scholarly journals The «nanoscalpel» for microsurgery of glial brain tumours

2021 ◽  
Vol 6 ◽  
pp. 53-59
Author(s):  
S.S. Zamay ◽  
Keyword(s):  
Magnetic Field ◽  
Mechanism Of Action ◽  
Brain Tumours ◽  
Biological Effects ◽  
Degree Of Saturation ◽  
Magnetic Disks ◽  
Primary Brain Tumours ◽  
Saturation Magnetisation ◽  
Neuroectodermal Origin ◽  
High Degree

Glial tumours are among the most common primary brain tumours of neuroectodermal origin characterised by infiltrative growth and widespread invasion of tumour cells into healthy tissue. A highly demanded method for therapy of such tumours may become magnetomechanical microsurgery substituting the scalpel with the «nanoscalpel» consisting of: (1) nanostructures converting the magnetic moment into the mechanical one, and (2) targeted ligands. Suitable structures for the nanoscalpel are magnetic disks with a high degree of saturation magnetisation and absent remanent magnetisation. The search for publications dated 1992-2021 was carried out in the PubMed and e-LIBRARY databases. The search keywords were «magnetic discs», «glial tumors», «microsurgery» and «magnetomechanical transduction». This review discusses biological effects of magnetic disks, their mechanism of action and toxicity. It has been concluded that a «nanoscalpel» remotely controlled using a magnetic field may become an effective and safe tool for microsurgery of glial brain tumours.

Over-All Accuracy of 99mTc-Pertechnetate Brain Scanning for Brain Tumours – Study of 471 Patients

1978 ◽  
Vol 17 (06) ◽  
pp. 249-253
Author(s):  
E. Pétursson ◽  
B. Sigurbjörnsson ◽  
D. Davidsson ◽  
O.G. Björnsson
Keyword(s):  
Brain Metastases ◽  
Brain Tumours ◽  
True Negative ◽  
Diagnostic Reliability ◽  
Radioisotope Scanning ◽  
Primary Brain Tumours ◽  
99Mtc Pertechnetate

A 3-year follow-up and re-evaluation of all scans on all patients referred for brain scanning in Iceland during 1 year was performed in order to assess the diagnostic reliability of radioisotope scanning for brain tumours. The study included 471 patients. Of these 25 had primary brain tumours and 7 brain metastases. Scans were positive and correctly interpreted in68 % of the patients with primary brain tumours and in 3 of the 7 patients with metastases. The over-all accuracy of brain scanning for brain tumours defined as the total number of correct positive scans and correct negative scans versus total number of scans examined was 96%, this figure being mainly influenced by the high number of true negative scans.

scholarly journals Mortality due to primary brain tumours in China and detection rate in people with suspected symptoms: a nationally representative cross-sectional survey

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Bin Jiang ◽  
Hongmei Liu ◽  
Dongling Sun ◽  
Haixin Sun ◽  
Xiaojuan Ru ◽  
...  
Keyword(s):  
Brain Tumour ◽  
Brain Tumours ◽  
Detection Rate ◽  
Epidemiological Data ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Detection Rates ◽  
Primary Brain Tumours ◽  
Symptom Screening ◽  
Nationally Representative

Abstract Background and purpose Epidemiological data on primary brain tumours (PBTs) are lacking due to the difficulty in case ascertainment among the population. Thus, we aimed to estimate mortality due to PBTs in China nationwide and the detection rate in people with suspected symptoms. Methods A multistage, complex sampling survey regarding mortality due to PBTs in Chinese individuals was carried out by reviewing all causes of death within a year. The detection rates in people with suspected symptoms were estimated based on PBT symptom screening and neurologist reviews and compared between groups by logistic regression analysis. Results Weighted mortality due to PBT was 1.6 (0.8–3.3) per 100,000 population in Chinese individuals, 1.8 (0.7–4.6) per 100,000 population in men, and 1.5 (0.5–4.5) per 100,000 population in women. Among 14,990 people with suspected symptoms, the PBT detection rate was 306.9 (95% CI 224.7–409.3) per 100,000 population in the total population, 233.0 (95% CI 135.7–373.1) per 100,000 population in men, and 376.9 (95% CI 252.4–546.3) per 100,000 population in women. People with an unsteady gait (OR 2.46; 95% CI 1.09–5.51; P=0.029), visual anomalies (3.84; 1.88–7.85; P<0.001), and headache (2.06; 1.10–3.86; P=0.023) were more likely to have a brain tumour than those without corresponding symptoms, while people with dizziness/vertigo were less likely to have a brain tumour than those without corresponding symptoms (0.45; 0.23–0.87; P=0.017). Conclusions Mortality due to PBT in China was low, with a nationwide estimate of 21,215 (10,427–43,165) deaths attributable to PBTs annually. However, the detection rate of PBTs can be greatly improved based on symptom screening in the population.

scholarly journals Magnetic Nanodiscs—A New Promising Tool for Microsurgery of Malignant Neoplasms

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1459
Author(s):  
Tatiana N. Zamay ◽  
Vladimir S. Prokopenko ◽  
Sergey S. Zamay ◽  
Kirill A. Lukyanenko ◽  
Olga S. Kolovskaya ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Remote Control ◽  
Tumor Cells ◽  
Biological Effects ◽  
Malignant Neoplasms ◽  
Rotating Magnetic Fields ◽  
Magnetic Structures ◽  
Promising Tool

Magnetomechanical therapy is one of the most perspective directions in tumor microsurgery. According to the analysis of recent publications, it can be concluded that a nanoscalpel could become an instrument sufficient for cancer microsurgery. It should possess the following properties: (1) nano- or microsized; (2) affinity and specificity to the targets on tumor cells; (3) remote control. This nano- or microscalpel should include at least two components: (1) a physical nanostructure (particle, disc, plates) with the ability to transform the magnetic moment to mechanical torque; (2) a ligand—a molecule (antibody, aptamer, etc.) allowing the scalpel precisely target tumor cells. Literature analysis revealed that the most suitable nanoscalpel structures are anisotropic, magnetic micro- or nanodiscs with high-saturation magnetization and the absence of remanence, facilitating scalpel remote control via the magnetic field. Additionally, anisotropy enhances the transmigration of the discs to the tumor. To date, four types of magnetic microdiscs have been used for tumor destruction: synthetic antiferromagnetic P-SAF (perpendicular) and SAF (in-plane), vortex Py, and three-layer non-magnetic–ferromagnet–non-magnetic systems with flat quasi-dipole magnetic structures. In the current review, we discuss the biological effects of magnetic discs, the mechanisms of action, and the toxicity in alternating or rotating magnetic fields in vitro and in vivo. Based on the experimental data presented in the literature, we conclude that the targeted and remotely controlled magnetic field nanoscalpel is an effective and safe instrument for cancer therapy or theranostics.

Fabrication and characterization of highly textured (Bi,Pb)2Sr2Ca2Cu3Ox superconducting ceramics using high magnetic field and cold isostatic pressing

1995 ◽  
Vol 10 (10) ◽  
pp. 2433-2443 ◽  
Author(s):  
Wai Lo ◽  
R. Stevens ◽  
R. Doyle ◽  
A.M. Campbell ◽  
W.Y. Liang
Keyword(s):  
Magnetic Field ◽  
Electron Microscopy ◽  
Cold Isostatic Pressing ◽  
Sintered Ceramic ◽  
Grain Alignment ◽  
Isostatic Pressing ◽  
Transmission Electron ◽  
Superconducting Ceramics ◽  
High Degree

High textured (Bi,Pb)2Sr2Ca2Cu3Ox ceramics have been fabricated by aligning deflocculated flakes of (Bi,Pb)2Sr2Ca2Cu3Ox suspended in an organic medium by means of a high de magnetic field (6 T) at room temperature followed by cold isostatic pressing. The proportion of the (Bi,Pb)2Sr2Ca2Cu3Ox phase in the precursor powder was carefully controlled, and the characteristics of the powder, such as size distribution and morphology, were determined. A high degree of grain alignment was found in the specimens after the magnetic alignment, although the bulk density of the materials was low. Cold isostatic pressing substantially increased the density of the magnetically prealigned specimens which also resulted in a slight decrease in the degree of grain alignment. This minor realignment was found to be due to the various kinds of processing defects that appeared in the specimens during compaction due to the grinding and cracking of the grains and their interlocking. The microstructural and superconducting properties of the sintered ceramic have been studied using texture goniometry, high resolution scanning electron microscopy, transmission electron microscopy, ac magnetic susceptometry, and critical current measurements.

Patients with Primary Brain Tumours Have Elevated Serum Titres of Antibodies to the Myelin Glycolipid Sulphatide

2001 ◽  
Vol 45 (1) ◽  
pp. 38-42 ◽  
Author(s):  
C. Nygren ◽  
H. v. Holst ◽  
K. Ericson ◽  
P. Fredman
Keyword(s):  
Brain Tumours ◽  
Elevated Serum ◽  
Primary Brain Tumours

Screening of Synthetic Heterocyclic Compounds as Antiplatelet Drugs

2021 ◽  
Vol 17 ◽  
Author(s):  
Marcel Hrubša ◽  
Khondekar Nurjamal ◽  
Alejandro Carazo ◽  
Nayana Nayek ◽  
Jana Karlíčková ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Biological Effects ◽  
Antiplatelet Drugs ◽  
Antiplatelet Drug ◽  
Breast Adenocarcinoma ◽  
Antiplatelet Activity ◽  
Major Mechanism ◽  
Treatment And Prevention ◽  
Impedance Aggregometry ◽  
Thromboxane Receptors

Background: Antiplatelet drugs represent the keystone in the treatment and prevention of diseases of ischemic origin, including coronary artery disease. The current palette of drugs represents efficient modalities in most cases, but their effect can be limited in certain situations or associated with specific side effects. In this study, representatives of compounds selected from series having scaffolds with known or potential antiplatelet activity were tested. These compounds were previously synthetized by us, but their biological effects have not yet been reported. Objective: The aim of this study was to examine the antiplatelet and anticoagulation properties of selected compounds and determine their mechanism of action. Methods: Antiplatelet activity of compounds and their mechanisms of action were evaluated using human blood by impedance aggregometry and various aggregation inducers and inhibitors and compared to appropriate standards. Cytotoxicity was tested using breast adenocarcinoma cell cultures and potential anticoagulation activity was also determined. Results: In total, four of 34 compounds tested were equally or more active than the standard antiplatelet drug acetylsalicylic acid (ASA). In contrast to ASA, all 4 active compounds decreased platelet aggregation triggered not only by collagen, but also partly by ADP. The major mechanism of action is based on antagonism at thromboxane receptors. In higher concentrations, inhibition of thromboxane synthase was also noted. In contrast to ASA, the tested compounds did not block cyclooxygenase-1. Conclusion: The most active compound, 2-amino-4-(1H-indol-3-yl)-6-nitro-4H-chromene-3-carbonitrile (2-N), which is 4-5x times more potent than ASA, is a promising compound for the development of novel antiplatelet drugs.

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