Remodeling of the common carotid artery in oncohematological pathology by ultrasound

The aimis the assessment of structural and functional state of common carotid artery by ultrasound in patients with non-Hodgkin malignant lymphomas (NHML) before and after chemotherapy.Materials and methods.The common carotid artery of 111 patients at different stages of NHML were examined via a “LOGIC 400” ultrasound.Results.The common carotid artery of patients with NHML is undergoing morphological modification with changes in thickness and diameter, which corresponds to a hypertrophic type of remodeling. There is an increase in the thickness of the complex “intima-media” and Kernogan`s index with decreasing the common carotid artery diameter by comparison with the control group. Chemotherapy improves the parameters of the common carotid artery while reducing the thickness of the complex “intima-media” and Kernogan`s index at different stages of NHML.Conclusion.Remodeling of the common carotid artery is associated with the developmental stage of NHML. Chemotherapy leads to an improvement of the morphological parameters of the common carotid artery, which evaluates the effect of the treatment.

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Functional State of the Mitochondria from Tissues of the Rat Brain after Chronic Occlusion of the Common Carotid Artery: Role of Lysyl Oxidase

Neurophysiology ◽

10.1007/s11062-018-9705-7 ◽

2017 ◽

Vol 49 (6) ◽

pp. 424-431

Author(s):

O. Yu. Harmatina ◽

V. I. Nosar’ ◽

E. É. Kolesnikova ◽

T. Yu. Lapikova-Bryginskaya ◽

L. V. Bratus’ ◽

...

Keyword(s):

Carotid Artery ◽

Rat Brain ◽

Functional State ◽

Common Carotid Artery ◽

Lysyl Oxidase ◽

Chronic Occlusion ◽

The Common

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ESTIMATION OF THE THICKNESS OF THE INTIMA-MEDIA COMPLEX IN CHILDREN WITH FAMILIAL HYPERCHOLESTEROLEMIA

Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) ◽

10.21508/1027-4065-2018-63-5-152-154 ◽

2018 ◽

Vol 63 (5) ◽

pp. 152-154

Author(s):

D. I. Sadykova ◽

L. F. Galimova ◽

I. V. Leontyeva ◽

E. S. Slastnikova

Keyword(s):

Carotid Artery ◽

Familial Hypercholesterolemia ◽

Common Carotid Artery ◽

Lipid Lowering ◽

Control Group ◽

Lipid Lowering Therapy ◽

Healthy Children ◽

Early Diagnostics ◽

Significant Difference ◽

The Common

Objective:to evaluate the diagnostic significance of measuring the thickness of the intima-media complex (IMC) in children with autosomal dominant familial hypercholesterolemia for early diagnostics and prompt treatment of atherosclerosis.Materials and methods.The study included 109 children – 64 children with familial hypercholesterolemia and 45 healthy children. Both groups were divided into 2 subgroups according to the age – from 3 to 8 years and from 9 to 18 years. We measured the intimamedia thickness (IMT) of the common carotid artery in all the children. To evaluate IMT we used an ultrasound scanner HD11XE (Philips, USA) with a linear (3–12MHz) sensor IMT.Results.We found a statistically significant difference (p=0.012) of the IMT of the common carotid artery in children with familial hypercholesterolemia (0.61 ± 0.02 mm) in comparison with the control group (0.49±0.02 mm), starting from the age of 9 years. There were no sex differences of IMT in patients older than 9 years.Conclusion.We found that children with familial hypercholesterolemia have higher values of IMT already from the age of 9 as compared with healthy children; the increase in TCIM is an additional criterion for the early diagnostics of atherosclerosis and evaluation of cardiovascular risk. These results emphasize the relevance of lipid-lowering therapy for patients with familial hypercholesterolemia in childhood, before the first signs of atherosclerosis appear.

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Endothelial-Dependent Vasodilation Is Impaired in Children with Sickle Cell Disease (SCD).

Blood ◽

10.1182/blood.v108.11.3778.3778 ◽

2006 ◽

Vol 108 (11) ◽

pp. 3778-3778

Author(s):

Mariane De Montalembert ◽

Yacine Aggoun ◽

Assa Niakate ◽

Isabelle Szezepanski ◽

Damien Bonnet

Keyword(s):

Steady State ◽

Carotid Artery ◽

Common Carotid Artery ◽

Vascular Function ◽

Intima Media Thickness ◽

Control Group ◽

The Common ◽

Dependent Flow ◽

And Gender ◽

Flow Mediated Vasodilation

Abstract Impairment of endothelium-dependent vasodilation has been reported in steady-state SCD adult patients, and could contribute to the occurrence of vaso-occlusive events. In order to study whether vascular tone abnormalities could be also observed in SCD children, we enrolled 21 SCD steady-state children (18 homozygous SS, 3 S-b0 thalassemics); 12 males, 9 females, mean aged 10.4 ± 3.3 yrs, mean Hb level: 7.6 ± 1.0 g/dL. None had had a transfusion in the 3 previous months, nor were treated with hydroxyurea. These SCD children were compared to a control group of 23 Afro-Caribbean AA and AS controls matched for age and gender. Blood pressure and vascular function parameters were measured after the child had been recumbent for at least 10 minutes. Flow-mediated (FMD) and nitroglycerine-mediated (GTNMD) dilation of the brachial artery were examined in cases and controls using echotracking techniques. Additionally, intima-media thickness (IMT) and mechanical properties of the common carotid artery were measured using previously described methods. Blood pressures in SCD and control children were comparable. IMT was not different in SCD children (0.42 ± 0.06 mm) vs controls (0.42 ± 0.03 mm). Systolic and diastolic diameters of the common carotid artery were significantly higher in SCD children than in controls (respectively, 6.8 ± 0.8 vs 5.7 ± 0.4, p<0.001, and 5.7 ±0.7 vs 5.0 ± 0.4 mm, p< 0.005) but the stiffness of the common carotid artery was not different in SCD children and in controls. Finally, FMD was significantly decreased in SCD children vs controls (5.6 ± 0.2 vs 8.0 ± 0.2 %, p: 0.008), while GTNMD was comparable in SCD patients and controls. We hypothesize that the increase of the carotid artery diameters, without modification of the distensibility, is related to the higher cardiac output secondary to anemia. Interestingly, we observed a significant decrease of the endothelial-dependent flow-mediated vasodilation in SCD children, which had never been reported before. This could result of impaired NO bioavailability, correlated with enhanced arginase activity and hemolysis rate. Oral arginine supplementation in SCD children could be an appropriate treatment.

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Clinical and molecular interrelations of dislipidemia and metabolic phenotype of osteoarthritis

I P Pavlov Russian Medical Biological Herald ◽

10.23888/pavlovj20173391-398 ◽

2017 ◽

Vol 25 (3) ◽

pp. 391-398

Author(s):

M. A. Kabalyk ◽

A. B. Sunyaykin

Keyword(s):

Carotid Artery ◽

Common Carotid Artery ◽

Clinical Manifestations ◽

Endothelial Damage ◽

Atherogenic Index ◽

Metabolic Phenotype ◽

Control Group ◽

Cardiovascular Comorbidity ◽

Tnf Α ◽

The Common

The work purpose: analysis of lipid parameters and inflammation markers in metabolic phenotype (MPh) osteoarthritis (OA) in correlation with the clinical manifestations of the disease. The study involved 90 patients with OA of the knee (average age of 64.66±8.43 year), of which 37 patients were with Diabetes mellitus type 2 (group MPh OA). 25 comparable volunteers were a control group. Lipid levels, interleukin-1β (IL-1β), tumor necrosis factor α (TNF-α), vasculo-endothelial growth factor A (VEGF-A), atherosclerotic changes of the common carotid artery by ultrasound were determined for all patients. It is shown that when MPh OA patients have a higher atherogenic index (as compared with the control group and patients with OA without the MPh), a greater thickness of the intima-media complex of the common carotid artery and the imbalance of cytokines in favor of increased pro-inflammatory molecules. In MPh OA group there was correlation of atherogenic lipids with proinflammatory cytokines (IL-1β, TNF-α), a marker of endothelial damage (VEGF-A) and clinical manifestations of OA. Thus, the results of the analysis confirm the important role of dyslipidemia and atherosclerosis in the pathogenesis of MPh OA, in particular indicate the possibility of integrating factors of cardiovascular comorbidity via molecular patterns IL-1β, TNF-α, VEGF-A.

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Resin Based Materials used to Observing the Variations of the Origin of the Superior Thyroid Artery with Importance in Cervical and Cranial Pathology

Materiale Plastice ◽

10.37358/mp.19.1.5134 ◽

2019 ◽

Vol 56 (1) ◽

pp. 115-119

Author(s):

Petru Bordei ◽

Dan Marcel Iliescu ◽

Lavinia Maria Rusali ◽

Razvan Hainarosie ◽

Radu Cristian Jecan ◽

...

Keyword(s):

Carotid Artery ◽

Common Carotid Artery ◽

Geographic Area ◽

External Carotid Artery ◽

External Carotid ◽

Superior Thyroid Artery ◽

Before And After ◽

The Common ◽

Materials Used ◽

Terminal Level

The superior thyroid artery shows a great variability in what concerns its origin. Most often, it appears as an independent branch of the external carotid artery, as its first collateral branch, or directly from the common carotid or at its terminal level. The superior thyroid artery origin was evaluated on 144 cases, using as study methods the dissection (39 cases), the plastic injection (22 cases) and the CT angiography evaluation (83 cases). It was studied, by percentage, the originating artery of the superior thyroid artery, the relation to the bifurcation of the common carotid artery, the neighboring arterial branches and the surface of the external carotid on which originated, the caliber of the external carotid artery before and after the origin of the superior thyroid artery. Most commonly, in 89 cases (61.80%), we describe the origin of the superior thyroid artery from the external carotid artery; from the common carotid artery originated 31 superior thyroid arteries (21.53%); at the level of the bifurcation of the common carotid artery, the superior thyroid artery had its origin in 21 cases (14.58%); in 2 cases (1.39%) we encountered the superior thyroid artery originating from a thyro-lingual trunk and in one case (0.69%), we met a thyro-linguo-facial trunk. The superior thyroid arteries may originate as an independent artery or as arterial trunks in varying proportions. When the origin of the superior thyroid artery is from the terminal common carotid, we propose to use the expression of terminal branching or the common carotid artery trifurcation. The results of our study are similar to those found in international literature, with statistical differences that may be attributed primarily to the total number of cases on which we worked and also working methods or may be attributed to other causes, such as the geographic area where the study was conducted and the amount of time the results were obtained.

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OR-022 Effects of aerobic exercise on the hemodynamics and structure of the common carotid artery in obese adolescents

Exercise Biochemistry Review ◽

10.14428/ebr.v1i2.9233 ◽

2018 ◽

Vol 1 (2) ◽

Author(s):

Wenxia Shi ◽

Ling Cao ◽

Xianzhe Xu

Keyword(s):

Blood Pressure ◽

Blood Flow ◽

Carotid Artery ◽

Aerobic Exercise ◽

Diastolic Blood Pressure ◽

Common Carotid Artery ◽

Exercise Intervention ◽

Control Group ◽

Obese Adolescents ◽

The Common

Objective With the population of obese adolescents increases dramatically, a series of cardiovascular diseases, especially atherosclerotic, are triggered by obese which seriously threatens the life and health of teenagers. The aim of this study is to investigate the effects of aerobic exercise intervention on the hemodynamics and structure of the common carotid artery in obese adolescents. Methods Forty obese adolescents (18 ± 2years) were randomly assigned into the experimental group (EG; n = 20) and control group (CG; n = 20). EG undertook 12 weeks of aerobic exercise training (AET), CG had not any exercise intervention. The carotid artery of both CG and EG were examined and compared. Carotid artery responses were assessed in both groups. Color doppler ultrasound was used to determine the tube diameter and axial flow of the common carotid before and after exercise intervention. The heart rate, systolic and diastolic blood pressure were simultaneously measured on the left brachial artery by a sphygmomanometer. Results Compared with CG, there were improvements of EG in peripheral resistance (22.90±6.70 VS 29.58±8.71. p＜0.01) and Systolic blood pressure (123.57±7.36 VS 130.25±6.79. p＜0.05) were verified after AET, except diastolic blood pressure. Following AET, blood flow velocity (0.28±0.05 VS 0.21±0.05. p＜0.01) and wall shear stress (6.25±0.90 VS 4.97±1.54. p＜0.05) increased prominently, which were also significant differences only in EG. In contrast, the vascular diameter demonstrated consistently upper compared with CG, but no differences between EG and CG. Conclusions Regular aerobic exercise lasting 12 weeks could effectively change the dynamic parameters of the common carotid artery in obese adolescents, but no changes in arterial diameter. These findings indicated that 12 weeks of aerobic exercise can induce some changes of the common carotid artery blood flow within the circulation function in a short time. But the changing in common carotid arteries structure is needed after a long-term blood flow to the stimulation.

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