level might influence the occurrence of sleep disturbance in PCOS.KEYWORDS: PCOS, androgen excess, testosterone, sleep disturbance, Athens Insomnia Scale

scholarly journals The synergistic effect of sex hormone-binding globulin and aromatase genes on polycystic ovary syndrome phenotype.

2008 ◽  
Vol 158 (6) ◽  
pp. 861-865 ◽  
Author(s):  
Nectaria Xita ◽  
Ioannis Georgiou ◽  
Leandros Lazaros ◽  
Vasiliki Psofaki ◽  
George Kolios ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Sex Hormone ◽  
The Body ◽  
Reproductive Age ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Aromatase Activity ◽  
Hormone Binding ◽  
Ovary Syndrome

ObjectiveExperimental evidence suggests that fetal exposure to androgen excess may program the development of polycystic ovary syndrome (PCOS) in utero. The aim of this study was to examine whether the sex hormone binding globulin (SHBG)(TAAAA)n and the cytochrome P450, family 19 (CYP19)(TTTA)n polymorphisms, known to influence sex hormone-binding globulin (SHBG) levels and aromatase activity respectively, play a synergistic role in the development of PCOS.Design and methodsWe studied 180 women with PCOS and 160 healthy women of reproductive age. The body mass index (BMI) was recorded and the hormonal profile determined from the third to fifth day of menstrual cycle. DNA was extracted from blood leucocytes and the SHBG(TAAAA)n and CYP19(TTTA)n polymorphisms were genotyped.ResultsGenotype analysis revealed 6 SHBG(TAAAA)n alleles with 6–11 repeats and 6 CYP19(TTTA)n alleles with 7–12 repeats. Women were subdivided into four groups: those with short SHBG (≤8 TAAAA repeats) and CYP19 alleles (≤9 TTTA repeats), those with short SHBG–long CYP19 alleles, those with long SHBG–short CYP19 alleles, and those with long SHBG and CYP19 alleles. Women with PCOS tended to have at greater frequency, long SHBG–short CYP19 alleles compared with controls (57.3 vs 42.4%, P=0.07). Importantly, PCOS women with long SHBG–short CYP19 alleles had the lowest SHBG levels (P=0.02) and the highest total testosterone (P=0.008), free androgen index (P=0.002), DHEAS (P=0.02), and testosterone/estradiol ratio (P=0.03), compared with those with other genotypes. This association was independent of age, BMI, and insulin resistance indexes.ConclusionWe speculate that the SHBG and CYP19 genes may have a synergistic role in the developmental programming of PCOS, by affecting androgen bioavailability and aromatization respectively.

scholarly journals Clinical and Biochemical Signs of Polycystic Ovary Syndrome in Young Women Born Preterm

2021 ◽  
Author(s):  
Marika Paalanne ◽  
Marja Vääräsmäki ◽  
Sanna Mustaniemi ◽  
Marjaana Tikanmäki ◽  
Karoliina Wehkalampi ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Parental Education ◽  
Polycystic Ovary ◽  
Clinical Signs ◽  
Later Life ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Ovary Syndrome ◽  
Free Androgen Index ◽  
Medical Birth Register

Objective: It has been suggested that adverse early life exposures increase the risk of developing polycystic ovary syndrome (PCOS) in later life. We hypothesized that women born preterm would have more biochemical and clinical signs of PCOS than women born at term. Design: The ESTER Preterm Birth Study participants were born in Northern Finland, and identified from the Northern Finland Birth Cohort and the Finnish Medical Birth Register. Altogether, 74 women born very or moderately preterm (<34 gestational weeks, VMPT), 127 born late preterm (at 34–36 weeks, LPT), and 184 born full term (≥37 weeks, controls) were included in the analysis (mean age 23.2y). Methods: We measured serum total testosterone and sex hormone binding globulin (SHBG) and calculated free androgen index (FAI). PCOS according to the clinical and biochemical signs was defined either as hirsutism and oligoamenorrhea (via questionnaire), or as oligoamenorrhea and elevated testosterone levels (>2.4 nmol/l). Results: Women born VMPT/LPT exhibited 33.0% (8.7, 62.8)/16.4% (-2.0, 38.1) higher testosterone, 28.5% (5.3, 45.9)/24.1% (5.6, 38.9) lower SHBG levels, and 64.6% (19.4, 127.1)/ 42.5% (11.1, 82.9) higher FAI than controls after adjusting for age and recruitment cohort, maternal BMI, smoking, and pregnancy disorders, parental education, history of hypertension, diabetes, myocardial infarction or stroke, and subject’s birth weight SD. Odds ratios for having PCOS were 1.67 (0.44, 6.23)/3.11 (1.26, 7.70). Conclusions: Women born preterm have a more hyperandrogenic hormonal profile, and those born LPT are approximately three times more likely at risk to have PCOS compared to women born at term.

scholarly journals 206 Attainment and maintenance of pubertal cyclicity may predict high A4 cows with reduced fertility

2019 ◽  
Vol 97 (Supplement_2) ◽  
pp. 118-119 ◽  
Author(s):  
Andrea S Cupp ◽  
Sarah Nafziger ◽  
Mohamed Abedal-Majed ◽  
Sarah Tenley ◽  
Mariah Hart ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Reproductive Tract ◽  
Culture Media ◽  
Polycystic Ovary ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Early Puberty ◽  
Ovary Syndrome ◽  
Ovarian Cortex ◽  
Calving Season

Abstract The UNL physiology herd has a population of cows that secrete excess androstenedione (A4) in follicular fluid. These High A4 cows are less fertile, have irregular cycles, are often anovulatory, and have similar characteristics to women with Polycystic Ovary Syndrome (PCOS). Ovarian cortex cultures of High A4 cows secrete more A4 than controls. High A4 cows reached puberty 45 d earlier than control cows. Thus, we hypothesized that heifers reaching puberty earlier were predisposed to become High A4 cows. To test this hypothesis, we collected blood plasma from weaning to breeding (2012–2017) in 611 heifers. A custom SAS program was developed using progesterone >1ng/ml to identify four distinct puberty groups: 1) Early Puberty- 317.0 ± 3.6 days of age (doa) with continued cyclicity (n = 143); 2) Typical Puberty- 378.4 ± 2.1 doa with continued cyclicity (n = 279); 3) Start-Stop Puberty- 265.3 ± 4.1 doa with discontinued cyclicity (n = 91); and 4) Non-Cycling- no P4≥1ng/ml (n = 98). The pattern of Sex Hormone Binding Globulin (SHBG) was increased prior to puberty in Early and Typical and reduced in Start-Stop and Non-Cycling heifers. Early heifers (4.9) had greater prebreeding reproductive tract scores, followed by Typical (4.7), Start-Stop (4.5), and Non-Cycling (4.0) heifers. At breeding, all heifers that showed estrus in response to PGF2a were artificially inseminated. Typical (78.9%), Early (79.5%) and Start-Stop heifers (50.3%) had a greater response compared to Non-Cycling heifers (12.6%). All heifers were exposed to bulls, and overall pregnancy rate was not different. However, a greater percentage of Typical (57.9%), Early (51.0%), and Start-Stop (45.2%) heifers calved in the first 21 d of the calving season compared to Non-Cycling (20.9%). Start-Stop (3.0ng/ml) and Non-Cycling (4.2ng/ml) heifers had increased A4 in ovarian cortex culture media compared to Typical (0.062ng/ml) or Early (0.091ng/ml) puberty heifers. Greater A4 produced by ovarian cortex of Start-Stop and Non-Cycling heifers, irregular cycles and reduced calves in the first 21 d indicates these females may be predisposed to becoming High A4 cows with decreased fertility.

A Direct Effect of Hyperinsulinemia on Serum Sex Hormone-Binding Globulin Levels in Obese Women with the Polycystic Ovary Syndrome*

1991 ◽  
Vol 72 (1) ◽  
pp. 83-89 ◽  
Author(s):  
JOHN E. NESTLER ◽  
LINDA P. POWERS ◽  
DENNIS W. MATT ◽  
KENNETH A. STEINGOLD ◽  
STEPHEN R. PLYMATE ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Direct Effect ◽  
Polycystic Ovary ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Obese Women ◽  
Hormone Binding ◽  
Ovary Syndrome

Results of treatment with myo-Inositol and D-chiro inositol combination in ratio 5:1 in women with polycystic ovary syndrome

GYNECOLOGY ◽  
2020 ◽  
Vol 22 (6) ◽  
pp. 84-89
Author(s):  
Tatiana A. Oboskalova ◽  
Anna V. Vorontsova ◽  
Maksim A. Zvychainyi ◽  
Karina G. Gushchina ◽  
Marietta M. Maitesian
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Nutritional Support ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Total Testosterone ◽  
Anthropometric Parameters ◽  
Ovary Syndrome ◽  
Free Androgen Index ◽  
Results Of Treatment

We conducted an observational descriptive study evaluating the effectiveness of therapeutic modification of lifestyle with adding of 1000 mg of myo-inositol and 200 mg of D-chiro inositol combination (ratio 5:1) for nutritional support in 104 women of reproductive age with polycystic ovary syndrome (classic phenotype and nonclassical phenotypes in the presence of hyperandrogenism) for 6 months. Revealed changes in anthropometric parameters (decrease in body mass index by 0.89 kg/m2; p0.05 and waist circumference by 3.0 cm; p0.05), skin status (decrease in the incidence of acne from 96.2 up to 58.6%; p0.05 and seborrhea from 34.6 to 5.8%; p0.05), hormonal profile (statistically significant change in all studied parameters; p0.05: decrease in total testosterone to 1.27 nmol/L and a free androgen index up to 4.12% under an increase in globulin binding sex hormones), carbohydrate metabolism (normalization of glucose tolerance without the development of hypoglycemia) and restoration of menstrual cycle (MC) parameters (regular MC in 76.9 %; p0.05, MC duration 33.4 days; p0.05) indicate a significant role of stage I therapy in patients with polycystic ovary syndrome and the possible benefits of 1000 mg of myo-inositol and 200 mg of D-chiro inositol combination as a nutritional support.

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