Association of genetic variations in the Wnt signaling pathway genes with myocardial infarction susceptibility in Chinese Han population

SummaryMatrix metalloproteinase (MMP) 3 plays an important role in the pathogenesis of myocardial infarction (MI). Up to now, there has been conflicting data regarding the possible contribution of the MMP3 -1612 5A/6A promoter polymorphism to MI. In this study, we have investigated the possible association of three polymorphisms (-1612 5A/6A, -376C/G, Glu45Lys) in the MMP3 gene with MI in a Chinese Han population. The polymorphisms were analyzed in 509 patients with MI, and in 518 healthy controls. The frequency of the 5A allele was 14% in the healthy controls, which is less than in Western populations (40%-52%). Logistic regression analyses of individual polymorphisms indicated that individuals carrying the -1612 5A allele had an increased risk of MI (odds ratio [OR] 1.75, 95% confidence interval [CI] 1.28 to 2.40), as did those carrying the -376 G allele (OR 1.78, 95% CI 1.33 to 2.38). The three polymorphisms studied were found to be in strong linkage disequilibria. Haplotype analyses showed that the 5A-G-Lys haplotype (-1612 5A, -376G and 45Lys) was independently associated with susceptibility to MI. Taken together, the effect of the MMP3 polymorphisms studied may be attributable to the -1612 5A/6A polymorphism. We conclude that the MMP3 -1612 5A/6A polymorphism is associated with MI in our population, implying that individuals of the 5A allele carriers have an increased risk of suffering MI.

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Genetic variations of MMP9 gene and intracerebral hemorrhage susceptibility: A case–control study in Chinese Han population

Journal of the Neurological Sciences ◽

10.1016/j.jns.2014.03.049 ◽

2014 ◽

Vol 341 (1-2) ◽

pp. 55-57 ◽

Cited By ~ 6

Author(s):

Jie Yang ◽

Bo Wu ◽

Sen Lin ◽

Junshan Zhou ◽

Yingbin Li ◽

...

Keyword(s):

Intracerebral Hemorrhage ◽

Case Control Study ◽

Case Control ◽

Genetic Variations ◽

Chinese Han Population ◽

Chinese Han ◽

Han Population ◽

Mmp9 Gene ◽

Control Study

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Genetic variations in MOV10 and CACNB2 are associated with hypertension in a Chinese Han population

Genetics and Molecular Research ◽

10.4238/2013.december.4.9 ◽

2013 ◽

Vol 12 (4) ◽

pp. 6220-6227 ◽

Cited By ~ 5

Author(s):

G.L. Hong ◽

X.Z. Chen ◽

Y. Liu ◽

Y.H. Liu ◽

X. Fu ◽

...

Keyword(s):

Genetic Variations ◽

Chinese Han Population ◽

Chinese Han ◽

Han Population

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The rs3850641 polymorphism of the TNFSF4 gene increases the risk of myocardial infarction in a Chinese Han population

Bioscience Reports ◽

10.1042/bsr20180526 ◽

2018 ◽

Vol 38 (4) ◽

Cited By ~ 2

Author(s):

Changqing Lu ◽

Helei Jia ◽

Aiguo Xu

Keyword(s):

Myocardial Infarction ◽

Case Control Study ◽

Case Control ◽

Chinese Han Population ◽

Chinese Han ◽

Han Population ◽

Flight Mass Spectrometry ◽

Ox40 Ligand ◽

Atherosclerosis Development ◽

Control Study

Tumor necrosis factor superfamily member 4 (TNFSF4), also known as Ox40 ligand (Ox40l), plays an important role in atherosclerosis development. Several studies reported the association between the rs3850641 polymorphism of the TNFSF4 gene and the risk of myocardial infarction (MI). However, the results are inconsistent. In order to explore the relationship between the rs3850641 polymorphism of the TNFSF4 gene and MI, we conducted a case–control study including 454 cases and 512 controls in a Chinese Han population. Genotyping was performed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The present study found that AA genotype (AA vs. GG: odds ratio (OR) & 95% confidence interval (CI), 2.00(1.04,3.86), P=0.039; AA vs. AG+GG: OR & 95% CI, 1.93(1.00,3.70), P=0.049) or A allele carriers (A vs. G: OR & 95% CI, 1.27(1.00,1.60), P=0.047) of the rs3850641 polymorphism of the TNFSF4 gene increased the risk of MI. In conclusion, this case–control study confirms that the rs3850641 polymorphism of the TNFSF4 gene increases the risk of MI.

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Association study of the thrombomodulin −33G>A polymorphism with coronary artery disease and myocardial infarction in Chinese Han population

International Journal of Cardiology ◽

10.1016/j.ijcard.2004.05.007 ◽

2005 ◽

Vol 100 (3) ◽

pp. 383-388 ◽

Cited By ~ 12

Author(s):

Jiangong Zhao ◽

Xiaoyang Zhou ◽

Jianfeng Huang ◽

Jianhong Chen ◽

Dongfeng Gu

Keyword(s):

Myocardial Infarction ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Association Study ◽

Chinese Han Population ◽

Chinese Han ◽

Han Population ◽

Artery Disease

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Notum Protects Against Myocardial Infarction-Induced Heart Dysfunction By Alleviating Cardiac Fibrosis

10.21203/rs.3.rs-1023805/v1 ◽

2021 ◽

Author(s):

Wei Su ◽

Ruonan Fang ◽

Yue Li ◽

Liangliang Li ◽

Jing Zhang ◽

...

Keyword(s):

Myocardial Infarction ◽

Wnt Signaling ◽

Signaling Pathway ◽

Cardiac Fibrosis ◽

Cardiac Fibroblasts ◽

Wnt Signaling Pathway ◽

New Strategy ◽

Feedback Inhibitor ◽

Reparative Process ◽

Organ Fibrosis

Abstract Cardiac fibrosis is a pathological reparative process that occurs subsequent to myocardial injury. It is associated with cardiac systolic and diastolic dysfunction and reduced cardiac compliance that eventually leads to heart failure. Delaying or inhibiting the progression of pathological myocardial fibrosis is of great significance for the treatment of many cardiovascular diseases. The Wnt signaling pathway is closely related to the occurrence of organ fibrosis, and Notum is a highly conserved secreted feedback inhibitor of Wnt signaling. It has been shown that Notum acts as a regulator in many organs, such as the aging intestinal epithelium, adult ventricular-subventricular zone neurogenesis, and mouse tooth root development. However, the role and mechanism of Notum on cardiac fibrosis are not well-understood. In this study, we found that Notum significantly increased survival rate and improved cardiac function following myocardial infarction in mice. More importantly, Notum inhibited the Wnt/β-catenin signaling pathway and senescence of cardiac fibroblasts, thereby decreasing the activation of cardiac fibroblasts, reducing the excessive deposition of extracellular matrix, and ultimately inhibiting the occurrence of cardiac fibrosis. Taken together, our findings demonstrated the anti-fibrotic effects of Notum on maladaptive cardiac fibrosis, and suggest that it may be a new strategy for the treatment of cardiac fibrosis.

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