scholarly journals Preparation and Characterization of Thiosemicarbazones Corrosion Inhibition Effect and the Antimicrobial and Anticancer Effect on their Metal Complexes

2017 ◽  
Vol 13 (3) ◽  
pp. 249
Author(s):  
Tahani I. Kashar ◽  
Marwa Abdel-Motaal ◽  
Khadija Emran ◽  
Noha A. Sukar
Keyword(s):  
Cast Iron ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Breast Cancer Cell Lines ◽  
Human Breast ◽  
Anticancer Effect ◽  
Ic50 Value ◽  
Elemental Analyses ◽  
Mcf 7

Benzofurane and naphthofuranethiosemicarbazone ligands 2a (L1 )and 2b(L2) and their Cu(II), Co(II), Ni(II), and Pd(II) complexes have been synthesized and characterized by elemental analyses, molar conductance, magnetic susceptibility measurements, IR, NMR, and electronic spectral studies. IR spectra show that the ligands is coordinated to the metal ions in a didentate manner with N,S doner sites. In the presence of tow thiosemicarbazones ligands 2a(L1) and 2b(L2), the corrosion resistance of cast iron in 10.M H2SO4 increases in the order, 2b(L2) >2a(L1). The effect of studied ligands inhibits the corrosion of cast iron extent depending on the structure and high donation of π-electron present inhibitor. Co(II) and Pd (II) complexes possess higher antimicrobial activity than free ligands and other complexes. The [L1Pd Cl2]H2O complexe shows higher IC50 value of 4.6 µg/ml toward human breast cancer cell lines (MCF-7). For other complexes, they are in the range of 2.7– 4.3 µg/ml toward the former cells which is related to their metal complexing ability in enzymes.

scholarly journals Facile microwave synthesis of a novel phenothiazine derivative and its cytotoxic activity

2020 ◽  
Vol 13 (4) ◽  
pp. 175-183
Author(s):  
Cenk A. Andac
Keyword(s):  
Microwave Synthesis ◽  
Breast Adenocarcinoma ◽  
Human Breast ◽  
Anticancer Effect ◽  
Phenothiazine Derivatives ◽  
Adenocarcinoma Cell Line ◽  
Human Breast Adenocarcinoma ◽  
Nmr Characterization ◽  
Mcf 7

Herein, a facile procedure for microwave synthesis and NMR characterization of phenothiazine derivatives 10-(3-hydroxypropyl)-2-(methylsulphanyl)-10H-phenothiazine (3) (25% yield) and 1-[3-(2-methylsulfanyl-10H-phenothiazine-10-yl)-propyl]pyrimidine-2,4-(1H,3H)-dione (6) (67% yield) is described. After successful microwave synthesis steps, MTT cytotoxicity experiments gave rise to greater anticancer effect of compound 6 in MCF-7 human breast adenocarcinoma cell line (IC50= 1.35 µM) as compared to literature values for tamoxifen (IC50= 8.3 µM) and doxorubicin (IC50= 27 µM).

scholarly journals Senyawa Damara-20,24-dien-3-on yang beraktivitas Sitotoksis terhadap Sel Mcf-7 dari Kulit Batang Chisocheton Marcrophyllus (Meliaceae)

2015 ◽  
Vol 5 (3) ◽  
Author(s):  
Nurlelasari Nurlelasari ◽  
Nurabi Ferdiana ◽  
Subekti Mauluddin ◽  
Desi Harneti ◽  
Moelyono Moektiwardoyo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cytotoxic Activity ◽  
Breast Cancer Cell ◽  
Human Breast Cancer ◽  
Chemical Structure ◽  
Human Breast Cancer Cell ◽  
Breast Cancer Cell Lines ◽  
Human Breast ◽  
Ic50 Value ◽  
Mcf 7

AbstrakSenyawa triterpenoid damaran, damara-20,24-dien-3-on telah diisolasi dari kulit batang Chisocheton Marcrophyllus (Meliaceae). Struktur kimia kedua senyawa tersebut telah ditetapkan berdasarkan data spektroskopi dan perbandingan data spektra yang diperoleh dari literatur. Senyawa damara-20,24-dien-3-on menunjukkan aktivitas sitotoksik terhadap sel kanker payudara manusia MCF-7 dengan nilai IC50 28 mM.Kata Kunci : aktivitas sitotoksik, sel MCF-7, triterpenoid damaran, Chisocheton Marcrophyllus,  MeliaceaeAbstractDammarane triterpenoid, damara-20,24-dien-3-on has been isolated from the bark of Chisocheton Marcrophyllus (Meliaceae). Chemical Structure of compound was dtermined on the basic of spektroscopic data and comparison with those spectra data previously reported. Compound damara-20,24-dien-3-on exhibited cytotoxic activity againts MCF-7 human breast cancer cell lines with IC50 value 28 mM respectively.Kata Kunci : cytotoxic activity, MCF-7 cell, dammarane triterpenoid, Chisocheton Marcrophyllus,  Meliaceae

scholarly journals Synthesis and characterization of a tetraaza macrocyclic ligand and its Cobalt(II), Nickel(II) and Copper(II) complexes

2010 ◽  
Vol 75 (7) ◽  
pp. 935-941 ◽  
Author(s):  
Sulekh Chandra ◽  
Monika Tyagi ◽  
Swati Agarwal
Keyword(s):  
Fungicidal Activity ◽  
Macrocyclic Ligand ◽  
Pathogenic Fungi ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Conductance Data ◽  
Square Planar ◽  
Nitrogen Donor ◽  
Elemental Analyses

Co(II), Ni(II), and Cu(II) complexes with a tetradentate nitrogen donor [N4] macrocyclic ligand, viz 1,5,8,13-tetraaza-2,9-dimethyl-4,11- diphenylcyclotetradeca-2,4,4,11-tetraene were synthesized. Their structures were determined based on elemental analyses; molar conductance and magnetic susceptibility measurements; and IR, 1H-NMR (ligand), and electronic spectral studies. Based on analytical and molar conductance data, the complexes may be formulated as [M(L)Cl2] and [M?(L)]Cl2 [where M = Co(II) and Cu(II), and M? = Ni(II)] due to their non-electrolytic and 1:2 electrolytic nature. Based on spectral studies, an octahedral geometry was assigned for the Co(II) complex, whereas square-planar and tetragonal geometry were proposed for the Ni(II) and Cu(II) complexes, respectively. The synthesized ligand and its complexes were screened for fungicidal activity against two pathogenic fungi (i.e., Fusarium. moniliformae and Rhizoctonia solani) to assess their growth inhibiting potential.

Brominated phenols: characterization of estrogen-like activity in the human breast cancer cell-line MCF-7

2002 ◽  
Vol 129 (1-2) ◽  
pp. 55-63 ◽  
Author(s):  
Christel M Olsen ◽  
Elise T.M Meussen-Elholm ◽  
Jørn A Holme ◽  
Jan K Hongslo
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Human Breast Cancer ◽  
Cancer Cell Line ◽  
Human Breast Cancer Cell ◽  
Human Breast ◽  
Mcf 7

scholarly journals A Bottom-Up Synthesis Approach to Silver Nanoparticles Induces Anti-Proliferative and Apoptotic Activities Against MCF-7, MCF-7/TAMR-1 and MCF-10A Human Breast Cell Lines

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4332
Author(s):  
Nurul Izzati Zulkifli ◽  
Musthahimah Muhamad ◽  
Nur Nadhirah Mohamad Zain ◽  
Wen-Nee Tan ◽  
Noorfatimah Yahaya ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Silver Nanoparticles ◽  
Cell Lines ◽  
Leaf Extract ◽  
Breast Cancer Cell Lines ◽  
Face Centered Cubic ◽  
Human Breast ◽  
Bottom Up ◽  
Mcf 7

A bottom-up approach for synthesizing silver nanoparticles (AgNPs-GA) phytomediated by Garcinia atroviridis leaf extract is described. Under optimized conditions, the AgNPs-GA were synthesized at a concentration of 0.1 M silver salt and 10% (w/v) leaf extract, 1:4 mixing ratio of reactants, pH 3, temperature 32 °C and 72 h reaction time. The AgNPs-GA were characterized by various analytical techniques and their size was determined to be 5–30 nm. FTIR spectroscopy indicates the role of phenolic functional groups in the reduction of silver ions into AgNPs-GA and in supporting their subsequent stability. The UV-Visible spectrum showed an absorption peak at 450 nm which reflects the surface plasmon resonance (SPR) of AgNPs-GA and further supports the stability of these biosynthesized nanoparticles. SEM, TEM and XRD diffractogram analyses indicate that AgNPs-GA were spherical and face-centered-cubic in shape. This study also describes the efficacy of biosynthesized AgNPs-GA as anti-proliferative agent against human breast cancer cell lines, MCF-7 and MCF-7/TAMR-1. Our findings indicate that AgNPs-GA possess significant anti-proliferative effects against both the MCF-7 and MCF-7/TAMR-1 cell lines, with inhibitory concentration at 50% (IC50 values) of 2.0 and 34.0 µg/mL, respectively, after 72 h of treatment. An induction of apoptosis was evidenced by flow cytometry using Annexin V-FITC and propidium iodide staining. Therefore, AgNPs-GA exhibited its anti-proliferative activity via apoptosis on MCF-7 and MCF-7/TAMR-1 breast cancer cells in vitro. Taken together, the leaf extract from Garcinia atroviridis was found to be highly capable of producing AgNPs-GA with favourable physicochemical and biological properties.

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