PROFILE OF SEX HORMONES, PROLACTIN AND SSH AT LATE STAGES OF LIVER METASTASIS FROM SARCOMA 45 IN MALE RATS

Differences in gender are in part responsible for the development of insulin resistance (IR) and associated hypertension. Currently, it is unclear whether these differences are dictated by gender itself or by the relative changes in plasma estrogen and/or testosterone. We investigated the interrelationships between testosterone and estrogen in the progression of IR and hypertension in vivo in intact and gonadectomized fructose-fed male rats. Treatment with estrogen significantly reduced the testosterone levels in both normal chow-fed and fructose-fed rats. Interestingly, fructose feeding induced a relative increase in estradiol levels, which did not affect IR in both intact and gonadectomized fructose-fed rats. However, increasing the estrogen levels improved insulin sensitivity in both intact and gonadectomized fructose-fed rats. In intact males, fructose feeding increased the blood pressure (140 ± 2 mmHg), which was prevented by estrogen treatment. However, the blood pressure in the fructose-fed estrogen rats (125 ± 1 mmHg) was significantly higher than that of normal chow-fed (113 ± 1 mmHg) and fructose-fed gonadectomized rats. Estrogen treatment did not affect the blood pressure in gonadectomized fructose-fed rats (105 ± 2 mmHg). These data suggest the existence of a threshold value for estrogen below which insulin sensitivity is unaffected. The development of hypertension in this model is dictated solely by the presence or absence of testosterone. In summary, the development of IR and hypertension is governed not by gender per se but by the interactions of specific sex hormones such as estrogen and testosterone.

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On the local damaging effect of biogenic degradation products of the BAK-1000 silicate matrix after implantation (experimental morphological study)

Nauchno-prakticheskii zhurnal «Patogenez» ◽

10.25557/2310-0435.2018.03.44-49 ◽

2018 ◽

pp. 44-49

Author(s):

А.Ф. Фидаров ◽

А.С. Григорьян ◽

Т.Д. Колокольцова ◽

А.А. Орлов ◽

Е.Е. Устинова ◽

...

Keyword(s):

Bone Tissue ◽

Morphological Study ◽

Degradation Products ◽

Healing Process ◽

Male Rats ◽

Tissue Integrity ◽

And Function ◽

Tissue Trauma ◽

Tissue Restoration ◽

Late Stages

Актуальность. Травматизм костных тканей остается одной из серьезных проблем современности. Восстановление структуры и функциональности костной ткани больных с посттравматическими поражениями подчеркивает высокую значимость и актуальность проведения исследований по поиску новых методов и материалов для восстановления целостности и оптимизации процессов заживления костной ткани. Целью исследования было экспериментально-морфологическое изучение эффективности применения остеокондуктивного апатитосиликатного композита БАК-1000 в качестве имплантационного материала для восстановления обширного дефекта костной ткани. Методика. Исследования проведены на крысах линии CD, самцах массой 600 ± 10 г (n = 12). После остеотомии с удалением фрагмента кости размером 0,3 х 0,5 см дефект заполняли стерильным имплантационным материалом БАК-1000 в виде цилиндрических блоков того же размера. Контроль восстановления костной ткани проводили гистологическим методом. Результаты показали, что БАК-1000 обладает выраженным местным побочным эффектом, приводящим к возникновению очагов патологического процесса на поздних сроках заживления. Заключение. Данные экспериментально-морфологического исследования подтверждают необходимость проведения более тщательных исследований предлагаемых для использования в клинической практике материалов или композитов на поздних сроках после применения. Background. Bone tissue trauma remains one of serious current challenges. Restoration of the bone tissue structure and function in posttraumatic lesions emphasizes a high relevance of searching for new methods and materials to restore the bone tissue integrity and optimize the healing process. The aim of this experimental morphological study was to evaluate the effectiveness of an osteoconductive apatite-silicate composite BAK-1000 as an implant material for restoration of large defects in bone tissue. Methods. The study was performed on male rats (CD strain) weighing 600 ± 10 g (n = 12). After osteotomy with removal of a 0.3 х 0.5 cm bone fragment, the defect was filled with sterile BAK-1000 implantation material in the form of cylindrical blocks of the same size. The bone tissue restoration process was monitored histologically. The results showed that BAC-1000 had a pronounced local side effect, leading to the emergence of pathological foci at late stages of healing. Conclusion. This experimental morphological study confirmed the need to study more thoroughly the materials or composites proposed for use in clinical practice at late terms following application.

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Sex hormones differentially influence voluntary running activity, food intake and body weight in aging female and male rats

European Journal of Applied Physiology ◽

10.1007/s00421-011-2271-y ◽

2011 ◽

Vol 112 (8) ◽

pp. 3007-3018 ◽

Cited By ~ 13

Author(s):

J. Andries Ferreira ◽

Andrea M. Foley ◽

Marybeth Brown

Keyword(s):

Body Weight ◽

Food Intake ◽

Sex Hormones ◽

Male Rats ◽

Running Activity ◽

Voluntary Running

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The expression of serum steroid sex hormones and steroidogenic enzymes following intraperitoneal administration of dehydroepiandrosterone (DHEA) in male rats

Steroids ◽

10.1016/j.steroids.2009.11.007 ◽

2010 ◽

Vol 75 (3) ◽

pp. 213-218 ◽

Cited By ~ 11

Author(s):

Lijie Song ◽

Xue Tang ◽

Yili Kong ◽

Haitian Ma ◽

Sixiang Zou

Keyword(s):

Sex Hormones ◽

Intraperitoneal Administration ◽

Male Rats ◽

Steroidogenic Enzymes ◽

Steroid Sex Hormones

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The effect of sex and sex hormones on the infection of rats by Trichinella spiralis

Canadian Journal of Zoology ◽

10.1139/z72-082 ◽

1972 ◽

Vol 50 (5) ◽

pp. 597-602 ◽

Cited By ~ 22

Author(s):

Sarojam K. Mankau ◽

Raymond Hamilton

Keyword(s):

Sex Hormones ◽

Worm Burden ◽

Testosterone Propionate ◽

Marked Decrease ◽

Trichinella Spiralis ◽

Male Rats ◽

Normal Male ◽

Normal Males

Male hooded rats infected with Trichinella spiralis larvae had three times more larvae in the muscles than females. Gonadectomized males injected with stilbestrol had a lower worm burden than normal males. Gonadectomized females injected with testosterone propionate harbored far more worms than normal females. Stilbestrol administered to normal male rats caused a marked decrease in T. spiralis, while testosterone administered to normal females resulted in a significant increase in the number of parasites.

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The Effect of Leptin on Sex Hormones and Antioxidant Enzyme Levels in Obese and Normal Male Rats

International Journal of Peptide Research and Therapeutics ◽

10.1007/s10989-018-9758-x ◽

2018 ◽

Vol 25 (3) ◽

pp. 1105-1111 ◽

Cited By ~ 2

Author(s):

Hossein Cheraghi ◽

Morteza Zendehdel ◽

Jamshid GhiasiGhalehkandi ◽

Parviz Tajik ◽

Negar Panahi

Keyword(s):

Antioxidant Enzyme ◽

Sex Hormones ◽

Male Rats ◽

Normal Male

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Male gender increases sensitivity to proteinuria induced by mild NOS inhibition in rats: role of sex hormones

AJP Renal Physiology ◽

10.1152/ajprenal.2000.279.4.f664 ◽

2000 ◽

Vol 279 (4) ◽

pp. F664-F670 ◽

Cited By ~ 31

Author(s):

A. Marjan G. Verhagen ◽

Diana M. A. Attia ◽

Hein A. Koomans ◽

Jaap A. Joles

Keyword(s):

Nitric Oxide ◽

Sex Hormones ◽

Oxide System ◽

Female Rats ◽

Male Rats ◽

Time Control ◽

Ovx Rats ◽

Increased Sensitivity ◽

Dose Dependent Increase

Men are at greater risk for renal injury than women. We studied whether male rats are more sensitive to the hypertensive and proteinuric effects of chronic nitric oxide sythase (NOS) inhibition than female rats. In addition, we studied whether androgens or estrogens are responsible for differences in sensitivity to proteinuria induced by chronic NOS inhibition. Females and males were treated with 10, 20, 30, and 100 mg/l N ω-nitro-l-arginine (l-NNA) during 24 wk. Systolic blood pressure (SBP) and proteinuria were measured regularly and compared with time-control measurements in control females and males. In females and males treatment with 10 mg/l l-NNA had no effect on SBP or proteinuria. Treatment with 20, 30, and 100 mg/l l-NNA resulted in a dose-dependent increase in SBP that was similar in males and females. However, females treated with 20 and 30 mg/ll-NNA were resistant to the development of proteinuria: maximum values were 16 ± 7 and 46 ± 21, respectively, vs. 16 ± 3 mg/day in controls, whereas males treated with those doses showed an increase in proteinuria [139 ± 35 ( P< 0.05) and 318 ± 82 ( P < 0.01), respectively, vs. 55 ± 11 mg/day in controls]. Treatment with 100 mg/ll-NNA increased proteinuria similarly in both females and males. To study the role of sex hormones in differences in sensitivity to proteinuria induced by mild chronic NOS inhibition, treatment with 20 mg/l l-NNA was repeated in ovariectomized (Ovx) and orchidectomized rats. Ovariectomy did not affect the increase in SBP caused by 20 mg/l l-NNA, but, in contrast to intact females, this dose of l-NNA did cause Ovx rats to develop proteinuria (51 ± 16 vs. 16 ± 7 mg/day in control Ovx rats; P < 0.05). Orchidectomy completely prevented the increased SBP as well as proteinuria induced by 20 mg/ll-NNA in male rats. In conclusion, male rats are more sensitive than female rats to develop proteinuria induced by mild chronic NOS inhibition. Estrogens provide some protection in females, whereas androgens are responsible for the increased sensitivity of male rats to proteinuria induced by mild chronic NOS inhibition. Risk factors associated with a compromised nitric oxide system may be more detrimental to the kidney in men than in women.

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