scholarly journals MARKERS OF DAMAGE TO NERVOUS TISSUE IN LIQUOR PATIENTS WITH VARIOUS FORMS OF NEUROSYPHILIS

2018 ◽  
Vol 21 (1) ◽  
pp. 61-64
Author(s):  
Yuriy A. Novikov ◽  
V. A Ochlopkov ◽  
V. S Novoselov ◽  
M. B Kidalov ◽  
E. N Kravchenko
Keyword(s):  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Clinical Examination ◽  
Nervous Tissue ◽  
Immune Status ◽  
Comparison Group ◽  
Acidic Protein ◽  
Immunological Changes ◽  
Glial Fibrillar Acidic Protein

The purpose: to study the features of markers of lesion of nervous tissue and cytokines in patients with various forms of neurosyphilis. Material and methods. The complex clinical examination of patients with syphilis was carried out in the venereological department of the Clinical dermatovenerologic dispensary in Omsk in the period from 2015 to 2017, in order to identify signs of damage to the nervous system. Results: the presence of regularities and features in the deviation of the immune status in neurosyphilis was found. Conclusion. Analysis of the immunological changes in the cerebrospinal fluid showed that the level of interleukin 12p40 is significantly higher in the cerebrospinal fluid of patients with neurosyphilis, while the maximum values of these indicators are in patients with manifest forms of pathology. In patients with neurosyphilis, the concentration of glial fibrillar acidic protein in CSF was statistically significantly increased then in comparison group.

scholarly journals INTERLEUKINS - 23, -12P40 AS MARKERS OF NEURAL TISSUE DAMAGE IN NEUROSYPHILIS

2019 ◽  
Vol 64 (2) ◽  
pp. 94-97 ◽  
Author(s):  
Yu. A. Novikov ◽  
V. A. Ochlopkov ◽  
A. V. Indutny ◽  
E. N. Kravchenko
Keyword(s):  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Tissue Damage ◽  
Immune Status ◽  
Clinical Symptoms ◽  
Neural Tissue ◽  
Laboratory Examination ◽  
Immunological Changes

To study the features of cytokines in patients with various forms of neurosyphilis. The complex laboratory examination of patients with neurosyphilis and syphilis without specific lesion of the nervous system was observed in the venereological department of the OSH “Clinical Dermatological and Venereological Dispensary” in Omsk in order to determine the concentration of interleukins - 23, 12p40 in CSF and assess their relationship with the course of syphilitic infection. The presence of regularities and features in the deviation of the immune status in the examined disease was established. Analysis of immunological changes in patients’ cerebrospinal fluid showed that in patients with neurosyphilis, regardless of the presence or absence of clinical symptoms, the levels of IL-23 and IL-12p40 in CSF significantly exceed those in patients without specific lesion of the nervous system.

Lumbar puncture

2020 ◽  
pp. 5781-5785
Author(s):  
R. Rhys Davies ◽  
Andrew J. Larner
Keyword(s):  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Clinical Practice ◽  
Lumbar Puncture ◽  
19Th Century ◽  
Nervous Tissue ◽  
Cerebrospinal Fluid Analysis ◽  
Fluid Analysis ◽  
Correct Analysis ◽  
The 19Th Century

Lumbar puncture for examination of the cerebrospinal fluid has been an integral part of neurological practice since the pioneering work of Quincke at the end of the 19th century. The proximity of nervous tissue and cerebrospinal fluid may afford insights into pathological processes within the nervous system through examination of the cerebrospinal fluid, which may not easily be accessed by other investigational modalities. Because of this importance, guidelines on routine cerebrospinal fluid analysis have been published. The related procedure of cervical or cisternal puncture may also be used to obtain cerebrospinal fluid, but is far less frequently performed. Cerebrospinal fluid samples should always be regarded as precious, and hence every effort made to ensure correct analysis and interpretation; suboptimal performance is not infrequently encountered in day-to-day clinical practice.

INFECTIOUS MONONUCLEOSIS ENCEPHALITIS

PEDIATRICS ◽  
1954 ◽  
Vol 13 (6) ◽  
pp. 536-543
Author(s):  
FAITH C. WALSH ◽  
CHARLES M. POSER ◽  
SIDNEY CARTER
Keyword(s):  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Sore Throat ◽  
Antibody Titer ◽  
Clinical Examination ◽  
Infectious Mononucleosis ◽  
Cervical Lymphadenopathy ◽  
Neurologic Complications ◽  
Heterophile Antibody ◽  
System Involvement

A case of severe encephalitis due to infectious mononucleosis is reported. An eight year old white boy developed meningeal signs, intermittent coma, opisthotonos, extensor spasms, mild papilledema and hyperpyrexia two weeks after the onset of a sore throat and cervical lymphadenopathy. The diagnosis of infectious mononucleosis was confirmed by a heterophile antibody titer of 1:1024. The neurologic complications of the disease are uncommon in adults and are even more unusual in children. Only seven cases were found in the literature. Any or all parts of the nervous system may become involved; cerebrospinal fluid abnormalities may be the only manifestations of such involvement. The prognosis in children has been uniformly favorable with little or no neurologic residuals. Electroencephalographic and cerebrospinal fluid studies made on patients with infectious mononucleosis indicate a higher incidence of nervous system involvement than is evident by clinical examination. Serial heterophile agglutination determinations in patients with unexplained nervous system manifestations may clarify the diagnosis.

scholarly journals Olfactory transmucosal SARS-CoV-2 invasion as port of Central Nervous System entry in COVID-19 patients

2020 ◽  
Author(s):  
Jenny Meinhardt ◽  
Josefine Radke ◽  
Carsten Dittmayer ◽  
Ronja Mothes ◽  
Jonas Franz ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Nervous Tissue ◽  
Olfactory Mucosa ◽  
The Body ◽  
Thromboembolic Events ◽  
Control Center ◽  
The Central Nervous System ◽  
The Brain

AbstractThe newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a pandemic respiratory disease presenting with fever, cough, and often pneumonia. Moreover, thromboembolic events throughout the body including the central nervous system (CNS) have been described. Given first indication for viral RNA presence in the brain and cerebrospinal fluid and in light of neurological symptoms in a large majority of COVID-19 patients, SARS-CoV-2-penetrance of the CNS is likely. By precisely investigating and anatomically mapping oro- and pharyngeal regions and brains of 32 patients dying from COVID-19, we not only describe CNS infarction due to cerebral thromboembolism, but also demonstrate SARS-CoV-2 neurotropism. SARS-CoV-2 enters the nervous system via trespassing the neuro-mucosal interface in the olfactory mucosa by exploiting the close vicinity of olfactory mucosal and nervous tissue including delicate olfactory and sensitive nerve endings. Subsequently, SARS-CoV-2 follows defined neuroanatomical structures, penetrating defined neuroanatomical areas, including the primary respiratory and cardiovascular control center in the medulla oblongata.

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