scholarly journals miRNA-200a/c as potential biomarker in epithelial ovarian cancer (EOC): evidence based on miRNA meta-signature and clinical investigations

Oncotarget ◽  
2016 ◽  
Vol 7 (49) ◽  
pp. 81621-81633 ◽  
Author(s):  
Yue Teng ◽  
Xuan Su ◽  
Xing Zhang ◽  
Yan Zhang ◽  
Chen Li ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Evidence Based ◽  
Clinical Investigations ◽  
Potential Biomarker

scholarly journals Follow-up of patients who are clinically disease-free after primary treatment for fallopian tube, primary peritoneal, or epithelial ovarian cancer: a Program in Evidence-Based Care guideline adaptation

2016 ◽  
Vol 23 (5) ◽  
pp. 343 ◽  
Author(s):  
T. Le ◽  
E.B. Kennedy ◽  
J. Dodge ◽  
L. Elit
Keyword(s):  
Ovarian Cancer ◽  
Overall Survival ◽  
Epithelial Ovarian Cancer ◽  
Fallopian Tube ◽  
Controlled Trial ◽  
Elevated Serum ◽  
Primary Treatment ◽  
Evidence Based ◽  
Guidance Document

Background A need for follow-up recommendations for survivors of fallopian tube, primary peritoneal, or epithelial ovarian cancer after completion of primary treatment was identified by Cancer Care Ontario’s Program in Evidence-Based Care.Methods We searched for existing guidelines, conducted a systematic review (medline, embase, and cdsr, January 2010 to March 2015), created draft recommendations, and completed a comprehensive review process. Outcomes included overall survival, quality of life, and patient preferences.Results The Cancer Australia guidance document Follow Up of Women with Epithelial Ovarian Cancer was adapted for the Ontario context. A key randomized controlled trial found that the overall survival rate did not differ between asymptomatic women who received early treatment based on elevated serum cancer antigen 125 (ca125) alone and women who waited for the appearance of clinical symptoms before initiating treatment (hazard ratio: 0.98; 95% confidence interval: 0.80 to 1.20; p = 0.85); in addition, patients in the delayed treatment group reported good global health scores for longer. No randomized studies were found for other types of follow-up. We recommend that survivors be made aware of the potential harms and benefits of surveillance, including a discussion of the limitations of ca125 testing. Women could be offered the option of no formal follow-up or a follow-up schedule that is agreed upon by the woman and her health care provider. Education about the most common symptoms of recurrence should be provided. Alternative models of care such as nurse-led or telephone-based follow-up (or both) could be emerging options.Conclusions The recommendations provided in this guidance document have a limited evidence base. Recommendations should be updated as further information becomes available.

Abstract 4655: Elevated level of serum miR-99a is correlated with serous epithelial ovarian cancer and can be a potential biomarker

2017 ◽  
Author(s):  
Akihiko Yoshimura ◽  
Kenjiro Sawada ◽  
Koji Nakamura ◽  
Yasuto Kinose ◽  
Erika Nakatsuka ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Elevated Level ◽  
Potential Biomarker ◽  
Serous Epithelial Ovarian Cancer

Abstract 5408: Elevated level of serum miR-1290 is correlated with high-grade serous ovarian epithelial ovarian cancer and might be a potential biomarker

2018 ◽  
Author(s):  
Masaki Kobayashi ◽  
Sawada Kenjiro ◽  
Yoshimura Akihiko ◽  
Miyamoto Mayuko ◽  
Nakatsuka Erika ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Elevated Level ◽  
High Grade ◽  
Potential Biomarker

Heat shock protein 27: a potential biomarker of peritoneal metastasis in epithelial ovarian cancer?

Tumor Biology ◽  
2013 ◽  
Vol 35 (2) ◽  
pp. 1051-1056 ◽  
Author(s):  
M. Zhao ◽  
J. X. Ding ◽  
K. Zeng ◽  
J. Zhao ◽  
F. Shen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Epithelial Ovarian Cancer ◽  
Peritoneal Metastasis ◽  
Heat Shock Protein 27 ◽  
Potential Biomarker

scholarly journals Inhibition of miR-214-3p Aids in Preventing Epithelial Ovarian Cancer Malignancy by Increasing the Expression of LHX6

Cancers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1917 ◽  
Author(s):  
Changwon Yang ◽  
Hee Seung Kim ◽  
Soo Jin Park ◽  
Eun Ji Lee ◽  
Se Ik Kim ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Target Genes ◽  
Apoptotic Cell ◽  
Serous Cystadenoma ◽  
Low Grade ◽  
Mrna Levels ◽  
Serous Ovarian Cancer ◽  
Potential Biomarker ◽  
Platinum Based Chemotherapy

In human epithelial ovarian cancer (EOC), various miRNAs can function as either oncogenes or tumor suppressor genes. We investigated miRNAs known to be involved in EOC progression and analyzed their expression in tissues and serum-derived exosomes from benign serous cystadenoma, borderline serous tumor, low-grade serous ovarian cancer, and high-grade serous ovarian cancer patients (HGSO). The HGSO group was divided based on the platinum-free interval, which is defined as the duration from the completion of platinum-based chemotherapy to recurrence. We also analyzed the mRNA levels of target genes that candidate miRNAs might regulate in patient tissues. miR-214-3p was highly expressed in tissues and exosomes derived from EOC with high malignancy and also found to regulate the expression of LIM homeobox domain 6 (LHX6) mRNA. Serum exosomal levels of miR-214-3p were significantly increased in platinum-resistant HGSO (25.2-fold, p < 0.001) compared to the exosomal expression of benign tumor patients. On transfection of miR-214-3p inhibitor in EOC cells, cell proliferation was inhibited while apoptotic cell death was increased. Collectively, we suggest that miR-214-3p in serum exosomes can be a potential biomarker for the diagnosis and prognosis of ovarian tumor, and its inhibition can be a supportive treatment for EOC.

Potential biomarker of circulating hsa-miR-1273g-3p level for detection of recurrent epithelial ovarian cancer

2018 ◽  
Vol 298 (6) ◽  
pp. 1173-1180 ◽  
Author(s):  
Tuba Günel ◽  
Ece Gumusoglu ◽  
Berkcan Dogan ◽  
Fatma Betül Ertem ◽  
Mohammad Kazem Hosseini ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Potential Biomarker
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