scholarly journals Platelet derived growth factor receptor alpha mediates nodal metastases in papillary thyroid cancer by driving the epithelial-mesenchymal transition

Oncotarget ◽  
2016 ◽  
Vol 7 (50) ◽  
pp. 83684-83700 ◽  
Author(s):  
Esther Ekpe-Adewuyi ◽  
Ana Lopez-Campistrous ◽  
Xiaoyun Tang ◽  
David N. Brindley ◽  
Todd P. W. McMullen
Keyword(s):  
Thyroid Cancer ◽  
Growth Factor ◽  
Papillary Thyroid Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor ◽  
Nodal Metastases ◽  
Papillary Thyroid ◽  
Mesenchymal Transition ◽  
Factor Receptor Alpha

Molecular imaging of platelet-derived growth factor receptor-alpha (PDGFRα) in papillary thyroid cancer using immuno-PET

2018 ◽  
Vol 58 ◽  
pp. 51-58 ◽  
Author(s):  
Michael Wagner ◽  
Melinda Wuest ◽  
Ingrit Hamann ◽  
Ana Lopez-Campistrous ◽  
Todd P.W. McMullen ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Molecular Imaging ◽  
Growth Factor ◽  
Papillary Thyroid Cancer ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor ◽  
Papillary Thyroid ◽  
Receptor Alpha ◽  
Factor Receptor Alpha

Platelet-derived growth factor receptor-α promotes lymphatic metastases in papillary thyroid cancer

2012 ◽  
Vol 228 (2) ◽  
pp. 241-250 ◽  
Author(s):  
Jingdong Zhang ◽  
Peng Wang ◽  
Mark Dykstra ◽  
Pascale Gelebart ◽  
David Williams ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Growth Factor ◽  
Papillary Thyroid Cancer ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor ◽  
Papillary Thyroid ◽  
Lymphatic Metastases

Autocrine activation of platelet-derived growth factor receptor α in metastatic papillary thyroid cancer

2018 ◽  
Vol 75 ◽  
pp. 146-153 ◽  
Author(s):  
Esther Ekpe Adewuyi ◽  
Jean Deschenes ◽  
Ana Lopez-Campistrous ◽  
Mireille M. Kattar ◽  
Sunita Ghosh ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Growth Factor ◽  
Papillary Thyroid Cancer ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor ◽  
Papillary Thyroid

scholarly journals KIAA1199, a Target of MicoRNA-486-5p, Promotes Papillary Thyroid Cancer Invasion by Influencing Epithelial-Mesenchymal Transition (EMT)

2019 ◽  
Vol 25 ◽  
pp. 6788-6796 ◽  
Author(s):  
Xuehua Jiao ◽  
Jiandong Ye ◽  
Xiujie Wang ◽  
Xueyan Yin ◽  
Guodong Zhang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Cancer Invasion ◽  
Papillary Thyroid ◽  
Mesenchymal Transition

scholarly journals Hsa_circRNA_102002 facilitates metastasis of papillary thyroid cancer through regulating miR-488-3p/HAS2 axis

2020 ◽  
Author(s):  
Wei Zhang ◽  
Ting Liu ◽  
Tianshu Li ◽  
Xudong Zhao
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Xenograft Model ◽  
Inhibitory Effect ◽  
Circular Rnas ◽  
Papillary Thyroid ◽  
Mesenchymal Transition ◽  
Mouse Xenograft Model ◽  
And Migration

Abstract As important modulators in various physiological processes, circular RNAs (circRNAs) have been increasingly demonstrated in tumors, including papillary thyroid cancer (PTC). Hsa_circRNA_102002 (circ_102002) is a circRNA derived from alternative splicing of ubiquitin-specific peptidase 22 (USP22) transcript, the role of which needs further investigation. Our results suggested the upregulation of circ_102002 in PTC tissues and cells, and its promoting effects on epithelial–mesenchymal transition (EMT) and cell migration. Mechanism studies showed that circ_102002 could sponge microRNA-488-3p (miR-488-3p) and downregulate its expression. The target relationship between miR-488-3p and hyaluronic acid synthetase 2 (HAS2) in PTC was systematically studied. In addition, our results showed that HAS2 overexpression could restore the inhibited cell EMT and migration. Moreover, the inhibitory effect of downregulation of circ_102002 on PTC growth was evaluated in a mouse xenograft model, which involved miR-488-3p and HAS2 regulation. These findings about the signal axis of circ_102002/miR-488-3p/HAS2 may further elucidate the PTC pathogenesis and improve clinical treatment.

Sign in / Sign up

Export Citation Format

Share Document