scholarly journals Development and validation of RNA binding protein-applied prediction model for gastric cancer

Aging ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 5539-5552
Author(s):  
Shuang Dai ◽  
Yan Huang ◽  
Ting Liu ◽  
Zi-Han Xu ◽  
Tao Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prediction Model ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Development And Validation

scholarly journals Development and validation of a prediction model for lung adenocarcinoma based on RNA-binding protein

2021 ◽  
Vol 9 (6) ◽  
pp. 474-474
Author(s):  
Longjun Yang ◽  
◽  
Rusi Zhang ◽  
Guangran Guo ◽  
Gongming Wang ◽  
...  
Keyword(s):  
Prediction Model ◽  
Lung Adenocarcinoma ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Development And Validation

scholarly journals RNA-binding protein RNPC1 acts as an oncogene in gastric cancer by stabilizing Aurora kinase B mRNA

2021 ◽  
pp. 112741
Author(s):  
Chun-Mei Ji ◽  
Xu Zhang ◽  
Wentong Fang ◽  
Ling Meng ◽  
Xiaolong Wei ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Aurora Kinase ◽  
Aurora Kinase B

scholarly journals The Aberrant Expression of MicroRNA-125a-5p/IGF2BP3 Axis in Advanced Gastric Cancer and Its Clinical Relevance

2020 ◽  
Vol 19 ◽  
pp. 153303382091733
Author(s):  
Jing Zhang ◽  
Fanghui Ding ◽  
Dan Jiao ◽  
Qiaozhi Li ◽  
Hong Ma
Keyword(s):  
Gastric Cancer ◽  
Growth Factor ◽  
Advanced Gastric Cancer ◽  
Messenger Rna ◽  
Poor Prognosis ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Advanced Stage ◽  
Insulin Like Growth Factor

RNA-binding proteins have been associated with cancer development. The overexpression of a well-known RNA-binding protein, insulin-like growth factor 2 messenger RNA–binding protein 3, has been identified as an indicator of poor prognosis in patients with various types of cancer. Although gastric cancer is a relatively frequent and potentially fatal malignancy, the mechanism by which insulin-like growth factor 2 messenger RNA–binding protein 3 regulates the development of this cancer remains unclear. This study aimed to investigate the role and regulatory mechanism of insulin-like growth factor 2 messenger RNA–binding protein 3 in gastric cancer. An analysis of IGF2BP3 expression patterns reported in 4 public gastric cancer–related microarray data sets from the Gene Expression Omnibus and The Cancer Genome Atlas-Stomach Adenocarcinoma revealed strong expression of this gene in gastric cancer tissues. Insulin-like growth factor 2 messenger RNA–binding protein 3 expression in gastric cancer was further confirmed via quantitative reverse transcription polymerase chain reaction and immunohistochemistry, respectively, in an in-house gastric cancer cohort (n = 30), and the association of insulin-like growth factor 2 messenger RNA–binding protein 3 expression with clinical parameters and prognosis was analyzed. Notably, stronger IGF2BP3 expression significantly correlated with poor prognosis, and significant changes in insulin-like growth factor 2 messenger RNA–binding protein 3 expression were only confirmed in patients with advanced-stage gastric cancer in an independent cohort. The effects of insulin-like growth factor 2 messenger RNA–binding protein 3 on cell proliferation were confirmed through in vitro experiments involving the HGC-27 gastric cancer cell line. MicroR-125a-5p, a candidate microRNA that target on insulin-like growth factor 2 messenger RNA–binding protein 3, decreased in advanced-stage gastric cancer. Upregulation of microR-125a-5p inhibited insulin-like growth factor 2 messenger RNA–binding protein 3, and dual-luciferase report assay indicated that microR-125a-5p inhibited the translation of IGF2BP3 by directly targeting the 3′ untranslated region. These results indicate that the microR-125a-5p/insulin-like growth factor 2 messenger RNA–binding protein 3 axis contributes to the oncogenesis of advanced gastric cancer.

scholarly journals Development and Validation of an RNA Binding Protein-associated Prognostic Model for Hepatocellular Carcinoma

2021 ◽  
Vol 000 (000) ◽  
pp. 000-000
Author(s):  
Hao Zhang ◽  
Peng Xia ◽  
Weijie Ma ◽  
Yufeng Yuan
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Model ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Development And Validation

scholarly journals Development and Validation of Nine-RNA Binding Protein Signature Predicting Overall Survival for Kidney Renal Clear Cell Carcinoma

2020 ◽  
Vol 11 ◽  
Author(s):  
Weimin Zhong ◽  
Chaoqun Huang ◽  
Jianqiong Lin ◽  
Maoshu Zhu ◽  
Hongbin Zhong ◽  
...  
Keyword(s):  
Overall Survival ◽  
Cell Carcinoma ◽  
Rna Binding ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Renal Clear Cell Carcinoma ◽  
Development And Validation ◽  
Protein Signature

Abstract 5162: Id1 is an oncogenic target of RNA binding protein HuR in gastric cancer

2016 ◽  
Author(s):  
Shuang Han ◽  
Xiaoqing Wu ◽  
Yuxiao Guo ◽  
Jing Zhang ◽  
Xuan Gu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein

scholarly journals Development and validation of a RNA binding protein-associated prognostic model for lung adenocarcinoma

Aging ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 3558-3573 ◽  
Author(s):  
Wei Li ◽  
Li-Na Gao ◽  
Pei-Pei Song ◽  
Chong-Ge You
Keyword(s):  
Lung Adenocarcinoma ◽  
Prognostic Model ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Development And Validation

scholarly journals Development and validation of a prognostic model for kidney renal clear cell carcinoma based on RNA binding protein expression

Aging ◽  
2020 ◽  
Author(s):  
Yuzhu Xiang ◽  
Shengcai Zhou ◽  
Jian Hao ◽  
Chunhong Zhong ◽  
Qimei Ma ◽  
...  
Keyword(s):  
Protein Expression ◽  
Cell Carcinoma ◽  
Prognostic Model ◽  
Rna Binding ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Renal Clear Cell Carcinoma ◽  
Development And Validation

scholarly journals A Novel RNA-Binding Protein-Based Nomogram for Predicting Survival of Patients with Gastric Cancer

2020 ◽  
Vol 27 ◽  
Author(s):  
Maoshu Zhu ◽  
Jiading Cai ◽  
Yulong Wu ◽  
Xinhong Wu ◽  
Lianghua Feng ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein
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