scholarly journals Quantitative Cell Numbers and Density of Mesangial Volume in a Rat Model with Induced Hyperglycemic and Treated with Mononuclear Derived CD133 Positive Cells

2014 ◽  
Vol 2 (2) ◽  
pp. 22-27 ◽  
Author(s):  
Durdi Qujeq ◽  
Friba Salmani ◽  
Fariedeh Feizi ◽  
◽  
◽  
...  
Keyword(s):  
Rat Model ◽  
Cell Numbers

scholarly journals In Vivo Efficacy of Anidulafungin against Mature Candida albicans Biofilms in a Novel Rat Model of Catheter-Associated Candidiasis

2010 ◽  
Vol 54 (10) ◽  
pp. 4474-4475 ◽  
Author(s):  
Soňa Kucharíková ◽  
Hélène Tournu ◽  
Michelle Holtappels ◽  
Patrick Van Dijck ◽  
Katrien Lagrou
Keyword(s):  
Candida Albicans ◽  
Rat Model ◽  
Systemic Administration ◽  
In Vivo Efficacy ◽  
Cell Numbers ◽  
Candida Albicans Biofilms

ABSTRACT The present study demonstrates the efficacy of anidulafungin on mature Candida albicans biofilms in vivo. One hundred fifty-seven catheter fragments challenged with C. albicans were implanted subcutaneously in rats. After formation of biofilms, rats were treated with daily intraperitoneal injections of anidulafungin for 7 days. Catheters retrieved from treated animals showed reduced cell numbers compared to those retrieved from untreated and fluconazole-treated animals. Systemic administration of anidulafungin is promising for the treatment of mature C. albicans biofilms.

scholarly journals Intrauterine valproate exposure is associated with alterations in hippocampal cell numbers and folate metabolism in a rat model of valproate teratogenicity

Seizure ◽  
2017 ◽  
Vol 46 ◽  
pp. 7-12 ◽  
Author(s):  
Alexander Semmler ◽  
Christian Frisch ◽  
Christiane Bleul ◽  
Desiree Smith ◽  
Laurent Bigler ◽  
...  
Keyword(s):  
Rat Model ◽  
Folate Metabolism ◽  
Cell Numbers ◽  
Hippocampal Cell

scholarly journals Effect of prebiotic supplementation on a probiotic bacteria mixture: comparison between a rat model and clinical trials

2007 ◽  
Vol 99 (4) ◽  
pp. 826-831 ◽  
Author(s):  
Kirsti Tiihonen ◽  
Tarja Suomalainen ◽  
Soile Tynkkynen ◽  
Nina Rautonen
Keyword(s):  
Clinical Trials ◽  
Lactic Acid ◽  
Rat Model ◽  
Human Subjects ◽  
Human Study ◽  
Probiotic Bacteria ◽  
Healthy Human ◽  
Cell Numbers ◽  
Healthy Human Subjects ◽  
Treatment Responses

The effects of a probiotic mixture (PRO), supplemented with either galacto-oligosaccharide (GOS) or polydextrose (PDX), on cell numbers of lactic acid bacteria (LAB) and bifidobacteria (BIF) were studied in conventional rats and healthy human subjects. In rats the baseline BIF cell numbers were below the detection limit and were increased by the 2-week GOSPRO intervention. In contrast baseline LAB numbers in rats were high and not affected by the treatments. The human study consisted of two independent but concurrent trials; both started with PRO followed by GOSPRO or PDXPRO periods. In the human subjects variation in numbers of BIF and LAB were high. The GOSPRO group exhibited high counts of faecal LAB and BIF at the start and showed little or no effects of the interventions. In contrast, the PDX group had low faecal LAB and BIF numbers at the start and clearly increased cell numbers of BIF after the PDXPRO period, and LAB after the PRO and PDXPRO period, compared with the run-in period. We propose here that responses to pro- and prebiotics are dependent on baseline numbers of LAB and/or BIF, and that the conventional rat model does not predict well the treatment responses in humans. The survival of PRO was presumably enhanced by the use of prebiotic supplementation and advocates the use of particular combinations of pro- and prebiotics.

scholarly journals Activities of Systemically Administered Echinocandins againstIn VivoMature Candida albicans Biofilms Developed in a Rat Subcutaneous Model

2013 ◽  
Vol 57 (5) ◽  
pp. 2365-2368 ◽  
Author(s):  
Soňa Kucharíková ◽  
Nidhi Sharma ◽  
Isabel Spriet ◽  
Johan Maertens ◽  
Patrick Van Dijck ◽  
...  
Keyword(s):  
Body Weight ◽  
Candida Albicans ◽  
Rat Model ◽  
Model System ◽  
Content Type ◽  
Cell Numbers ◽  
Candida Albicans Biofilms

ABSTRACTThis study addresses the effects of micafungin, caspofungin, and anidulafungin againstCandida albicansbiofilms developed in a subcutaneous catheter rat model system. Doses of 5, 10, and 30 mg/kg (of body weight)/day (the last only for micafungin) were given intravenously for 5, 7, and 10 days. All three echinocandins caused a significant reduction of theCandidacell numbers on the implanted catheters and are thus promising for the treatment of biofilm-related infections.

scholarly journals Action of Deferoxamine againstPneumocystis carinii

2001 ◽  
Vol 45 (12) ◽  
pp. 3560-3565 ◽  
Author(s):  
Allen B. Clarkson ◽  
David Turkel-Parrella ◽  
Jonathan H. Williams ◽  
Lung Chi Chen ◽  
Terry Gordon ◽  
...  
Keyword(s):  
High Pressure ◽  
Animal Model ◽  
Rat Model ◽  
Mode Of Action ◽  
Pneumocystis Carinii ◽  
Irreversible Damage ◽  
Cell Numbers ◽  
Chromatography Analysis ◽  
Calcein Am

ABSTRACT We found earlier that deferoxamine (DFO), a drug used for treatment of iron overload, is active against a rat model of Pneumocystis carinii pneumonia (PCP). We had assumed a mode of action by deprivation of nutritional iron; however, data here show that DFO penetrates P. carinii, causing irreversible damage, thus indicating a different mode of action. Penetration was demonstrated by showing DFO uptake by high-pressure liquid chromatography analysis. By using calcein-AM as an indicator, exposure to DFO was shown to cause a reduction inP. carinii cytoplasmic free iron. Exposure to ≥100 μM DFO for ≥8 h in vitro caused growth to cease and cell numbers to decline over several days. This direct and irreversible damage to P. carinii led to the prediction that infrequent delivery of DFO to the lungs via an aerosol would be an effective treatment in the animal model of PCP. This prediction was confirmed by demonstrating that a once-a-week aerosol treatment of rats was 100% effective both as a prophylactic and as a curative treatment in a rat model of PCP.

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