Nonenzymatic Evaluation of Antioxidant and Lipid Peroxidation Level in Breast Cancer Patients Receiving Juice of Wheat Grass during Treatment

For breast cancer, chemotherapy is the most common treatment in the world. In breast cancer patients, oxidative stress leads to accumulation of free radicals, which generate more oxidative stress during chemotherapy. This chemotherapeutic approach also leads to enhanced generation of reactive oxygen species and increased oxidative stress as a result. Blood samples were collected from 30 subjects (15 patients who received wheat grass juice (WGJ) and 15 patients who were only on chemotherapy) in the age range 25-60. The goal of the present investigation was to study the relationship between oxidative stress and breast cancer by measuring the non-enzymatic antioxidant levels of Glutathione reductase (GSH) and Malondialdehyde (MDA), which are the markers of lipid peroxidation in breast cancer patients and effect of wheat grass juice on these markers. From the results obtained, it was clear that MDA levels were higher whereas GSH levels decreased in breast cancer patients compared with normal controls. Significant changes in the MDA and GSH values were observed between the group receiving WGJ and the group receiving only chemotherapy. The administration of WGJ along with the treatment reduces the extent of oxidative damage and related complications in breast cancer patients.

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A Novel Systematic Oxidative Stress Score Predicts the Prognosis of Patients with Operable Breast Cancer

Oxidative Medicine and Cellular Longevity ◽

10.1155/2021/9441896 ◽

2021 ◽

Vol 2021 ◽

pp. 1-14

Author(s):

Kaiming Zhang ◽

Liqin Ping ◽

Tian Du ◽

Yan Wang ◽

Ya Sun ◽

...

Keyword(s):

Breast Cancer ◽

Oxidative Stress ◽

Cancer Patients ◽

Operable Breast Cancer ◽

Breast Cancer Patients ◽

Training Set ◽

Oxidative Stress Biomarkers ◽

Stress Biomarkers ◽

Validation Set ◽

The Relationship

Background. Breast cancer was associated with imbalance between oxidation and antioxidation. Local oxidative stress in tumors is closely related to the occurrence and development of breast cancer. However, the relationship between systematic oxidative stress and breast cancer remains unclear. This study is aimed at exploring the prognostic value of systematic oxidative stress in patients with operable breast cancer. Methods. A total of 1583 operable female breast cancer patients were randomly assigned into the training set and validation set. The relationship between systematic oxidative stress biomarkers and prognosis were analyzed in the training and validation sets. Results. The systematic oxidative stress score (SOS) was established based on five systematic oxidative stress biomarkers including serum creatinine (CRE), serum albumin (ALB), total bilirubin (TBIL), lactate dehydrogenase (LDH), and blood urea nitrogen (BUN). SOS was an independent prognostic factor for operable breast cancer patients. A nomogram based on SOS and clinical characteristics could accurately predict the prognosis of operable breast cancer patients, and the area under the curve (AUC) of the nomogram was 0.823 in the training set and 0.872 in the validation set, which was much higher than the traditional prognostic indicators. Conclusions. SOS is an independent prognostic indicator for operable breast cancer patients. A prediction model based on SOS could accurately predict the outcome of operable breast cancer patients.

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Antioxidants and Lipid Peroxidation Status In Women with Breast Cancer

IIUM Medical Journal Malaysia ◽

10.31436/imjm.v14i1.459 ◽

2020 ◽

Vol 14 (1) ◽

Author(s):

Seraj AK ◽

Shankhar M ◽

Raju KD ◽

Punam J ◽

Anju P ◽

...

Keyword(s):

Breast Cancer ◽

Oxidative Stress ◽

Lipid Peroxidation ◽

Superoxide Dismutase ◽

Vitamin C ◽

Cancer Patients ◽

Compensatory Mechanism ◽

Breast Cancer Patients ◽

Antioxidant Defences ◽

Cross Sectional

Introduction: Breast cancer is one of the most common malignancy in women and is the leading cause of cancer related death worldwide. Reactive oxygen species (ROS) play an important role in the development of tumours. Several mechanisms leading to oxidative stress have been proposed in cancer patients. In this study we aimed to measure and compare the levels of zinc, superoxide dismutase, catalase, vitamin C, vitamin E, and malondialdehyde in breast cancer patients and age matched healthy controls. Methods: In this comparative cross sectional study, 30 confirmed breast cancer cases and 30 age and sex matched controls were enrolled after taking their consent. Blood sample was collected in EDTA vial, and the parameters of oxidative stress were evaluated by spectrophotometric and atomic absorption spectrophotometric methods. Results: Zinc and MDA level were significantly higher (p<0.001) in cases (106.4 µg/dl and 7.12 nmol/ml) compared to controls (89.8µg/ dl and 3.99nmol/ml). In contrast, there were lower catalase, vitamin C and E levels in cases (28.7±14.56, 0.92±0.35 and 0.68±0.13 mg/dl) compared to controls (37.1±14.7,1.62±0.59 and 1.02±0.22 mg/dl) and were statistically significant (p<0.05 and p<0.001). Whereas, superoxide dismutase was lower in cases compared to controls, but was not statistically significant. Conclusion: Zinc was found to be higher in our study as it is a pivotal element in all rapidly growing tissues. Enhanced lipid peroxidation observed in the circulation of breast cancer patients in our study can be attributed to over production of ROS and deficiency of antioxidant defences. Oxidative stress in cancer cells may trigger excessive consumption of antioxidants as a compensatory mechanism which lead to its lower concentration.

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The relationship between psychosocial, demographic and navigation contact variables in underserved breast cancer patients

PsycEXTRA Dataset ◽

10.1037/e741372011-200 ◽

2010 ◽

Author(s):

Andrea Apodaca

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Breast Cancer Patients ◽

The Relationship

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The relationship of self-acceptance with decision making duration in cancer patient to perform mastectomy

Breast Disease ◽

10.3233/bd-219016 ◽

2021 ◽

pp. 1-5

Author(s):

Ayu Ratuati Setiawan ◽

Feny Tunjungsari ◽

Mochamad Aleq Sander

Keyword(s):

Breast Cancer ◽

Decision Making ◽

Cancer Patients ◽

Breast Cancer Patients ◽

Cross Sectional ◽

Abnormal Growth ◽

Self Acceptance ◽

Observation Method ◽

Relationship Of ◽

The Relationship

BACKGROUND: Cancer is a disease caused by abnormal growth of body cells that turn malignant and continue to grow uncontrollably. One of the treatments for breast cancer is mastectomy. The quickness of decision-making determines the survival rate of prognosis patients. OBJECTIVE: This study aimed to determine the relationship of self-acceptance with decision-making duration in cancer patients to perform a mastectomy. METHODS: An analytic observation method with cross-sectional design. The samples were taken by purposive sampling method with 50 samples of breast cancer patients. Data collected include age, last level of education, marital status, profession, stage of cancer during mastectomy, self-acceptance score, and decision-making duration to perform a mastectomy. RESULTS: The data analyzed with the Kruskal–Wallis test. The test showed the relationship of self-acceptance (p = 0.027) with decision-making duration in breast cancer patients to perform a mastectomy. CONCLUSION: In Conclusion, there is a relationship of self-acceptance with decision-making duration in breast cancer patients to perform a mastectomy.

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The relationship of plasma 7α-hydroxy dehydroepiandrosterone to disease stage and adrenal androgens in breast cancer patients

European Journal of Cancer (1965) ◽

10.1016/0014-2964(80)90154-1 ◽

1980 ◽

Vol 16 (2) ◽

pp. 223-228 ◽

Cited By ~ 13

Author(s):

S.J.M. Skinner ◽

R.A.F. Couch ◽

S. Thambyah ◽

R.J. Dobbs ◽

S.M. Jordan ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Disease Stage ◽

Breast Cancer Patients ◽

Adrenal Androgens ◽

Relationship Of ◽

The Relationship

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Roles of Superoxide dismutase(SOD) , Malondialdehyde (MDA), 8-iso-prostaglandinF2α ( 8-iso-PGF2α)as oxidative stress in development and progression of Brest cancer in Iraqi females patients

Al-Qadisiyah Journal Of Pure Science ◽

10.29350/jops.2020.25.1.1053 ◽

2020 ◽

Vol 25 (1) ◽

pp. 1-4

Author(s):

Ferdous Abbas Jabir ◽

Ahmed Sabah Shaker

Keyword(s):

Breast Cancer ◽

Oxidative Stress ◽

Cancer Patients ◽

Antioxidant Defenses ◽

Blood Levels ◽

P Value ◽

Oxygen Species ◽

Breast Cancer Patients ◽

Markers Of Oxidative Stress ◽

The Mean

Oxidative stress occurs as a result of disturbance in the balance between the production of reactive oxygen species (free radicals) and antioxidant defenses. Markers of oxidative stress were measured the markers of oxidative stress in breast cancer patients after diagnosis of breast cancer and compared these plasma blood levels controls This study was conducted to three markers of oxidative stress ;these are (SOD) enzyme ,malondialdehyde (MDA)and8-iso-prostaglandinF2α plasma of patients with breast cancer and compare with controls .In this study ; the mean MDA (ng/ml) levels for the breast cancer patients and the controls were55.91±3.31 and40.61±3.76 respectively, while the SOD (pg/ml) levels were1530.37±80.4 and1851.4 9±93.65 respectively and the 8-iso-PGF2α (ng/ml ) levels were 40.16±3.31 and 30.16±2.34 difference of the mean were statistically significant (p value <0.05).

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