scholarly journals Extracellular vesicle derived miR-544 downregulates expression of tumor suppressor promyelocytic leukemia zinc finger resulting in increased peritoneal metastasis in gastric cancer

Aging ◽  
2020 ◽  
Author(s):  
Wencheng Kong ◽  
Xinchun Liu ◽  
Guang Yin ◽  
Sixin Zheng ◽  
Akao Zhu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Suppressor ◽  
Zinc Finger ◽  
Peritoneal Metastasis ◽  
Extracellular Vesicle ◽  
Promyelocytic Leukemia ◽  
Promyelocytic Leukemia Zinc Finger

scholarly journals Promyelocytic Leukemia Zinc Finger Protein Activates GATA4 Transcription and Mediates Cardiac Hypertrophic Signaling from Angiotensin II Receptor 2

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e35632 ◽  
Author(s):  
Ning Wang ◽  
Gerald D. Frank ◽  
Ronghua Ding ◽  
Zhongjia Tan ◽  
Amita Rachakonda ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Promyelocytic Leukemia ◽  
Angiotensin Ii Receptor ◽  
Promyelocytic Leukemia Zinc Finger ◽  
Finger Protein ◽  
Hypertrophic Signaling

scholarly journals Promyelocytic Leukemia Zinc Finger Protein Regulates Interferon-Mediated Innate Immunity

Immunity ◽  
2009 ◽  
Vol 30 (6) ◽  
pp. 802-816 ◽  
Author(s):  
Dakang Xu ◽  
Michelle Holko ◽  
Anthony J. Sadler ◽  
Bernadette Scott ◽  
Shigeki Higashiyama ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Promyelocytic Leukemia ◽  
Promyelocytic Leukemia Zinc Finger ◽  
Finger Protein

scholarly journals The ETO Protein Disrupted in t(8;21)-Associated Acute Myeloid Leukemia Is a Corepressor for the Promyelocytic Leukemia Zinc Finger Protein

2000 ◽  
Vol 20 (6) ◽  
pp. 2075-2086 ◽  
Author(s):  
Ari M. Melnick ◽  
Jennifer J. Westendorf ◽  
Adam Polinger ◽  
Graeme W. Carlile ◽  
Sally Arai ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Transcription Factor ◽  
Zinc Finger ◽  
Transcriptional Repression ◽  
Histone Deacetylases ◽  
Myeloid Leukemia ◽  
Histone Deacetylase Inhibitors ◽  
Promyelocytic Leukemia ◽  
Promyelocytic Leukemia Zinc Finger ◽  
Acute Myeloid

ABSTRACT The ETO protein was originally identified by its fusion to the AML-1 transcription factor in translocation (8;21) associated with the M2 form of acute myeloid leukemia (AML). The resulting AML-1–ETO fusion is an aberrant transcriptional regulator due to the ability of ETO, which does not bind DNA itself, to recruit the transcriptional corepressors N-CoR, SMRT, and Sin3A and histone deacetylases. The promyelocytic leukemia zinc finger (PLZF) protein is a sequence-specific DNA-binding transcriptional factor fused to retinoic acid receptor α in acute promyelocytic leukemia associated with the (11;17)(q23;q21) translocation. PLZF also mediates transcriptional repression through the actions of corepressors and histone deacetylases. We found that ETO is one of the corepressors recruited by PLZF. The PLZF and ETO proteins associate in vivo and in vitro, and ETO can potentiate transcriptional repression by PLZF. The N-terminal portion of ETO forms complexes with PLZF, while the C-terminal region, which was shown to bind to N-CoR and SMRT, is required for the ability of ETO to augment transcriptional repression by PLZF. The second repression domain (RD2) of PLZF, not the POZ/BTB domain, is necessary to bind to ETO. Corepression by ETO was completely abrogated by histone deacetylase inhibitors. This identifies ETO as a cofactor for a sequence-specific transcription factor and indicates that, like other corepressors, it functions through the action of histone deactylase.

scholarly journals Promyelocytic leukemia zinc finger is involved in the formation of deep layer cortical neurons

2019 ◽  
Vol 26 (1) ◽  
Author(s):  
Hsin-Chuan Lin ◽  
Yung-Hao Ching ◽  
Chi-Chen Huang ◽  
Ping-Chieh Pao ◽  
Yi-Hua Lee ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Cortical Neurons ◽  
Deep Layer ◽  
Promyelocytic Leukemia ◽  
Promyelocytic Leukemia Zinc Finger

scholarly journals The Transcription Factor Promyelocytic Leukemia Zinc Finger Protein Is Associated With Expression of Liver‐Homing Receptors on Human Blood CD56 bright Natural Killer Cells

2020 ◽  
Vol 4 (3) ◽  
pp. 409-424 ◽  
Author(s):  
Leonard U. Hess ◽  
Glòria Martrus ◽  
Annerose E. Ziegler ◽  
Annika E. Langeneckert ◽  
Wilhelm Salzberger ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Zinc Finger ◽  
Human Blood ◽  
Zinc Finger Protein ◽  
Promyelocytic Leukemia ◽  
Promyelocytic Leukemia Zinc Finger ◽  
Killer Cells ◽  
Finger Protein

AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein

Blood ◽  
2000 ◽  
Vol 96 (12) ◽  
pp. 3939-3947 ◽  
Author(s):  
Ari Melnick ◽  
Graeme W. Carlile ◽  
Melanie J. McConnell ◽  
Adam Polinger ◽  
Scott W. Hiebert ◽  
...  
Keyword(s):  
Fusion Protein ◽  
Zinc Finger ◽  
Transcriptional Repression ◽  
Target Genes ◽  
Zinc Finger Protein ◽  
Promyelocytic Leukemia ◽  
Dominant Negative ◽  
Myelogenous Leukemia ◽  
Promyelocytic Leukemia Zinc Finger ◽  
Dominant Negative Inhibitor

Abstract The AML-1/ETO fusion protein, created by the (8;21) translocation in M2-type acute myelogenous leukemia (AML), is a dominant repressive form of AML-1. This effect is due to the ability of the ETO portion of the protein to recruit co-repressors to promoters of AML-1 target genes. The t(11;17)(q21;q23)-associated acute promyelocytic leukemia creates the promyelocytic leukemia zinc finger PLZFt/RARα fusion protein and, in a similar manner, inhibits RARα target gene expression and myeloid differentiation. PLZF is expressed in hematopoietic progenitors and functions as a growth suppressor by repressing cyclin A2 and other targets. ETO is a corepressor for PLZF and potentiates transcriptional repression by linking PLZF to a histone deacetylase-containing complex. In transiently transfected cells and in a cell line derived from a patient with t(8;21) leukemia, PLZF and AML-1/ETO formed a tight complex. In transient assays, AML-1/ETO blocked transcriptional repression by PLZF, even at substoichiometric levels relative to PLZF. This effect was dependent on the presence of the ETO zinc finger domain, which recruits corepressors, and could not be rescued by overexpression of co-repressors that normally enhance PLZF repression. AML-1/ETO also excluded PLZF from the nuclear matrix and reduced its ability to bind to its cognate DNA-binding site. Finally, ETO interacted with PLZF/RARα and enhanced its ability to repress through the RARE. These data show a link in the transcriptional pathways of M2 and M3 leukemia.

scholarly journals The GTPase domain of Galphao contributes to the functional interaction of Galphao with the promyelocytic leukemia zinc finger protein

2009 ◽  
Vol 14 (1) ◽  
Author(s):  
Jung Won ◽  
Sung Ghil
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Promyelocytic Leukemia ◽  
Functional Interaction ◽  
Gtpase Domain ◽  
Promyelocytic Leukemia Zinc Finger ◽  
Downstream Effector ◽  
Finger Protein ◽  
Family Based ◽  
G Protein Coupled

AbstractGo, one of the most abundant heterotrimeric G proteins in the brain, is classified as a member of the Gi/Go family based on its homology to Gi proteins. Recently, we identified promyelocytic leukemia zinc finger protein (PLZF) as a candidate downstream effector for the alpha subunit of Go (Gαo). Activated Gαo interacts with PLZF and augments its function as a repressor of transcription and cell growth. G protein-coupled receptor-mediated Gαo activation also enhanced PLZF function. In this study, we determined that the GTPase domain of Gαo contributes to Gαo:PLZF interaction. We also showed that the Gαo GTPase domain is important in modulating the function of PLZF. This data indicates that the GTPase domain of Gαo may be necessary for the functional interaction of Gαo with PLZF.

scholarly journals The Promyelocytic Leukemia Zinc Finger Transcription Factor Is Critical for Human Endometrial Stromal Cell Decidualization

PLoS Genetics ◽  
2016 ◽  
Vol 12 (4) ◽  
pp. e1005937 ◽  
Author(s):  
Ramakrishna Kommagani ◽  
Maria M. Szwarc ◽  
Yasmin M. Vasquez ◽  
Mary C. Peavey ◽  
Erik C. Mazur ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Zinc Finger ◽  
Stromal Cell ◽  
Promyelocytic Leukemia ◽  
Endometrial Stromal Cell ◽  
Promyelocytic Leukemia Zinc Finger ◽  
Zinc Finger Transcription Factor ◽  
Human Endometrial Stromal Cell

scholarly journals The Promyelocytic Leukemia Zinc Finger (PLZF ) gene is a novel transcriptional target of the CCAAT-Displacement-Protein (CUX1) repressor

FEBS Journal ◽  
2010 ◽  
Vol 277 (20) ◽  
pp. 4241-4253 ◽  
Author(s):  
Isabelle Fréchette ◽  
Mathieu Darsigny ◽  
Karine Brochu-Gaudreau ◽  
Christine Jones ◽  
François Boudreau
Keyword(s):  
Zinc Finger ◽  
Promyelocytic Leukemia ◽  
Promyelocytic Leukemia Zinc Finger ◽  
Ccaat Displacement Protein ◽  
Transcriptional Target
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