scholarly journals ANALISIS HUBUNGAN ANTARA SKORING MAGNETIC RESONANCE IMAGING-ANXIETY QUESTIONNAIRE (MRI-AQ) DENGAN DENYUT JANTUNG TERHADAP TINGKAT KECEMASAN PASIEN PADA PEMERIKSAAN MRI LUMBOSAKRAL

2019 ◽  
Vol 2 (3) ◽  
pp. 112
Author(s):  
Mirza Isna Amaliya ◽  
Rosy Setiawati ◽  
Amilia Kartika Sari ◽  
Lailatul Muqmiroh ◽  
Muhaimin Muhaimin
Keyword(s):  
Magnetic Resonance Imaging ◽  
Heart Rate ◽  
Magnetic Resonance ◽  
Pearson Correlation ◽  
T Test ◽  
Resonance Imaging ◽  
Mri Examination ◽  
Pearson Correlation Test ◽  
Paired T Test ◽  
Anxiety Questionnaire

Background: Anxiety during MRI examination becomes a common constraint and can have a negative effect that is the quality of the resulting image due to the existence of motion artifacts until the failure of the examination. Purpose: One of the signs of anxiety can be seen an increase in heart rate, in addition there is one questionnaire specifically aimed to determine the level of anxiety in patients with MRI examination, namely Magnetic Resonance Immunization-Anxiety Quistionnaire (MRI-AQ). Method: This research used correlational method with cross-sectional approach. The sampling technique used is purposive sampling. In this research, there were 30 samples. Each sample will be measured heart rate before, during, and after Lumbosacral MRI examination. A Magnetic Resonance Imaging Anxiety Questionnaire (MRI-AQ) was then completed at the time of examination. Collected data were then tested for differences using paired-t test and pearson correlation test. Result: The result of paired-t test shows that there was difference of heart rate during and after examination with p-value 0,036 <α. The patient's heart rate during Lumbosacral MRI was higher than the patient's heart rate after Lumbosacral MRI at 85.63 bpm ± 14.709. Conclusion: Pearson correlation test results showed a correlation between Magnetic Resonance Imaging- Anxiety Questionnaire (MRI-AQ) with heart rate to patient anxiety level at Lumbosacral MRI Examination, this is reinforced by correlation value r = 0.636.

Reliability and Longitudinal Validity of Computer-assisted Methods for Measuring Joint Damage Progression in Subjects with Rheumatoid Arthritis

2012 ◽  
Vol 40 (1) ◽  
pp. 23-29 ◽  
Author(s):  
MERVYN QI WEI POH ◽  
MARISSA LASSERE ◽  
PAUL BIRD ◽  
JOHN EDMONDS
Keyword(s):  
Rheumatoid Arthritis ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Volume Measurement ◽  
T Test ◽  
Computer Assisted ◽  
Resonance Imaging ◽  
Link Type ◽  
Longitudinal Validity ◽  
Paired T Test

Objective.To compare the metric properties of a computer-assisted erosion segmentation volume measurement with scoring using the Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS) in a longitudinal cohort of patients with rheumatoid arthritis (RA).Methods.Thirty-two sets of baseline and 2-year followup magnetic resonance imaging (MRI) of metacarpal phalangeal 2–5 joints of patients with RA were scored using RAMRIS and segmented using OSIRIS software. The smallest detectable difference (SDD), standardized response mean (SRM), and paired t-test were used to evaluate the sensitivity to change. Eleven of the 32 patients’ MRI were segmented by both readers to evaluate interreader agreement. The 28-joint Disease Activity Score (DAS28) and Sharp erosion scores further evaluated construct and longitudinal validity.Results.Reliability of erosion progression by computer-assisted volume measurement was superior to RAMRIS [intrareader interclass correlation coefficient (ICC) 0.97 (0.94–0.99) vs 0.52 (0.22–0.73)] and interreader ICC of volume measurement was 0.85 (0.53–0.96). Computer-assisted volume measurements identified 10 of 32 patients who progressed more than the SDD progression, whereas RAMRIS identified only 4 of 32 patients (p = 0.0013). By a paired t-test, however, all MRI measures progressed significantly over 2 years (irrespective of treatment arm) and there was little difference by SRM. Construct correlational validity of the MRI methods was 0.47–0.90 for status scores and 0.33–0.81 for progression. There was no relationship between the average DAS28 and erosion progression by any imaging method.Conclusion.Computer-assisted measurement of erosion volume has good performance metrics. It had excellent intrareader and interreader reliability and was more sensitive to change than RAMRIS in this group of patients. www.ClinicalTrials.gov, NCT00451971.

Nitrate induced vasoplegia depletes cardiac energy reserves: a model for acute cardiomyopathy in septic shock?

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
W Watson ◽  
P.G Green ◽  
M.K Burrage ◽  
R.R Chamley ◽  
A.J Lewis ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Heart Rate ◽  
Septic Shock ◽  
Creatine Kinase ◽  
Cardiac Output ◽  
Magnetic Resonance ◽  
Resonance Spectroscopy ◽  
Funding Source ◽  
Resonance Imaging ◽  
Cardiac Volumes

Abstract Introduction The healthy heart is at its most efficient when contractile filaments are stretched with preload. To produce the same cardiac output, oxygen requirement rises are proportionally greater with increased inotropy or heart rate than with increased preload. We hypothesized that in vasoplegia, loss of preload (owing to dilation of capacitance veins) and compensatory rises in heart rate and contractility would compromise the efficiency of the heart. We speculated that this may be one factor impairing cardiac function in conditions of distributive shock such as sepsis and looked to model the effects. We used cardiac magnetic resonance imaging to capture changes in cardiac volumes and contractility and magnetic resonance spectroscopy to investigate changes in ATP metabolism within the myocardium in healthy volunteers given GTN as a vasodilator. Methods We recruited 7 healthy volunteers (mean age 40 years, range 28–62 years; mean BMI 21.9, range 18.5–24.5) and measured their baseline cardiac volumes and function, PCr/ATP ratio and Creatine Kinase first order rate constant (CKkf), using cardiac magnetic resonance imaging and magnetic resonance spectroscopy and saturation transfer at 3 Tesla. At the same visit, they received a glyceryl trinitrate (GTN) infusion to induce vasoplegia and the measurements were repeated. We targeted GTN infusion rate to a fall in mean arterial pressure of 15mmHg. Results The GTN infusion brought about a fall in mean arterial pressure (from a baseline of 79±7mmHg to 64±7 mmHg, p&lt;0.0001) and a fall in LV end diastolic volume (169±57 ml vs 148±58 ml, p=0.003) indicating a reduction in preload. As expected, there was a compensatory rise in heart rate (61±7 bpm vs 69±10bpm, p=0.0005) and ejection fraction (62±3% vs 67±3%, p=0.001), however cardiac output remained unchanged (6.72±1.49 L/min vs 6.68±1.48 L/min, p=0.87). Cardiac work (calculated as stroke volume x MAP x heart rate) fell (477±123 vs 424±119 L.mmHg/min, p=0.03). There was a fall in PCr/ATP ratio on GTN (2.18±0.25 vs 1.91±0.2, p 0.03) while CKkf more than doubled (0.14±0.06 s-1 vs 0.23±0.08 s-1, p=0.02) and creatine kinase flux also showed a significant increase (1.65±0.78 μmol/g/s vs 2.28±0.71 μmol/g/s, p=0.05). Conclusions What is novel here is that we show a fall in PCr/ATP ratio: as ATP concentrations in the cell are strictly maintained, this suggests phosphocreatine pool depletion occurs when preload is lost and cardiac output is maintained by an increase in inotropy and chronotropy. The rise in CKkf and CK flux confirm the increased energy demand. Progressive energetic depletion during high demand may give rise to contractile dysfunction over time as the heart is unable to keep up with increased requirements for ATP, and progressively becomes more starved of energy. This could be a mechanism of cardiac dysfunction in septic shock and other vasoplegic states. Figure 1 Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): British Heart Foundation

The Aqueduct of Sylvius: Applied 3-T Magnetic Resonance Imaging Anatomy and Morphometry With Neuroendoscopic Relevance

2013 ◽  
Vol 73 (2) ◽  
pp. ons132-ons140 ◽  
Author(s):  
Tomasz Matys ◽  
Avril Horsburgh ◽  
Ramez W. Kirollos ◽  
Tarik F. Massoud
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Pearson Correlation ◽  
Third Ventricle ◽  
Magnetic Resonance Images ◽  
Resonance Imaging ◽  
The Third ◽  
Aqueduct Of Sylvius ◽  
Pars Anterior

Abstract BACKGROUND: The aqueduct of Sylvius (AqSylv) is a structure of increasing importance in neuroendoscopic procedures. However, there is currently no clear and adequate description of the normal anatomy of the AqSylv. OBJECTIVE: To study in detail hitherto unavailable normal magnetic resonance imaging morphometry and anatomic variants of the AqSylv. METHODS: We retrospectively studied normal midsagittal T1-weighted 3-T magnetic resonance images in 100 patients. We measured widths of the AqSylv pars anterior, ampulla, and pars posterior; its narrowest point; and its length. We recorded angulation of the AqSylv relative to the third ventricle as multiple deviations of the long axis of the AqSylv from the Talairach bicommissural line. We statistically determined age- and sex-related changes in AqSylv morphometry using the Pearson correlation coefficient. We measured angulation of the AqSylv relative to the fourth ventricle and correlated this to the cervicomedullary angle (a surrogate for head position). RESULTS: Patients were 13 to 83 years of age (45% male, 55% female). Mean morphometrics were as follows: pars anterior width, 1.1 mm; ampulla width, 1.2 mm; pars posterior width, 1.4 mm; length, 14.1 mm; narrowest point, 0.9 mm; and angulation in relation to the third and fourth ventricles, 26° and 18°, respectively. Age correlated positively with width and negatively with length of the AqSylv. There was no correlation between AqSylv alignment relative to the foramen magnum and the cervicomedullary angle. CONCLUSION: Normative dimensions of the AqSylv in vivo are at variance with published cadaveric morphometrics. The AqSylv widens and shortens with cerebral involution. Awareness of these normal morphometrics is highly useful when stent placement is an option during aqueductoplasty. Reported data are valuable in guiding neuroendoscopic management of hydrocephalus and aqueductal stenosis.

scholarly journals Neuroimaging brainstem circuitry supporting cardiovagal response to pain: a combined heart rate variability/ultrahigh-field (7 T) functional magnetic resonance imaging study

2016 ◽  
Vol 374 (2067) ◽  
pp. 20150189 ◽  
Author(s):  
Roberta Sclocco ◽  
Florian Beissner ◽  
Gaelle Desbordes ◽  
Jonathan R. Polimeni ◽  
Lawrence L. Wald ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Magnetic Resonance ◽  
Spatial Resolution ◽  
Pain Processing ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Ultrahigh Field ◽  
Brainstem Nuclei

Central autonomic control nuclei in the brainstem have been difficult to evaluate non-invasively in humans. We applied ultrahigh-field (7 T) functional magnetic resonance imaging (fMRI), and the improved spatial resolution it affords (1.2 mm isotropic), to evaluate putative brainstem nuclei that control and/or sense pain-evoked cardiovagal modulation (high-frequency heart rate variability (HF-HRV) instantaneously estimated through a point-process approach). The time-variant HF-HRV signal was used to guide the general linear model analysis of neuroimaging data. Sustained (6 min) pain stimulation reduced cardiovagal modulation, with the most prominent reduction evident in the first 2 min. Brainstem nuclei associated with pain-evoked HF-HRV reduction were previously implicated in both autonomic regulation and pain processing. Specifically, clusters consistent with the rostral ventromedial medulla, ventral nucleus reticularis (Rt)/nucleus ambiguus (NAmb) and pontine nuclei (Pn) were found when contrasting sustained pain versus rest. Analysis of the initial 2-min period identified Rt/NAmb and Pn, in addition to clusters consistent with the dorsal motor nucleus of the vagus/nucleus of the solitary tract and locus coeruleus. Combining high spatial resolution fMRI and high temporal resolution HF-HRV allowed for a non-invasive characterization of brainstem nuclei, suggesting that nociceptive afference induces pain-processing brainstem nuclei to function in concert with known premotor autonomic nuclei in order to affect the cardiovagal response to pain.

scholarly journals Magnetic Resonance Imaging and Dynamic X-ray's correlations with Dynamic Electrophysiological Findings in Cervical Spondylotic Myelopathy: a retrospective cohort study.

2020 ◽  
Author(s):  
Zhengran Yu ◽  
Kaiyuan Lin ◽  
Jiacheng Chen ◽  
Kuan-Hung Chen ◽  
Yuguang Chen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Spinal Cord ◽  
Magnetic Resonance ◽  
Cervical Spondylotic Myelopathy ◽  
T Test ◽  
Resonance Imaging ◽  
Segmental Instability ◽  
X Ray ◽  
Clinical Assessments ◽  
Radiographic Parameters

Abstract Background: Dynamic somatosensory evoked potentials (DSSEP) can be used to disclose abnormalities of ascending sensory pathways at dynamic positions and diagnose cervical spondylotic myelopathy (CSM). However, radiographic tests including magnetic resonance imaging (MRI) and dynamic X-ray are used much more widely in the management of CSM. Our study aims to clarify the correlations between several radiographic parameters and the DSSEP results, and further determine their reliability with clinical data.Methods: We retrospectively enrolled 38 CSM patients with surgical intervention. DSSEP tests were performed before surgery. Amplitude ratios of DSSEP N13 and N20 waves at extension and flexion were calculated and recorded as N13_E, N20_E, N13_F, N20_F respectively. Baseline severity was evaluated with the modified Japanese Orthopedic Association (mJOA) score and the Nurick grades. Prognosis was evaluated based on the 2-year recovery rate. Sagittal diameter and transverse areas of the cord and canal were measured and the Spinal cord/Canal Area Ratio were calculated. The compressive ratios at the compressed site (Compression_Ratio), central (Central_Ratio) and 1/4-lateral points (1/4-Lateral_Compression_Ratio), and intramedullary T2 hyperintensity patterns (Ax-CCM types) were also collected from MRI axial images. Dynamic X-rays were used to test for segmental instability of the cervical spine. The correlations between radiologic findings, DSSEP data, and clinical assessments were investigated.Results: We found that DSSEP N13_E and N13_F correlated with the Compression_Ratio, Central_Ratio, 1/4-Lateral_Compression_Ratio (Pearson, p<0.05) and Ax-CCM types (ANOVA, p<0.05) in MRI axial images and cervical segmental instability in dynamic X-ray (t-test, p<0.05). Apart from the 1/4-Lateral_Compression_Ratio, these radiographic parameters above also correlated with the baseline clinical assessments (Spearman or ANOVA or t-test, p<0.05) and postoperative recovery rate (Pearson or ANOVA or t-test, p<0.05).Conclusions: We found that the preoperative Compression_Ratio, Central_Ratio and 1/4-Lateral_Compression_Ratio in MRI and cervical segmental instability in dynamic X-ray could reflect the dynamic neural dysfunction of the spinal cord. Different Ax-CCM types corresponded to different DSSEP results at extension and flexion, suggesting divergent pathophysiology. These radiographic parameters could help evaluate disease severity and predict postoperative prognosis.Trial registration: The trial "动态诱发电位对脊髓型颈椎病诊断和预后评估(Dynamic Somatosensory Evoked Potentials for the diagnostic and prognostic evaluation for Cervical Spondylotic Myelopathy)" was retrospectively registered on April 30th, 2020 and the registration number is "伦审[2020]151号".

scholarly journals Molecular Mechanisms of Adenosine Stress T1 Mapping

2021 ◽  
Author(s):  
Soham A. Shah ◽  
Claire E. Reagan ◽  
Brent A. French ◽  
Frederick H. Epstein
Keyword(s):  
Magnetic Resonance Imaging ◽  
Heart Rate ◽  
Magnetic Resonance ◽  
Myocardial Perfusion ◽  
Perfusion Imaging ◽  
T1 Mapping ◽  
Myocardial Perfusion Reserve ◽  
Adenosine Stress ◽  
Resonance Imaging ◽  
Perfusion Reserve

Background: Adenosine stress T1 mapping is an emerging magnetic resonance imaging method to investigate coronary vascular function and myocardial ischemia without application of a contrast agent. Using gene-modified mice and 2 vasodilators, we elucidated and compared the mechanisms of adenosine myocardial perfusion imaging and adenosine T1 mapping. Methods: Wild-type (WT), A 2A AR −/− (adenosine A 2A receptor knockout), A 2B AR −/− (adenosine A 2B receptor knockout), A 3 AR −/− (adenosine A 3 receptor knockout), and eNOS −/− (endothelial nitric oxide synthase knockout) mice underwent rest and stress perfusion magnetic resonance imaging (n=8) and T1 mapping (n=10) using either adenosine, regadenoson (a selective A 2A AR agonist), or saline. Myocardial blood flow and T1 were computed from perfusion imaging and T1 mapping, respectively, at rest and stress to assess myocardial perfusion reserve and T1 reactivity (ΔT1). Changes in heart rate for each stress agent were also calculated. Two-way ANOVA was used to detect differences in each parameter between the different groups of mice. Results: Myocardial perfusion reserve was significantly reduced only in A 2A AR −/− compared to WT mice using adenosine (1.06±0.16 versus 2.03±0.52, P <0.05) and regadenoson (0.98±026 versus 2.13±0.75, P <0.05). In contrast, adenosine ΔT1 was reduced compared with WT mice (3.88±1.58) in both A 2A AR −/− (1.63±1.32, P <0.05) and A 2B AR −/− (1.55±1.35, P <0.05). Furthermore, adenosine ΔT1 was halved in eNOS −/− (1.76±1.46, P <0.05) versus WT mice. Regadenoson ΔT1 was approximately half of adenosine ΔT1 in WT mice (1.97±1.50, P <0.05), and additionally, it was significantly reduced in eNOS −/− mice (−0.22±1.46, P <0.05). Lastly, changes in heart rate was 2× greater using regadenoson versus adenosine in all groups except A 2A AR −/− , where heart rate remained constant. Conclusions: The major findings are that (1) although adenosine myocardial perfusion reserve is mediated through the A 2A receptor, adenosine ΔT1 is mediated through the A 2A and A 2B receptors, (2) adenosine myocardial perfusion reserve is endothelial independent while adenosine ΔT1 is partially endothelial dependent, and (3) ΔT1 mediated through the A 2A receptor is endothelial dependent while ΔT1 mediated through the A 2B receptor is endothelial independent.

scholarly journals Intrinsic Brain Abnormalities of Irritable Bowel Syndrome with Diarrhea: A Preliminary Resting-State Functional Magnetic Resonance Imaging Study

2020 ◽  
Author(s):  
Weiqun Ao ◽  
Yougen Cheng ◽  
Mingxian Chen ◽  
Fuquan Wei ◽  
Guangzhao Yang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Irritable Bowel Syndrome ◽  
Magnetic Resonance ◽  
Resting State ◽  
Pearson Correlation ◽  
Imaging Study ◽  
Brain Regions ◽  
Resonance Imaging ◽  
Left Hippocampus ◽  
Irritable Bowel

Abstract Background: The aim of the present study was to explore the brain active characteristics of patients with irritable bowel syndrome with diarrhea (IBS-D) using resting-state funcational magnetic resonance imaging (rsfMRI) technology.Methods: Thirteen IBS-D patients and fourteen healthy controls (HC) were enrolled. All subjects underwent head MRI examination during resting state. A voxel-based analysis of fractional amplitude of lowfrequency fluctuation (fALFF) maps between IBS-D and HC was performed using a two-sample t-test. The relationship between the fALFF values in abnormal brain regions and the scores of Symptom Severity Scale (IBS-SSS) were analyzed using Pearson correlation analysis. Results: Compared with HC, IBS-D patients had lower fALFF values in the left medial superior frontal gyrus and higher fALFF values in the left hippocampus and right precuneus. There was a positive correlation between the duration scores of IBS-SSS and fALFF values in the right precuneus. Conclusion: The altered fALFF values in the medial superior frontal gyri, left hippocampus and right precuneus revealed changes of intrinsic neuronal activity, further revealing the abnormality of gut-brain axis of IBS-D.

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