scholarly journals Clinical and molecular interrelations of dislipidemia and metabolic phenotype of osteoarthritis

2017 ◽  
Vol 25 (3) ◽  
pp. 391-398
Author(s):  
M. A. Kabalyk ◽  
A. B. Sunyaykin
Keyword(s):  
Carotid Artery ◽  
Common Carotid Artery ◽  
Clinical Manifestations ◽  
Endothelial Damage ◽  
Atherogenic Index ◽  
Metabolic Phenotype ◽  
Control Group ◽  
Cardiovascular Comorbidity ◽  
Tnf Α ◽  
The Common

The work purpose: analysis of lipid parameters and inflammation markers in metabolic phenotype (MPh) osteoarthritis (OA) in correlation with the clinical manifestations of the disease. The study involved 90 patients with OA of the knee (average age of 64.66±8.43 year), of which 37 patients were with Diabetes mellitus type 2 (group MPh OA). 25 comparable volunteers were a control group. Lipid levels, interleukin-1β (IL-1β), tumor necrosis factor α (TNF-α), vasculo-endothelial growth factor A (VEGF-A), atherosclerotic changes of the common carotid artery by ultrasound were determined for all patients. It is shown that when MPh OA patients have a higher atherogenic index (as compared with the control group and patients with OA without the MPh), a greater thickness of the intima-media complex of the common carotid artery and the imbalance of cytokines in favor of increased pro-inflammatory molecules. In MPh OA group there was correlation of atherogenic lipids with proinflammatory cytokines (IL-1β, TNF-α), a marker of endothelial damage (VEGF-A) and clinical manifestations of OA. Thus, the results of the analysis confirm the important role of dyslipidemia and atherosclerosis in the pathogenesis of MPh OA, in particular indicate the possibility of integrating factors of cardiovascular comorbidity via molecular patterns IL-1β, TNF-α, VEGF-A.

scholarly journals Remodeling of the common carotid artery in oncohematological pathology by ultrasound

2018 ◽  
Vol 17 (4) ◽  
pp. 47-53
Author(s):  
V. D. Koptev ◽  
V. V. Nimaev ◽  
V. N. Gorchakov
Keyword(s):  
Carotid Artery ◽  
Developmental Stage ◽  
Functional State ◽  
Common Carotid Artery ◽  
Control Group ◽  
Morphological Parameters ◽  
Malignant Lymphomas ◽  
Before And After ◽  
Morphological Modification ◽  
The Common

The aimis the assessment of structural and functional state of common carotid artery by ultrasound in patients with non-Hodgkin malignant lymphomas (NHML) before and after chemotherapy.Materials and methods.The common carotid artery of 111 patients at different stages of NHML were examined via a “LOGIC 400” ultrasound.Results.The common carotid artery of patients with NHML is undergoing morphological modification with changes in thickness and diameter, which corresponds to a hypertrophic type of remodeling. There is an increase in the thickness of the complex “intima-media” and Kernogan`s index with decreasing the common carotid artery diameter by comparison with the control group. Chemotherapy improves the parameters of the common carotid artery while reducing the thickness of the complex “intima-media” and Kernogan`s index at different stages of NHML.Conclusion.Remodeling of the common carotid artery is associated with the developmental stage of NHML. Chemotherapy leads to an improvement of the morphological parameters of the common carotid artery, which evaluates the effect of the treatment.

scholarly journals ESTIMATION OF THE THICKNESS OF THE INTIMA-MEDIA COMPLEX IN CHILDREN WITH FAMILIAL HYPERCHOLESTEROLEMIA

2018 ◽  
Vol 63 (5) ◽  
pp. 152-154
Author(s):  
D. I. Sadykova ◽  
L. F. Galimova ◽  
I. V. Leontyeva ◽  
E. S. Slastnikova
Keyword(s):  
Carotid Artery ◽  
Familial Hypercholesterolemia ◽  
Common Carotid Artery ◽  
Lipid Lowering ◽  
Control Group ◽  
Lipid Lowering Therapy ◽  
Healthy Children ◽  
Early Diagnostics ◽  
Significant Difference ◽  
The Common

Objective:to evaluate the diagnostic significance of measuring the thickness of the intima-media complex (IMC) in children with autosomal dominant familial hypercholesterolemia for early diagnostics and prompt treatment of atherosclerosis.Materials and methods.The study included 109 children – 64 children with familial hypercholesterolemia and 45 healthy children. Both groups were divided into 2 subgroups according to the age – from 3 to 8 years and from 9 to 18 years. We measured the intimamedia thickness (IMT) of the common carotid artery in all the children. To evaluate IMT we used an ultrasound scanner HD11XE (Philips, USA) with a linear (3–12MHz) sensor IMT.Results.We found a statistically significant difference (p=0.012) of the IMT of the common carotid artery in children with familial hypercholesterolemia (0.61 ± 0.02 mm) in comparison with the control group (0.49±0.02 mm), starting from the age of 9 years. There were no sex differences of IMT in patients older than 9 years.Conclusion.We found that children with familial hypercholesterolemia have higher values of IMT already from the age of 9 as compared with healthy children; the increase in TCIM is an additional criterion for the early diagnostics of atherosclerosis and evaluation of cardiovascular risk. These results emphasize the relevance of lipid-lowering therapy for patients with familial hypercholesterolemia in childhood, before the first signs of atherosclerosis appear.

Endothelial-Dependent Vasodilation Is Impaired in Children with Sickle Cell Disease (SCD).

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 3778-3778
Author(s):  
Mariane De Montalembert ◽  
Yacine Aggoun ◽  
Assa Niakate ◽  
Isabelle Szezepanski ◽  
Damien Bonnet
Keyword(s):  
Steady State ◽  
Carotid Artery ◽  
Common Carotid Artery ◽  
Vascular Function ◽  
Intima Media Thickness ◽  
Control Group ◽  
The Common ◽  
Dependent Flow ◽  
And Gender ◽  
Flow Mediated Vasodilation

Abstract Impairment of endothelium-dependent vasodilation has been reported in steady-state SCD adult patients, and could contribute to the occurrence of vaso-occlusive events. In order to study whether vascular tone abnormalities could be also observed in SCD children, we enrolled 21 SCD steady-state children (18 homozygous SS, 3 S-b0 thalassemics); 12 males, 9 females, mean aged 10.4 ± 3.3 yrs, mean Hb level: 7.6 ± 1.0 g/dL. None had had a transfusion in the 3 previous months, nor were treated with hydroxyurea. These SCD children were compared to a control group of 23 Afro-Caribbean AA and AS controls matched for age and gender. Blood pressure and vascular function parameters were measured after the child had been recumbent for at least 10 minutes. Flow-mediated (FMD) and nitroglycerine-mediated (GTNMD) dilation of the brachial artery were examined in cases and controls using echotracking techniques. Additionally, intima-media thickness (IMT) and mechanical properties of the common carotid artery were measured using previously described methods. Blood pressures in SCD and control children were comparable. IMT was not different in SCD children (0.42 ± 0.06 mm) vs controls (0.42 ± 0.03 mm). Systolic and diastolic diameters of the common carotid artery were significantly higher in SCD children than in controls (respectively, 6.8 ± 0.8 vs 5.7 ± 0.4, p<0.001, and 5.7 ±0.7 vs 5.0 ± 0.4 mm, p< 0.005) but the stiffness of the common carotid artery was not different in SCD children and in controls. Finally, FMD was significantly decreased in SCD children vs controls (5.6 ± 0.2 vs 8.0 ± 0.2 %, p: 0.008), while GTNMD was comparable in SCD patients and controls. We hypothesize that the increase of the carotid artery diameters, without modification of the distensibility, is related to the higher cardiac output secondary to anemia. Interestingly, we observed a significant decrease of the endothelial-dependent flow-mediated vasodilation in SCD children, which had never been reported before. This could result of impaired NO bioavailability, correlated with enhanced arginase activity and hemolysis rate. Oral arginine supplementation in SCD children could be an appropriate treatment.

scholarly journals CHANGES IN THE SECRETARY ABILITY OF MONONUCLEAR CELLS IN PATIENTS WITH ATHEROSCLEROSIS AND ACCOMPANYING PATHOLOGY, DEPENDING ON THE C-PEPTIDE BLOOD PLASMA

2019 ◽  
Vol 72 (4) ◽  
pp. 584-588
Author(s):  
Olena O. Karlova ◽  
Olena V. Kuzminska ◽  
Alina I. Baryshnik
Keyword(s):  
Metabolic Syndrome ◽  
Carotid Artery ◽  
Adhesion Molecule ◽  
Common Carotid Artery ◽  
Mononuclear Cells ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
C Peptide ◽  
Tnf Α ◽  
The Common

Introduction: Atherosclerosis is a trigger in the development of cardiovascular disease. Complications of atherosclerosis give reason to search for new criteria, diagnostic concepts, treatment methods and active preventive measures. The aim of our work is to study of the structural changes in the intima-media complex of the common carotid artery, pro-inflammatory cytokines (TNF-α, IL-6) secreted by mononuclear cells; the level of the intercellular adhesion molecule (according to sICAM-1), the level of the C-peptide of the blood, as well as the study of the relationship between these factors affecting the development of atherosclerosis. Materials and methods: In the group of 110 patients are studied the levels of secretion of TNF-α, IL-6, the soluble intercellular adhesion molecule-1, the level of blood C-peptide, performed of duplex scanning of the brachiocephalic vessels, studied of biopsy of the skin. Results and conclusions: In the group of patients with atherosclerosis and the accompanying metabolic syndrome, endothelial activation is noted under the influence of risk factors (hyperinsulinemia, arterial hypertension, hypercholesterolemia), accompanied with the activation of mononuclear cells (with marked hyperproduction of proinflammatory cytokines (IL-6) and thickening of the intima-media complex of the common carotid artery with an increase in body weight. Patients with metabolic syndrome develop microangiopathy (edema of endothelial cells, thickening and reduplication of the basement membranes, focal reaction of the pericytes).

scholarly journals OR-022 Effects of aerobic exercise on the hemodynamics and structure of the common carotid artery in obese adolescents

2018 ◽  
Vol 1 (2) ◽  
Author(s):  
Wenxia Shi ◽  
Ling Cao ◽  
Xianzhe Xu
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Carotid Artery ◽  
Aerobic Exercise ◽  
Diastolic Blood Pressure ◽  
Common Carotid Artery ◽  
Exercise Intervention ◽  
Control Group ◽  
Obese Adolescents ◽  
The Common

Objective With the population of obese adolescents increases dramatically, a series of cardiovascular diseases, especially atherosclerotic, are triggered by obese which seriously threatens the life and health of teenagers. The aim of this study is to investigate the effects of aerobic exercise intervention on the hemodynamics and structure of the common carotid artery in obese adolescents. Methods  Forty obese adolescents (18 ± 2years) were randomly assigned into the experimental group (EG; n = 20) and control group (CG; n = 20). EG undertook 12 weeks of aerobic exercise training (AET), CG had not any exercise intervention. The carotid artery of both CG and EG were examined and compared. Carotid artery responses were assessed in both groups. Color doppler ultrasound was used to determine the tube diameter and axial flow of the common carotid before and after exercise intervention. The heart rate, systolic and diastolic blood pressure were simultaneously measured on the left brachial artery by a sphygmomanometer. Results Compared with CG, there were improvements of EG in peripheral resistance (22.90±6.70 VS 29.58±8.71. p＜0.01) and Systolic blood pressure (123.57±7.36 VS 130.25±6.79. p＜0.05) were verified after AET, except diastolic blood pressure. Following AET, blood flow velocity (0.28±0.05 VS 0.21±0.05. p＜0.01) and wall shear stress (6.25±0.90 VS 4.97±1.54. p＜0.05) increased prominently, which were also significant differences only in EG. In contrast, the vascular diameter demonstrated consistently upper compared with CG, but no differences between EG and CG. Conclusions  Regular aerobic exercise lasting 12 weeks could effectively change the dynamic parameters of the common carotid artery in obese adolescents, but no changes in arterial diameter. These findings indicated that 12 weeks of aerobic exercise can induce some changes of the common carotid artery blood flow within the circulation function in a short time. But the changing in common carotid arteries structure is needed after a long-term blood flow to the stimulation.

scholarly journals Idiopathic Free-Floating Thrombus of the Common Carotid Artery

2002 ◽  
Vol 29 (1) ◽  
pp. 97-99 ◽  
Author(s):  
Brian Silver ◽  
Irene Gulka ◽  
Michael Nicolle ◽  
Ramesh Sahjpaul ◽  
Vladimir Hachinski
Keyword(s):  
Carotid Artery ◽  
Common Carotid Artery ◽  
Multimodal Imaging ◽  
Doppler Ultrasonography ◽  
Resonance Imaging ◽  
Wall Defect ◽  
Floating Thrombus ◽  
Weighted Magnetic Resonance Imaging ◽  
The Common ◽  
One Year

Background:The observation of an intraluminal common carotid artery thrombus overlying a wall defect at ultrasonography or angiography is unusual. To our knowledge, there are no previous reports of a free-floating thrombus in the common carotid artery.Case Report:A 45-year-old woman who was previously healthy and on no medications presented with acute hemiparesis and aphasia. Following testing that included carotid duplex and trancranial Doppler ultrasonography, diffusion-weighted magnetic resonance imaging, and digital subtraction angiography, the patient underwent emergency open embolectomy. No underlying wall defect was seen at the time of imaging or surgery. No obvious hypercoagulable state could be identified. Her NIH Stroke Scale score improved from 26 at admission to 2 at three months and 1 at one year.Conclusions:Multimodal imaging may have improved diagnosis and management in this patient with a unique finding. The source of the thrombus remains obscure.

scholarly journals Elevated end-diastolic ratio of the common carotid artery due to cerebral arteriovenous malformation: Two case reports

2018 ◽  
Vol 13 (4) ◽  
pp. 917-920
Author(s):  
Koji Tanaka ◽  
Shoji Matsumoto ◽  
Takeshi Yamada ◽  
Daisuke Kondo ◽  
Hideo Chihara ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Arteriovenous Malformation ◽  
Common Carotid Artery ◽  
Case Reports ◽  
Cerebral Arteriovenous Malformation ◽  
The Common
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