scholarly journals Psycholinguistic Preconditions of Speech Formation of Children with General Speech Retardation

2021 ◽  
Vol 12 (4) ◽  
pp. 263-277
Author(s):  
Iryna Brushnevska ◽  
Julia Ribtsun ◽  
Liudmyla Stasiuk ◽  
Nataliia Ilina ◽  
Iryna Vasylehko ◽  
...  
Keyword(s):  
Dominant Role ◽  
Psychological Mechanisms ◽  
Speech Activity ◽  
Effective Interventions ◽  
Prediction Function ◽  
Probability Prediction ◽  
Verbal Probability ◽  
First Time

The article addresses psycholinguistic preconditions for development of the communicative component of speech activity in 5-year-olds with general speech retardation (GSR). The development of speech activity is analyzed through the lens of psycholinguistic motivation for the emergence of speech units. The authors for the first time identified psychological mechanisms that underlie disorders in the development of the communication component of speech activity in 5-year-olds with GSR and suggested effective interventions. The research involved a study of probability prediction within the structure of the communicative component of speech activity of 5-year-olds with GSR. The author-developed classification of non-verbal and verbal probability prediction formed the basis for a theory-based diagnostic tool to assess the communicative component of speech activity in 5-year-olds with GSR. The research demonstrated the importance of probability prediction as a dynamic process and indicator of practical realization of utterance and holistically developed coherent speech. The analysis of disorders in cognitive and speech operations and functions identified in the study points to the dominant role of weak probability prediction function at non-verbal and verbal levels. Weak probability prediction was defined as the cause of poorly developed communication component of speech activity in 5-year-olds with GSR.

Modern Museum and Paramuseum: Existential Alienation and Actualization

2021 ◽  
Vol 13 (3-2) ◽  
pp. 410-425
Author(s):  
Denis Ignatyev ◽  
◽  
Anastasia Nikiforova ◽  
Keyword(s):  
Cultural Memory ◽  
Cultural Objects ◽  
The Past ◽  
Synergistic Approach ◽  
Historical Objects ◽  
First Time ◽  
Scientific Life ◽  
Northwestern Russia

The article is devoted to the study of the problem of alienation of culture in a modern museum and the processes of actualization of objects and phenomena of history in the space of the paramuseum. In the center of the author’s attention is the theme of creating the illusion of existential comfort. It explores the contradiction between the need for museification of culture in order for a modern person to be able to appeal to it when building one’s own identity, and the constant desire to place the culture of the past on a safe reservation. The issue of aestheticization of cultural objects in the museum space and the role of a museum in interpreting, preserving and distorting their meaning is raised. The museum, created as a repository of antiquities, a collection of masterpieces, today has become the most sensitive system that responds to changes in the life of culture and society. An axiological analysis of modern museums shows their growing popularity as an element of the entertainment industry, while their aesthetic, analytical, and intellectual role is becoming obscure. Respect for the museum as a keeper of cultural memory, for the focus of scientific life is disappearing. Instead, a simplified “attraction museum” and paramuseum is coming to the fore, creating endless games with historical objects, reconstructions, visitors and interpretations of the events of history and culture. The authors of the article are among the first to turn to the concept of “paramuseum” and give it a comprehensive assessment. For the first time, a scientific classification of paramuseums (on the example of paramuseums of northwestern Russia) is proposed. Their main features and characteristics are identified. A synergistic approach to the processes of actualization and alienation of cultural objects in the museum environment made it possible to include the viewer, the recipient, as the third, necessary component of this system. This made it possible to conclude that museum values are alienated or updated not by themselves, but only in relation to the “person watching.” Thus, modern museums and paramuseums are a form of value-based self-consciousness of society, demonstrating the total stratification of post-culture society, its fragmentation into value clusters that can represent culture as a whole only in the process of analytical consciousness, but not in the collection of subject series.

scholarly journals The Behavioral Immune System Shapes Political Intuitions: Why and How Individual Differences in Disgust Sensitivity Underlie Opposition to Immigration

2017 ◽  
Vol 111 (2) ◽  
pp. 277-294 ◽  
Author(s):  
LENE AARØE ◽  
MICHAEL BANG PETERSEN ◽  
KEVIN ARCENEAUX
Keyword(s):  
Immune System ◽  
Emotional Processing ◽  
Meta Analysis ◽  
The United States ◽  
Behavioral Immune System ◽  
Psychological Mechanisms ◽  
Nationally Representative ◽  
First Time ◽  
Representative Samples

We present, test, and extend a theoretical framework that connects disgust, a powerful basic human emotion, to political attitudes through psychological mechanisms designed to protect humans from disease. These mechanisms work outside of conscious awareness, and in modern environments, they can motivate individuals to avoid intergroup contact by opposing immigration. We report a meta-analysis of previous tests in the psychological sciences and conduct, for the first time, a series of tests in nationally representative samples collected in the United States and Denmark that integrate the role of disgust and the behavioral immune system into established models of emotional processing and political attitude formation. In doing so, we offer an explanation for why peaceful integration and interaction between ethnic majority and minorities is so hard to achieve.

scholarly journals Paying attention to reading: The neurobiology of reading and dyslexia

2008 ◽  
Vol 20 (4) ◽  
pp. 1329-1349 ◽  
Author(s):  
Sally E. Shaywitz ◽  
Bennett A. Shaywitz
Keyword(s):  
Great Part ◽  
Functional Brain Imaging ◽  
Neural Systems ◽  
Adjunct Treatment ◽  
Hyperactivity Disorder ◽  
Effective Interventions ◽  
Neural Signature ◽  
First Time ◽  
Attentional Mechanisms

AbstractExtraordinary progress in functional brain imaging, primarily advances in functional magnetic resonance imaging, now allows scientists to understand the neural systems serving reading and how these systems differ in dyslexic readers. Scientists now speak of the neural signature of dyslexia, a singular achievement that for the first time has made what was previously a hidden disability, now visible. Paralleling this achievement in understanding the neurobiology of dyslexia, progress in the identification and treatment of dyslexia now offers the hope of identifying children at risk for dyslexia at a very young age and providing evidence-based, effective interventions. Despite these advances, for many dyslexic readers, becoming a skilled, automatic reader remains elusive, in great part because though children with dyslexia can be taught to decode words, teaching children to read fluently and automatically represents the next frontier in research on dyslexia. We suggest that to break through this “fluency” barrier, investigators will need to reexamine the more than 20-year-old central dogma in reading research: the generation of the phonological code from print is modular, that is, automatic and not attention demanding, and not requiring any other cognitive process. Recent findings now present a competing view: other cognitive processes are involved in reading, particularly attentional mechanisms, and that disruption of these attentional mechanisms play a causal role in reading difficulties. Recognition of the role of attentional mechanisms in reading now offer potentially new strategies for interventions in dyslexia. In particular, the use of pharmacotherapeutic agents affecting attentional mechanisms not only may provide a window into the neurochemical mechanisms underlying dyslexia but also may offer a potential adjunct treatment for teaching dyslexic readers to read fluently and automatically. Preliminary studies suggest that agents traditionally used to treat disorders of attention, particularly attention-deficit/hyperactivity disorder, may prove to be an effective adjunct to improving reading in dyslexic students.

scholarly journals Evolutionary paths among different red galaxy types at 0.3 < z < 1.5 and the build-up of massive E-S0's

2012 ◽  
Vol 8 (S295) ◽  
pp. 176-176
Author(s):  
Jesús Gallego ◽  
Mercedes Prieto ◽  
M. Carmen Eliche-Moral ◽  
Marc Balcells ◽  
David Cristóbal-Hornillos ◽  
...  
Keyword(s):  
Galaxy Formation ◽  
Dominant Role ◽  
Regional Government ◽  
Massive Galaxies ◽  
Combining Data ◽  
Red Galaxies ◽  
Evolutionary Paths ◽  
First Time ◽  
Red Sequence

AbstractSome recent observations seem to disagree with hierarchical theories of galaxy formation on the role of major mergers in a late build-up of massive early-type galaxies. We re-address this question by analysing the morphology, structural distortion level, and star formation enhancement of a sample of massive galaxies (M* > 5 × 1010M⊙) lying on the Red Sequence and its surroundings at 0.3 < z < 1.5. We have used an initial sample of ~1800 sources with Ks < 20.5 mag over an area ~155 arcmin2 on the Groth Strip, combining data from the Rainbow Extragalactic Database and the GOYA Survey. Red galaxy classes that can be directly associated to intermediate stages of major mergers and to their final products have been defined. For the first time we report observationally the existence of a dominant evolutionary path among massive red galaxies at 0.6 < z < 1.5, consisting in the conversion of irregular disks into irregular spheroids, and of these ones into regular spheroids. This result points to: 1) the massive red regular galaxies at low redshifts derive from the irregular ones populating the Red Sequence and its neighbourhood at earlier epochs up to z ~ 1.5; 2) the progenitors of the bulk of present-day massive red regular galaxies have been blue disks that have migrated to the Red Sequence majoritarily through major mergers at 0.6 < z < 1.2 (these mergers thus starting at z ~ 1.5); 3) the formation of E-S0's that end up with M* > 1011M⊙ at z = 0 through gas-rich major mergers has frozen since z ~ 0.6. Our results support that major mergers have played the dominant role in the definitive build-up of present-day E-S0's with M* > 1011M⊙ at 0.6 < z < 1.2, in good agreement with the hierarchical scenario proposed in the Eliche-Moral et al. (2010a) model (see also Eliche-Moral et al. 2010b). This study is published in Prieto et al. (2012).Supported by the Spanish Ministry of Science and Innovation (MICINN) under projects AYA2009-10368, AYA2006-12955, AYA2010-21887-C04-04, and AYA2009-11137, by the Madrid Regional Government through the AstroMadrid Project (CAM S2009/ESP-1496), and by the Spanish MICINN under the Consolider-Ingenio 2010 Program grant CSD2006-00070: “First Science with the GTC” (http://www.iac.es/consolider-ingenio-gtc/). S. D. H. & G.

scholarly journals Classifying Intimate Partner Violence: A Functional Typology

2021 ◽  
Author(s):  
◽  
Annabelle Wride
Keyword(s):  
Intimate Partner Violence ◽  
Partner Violence ◽  
Intimate Partner ◽  
Theoretical Development ◽  
Specific Reference ◽  
Effective Interventions ◽  
Alternative Approach ◽  
Offending Behaviour

<p>A neglect of theoretical development has impaired psychological explanations for intimate partner violence (IPV), which in turn has hindered effective interventions for people who perpetrate IPV. This thesis addresses this problem by applying recent perspectives on classification to examine whether typologies of IPV facilitate useful explanations of these behaviours, and proposes an alternative strategy for classifying IPV. First, the role of classification is discussed, in terms of the theoretical requirements typologies should fulfil, and with specific reference to the classification of offending behaviour. Second, two of the most influential typologies of IPV – Holtzworth-Munroe and Stuart’s (1994), and Johnson’s (1995, 2006) typologies – are critically analysed according to their conceptual problems. Third, a preliminary alternative approach to classifying IPV is proposed, in response to recent theoretical developments that suggest a focus on the function of IPV behaviours is required. This Motivational Systems Typology classifies individuals who have perpetrated IPV based on their motivations, and its capacity for facilitating explanations of IPV is demonstrated through an exemplar. Finally, the implications of this typology for understandings of IPV and classification are discussed.</p>

scholarly journals Splicing of a Critical Exon of Human Survival Motor Neuron Is Regulated by a Unique Silencer Element Located in the Last Intron

2006 ◽  
Vol 26 (4) ◽  
pp. 1333-1346 ◽  
Author(s):  
Nirmal K. Singh ◽  
Natalia N. Singh ◽  
Elliot J. Androphy ◽  
Ravindra N. Singh
Keyword(s):  
Motor Neuron ◽  
Antisense Oligonucleotide ◽  
Muscular Atrophy ◽  
Dominant Role ◽  
Survival Motor Neuron ◽  
Exon Junction Complex ◽  
Splicing Silencer ◽  
Smn Protein ◽  
First Time

ABSTRACT Humans have two nearly identical copies of the Survival Motor Neuron (SMN) gene, SMN1 and SMN2. In spinal muscular atrophy (SMA), SMN2 is not able to compensate for the loss of SMN1 due to exclusion of exon 7. Here we describe a novel inhibitory element located immediately downstream of the 5′ splice site in intron 7. We call this element intronic splicing silencer N1 (ISS-N1). Deletion of ISS-N1 promoted exon 7 inclusion in mRNAs derived from the SMN2 minigene. Underlining the dominant role of ISS-N1 in exon 7 skipping, abrogation of a number of positive cis elements was tolerated when ISS-N1 was deleted. Confirming the silencer function of ISS-N1, an antisense oligonucleotide against ISS-N1 restored exon 7 inclusion in mRNAs derived from the SMN2 minigene or from endogenous SMN2. Consistently, this oligonucleotide increased the levels of SMN protein in SMA patient-derived cells that carry only the SMN2 gene. Our findings underscore for the first time the profound impact of an evolutionarily nonconserved intronic element on SMN2 exon 7 splicing. Considering that oligonucleotides annealing to intronic sequences do not interfere with exon-junction complex formation or mRNA transport and translation, ISS-N1 provides a very specific and efficient therapeutic target for antisense oligonucleotide-mediated correction of SMN2 splicing in SMA.

scholarly journals Describing place through user generated content

First Monday ◽  
2011 ◽  
Author(s):  
Ross Purves ◽  
Alistair Edwardes ◽  
Jo Wood
Keyword(s):  
User Generated Content ◽  
Free Text ◽  
First Time

Geographically referenced user generated content provides us with an opportunity to, for the first time, gather perspectives on place over large areas by exploring how very many people describe information. We present a framework for analysing large collections of user generated content. This involves classification of descriptive terms attached by users to photographs into facets of elements, qualities, and activities. We apply this framework to two contrasting photographic archives — Flickr and Geograph, representing weakly and strongly moderated content respectively. We propose a method for removing user-generated bias from such collections though the user of term profiles that can assess the effect of the most and least prolific contributors to a collection. Analysis and visualization of co–occurrence between terms suggests clear differences in the description of place between the two collections, both in terms of the facets used and their geographical footprints. This is attributed to the role of moderation/editorialising of content; to the role tags and free–text has on descriptive behaviour and on the geographic footprint of content supplied to the two collections.

scholarly journals Trial Proteomic Qualitative and Quantitative Analysis of the Protein Matrix of Submandibular Sialoliths

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6725
Author(s):  
Paulina Czaplewska ◽  
Aleksandra E. Bogucka ◽  
Natalia Musiał ◽  
Dmitry Tretiakow ◽  
Andrzej Skorek ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Protein Extraction ◽  
Sodium Dodecyl ◽  
Extraction Process ◽  
The Matrix ◽  
Human Proteins ◽  
Protein Components ◽  
First Time

Our studies aimed to explore the protein components of the matrix of human submandibular gland sialoliths. A qualitative analysis was carried out based on the filter aided sample preparation (FASP) methodology. In the protein extraction process, we evaluated the applicability of the standard demineralization step and the use of a lysis buffer containing sodium dodecyl sulfate (SDS) and dithiothreitol (DTT). The analysis of fragmentation spectra based on the human database allowed for the identification of 254 human proteins present in the deposits. In addition, the use of multi-round search in the PEAKS Studio program against the bacterial base allowed for the identification of 393 proteins of bacterial origin present in the extract obtained from sialolith, which so far has not been carried out for this biological material. Furthermore, we successfully applied the SWATH methodology, allowing for a relative quantitative analysis of human proteins present in deposits. The obtained results correlate with the classification of sialoliths proposed by Tretiakow. The performed functional analysis allowed for the first time the selection of proteins, the levels of which differ between the tested samples, which may suggest the role of these proteins in the calcification process in different types of sialoliths. These are preliminary studies, and drawing specific conclusions requires research on a larger group, but it provides us the basis for the continuation of the work that has already begun.

scholarly journals TRANSATLANTIC AFFILIATIONS OF SCIENTIFIC COLLABORATION IN STRATEGIC MANAGEMENT: A QUARTER-CENTURY OF BIBLIOMETRIC EVIDENCE

2020 ◽  
Vol 21 (3) ◽  
pp. 627-646
Author(s):  
Oskar Kosch ◽  
Marek Szarucki
Keyword(s):  
Strategic Management ◽  
Scientific Collaboration ◽  
Web Of Science ◽  
Dominant Role ◽  
Knowledge Exchange ◽  
The United States ◽  
Quarter Century ◽  
The Us ◽  
First Time

The main objective of the paper is to identify and explore patterns and dynamics of transatlantic scientific collaboration in the field of strategic management between the United States (US) and European countries (EUC) during the last quarter century. Scholarly connections between countries, cities and institutions on the basis of co-author affiliations were analysed to determine the knowledge flow from a geographical perspective. This is the first time international scientific collaboration between researchers in the field of strategic management has been studied to such an extent. We employed all sources of relevant data from the Web of Science and Scopus databases and explored 453 results. Utilizing a bibliometric analysis, our study offers a comprehensive and up-todate identification and assessment of the current situation and dynamics of transatlantic scientific collaboration. The obtained results confirm the dominant role of the US in this type of collaboration. Also, the dominant role of several clusters in terms of collaboration, both on country and institution levels can also be observed. The study confirms the weaker position of Eastern and Central Europe countries in this collaboration and provides some recommendations to increase this type of knowledge exchange in the future.

scholarly journals Classifying Intimate Partner Violence: A Functional Typology

2021 ◽  
Author(s):  
◽  
Annabelle Wride
Keyword(s):  
Intimate Partner Violence ◽  
Partner Violence ◽  
Intimate Partner ◽  
Theoretical Development ◽  
Specific Reference ◽  
Effective Interventions ◽  
Alternative Approach ◽  
Offending Behaviour

<p>A neglect of theoretical development has impaired psychological explanations for intimate partner violence (IPV), which in turn has hindered effective interventions for people who perpetrate IPV. This thesis addresses this problem by applying recent perspectives on classification to examine whether typologies of IPV facilitate useful explanations of these behaviours, and proposes an alternative strategy for classifying IPV. First, the role of classification is discussed, in terms of the theoretical requirements typologies should fulfil, and with specific reference to the classification of offending behaviour. Second, two of the most influential typologies of IPV – Holtzworth-Munroe and Stuart’s (1994), and Johnson’s (1995, 2006) typologies – are critically analysed according to their conceptual problems. Third, a preliminary alternative approach to classifying IPV is proposed, in response to recent theoretical developments that suggest a focus on the function of IPV behaviours is required. This Motivational Systems Typology classifies individuals who have perpetrated IPV based on their motivations, and its capacity for facilitating explanations of IPV is demonstrated through an exemplar. Finally, the implications of this typology for understandings of IPV and classification are discussed.</p>

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