Features of modern clinical research blood analysis in the assessment of erythropoiesis in deep-premature newborns

2021 ◽  
Vol 66 (1) ◽  
pp. 26-34
Author(s):  
Galina Nikolaevna Kuzmenko ◽  
N. V. Kharlamova ◽  
S. B. Nazarov ◽  
E. A. Matveeva ◽  
Yu. A. Ivanenkova
Keyword(s):  
Neonatal Period ◽  
Venous Blood ◽  
Diagnostic Procedures ◽  
Blood Parameters ◽  
Blood Analysis ◽  
Iron Availability ◽  
Average Amount ◽  
Premature Newborns ◽  
Early Neonatal Period ◽  
Premature Babies

One of the urgent problems of nursing premature babies is the timely prediction, diagnosis and treatment of anemia, the frequency of which reaches 90%. Of particular importance is the study of reticulocytic blood parameters in deep-premature newborns, since the correct assessment of hemograms is crucial in the management of this category of children. To determine the characteristics of red blood cells and reticulocyte parameters of venous blood hemogram in premature newborns 24-32 weeks of gestation in the dynamics of the neonatal period. 111 newborns were examined at 24-32 weeks of gestation in the early neonatal period (on day 3-7) and at the age of 1 month of life. Along with standard diagnostic procedures, in accordance with current clinical recommendations and standards, 28 parameters of erythrocyte and reticulocyte hemogram parameters were determined for children. Venous blood was examined using an automatic hematological analyzer ADVIA 2120i, Siemens, USA. In deep-premature newborns in the early neonatal period, there is a high activity of erythropoiesis, respectively, the severity of respiratory and metabolic disorders with rejuvenation of reticulocytic subpopulations. Negative values of Delta hemoglobin were found against the background of a decrease in the average amount of hemoglobin in reticulocytes in children 24-27 weeks of gestation, which characterizes the lowest values of iron availability for erythropoiesis in this category of newborns. It is shown that a decrease in reticulocyte counts and normochromia in all examined newborns by the age of one month are accompanied by high levels of immature reticulocyte fraction, while a third of children still have limited iron availability for erythropoiesis.

GLYCOGEN STORAGE DISEASE OF THE LIVER

PEDIATRICS ◽  
1954 ◽  
Vol 14 (6) ◽  
pp. 632-645
Author(s):  
JEROME L. SCHULMAN ◽  
PHOEBE SATUREN
Keyword(s):  
Blood Sugar ◽  
Glycogen Storage Disease ◽  
Storage Disease ◽  
Neonatal Period ◽  
Normal Values ◽  
Cerebral Metabolism ◽  
Diagnostic Procedures ◽  
Glycogen Storage ◽  
Early Neonatal Period ◽  
Essentially Normal

1. Three cases of glycogen storage disease occurring in the early neonatal period are presented. Two of these were in siblings, 1 of whom died at the age of 1 day. 2. Tachypnea and enlargement of the liver were the prominent manifestations of the illness. The similarity between this syndrome and other syndromes points up the need for instituting suitable clinical and pathologic diagnostic procedures in the early neonatal period. 3. Determinations of glycogen and glucose-6-phosphatase in the liver in 2 of these patients are presented. 4. Quantitatively standardized glucagon tolerance curves are presented in 2 of these patients and compared with those obtained in normal infants. The character of the response suggests its value as a diagnostic test in this condition. 5. Electroencephalographic tracings during periods with marked hypoglycemia and during periods with normal values for blood sugar were found to be essentially normal. It is suggested that some unusual mechanism for the maintenance of cerebral metabolism during hypoglycemia may be present.

Effects of Long-term Creatine Supplementation on Liver and Kidney Functions in American College Football Players

2002 ◽  
Vol 12 (4) ◽  
pp. 453-460 ◽  
Author(s):  
David L. Mayhew ◽  
Jerry L. Mayhew ◽  
John S. Ware
Keyword(s):  
Venous Blood ◽  
Creatine Supplementation ◽  
Blood Parameters ◽  
Blood Analysis ◽  
American Football ◽  
Control Group ◽  
Daily Consumption ◽  
Training Experience ◽  
Liver And Kidney

The purpose of this study was to determine the effect of long-term Cr supplementation on blood parameters reflecting liver and kidney function. Twenty-three members of an NCAA Division II American football team (ages = 19–24 years) with at least 2 years of strength training experience were divided into a Cr monohydrate group (CrM, n = 10) in which they voluntarily and spontaneously ingested creatine, and a control group (n = 13) in which they took no supplements. Individuals in the CrM group averaged regular daily consumption of 5 to 20 g (mean ± SD = 13.9 ± 5.8 g) for 0.25 to 5.6 years (2.9 ± 1.8 years). Venous blood analysis for serum albumin, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, bilirubin, urea, and creatinine produced no significant differences between groups. Creatinine clearance was estimated from serum creatinine and was not significantly different between groups. Within the CrM group, correlations between all blood parameters and either daily dosage or duration of supplementation were nonsignificant. Therefore, it appears that oral supplementation with CrM has no long-term detrimental effects on kidney or liver functions in highly trained college athletes in the absence of other nutritional supplements.

A Case of Congenital Glucose Galactose Malabsorption with a New Mutation in the SLC5A1 Gene

2020 ◽  
Author(s):  
Hasan Akduman ◽  
Dilek Dilli ◽  
Serdar Ceylaner
Keyword(s):  
Mutation Analysis ◽  
Autosomal Recessive ◽  
Glucose Transporter ◽  
Neonatal Period ◽  
Autosomal Recessive Disorder ◽  
Homozygous Mutation ◽  
New Mutation ◽  
Early Neonatal Period ◽  
Sodium Dependent ◽  
Hypernatremic Dehydration

AbstractCongenital glucose-galactose malabsorption (CGGM) is an autosomal recessive disorder originating from an abnormal transporter mechanism in the intestines. It was sourced from a mutation in the SLC5A1 gene, which encodes a sodium-dependent glucose transporter. Here we report a 2-day-old girl with CGGM who presented with severe hypernatremic dehydration due to diarrhea beginning in the first hours of life. Mutation analysis revealed a novel homozygous mutation NM_000343.3 c.127G > A (p.Gly43Arg) in the SLC5A1 gene. Since CGGM can cause fatal diarrhea in the early neonatal period, timely diagnosis of the disease seems to be essential.

FEATURES OF CARDIORESPIRATORY ADAPTATION OF LATER PRETERM INFANTS IN THE EARLY NEONATAL PERIOD

2018 ◽  
Vol 14 (66) ◽  
pp. 100
Author(s):  
G. A. Solovyova ◽  
V. I. Pokhilko ◽  
S. N. Tsvirenko ◽  
N. I. Gasyuk ◽  
Yu. Yu. Klimchuk
Keyword(s):  
Preterm Infants ◽  
Neonatal Period ◽  
Early Neonatal Period

scholarly journals C16 Hydroxylation of 3.BETA.-Hydroxy-.DELTA.5-steroids during the Early Neonatal Period.

1997 ◽  
Vol 20 (12) ◽  
pp. 1295-1299 ◽  
Author(s):  
Noriko TAGAWA ◽  
Satoshi KUSUDA ◽  
Yoshiharu KOBAYASHI
Keyword(s):  
Neonatal Period ◽  
Early Neonatal Period

Plasma 17-OH-Progesterone in Fullterm and Preterm Infants at Birth and during the Early Neonatal Period

1981 ◽  
Vol 15 (2) ◽  
pp. 65-71 ◽  
Author(s):  
B. Godó ◽  
H.K.A. Visser ◽  
H.J. Degenhart
Keyword(s):  
Preterm Infants ◽  
Neonatal Period ◽  
Early Neonatal Period

scholarly journals Monitoring of physiological and blood parameters during perinatal and neonatal period in calves

2010 ◽  
Vol 62 (1) ◽  
pp. 1-12 ◽  
Author(s):  
G. Piccione ◽  
S. Casella ◽  
P. Pennisi ◽  
C. Giannetto ◽  
A. Costa ◽  
...  
Keyword(s):  
Heart Rate ◽  
Respiratory Rate ◽  
Total Cholesterol ◽  
Rectal Temperature ◽  
Neonatal Period ◽  
Blood Parameters ◽  
External Jugular Vein ◽  
Individual Values ◽  
Functional Development ◽  
Adaptation Processes

Rectal temperature, heart and respiratory rates, and the course of some blood parameters were monitored in calves during perinatal and neonatal periods. The study was carried out on eight Limousine calves. From all subjects, rectal temperature, heart rate, and respiratory rate were measured. Blood samples were taken at the same hour (9am) from the external jugular vein, and then centrifuged and stored until analyses. By means of an UV spectrophotometer, the following blood parameters were assessed for each subject: total protein, total cholesterol, triglycerides, glucose, non-esterified fatty acids (NEFA), urea, creatinine, cholinesterase, lactate dehydrogenase (LDH), hydroxybutirate, glutamate pyruvate transaminases (GPT), glutamate oxalacetate transaminases (GOT), direct and total bilirubin, magnesium, iron, potassium, phosphorus, chloride and sodium. The results showed a significant effect of days of life (P<0.05) only on total cholesterol, creatinine and GOT during the first week of life and a significant effect of days of life on rectal temperature, heart rate, respiratory rate, total cholesterol, NEFA, creatinina, and GOT during the first month of life. A correlation among individual values for postnatal age (days of life) and heart rate in calves during the first month of life was observed. In conclusion, modifications of studied parameters could be attributed to functional development of calves in neonatal period and contribute to the knowledge of adaptation processes in calf during the first week and the first month of life resulting useful for the diagnosis and treatment of any neonatal diseases.

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