Porphyria cutanea tarda concomitant with chronic hepatitis C

Porphyrias form a group of rare metabolic diseases associated with disorders in the heme biosynthesis enzymes, leading to porphyrin accumulation in tissues. The disease is rare and is often diagnosed too late. The most incident is porphyria cutanea tarda. All patients with this condition should be tested for viral hepatites and hemochromatosis. A clinical case is presented: a patient with porphyria cutanea tarda associated with alcohol abuse and viral hepatitis C.

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THE SIGNS OF CARBOHYDRATE-LIPID METABOLISM DISTURBANCE IN PATIENTS WITH CHRONIC HEPATITIS C

Hepatology and Gastroenterology ◽

10.25298/2616-5546-2021-5-1-56-60 ◽

2021 ◽

Vol 5 (1) ◽

pp. 56-60

Author(s):

G. M. Jeenalieva ◽

Keyword(s):

Metabolic Syndrome ◽

Chronic Hepatitis ◽

Lipid Metabolism ◽

Hepatitis C ◽

Viral Hepatitis ◽

Chronic Hepatitis C ◽

Fold Increase ◽

Russian Society ◽

The Metabolic Syndrome ◽

Viral Hepatitis C

Background. Viral hepatitis C (CHC) is an urgent problem due to its prevalence, high risk of developing liver cirrhosis and hepatocellular carcinoma. Viral hepatitis C can cause disruption of many biochemical processes in the liver cells, primarily that of carbohydrate - lipid metabolism. Objective. To study carbohydrate-lipid metabolism disturbances in patients with CHC. Material and methods. The study included 124 patients with paucisymptomatic chronic hepatitis C. The metabolic syndrome was diagnosed according to the indicators recommended by the Committee of Experts of the Russian Society of Cardiology (2007). Results. The parameters of lipid metabolism were studied in 52 of 124 patients with CHC. 29 of 52 patients with CHC (55.7%) showed a decrease in HDL cholesterol and an increase in LDL cholesterol, including a 2- fold increase in VLDL. The metabolic syndrome was detected in 22.5% of patients with CHC, 62.9% of patients had the manifestations of dyslipidemia (steatosis or steatohepatitis of the liver, obesity, arterial hypertension, insulin resistance, type 2 diabetes mellitus). Conclusions. In patients with CHC, carbohydrate-lipid metabolism disturbance was revealed as an integral indicator of metabolic syndrome, its incidence rising with the increase in activity and duration of the infectious process.

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Features of ophthalmic disorders in patients with chronic viral hepatitis C before and after antiviral treatment

Kazan medical journal ◽

10.17816/kmj2127 ◽

2012 ◽

Vol 93 (6) ◽

pp. 989-991

Author(s):

G E Akberova ◽

F R Saifullina ◽

I M Khaertynova

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Viral Hepatitis ◽

Color Vision ◽

Chronic Hepatitis C ◽

Antiviral Treatment ◽

Chronic Viral Hepatitis ◽

Viral Hepatitis C ◽

Before And After ◽

Chronic Viral Hepatitis C

Aim. To study the features of ophthalmic disorders in patients with chronic viral hepatitis C before and after antiviral treatment. Methods. 40 patients (80 eyes) with chronic hepatitis C were observed (the main group). The control group consisted of 20 healthy subjects (40 eyes). To diagnose chronic hepatitis C infection and to assess liver damage a set of clinical, epidemiological and laboratory tests was performed. All patients underwent liver ultrasonography. The diagnosis of chronic hepatitis C was set up according to presence of immunoglobulin M and G to hepatitis C virus and presence of viral RNA on polymerase chain reaction in peripheral blood. Along with standard opthalmic examination, visual field testing using the white and chromatic light and visual lability testing were performed. Results. Color vision impairments were diagnosed in 50% of patients with chronic hepatitis C, with decreased visual lability for the red and green colors in 100% of cases. After 6 months of antiviral treatment restoration of visual function was observed. The durability of visual impairments in patients with chronic hepatitis C depended on the severity of the disease. Conclusion. In patients with chronic hepatitis C with the short term of the disease ophthalmic disorders such as decreased peripheral vision, color vision impairments, decreased visual lability are reversible.

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Evaluation of Macular and choroidal Thickness measurements in HCV patients taking Recent anti viral hepatitis C Drugs (daclatasvir / sofosbuvir) Combination

QJM ◽

10.1093/qjmed/hcab109.005 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Doaa Saad Yusuf ◽

AG Salman ◽

Tarek M Yosef ◽

Walid Mohamed Elzawahry ◽

Walaa Hashem

Keyword(s):

Optical Coherence Tomography ◽

Chronic Hepatitis ◽

Hepatitis C ◽

Viral Hepatitis ◽

Chronic Hepatitis C ◽

Choroidal Thickness ◽

University Hospital ◽

Research Centre ◽

Optical Coherence ◽

Viral Hepatitis C

Abstract Purpose This study aims to evaluate the effect of oral (sofosbuvir / daclatasvir) Combination on the macular and choroidal thickness of Egyptian patients with chronic hepatitis C virus infection using Optical Coherence Tomography (OCT) Methods This study was conducted on 30 subjects recruited from Viral Hepatitis Treatment and Research Centre and examined at Ophthalmology Out Patients Clinics, Ain Shams University Hospital during the period from June 2018 to February 2019. All participants underwent full general and ocular history taking and a precise ophthalmological clinical evaluation including assessment by OCT before starting our Direct Acting Antiviral Drugs (DAAs), sofosbuvir and daclatasvir (SOF/ DAC) combination for 12 weeks then, they reassessed again at the end of the treatment by Spectral Domain optical coherence tomography (SD –OCT) Retina Scan RS - 3000 advance(NIDEK Co., Gamagori Japan) (figure 1). Results Our study included 60 eyes of 30 patients with chronic hepatitis C with no evidence of changes on macular and choroidal thickness have been reported at 3 months after treatment onset in all subjects; the difference was statistically insignificant for macular and choroidal thickness. Conclusions Our study showed that all the participants who were followed before and after treatment showing that there were no changes on the best corrected visual acuity (BCVA), there were no changes on macular and choroidal thickness observed throughout all the study period.

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Modern clinical laboratory aspects of chronic hepatitis C

Experimental and Clinical Gastroenterology ◽

10.31146/1682-8658-ecg-191-7-37-42 ◽

2021 ◽

pp. 37-42

Author(s):

O. N. Sumlivaia ◽

M. S. Nevzorova ◽

A. T. Sayfitova ◽

S. A. Vysotin

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Viral Hepatitis ◽

Chronic Hepatitis C ◽

Clinical Examination ◽

Liver Damage ◽

Clinical Laboratory ◽

Diagnostic Value ◽

Control Group ◽

Viral Hepatitis C

Aim. Assess the current diagnostic value of clinical laboratory markers of liver damage in chronic viral hepatitis C. Materials and methods. Comprehensive clinical examination of 194 patients with the diagnosis chronic hepatitis C and 73 almost healthy faces was conducted. Results. According to the clinical examination, 91% of patients have hepatomegaly. According to the results of elastography, the subgroup without fibrosis F0 49 (25%) people, with fibrosis of stages F1-F3-145 (75%) patients. The occurrence of HCV genotypes was: HCV-1-33%, HCV-2-12% and HCV-3-55%. The virusemia indicator showed large variations of values. During the research it was established that indirect indicators of a fibrosis of a liver: levels of AST and ALT, GGTP, a direct and general bilirubin, the APRI index are authentically exceeded by indexes of control group while the level of thrombocytes and de Ritis’s coefficient authentically decrease. Conclusions. The current course of chronic hepatitis C occurs with hepatomegalia, often associated with gastrointestinal and cardiovascular damage. The most common virus among patients is the HVC-3 genotype virus. When examining indirect markers of fibrosis in viral hepatitis C, the APRI test is an early predictor and has high predictive value. Platelet levels decrease with viral liver damage. As a consequence, the APRI index increases and the de Ritis ratio decreases.

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NEW PROGNOSTIC METHOD FOR ESTIMATION OF LIPID DISTRESS SYNDROME DEVELOPMENT IN PATIENTS WITH CHRONIC HEPATITIS C

Science and Innovations in Medicine ◽

10.35693/2500-1388-2019-4-1-16-19 ◽

2019 ◽

Vol 4 (1) ◽

pp. 16-19

Author(s):

Dmitrii Yu. Konstantinov ◽

German V. Nedugov ◽

Larisa L. Popova ◽

Elena A. Konstantinova

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Viral Hepatitis ◽

Antiviral Therapy ◽

Chronic Hepatitis C ◽

Distress Syndrome ◽

Function Analysis ◽

Chronic Viral Hepatitis ◽

Viral Hepatitis C ◽

Chronic Viral Hepatitis C

Objectives - to work out a prognostic method, based on clinical and laboratory data, which can predict the development of lipid distress syndrome in patients with chronic viral hepatitis C. Material and methods. We studied the outcomes of chronic viral hepatitis C with respect to development of lipid distress syndrome in 267 patients who did not receive antiviral therapy during the observation period lasting for 1 to 7 years. Results. Discriminant function analysis of the data acquired after examination of 167 patients helped us to work out a discriminative model of predicting the development of lipid distress syndrome in patients with chronic viral hepatitis C in the absence of antiviral therapy. Crosschecking of prediction accuracy was carried out on the data of examination of other 100 patients. Conclusion. The designed technique for predicting the development of lipid distress syndrome in patients with chronic hepatitis C is characterized by point estimates of sensitivity and prognostic value of the negative result equal to 100%.

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Histopathological and immunocytochemical changes in the liver of patients with chronic hepatitis C

Vojnosanitetski pregled ◽

10.2298/vsp0401029j ◽

2004 ◽

Vol 61 (1) ◽

pp. 29-34

Author(s):

Maja Jovanovic ◽

Ljiljana Konstantinovic ◽

Vuka Katic ◽

Slavisa Ciric ◽

Velimir Kostic ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Liver Damage ◽

Liver Parenchyma ◽

Hepatic Tissue ◽

Biopsy Specimens ◽

Viral Hepatitis C ◽

Viremia Level ◽

Chronic Active Viral Hepatitis

Background. The presence of lymphocytes within the liver parenchyma is related to immunologically mediated liver damage in chronic hepatitis C. The aim of the study was to make histological, histochemical, and immunocytochemical assessment of liver biopsy specimens in patients with chronic hepatitis C virus (HCV) infection. Methods. Biopsy specimens of 20 patients with chronic HCV disease were analyzed, using standard staining procedures to verify histologic liver lesions, as well as immunoenzymatic staining with monoclonal antibodies to detect CD4+ T-lymphocytes, B-lymphocytes, and macrophages. Results. Micromorphologic characteristics of chronic active viral hepatitis C were present in all the patients, differing, hower, by the level of their activity. Dominant changes were found within the portal space, consisting of mononuclear lympho-plasmocytic infiltration and macrophages. Immunocytochemical investigation of mononuclear and macrophageal infiltration showed the correlation between micromorphological findings and the degree of the activity. Conclusion. The presence of lymphocytic and macrophageal infiltration within the hepatic tissue directly correlated with the intensity of the liver damage. Analysis of the population of cellular infiltrate in the liver together with the monitoring of viremia level and the level of hepatocyte necrosis, could be useful tools for elucidation of the pathogenesis of chronic hepatitis C.

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Significance of iron reduction for the therapy of chronic hepatitis C

Vojnosanitetski pregled ◽

10.2298/vsp0502161n ◽

2005 ◽

Vol 62 (2) ◽

pp. 161-164 ◽

Cited By ~ 1

Author(s):

Darko Nozic ◽

Bela Balint ◽

Nebojsa Stankovic ◽

Jovan Dimitrijevic ◽

Gorana Neskovic

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Iron Overload ◽

Antiviral Therapy ◽

Chronic Hepatitis C ◽

Iron Reduction ◽

Elevated Serum ◽

Chronic Viral Hepatitis ◽

Viral Hepatitis C ◽

Iron Deposits

Background. It has been established that many patients with chronic hepatitis C have elevated serum iron, feritin levels and iron deposits in the liver. Therefore, the liver damage due to hepatitis C virus may be aggravated with iron overload. In many studies higher levels of iron in the blood and the liver were connected with the decreased response to interferon-alfa therapy for chronic viral hepatitis C. Recent introduction of pegylated interferons plus ribavirin has improved the therapeutic response, so it is now possible to cure more than 50% of the patients. Case report. Three patients with chronic hepatitis C and iron overload were presented. Iron reduction therapy using phlebotomy or eritrocytapheresis with plasmapheresis was done at different times in regard to specific antiviral therapy or as a sole therapy. Conclusion. It has been shown that iron reduction, sole or combined with antiviral therapy, led to the deacreased aminotransferase serum activity and might have slow down the evolution of chronic hepatitis C viral infection.

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Chronic hepatitis C associated with porphyria cutanea tarda which showed hepatic focal fatty change arising in a non-alcoholic patient.

Kanzo ◽

10.2957/kanzo.40.350 ◽

1999 ◽

Vol 40 (6) ◽

pp. 350-354 ◽

Cited By ~ 2

Author(s):

Kazufumi DOHMEN ◽

Shingo ONOHARA ◽

Hironari AJIBE ◽

Masafumi SHIRAHAMA ◽

Yuichi MIYAMOTO ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Porphyria Cutanea Tarda ◽

Alcoholic Patient ◽

Fatty Change

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Hepatitis C and Kidney Disease

Hepatitis Research and Treatment ◽

10.1155/2010/534327 ◽

2010 ◽

Vol 2010 ◽

pp. 1-8

Author(s):

Ashik Hayat ◽

Ahmad Mitwalli

Keyword(s):

Chronic Hepatitis ◽

Kidney Transplantation ◽

Hepatitis C ◽

Kidney Disease ◽

Chronic Hepatitis C ◽

Porphyria Cutanea Tarda ◽

Lymphoproliferative Disorders ◽

Seronegative Arthritis ◽

Extrahepatic Manifestations ◽

Special Circumstances

Multiple extrahepatic manifestations have been associated with chronic hepatitis C, the most important among them being cryoglobulinemia, glomerulonephritis, porphyria cutanea tarda, lichen planus, seronegative arthritis, and lymphoproliferative disorders as in the sudies of Bonkovsky and Mehta (2001) and El-Serag et al. (2002). We will discuss in this paper chronic hepatitis C- related kidney disease and course and management of patients with chronic hepatitis C in special circumstances like hemodialysis and kidney transplantation.

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