scholarly journals Activity of kallikrein-kinin system at patients with asiderotic anemia

2004 ◽  
Vol 3 (2) ◽  
pp. 56-61
Author(s):  
N. N. Zhilkova
Keyword(s):  
Disease Duration ◽  
Proteinase Inhibitors ◽  
Stable State ◽  
Continuous Treatment ◽  
Kinin System ◽  
Α2 Macroglobulin ◽  
Short Disease Duration ◽  
Severity Of The Disease ◽  
Kallikrein Kinin System ◽  
Severity Degree

The aim of investigation is to study the state of kallikrein-kinin system (KKS) and proteinase inhibitors at patients with asiderotic anemia prior to and after the treatment. 58 patients with asiderotic anemia prior to the treatment and in dynamics after 3 weeks have been examined. KKS state has been estimated by kallikrein, prekallikrein, proteinase α1-inhibitor (Pα1I) and α2-macroglobulin (α2-MG) levels in blood plasma having been investigated by Paskhina’s et al.chromatographic method and by Nartikova’s and Paskhina’s unified enzymatic method.Patients with asiderotic anemia had the rise of KKS activity. Its change differences depending on the disease duration have been revealed. At short disease duration a regulated KKS activation and its stable state have been marked. After the treatment at patients with medium severity degree it happens a normalization of all KKS parameters, at patients with serious anemia the high activity of Pα1I persists. The continuous treatment of anemia has led to the development of pathological type activation that had persisted at patients after the treatment.It has been revealed that the degree of KKS activation intensity and its renewal after the implemented treatment depended on the duration and severity of the disease.

KALLIKREIN-KININ SYSTEM IN PATIENTS WITH SHOCK. COMPARISON BETWEEN SEPTIC AND CARDIOGENIC SHOCK

1987 ◽  
Author(s):  
F Martínez-Brotóns ◽  
J R Oncins ◽  
J Mestres ◽  
V Amargós ◽  
C Reynaldo
Keyword(s):  
Septic Shock ◽  
Cardiogenic Shock ◽  
Hemodynamic Instability ◽  
Factor Xii ◽  
Kinin System ◽  
Normal Limits ◽  
Α2 Macroglobulin ◽  
At Iii ◽  
Functional Measure ◽  
Kallikrein Kinin System

Alterations of the kallikrein-kinin system (KKS) consistent with activation and increased consumption have been reported in septic patients and it has been suggested that this activation could contribute to the development of septic shock. As similar alterations have been found in other critically ill patients, many of them prone to shock, we wonder if activation of the KKS could be a consequence rather than a cause of the hemodynamic instability. To answer this question we compared 12 patients with septic shock (8 fatal) with 10 cases of cardiogenic shock secondary to myocardial infarction (8 fatal) as a model of non septic shock. In adition 25 episodes of uncomplicated sepsis and 10 intra-intensive care unit controls were studied. A functional measure of factor XII, high molecular weight kininogen (HMWK) (coagulative methods), prekallikrein (PK), Cl-inhibitor (Cl-INH), α2-macroglobulin (α2-M)- Antithrombin III (AT-III) and kallikrein inhibitor activity (KIA) (chromogenic methods) was performedRESULTS: Patients with septic shock, specially in fatal cases, showed a highly significant decrease in activities of factor XII (P<0.001), PK (P<0.0001), HMWK (P<0.005), α2-M (P<0.001), AT-III (P<0.0001) and KIA (P<0.005). Cl-INH activity was increased in uncomplicated sepsis (P<0.001) but came back to normal or was slightly decreased in septic shock. Components and inhibitors of the KKS were within normal limits in all patients with cardiogenic shock.Our findings support the idea of a contribution of the KKS to the development of septic shock but this system neither seems to play a role in the pathogenesis of cardiogenic shock nor to be altered as a consequence of it.

scholarly journals Activity of kallikrein-kinin system in children in norm and at some pathological states

2009 ◽  
Vol 8 (4(2)) ◽  
pp. 61-69
Author(s):  
Ye. I. Kondratiyeva ◽  
T. Ye. Tropova ◽  
G. A. Sukhanova ◽  
A. A. Terentiyeva ◽  
T. S. Krivonogova ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Protease Inhibitor ◽  
Blood Plasma ◽  
Inflammatory Diseases ◽  
Healthy Children ◽  
Urinary System ◽  
Kinin System ◽  
Α2 Macroglobulin ◽  
Kallikrein Kinin System ◽  
Ischemic Encephalopathy

Proteolytic systems of tissue and blood plasma take part in the processes of adaptation and protection of an organism, as well as in development of pathological reactions. We have studied the activity of kallikrein, kallikreinogen, angiotensine transforming enzyme, α1-protease inhibitor, and α2-macroglobulin in healthy children in different age periods, in newborns with hypoxic-ischemic encephalopathy, in children with infectious-inflammatory diseases of the urinary system, obesity, and metabolic syndrome.The activity of the kallikrein-kinin system was increased in all the groups against the background of the decreased inhibitory activity of blood plasma of different intensity, which can be used for the prediction of the course of diseases.

scholarly journals New quality criteria for fresh frozen plasma

2019 ◽  
Vol 10 (1) ◽  
pp. 65-71
Author(s):  
Elena V. Ryabikina ◽  
Elena A. Chernogubova ◽  
Yuri V. Shatokhin ◽  
Irina V. Snezhko ◽  
Olga V. Gerasimova ◽  
...  
Keyword(s):  
Blood Donation ◽  
Quality Criteria ◽  
Fresh Frozen Plasma ◽  
Kinin System ◽  
Α2 Macroglobulin ◽  
Fresh Frozen ◽  
Main Components ◽  
Kallikrein Kinin System ◽  
Frozen Plasma

Objective:development of new quality criteria for fresh frozen plasma.Matherials and methods: at diff erent times of storage of fresh frozen plasma harvested standardly and from the donors aft er Biolan exposure, the parameters of the kallikrein-kinin system were determined: the activity of kallikrein, the inhibitory activity of the α1 -proteinase inhibitor, α2 -macroglobulin, the total arginine-esterase activity and the level of prekallikrein.Results:during the quarantine process of fresh frozen plasma, prepared in a standard way, the processes of proteolysis activation is noticed already by 10th day from the beginning of FFP storage, and the preparation of donors for the blood donation with help of the biolan adaptogen provides better preservation of the components of the kallikrein-kinin system.Conclusions:analysis of the main components of the kallikrein-kinin system can be used as an additional criterion of the quality of fresh frozen plasma before the transfusion procedure.

Studies on Components of the plasma kallikrein-Kinin System in Normal Subjects and Patients with Septicemia

1979 ◽  
Author(s):  
A.O. Aasen ◽  
M.J. Gallimore ◽  
K. Lyngaas ◽  
M. Larsbraaten ◽  
E. Amundsen ◽  
...  
Keyword(s):  
Enzyme System ◽  
Normal Subjects ◽  
Plasma Kallikrein ◽  
Plasma Samples ◽  
Kinin System ◽  
The Past ◽  
Α2 Macroglobulin ◽  
Kallikrein Kinin System ◽  
Fatal Sepsis ◽  
Esterase Inhibitor

Over the past decade evidence that the plasma kallikrein-kinin system is activated during septicemia has accumulated. We have used several tests, including newly developed chromogenic peptide substrate assays, to study components of this proteolytic enzyme system in plasma samples from normal subjects and patients with septicemia. The parameters studied were Hageman factor(HF), plasma kallikrein (KK), plasma prekallikrein (PKK), high molecular weight kininogen(HMwK), functional kallikrein inhibition (KKI), c1-esterase inhibitor (CIINH) , α2-macroglobulin (α2 M)and α1-antitrypsin (α1AT ). In samples from patients with fatal sepsis, levels of HF, PKK, HMwK, α2M and KKI were all markedly reduced and spontaneous KK activity was detected. CIINH and α1AT levels were much higher than normal. In plasma samples from three patients with septicemia who subsequently recovered mean plasma levels of PKK, KKI, HMwK and CIINH were higher than in the samples from the patients who died. Our results emphasize that the plasma kallikrein-kinin system becomes activated during septicemia and suggest that functional kallikrein inhibition contributes to survival.

Evidence for a role of kallikrein-kinin system in patients with shock after blunt trauma

1998 ◽  
Vol 274 (6) ◽  
pp. R1556-R1560 ◽  
Author(s):  
Katsuhiko Sugimoto ◽  
Mitsuhiro Hirata ◽  
Masataka Majima ◽  
Makoto Katori ◽  
Takashi Ohwada
Keyword(s):  
Molecular Weight ◽  
Blunt Trauma ◽  
Human Subjects ◽  
Stable State ◽  
Unstable State ◽  
Kinin System ◽  
Kallikrein Kinin System ◽  
Precise Role

Bradykinin (BK) is activated via plasma and/or tissue kallikrein-kinin (K-K) system pathways during hypotension after blunt trauma. The precise role of the K-K system in human subjects has not been defined. We developed a new method for measuring levels of BK in the blood and examined the role of the K-K system in patients with shock after trauma. Eight patients were entered into this study. We measured the levels of a high-molecular-weight kininogen (HMWK), a low-molecular-weight kininogen (LMWK), BK, and (1—5)-BK in the blood of patients in an unstable state (Pre) and a stable state (Post). At Pre, the blood BK level was significantly elevated, the HMWK and LMWK levels were significantly lower, and the (1—5)-BK level was significantly higher than the respective levels at Post. Our data suggest a significant role for the K-K system in the pathogenesis of shock after blunt trauma. This newly developed method for determination of the activation of the plasma K-K system appears to be useful for determining the severity of a trauma.

Activation of the kallikrein-kinin system and release of new kinins through alternative cleavage of kininogens by microbial and human cell proteinases

2004 ◽  
Vol 385 (11) ◽  
pp. 989-996 ◽  
Author(s):  
Takahisa Imamura ◽  
Jan Potempa ◽  
James Travis
Keyword(s):  
Human Cell ◽  
Proteinase Inhibitors ◽  
Biological Activities ◽  
Smooth Muscle Contraction ◽  
Cysteine Proteinases ◽  
Kinin System ◽  
Hageman Factor ◽  
Bacterial Pathogenicity ◽  
Permeability Increase ◽  
Kallikrein Kinin System

AbstractKinins are released from kininogens through the activation of the Hageman factor-prekallikrein system or by tissue kallikrein. These peptides exert various biological activities, such as vascular permeability increase, smooth muscle contraction, pain sensation and induction of hypotension. In many instances kinins are thought to be involved in the pathophysiology of various diseases. Recent studies have revealed that microbial and human cell proteinases activate Hageman factor and/or prekallikrein, or directly release kinin from kininogens. This review discusses the activation of the kinin-release system by mast-cell tryptase and microbial proteinases, including gingipains, which are cysteine proteinases fromPorphyromonas gingivalis, the major pathogen of periodontal disease. Each enzyme is evaluated in the context of its association to allergy and infectious diseases, respectively. Furthermore, a novel system of kinin generation directly from kininogens by the concerted action of two proteinases is described. An interesting example of this system with implications to bacterial pathogenicity is the release of kinins from kininogens by neutrophil elastase and a synergistic action of cysteine proteinases fromStaphylococcus aureus. This alternative production of kinins by proteinases present in diseased sites indicates a significant contribution of proteinases other than kallikreins in kinin generation. Therefore kinin receptor antagonists and proteinase inhibitors may be useful as therapeutic agents.

Einfluss mechanischer Dehnung von alveolären Typ II Zellen auf das Kallikrein-Kinin System

Pneumologie ◽  
2016 ◽  
Vol 70 (S 01) ◽  
Author(s):  
J Knauth ◽  
A Schweinberger ◽  
H Kuhn ◽  
H Wirtz
Keyword(s):  
Kinin System ◽  
Kallikrein Kinin System
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