scholarly journals Development and validation of a prognostic model for kidney renal clear cell carcinoma based on RNA binding protein expression

Aging ◽  
2020 ◽  
Author(s):  
Yuzhu Xiang ◽  
Shengcai Zhou ◽  
Jian Hao ◽  
Chunhong Zhong ◽  
Qimei Ma ◽  
...  
Keyword(s):  
Protein Expression ◽  
Cell Carcinoma ◽  
Prognostic Model ◽  
Rna Binding ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Renal Clear Cell Carcinoma ◽  
Development And Validation

scholarly journals Development and Validation of Nine-RNA Binding Protein Signature Predicting Overall Survival for Kidney Renal Clear Cell Carcinoma

2020 ◽  
Vol 11 ◽  
Author(s):  
Weimin Zhong ◽  
Chaoqun Huang ◽  
Jianqiong Lin ◽  
Maoshu Zhu ◽  
Hongbin Zhong ◽  
...  
Keyword(s):  
Overall Survival ◽  
Cell Carcinoma ◽  
Rna Binding ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Renal Clear Cell Carcinoma ◽  
Development And Validation ◽  
Protein Signature

scholarly journals Development and validation of a RNA binding protein-associated prognostic model for head and neck squamous cell carcinoma

Aging ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 7975-7997
Author(s):  
Xiuping Yang ◽  
Baoai Han ◽  
Runshi Zhang ◽  
Yuan Su ◽  
Davood K. Hosseini ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Prognostic Model ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Neck Squamous Cell Carcinoma ◽  
Development And Validation

scholarly journals LncRNA CDKN2B-AS1 stabilized by IGF2BP3 drives the malignancy of renal clear cell carcinoma through epigenetically activating NUF2 transcription

2021 ◽  
Vol 12 (2) ◽  
Author(s):  
Xina Xie ◽  
Jiatian Lin ◽  
Xiaoqin Fan ◽  
Yuantang Zhong ◽  
Yequn Chen ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Survival Data ◽  
Kinase Inhibitor ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Binding Protein ◽  
Renal Clear Cell Carcinoma ◽  
Receiver Operating Curve ◽  
Migration And Invasion ◽  
Integrated Analysis

AbstractBecause of the lack of sensitivity to radiotherapy and chemotherapy, therapeutic options for renal clear cell carcinoma (KIRC) are scarce. Long noncoding RNAs (lncRNAs) play crucial roles in the progression of cancer. However, their functional roles and upstream mechanisms in KIRC remain largely unknown. Exploring the functions of potential essential lncRNAs may lead to the discovery of novel targets for the diagnosis and treatment of KIRC. Here, according to the integrated analysis of RNA sequencing and survival data in TCGA-KIRC datasets, cyclin-dependent kinase inhibitor 2B antisense lncRNA (CDKN2B-AS1) was discovered to be the most upregulated among the 14 lncRNAs that were significantly overexpressed in KIRC and related to shorter survival. Functionally, CDKN2B-AS1 depletion suppressed cell proliferation, migration, and invasion both in vitro and in vivo. Mechanistically, CDKN2B-AS1 exerted its oncogenic activity by recruiting the CREB-binding protein and SET and MYND domain-containing 3 epigenetic-modifying complex to the promoter region of Ndc80 kinetochore complex component (NUF2), where it epigenetically activated NUF2 transcription by augmenting local H3K27ac and H3K4me3 modifications. Moreover, we also showed that CDKN2B-AS1 interacted with and was stabilized by insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), an oncofetal protein showing increased levels in KIRC. The Kaplan–Meier method and receiver operating curve analysis revealed that patients whose IGF2BP3, CDKN2B-AS1 and NUF2 are all elevated showed the shortest survival time, and the combined panel (containing IGF2BP3, CDKN2B-AS1, and NUF2) possessed the highest accuracy in discriminating high-risk from low-risk KIRC patients. Thus, we conclude that the stabilization of CDKN2B-AS1 by IGF2BP3 drives the malignancy of KIRC through epigenetically activating NUF2 transcription and that the IGF2BP3/CDKN2B-AS1/NUF2 axis may be an ideal prognostic and diagnostic biomarker and therapeutic target for KIRC.

Development and validation of a nine redox related long noncoding RNA prognostic signature in renal clear cell carcinoma

2021 ◽  
Vol 79 ◽  
pp. S743
Author(s):  
Q-D. Xia ◽  
Y. Xun ◽  
J.-L. Lu ◽  
J. Hu ◽  
C. Li ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Renal Clear Cell Carcinoma ◽  
Prognostic Signature ◽  
Development And Validation

scholarly journals RNA binding protein MEX3A controls G1/S transition via regulating the RB/E2F pathway in clear cell renal cell carcinoma

2021 ◽  
Author(s):  
Yuntan Qiu ◽  
Meng Meng ◽  
Chuanzhen Cao ◽  
Jingyuan Zhang ◽  
Xu Cheng ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Rna Binding ◽  
Clear Cell ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Cell Renal Cell Carcinoma

scholarly journals Development and Validation of an RNA Binding Protein-associated Prognostic Model for Hepatocellular Carcinoma

2021 ◽  
Vol 000 (000) ◽  
pp. 000-000
Author(s):  
Hao Zhang ◽  
Peng Xia ◽  
Weijie Ma ◽  
Yufeng Yuan
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Model ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Development And Validation

scholarly journals RNA-binding protein QKI-5 inhibits the proliferation of clear cell renal cell carcinoma via post-transcriptional stabilization of RASA1 mRNA

Cell Cycle ◽  
2016 ◽  
Vol 15 (22) ◽  
pp. 3094-3104 ◽  
Author(s):  
Rui-Li Zhang ◽  
Jun-Ping Yang ◽  
Li-Xia Peng ◽  
Li-Sheng Zheng ◽  
Ping Xie ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Rna Binding ◽  
Clear Cell ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Cell Renal Cell Carcinoma

scholarly journals Lower mRNA and Protein Expression Levels of LC3 and Beclin1, Markers of Autophagy, were Correlated with Progression of Renal Clear Cell Carcinoma

2013 ◽  
Vol 43 (12) ◽  
pp. 1261-1268 ◽  
Author(s):  
Q. Deng ◽  
Z. Wang ◽  
L. Wang ◽  
L. Zhang ◽  
X. Xiang ◽  
...  
Keyword(s):  
Protein Expression ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Renal Clear Cell Carcinoma ◽  
Expression Levels ◽  
Mrna And Protein Expression

scholarly journals The RNA-binding protein QKI suppresses tumorigenesis of clear cell renal cell carcinoma by regulating the expression of HIF-1α

2020 ◽  
Vol 11 (6) ◽  
pp. 1359-1370 ◽  
Author(s):  
Fei Shi ◽  
Di Wei ◽  
Zheng Zhu ◽  
Fei Yan ◽  
Fuli Wang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Rna Binding ◽  
Clear Cell ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Cell Renal Cell Carcinoma
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