scholarly journals Predictors of Mortality among Patients Lost to Follow up Antiretroviral Therapy

Jurnal NERS ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. 114 ◽  
Author(s):  
Putu Dian Prima Kusuma Dewi ◽  
Gede Budi Widiarta
Keyword(s):  
Incidence Rate ◽  
Median Time ◽  
Secondary Data ◽  
Primary Data ◽  
People Living With Hiv ◽  
Risk Of Death ◽  
Living With Hiv ◽  
Lost To Follow Up

Introduction: The death of HIV/AIDS patients after receiving therapy in Bali is the seventh highest percentage of deaths in Indonesia. LTFU increases the risk of death in PLHA, given the saturation of people with HIV taking medication. The level of consistency in the treatment is very important to maintain the resilience and quality of life of people living with HIV. This study aims to determine the incidence rate, median time and predictors of death occurring in LTFU patients as seen from their sociodemographic and clinical characteristics.Methods: This study used an analytical longitudinal approach with retrospective secondary data analysis in a cohort of HIV-positive patients receiving ARV therapy at the Buleleng District Hospital in the period 2006-2015. The study used the survival analysis available within the STATA SE 12 softwareResults: The result showed that the incidence rate of death in LTFU patients was 65.9 per 100 persons, with the median time occurrence of 0.2 years (2.53 months). The NNRTI-class antiretroviral evapirens agents were shown to increase the risk of incidence of death in LTFU patients 3.92 times greater than the nevirapine group (HR 3.92; p = 0.007 (CI 1.46-10.51). Each 1 kg increase in body weight decreased the risk of death in LTFU patients by 6% (HR 0.94; p = 0.035 (CI 0.89-0.99).Conclusion: An evaluation and the monitoring of patient tracking with LTFU should be undertaken to improve sustainability. Furthermore, an observation of the LTFU patient's final condition with primary data and qualitative research needs to be done so then it can explore more deeply the reasons behind LTFU.

scholarly journals MORTALITY OF HIV/AIDS-INFECTED PEOPLE WITH ANTIRETROVIRAL THERAPY: A GENDER ANALYSIS

2018 ◽  
Vol 4 (6) ◽  
pp. 559-565
Author(s):  
Putu Dian Prima Kusuma Dewi ◽  
Putu Sukma Megaputri ◽  
Lina Anggaraeni Dwijayanti ◽  
Dewa Ayu Putu Indra Pranita ◽  
Made Juniari Dewi
Keyword(s):  
Antiretroviral Therapy ◽  
Incidence Rate ◽  
Total Mortality ◽  
Secondary Data ◽  
People Living With Hiv ◽  
Infected People ◽  
Risk Of Death ◽  
Cell Counts ◽  
Living With Hiv ◽  
Hiv Aids

Background: Mortality in people living with HIV/AIDS is one of measures to the success of its treatment. Study related to their deaths seen from gender is still very limited.Objective: The aim of this study was to determine the incidence rate of mortality between men and women living with HIV/AIDS and receiving antiretroviral therapy.Methods: This was a retrospective study using secondary data of HIV/AIDS-infected patients in Buleleng District Hospital in the period of 2006-2015. This research used Survival analysis, Kaplan-meier, incident rate comparison and logistic regression with STATA SE 12.Results: A total of 1204 HIV/AIDS-infected patients data was included. The incidence of total mortality rates was 27.7 per 1000 person-years. Based on gender, the mortality in men (35 per 1000 person-years) was higher than women (14 per 1000 person-years) with the incidence rate ratio (IRR) of 2.39 (p 0.01).  Fifty percent of cases of mortality occured at 0.15 years of observation. The median time of mortality in men was 0.14 years (1.7 months) and in women was 0.15 years (1.8 months). The poor clinical condition was seen from a body weight <50 kg, which increased the risk of death with aOR 3.85 (p 0.01 CI 2.40-6.16). Nevirapine increased the risk of mortality (aOR 2.18; p 0.01; CI 1.18-4.03). and CD4 cell counts of ≤ 200 cells / mm3 reduced the risk of death by 69% (AOR 0.31; p 0.01; CI 0.18-0.53).Conclusion: The incidence of mortality in men was greater than it in women, which is caused by poor clinical conditions. It is better to evaluate the success of antiretroviral therapy by considering the needs of patients according to their gender. Further research is needed in regard to adherence of treatment and loss to follow-up events.

scholarly journals Cohort Profile: The Nigerian HIV Geriatric Cohort Study

2019 ◽  
Author(s):  
Gbenga Ayodele Kayode ◽  
Patrick Dakum ◽  
Yohanna Kambai Avong ◽  
Michael Kolawole Odutola ◽  
James Okuma ◽  
...  
Keyword(s):  
Hiv Treatment ◽  
People Living With Hiv ◽  
Art Initiation ◽  
Review Period ◽  
Level Data ◽  
Living With Hiv ◽  
Lost To Follow Up ◽  
Differentiated Care

Abstract Background: An estimated 280,000 adults aged 50 years and above live with HIV in Nigeria, a population set to increase with ART efficacy and expanding coverage. To learn how elderly people living with HIV (EPLHIV) in Nigeria fare, despite not being prioritized by the national treatment program, and to deepen knowledge for their differentiated care and achieve better outcomes, the Nigerian HIV Geriatric Cohort (NHGC) was setup. Methods: Patient-level data spanning the period 2004 to 2018, obtained from comprehensive HIV treatment hospitals, that are supported by four major PEPFAR-implementing partners in Nigeria was used. These 4 entities collaborated as member organizations of the Nigeria Implementation Science Alliance. We defined geriatric/elderly as those aged 50 years and above. From de-identified treatment records, demographic and clinical data of EPLHIV ≥50-year-old at ART initiation during the review period was extracted, merged into a single REDcap® database, and described using STATA 13. Results: A total of 101,652 unique EPLHIV entries were analysed. This cohort’s data was of 53,608 (52.7%) women, 51,037 (71.4%) of EPLHIV identified as married and 33,446 (51.1%) unemployed. Mean age was 57.1 years (SD=6.9) with average duration on ART as 4.6 years (SD=3.5). ART profile showed that 88,792 (95.7%) were on 1st-line and 55,905 (64.9%) were on TDF-based regimens. Mean-body mass index (BMI) was 23.0 kg/m2 (SD=5.4 kg/m2) with 56,010(55.1%), 19,619(19.3%) and 8844 (8.7%) showing normal (18.5kg/m2–24.9kg/m2), overweight (BMI 25- <30kg/m2) and obese (BMI ≥30kg/m2) ranges respectively. Hypertensive readings (systolic-BP >140mmHg or diastolic-BP >90mmHg) was found in 21,550 (21.2%) ELHIV records. Mean CD4 count was 420cells/µL (SD=285cells/µL) and 83,660(82.3%) had a viral load result showing <1000copies/ml. As for treatment outcomes, available records showed that 54.1% were active-in-treatment, 28.4% were lost-to-follow-up and 6.8% died. Poor population death records and aversion to autopsies makes it almost impossible to estimate AIDS-related deaths. Conclusions: The study described the clinical and non-clinical profile of EPLHIV in Nigeria. This study provides vital information for stakeholders in HIV prevention, care and treatment to understand the characteristics of EPLHIV. Findings from further analysis of this cohort will be applied to improve the quality of health of EPLHIV.

scholarly journals Does undernutrition increase the risk of lost to follow-up in adults living with HIV in sub-Saharan Africa? Protocol for a systematic review and meta-analysis

BMJ Open ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. e048022
Author(s):  
Animut Alebel ◽  
Daniel Demant ◽  
Pammla Petrucka ◽  
David Sibbritt
Keyword(s):  
Systematic Review ◽  
Effect Size ◽  
Grey Literature ◽  
Sub Saharan Africa ◽  
People Living With Hiv ◽  
Significance Level ◽  
Sub Saharan ◽  
Living With Hiv ◽  
Lost To Follow Up

IntroductionUndernutrition is considered a marker for poor prognosis among people living with HIV (PLHIV), particularly in sub-Saharan Africa (SSA), where undernutrition and HIV are both highly prevalent. Evidence suggests that undernutrition (body mass index <18.5 kg/m2) is one of the main factors that significantly increases the risk of lost to follow-up (LTFU) in PLHIV. However, primary studies in SSA have reported inconsistent findings on the relationship between undernutrition and LTFU among adults living with HIV. To the best of our knowledge, no systematic review which aimed to summarise the available evidence. Hence, this review aims to determine the pooled effect of undernutrition on LTFU among adults living with HIV in SSA.Methods and analysisPubMed, EMBASE, Web of Science, Scopus, and, for grey literature, Google Scholar will be systematically searched to include relevant articles published since 2005. Studies reporting the effect of undernutrition on LTFU in adults living with HIV in SSA will be included. The Newcastle-Ottawa Scale will be used for quality assessment. Data from eligible studies will be extracted using a standardised data extraction tool. Heterogeneity between included studies will be assessed using Cochrane Q-test and I2 statistics. The Egger’s and Begg’s tests at a 5% significance level will be used to evaluate publication bias. As heterogeneity is anticipated, the pooled effect size will be estimated using a random-effects model. The final effect size will be reported using the adjusted HR with a 95% CI.Ethics and disseminationEthical approval is not required for a protocol for a systematic review. The results of this systematic review will be published in a peer-reviewed journal and will be publicly available.PROSPERO registration numberCRD42021277741.

scholarly journals Re-engagement in care of people living with HIV lost to follow-up after initiation of antiretroviral therapy in Mali: Who returns to care?

PLoS ONE ◽  
2020 ◽  
Vol 15 (9) ◽  
pp. e0238687
Author(s):  
Aliou Baldé ◽  
Laurence Lièvre ◽  
Almoustapha Issiaka Maiga ◽  
Fodié Diallo ◽  
Issouf Alassane Maiga ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
People Living With Hiv ◽  
Engagement In Care ◽  
Living With Hiv ◽  
Lost To Follow Up

scholarly journals Incidence Rate and Risk Factors for Tuberculosis among People Living with HIV: A 2015–2017 Cohort from Tashkent, Uzbekistan

2021 ◽  
Vol 18 (11) ◽  
pp. 5746
Author(s):  
Dilbar Sadirova ◽  
Ruzanna Grigoryan ◽  
Nargiza Parpieva ◽  
Venera Barotova ◽  
Aleksandr Trubnikov ◽  
...  
Keyword(s):  
Risk Factors ◽  
Incidence Rate ◽  
Secondary Data ◽  
Hazard Ratio ◽  
Active Tuberculosis ◽  
P Value ◽  
People Living With Hiv ◽  
Newly Diagnosed ◽  
Immunodeficiency Virus ◽  
Living With Hiv

People living with the human immunodeficiency virus (PLHIV) have a higher risk of developing active tuberculosis (TB) disease, and TB remains a major cause of death in PLHIV. Uzbekistan is facing a substantial TB epidemic, which increases the risk of PLHIV developing active TB. Our retrospective cohort study aimed to evaluate the incidence rate and assess the risk factors for developing active TB among PLHIV. We collected secondary data extracted from medical charts of all patients, newly diagnosed at the AIDS Center in Tashkent, during the period of 2015–2017. The incidence rate of TB among PLHIV was 5.1 (95% CI: 4.5–6.0) per 1000 person/month. Adjusted regression analysis showed three major risk factors for TB, namely, being less than 15 years old (hazard ratio (HR) 5.83; 95% CI: 3.24–10.50, p value = 0.001),low CD4 count (adjusted hazard ratio(aHR) 21.0; 95% CI: 9.25–47.7, p value < 0.001), and antiretroviral therapy (ART) interruption/not receiving ART (aHR 5.57; 95% CI: 3.46–8.97 and aHR 6.2; 95% CI: 3.75–10.24, p value < 0.001, respectively) were significantly associated with developing active TB among PLHIV. Our findings indicate that taking prescribed ART without interruptions and maintaining CD4cell counts higher than 320 cells/μL are essential to prevent the development of active TB among PLHIV.

scholarly journals Psikoedukasi “Bidan Cerdas” untuk Menurunkan Stigma terhadap Orang dengan HIV/AIDS (ODHA)

2019 ◽  
Vol 3 (2) ◽  
pp. 93
Author(s):  
Adhesatya Ningsih Moodoeto ◽  
Esti Hayu Purnamaningsih
Keyword(s):  
Health Workers ◽  
Negative Impact ◽  
People Living With Hiv ◽  
Mixed Design ◽  
Post Test ◽  
Living With Hiv ◽  
Experimental Group ◽  
Hiv Aids

Lack of knowledge about HIV /AIDS makes people including health workers stigmatize people living with HIV (PLWHA). It has a negative impact on PLWHA because of the constraints of quality of service, lowering of health, reluctance of VCT, and non-compliance of ARVs. The aim of this research to reduce the stigma of midwives against PLWHA through psychoeducation program of "Bidan Cerdas". Subject of this research is midwife. This research uses the experiment design of Non Random Untreated Kontrol Group Design with Dependent Pretest and Posttest Samples. Stigma to PLWHA measurement uses stigma scale developed by Genberg, et., al (2009). The research hypothesis was tested with Mixed Design ANOVA. The results of the analysis in the experimental group showed p<0.05 in Pre Test to Post Test, and p<0.05 on Post Test data to Follow Up. It concluded that psychoeducation program of "Bidan Cerdas" can reduce stigma against PLWHA.

scholarly journals Failure to return pillbox is a predictor of being lost to follow‐up among people living with HIV on antiretroviral therapy in rural Tanzania

HIV Medicine ◽  
2021 ◽  
Author(s):  
Robert C. Ndege ◽  
James Okuma ◽  
Aneth V. Kalinjuma ◽  
Julius Mkumbo ◽  
Elizabeth Senkoro ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
People Living With Hiv ◽  
Rural Tanzania ◽  
Living With Hiv ◽  
Lost To Follow Up
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