Comparison of the effect of non-surgical periodontal  therapy with and without systemic Doxycycline on  glycemic status and clinical periodontal parameters  in type II diabetic patients with chronic periodontitis

ABSTRACTObjective: Periodontitis, a chronic inflammatory disease characterized by destruction of the periodontal ligament and alveolar bone is the sixthcomplication of diabetes mellitus. Periodontal treatment that reduces gingival inflammation aids in the control of hyperglycemia. Therefore, thepresent study was designed to determine the effect of treating chronic periodontitis with oral antibiotics azithromycin and metronidazole on the levelof serum glycated hemoglobin in type-II diabetic patients.Methods: This prospective observational study was carried out in the dental department of a tertiary care hospital for 9 months. Clinical andbiochemistry reports of 90 patients were collected in designed case report forms. All statistical analyses were performed using IBM Statistical Packagefor Social Sciences 17 and Graph Pad Prism 7.0.Results: Significant reduction in all the clinical and dental parameters was comparatively higher in patients who received azithromycin than inpatients who received metronidazole and scaling and root planning alone.Conclusion: Periodontal therapy with oral azithromycin can be employed as a supportive strategy for the management of diabetes mellitus.Henceforth, prevention and control of periodontal disease along with antibiotics must be considered an integral part of glycemic control. However,due to the lesser sample size in this study, further investigations are required to confirm the effect of periodontal therapy on systemic diseases.Keywords: Periodontitis, Azithromycin, Metronidazole, Glycemic control, Diabetes mellitus.

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Evaluation of micronutrient (Zinc, Magnesium, and Copper) levels in serum and glycemic status after nonsurgical periodontal therapy in type 2 diabetic patients with chronic periodontitis

Contemporary Clinical Dentistry ◽

10.4103/0976-237x.205036 ◽

2017 ◽

Vol 8 (1) ◽

pp. 26 ◽

Cited By ~ 1

Author(s):

Gopalakrishnan Sundaram ◽

T Ramakrishnan ◽

Harinath Parthasarathy ◽

Joyson Moses ◽

T Lalitha

Keyword(s):

Chronic Periodontitis ◽

Periodontal Therapy ◽

Diabetic Patients ◽

Glycemic Status ◽

Type 2 Diabetic Patients ◽

Nonsurgical Periodontal Therapy ◽

Type 2 Diabetic

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Effect of Bioconditioning on Surface Characteristics of Periodontally-affected Roots of Diabetic Patients

World Journal of Dentistry ◽

10.5005/jp-journals-10015-1264 ◽

2014 ◽

Vol 5 (2) ◽

pp. 81-86

Author(s):

Hossam A Eid ◽

Khalid M Abdelaziz ◽

Refaat A Eid

Keyword(s):

Citric Acid ◽

Chronic Periodontitis ◽

Negative Impact ◽

Surface Characteristics ◽

Diabetic Patients ◽

Type Ii ◽

Sem Images ◽

Root Surfaces ◽

Tetracycline Hcl

ABSTRACT Objective Advanced glycosylated end products (AGEs) in type II diabetic patients are usually precipitated on the periodontallyaffected root surfaces. The presence of periodontopathic microbes, at the same time, may also add a negative impact on the prognosis of the regenerative periodontal surgery. This in vitro study aimed to evaluate the effect of chemical conditioning on surface characteristics of periodontally-affected roots of diabetic patients. Methods Three groups (n = 25) of freshly-extracted teeth were collected from the outpatient clinics, College of Dentistry, King Khalid University. In group 1, teeth were collected from healthy individuals for orthodontic purpose. Teeth of group 2 were collected from healthy patients with chronic periodontitis, while those of group 3 were collected from diabetic patients with chronic periodontitis. Roots of the collected teeth were examined using the scanning electron microscope (SEM) before and after mechanical surface planning and chemical treatment using normal saline, EDTA gel, Tetracycline HCL (TC) or citric acid (CA) each for 4 minutes (n = 5 from each group). Results Interpretation of SEM images revealed undesirable etching effect of the chemicals used on the surfaces of healthy roots. Although EDTA showed an effective cleanse of the smear debris, it seemed to have no power on surface cuticles existed on roots of diabetic individuals. Tetracycline HCl provided acceptable conditioning of periodontally-affected root surfaces. Citric acid showed a powerful removal of both smear debris and cuticle layers off the periodontally-affected roots of diabetic individuals. Conclusion Topical application of EDTA, TC or CA shows sensible effect on the periodontally affected root surfaces. However, each of these chemicals exhibits different conditioning power. Citric acid is a promising agent to biomodify the periodontally-affected root surfaces of diabetic patients. Clinical relevance Citric acid is an acceptable biomodifier for the periodontally-affected root surfaces. This approach may improve the prognosis of periodontal therapies especially in type II diabetic patients. How to cite this article Abdelaziz KM, Eid HA, Eid RA. Effect of Bioconditioning on Surface Characteristics of Periodontally- affected Roots of Diabetic Patients. World J Dent 2014;5(2):81-86.

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