scholarly journals Bacteriological Profile of Blood Culture from Adult Sepsis Patients from a Rural Based Tertiary Care and Teaching Hospital, Piparia, Vadodara, India

Author(s):  
Radhika Khara ◽  
Sucheta J. Lakhani
Author(s):  
Raveendra D. Totad ◽  
Praveen Ganganahalli

Background: Blood stream infections, ranging from self-limiting bacteraemia to life threatening septicaemia, remain one of the most important cause of morbidity and mortality worldwide. Sepsis is a systemic illness caused by microbial invasion of normally sterile parts of the body. Bacteria isolated from blood stream infections are numerous and diseases related to them need urgent treatment with antimicrobial drugs. Aim was to study the bacteriological profile of positive blood cultures and to find their antibiotic sensitivity patternMethods: A retrospective analysis of positive blood culture reports was done in the microbiology laboratory of present tertiary care teaching hospital (Al-Ameen Medical College, Vijayapura) for the consecutive year 2017, 2018 and 2019.Results: Total 21% samples found positive on blood culture shows Staphylococcus aureus as most common organism followed by Klebseilla and E.Coli antibiotic sensitivity pattern shows maximum sensitive to gentamicin (92%) and vancomycin (92%) as maximum resistance to penicillin (55%). Gram-positive organisms show more resistance to penicillin and least to vancomycin whereas gram-negative organisms show more resistance to cephalosporin group of antibiotics and least resistance to ciprofloxacin/gentamicin.Conclusions: Resistance pattern of organisms to some commonly used drugs has given warning signal to clinicians to search for alternate effective antibiotics and hospital authorities to formulate antibiotic policy for rationale use of antibiotics to prevent drug resistance.


2021 ◽  
Vol 10 (Suppl 1) ◽  
pp. e001335
Author(s):  
Charu Malhotra ◽  
Akshay Kumar ◽  
Ankit Kumar Sahu ◽  
Akshaya Ramaswami ◽  
Sanjeev Bhoi ◽  
...  

IntroductionFailure of early identification of sepsis in the emergency department (ED) leads to significant delays in antibiotic administration which adversely affects patient outcomes.AimThe primary objective of our Quality Improvement (QI) project was to reduce the door-to-antibiotic time (DTAT) by 30% from the preintervention in patients with suspected sepsis. Secondary objectives were to increase the blood culture collection rate by 30% from preintervention, investigate the predictors of improving DTAT and study the effect of these interventions on 24-hour in-hospital mortality.MethodsThis QI project was conducted in the ED of a tertiary care teaching hospital of North India; the ED receives approximately 400 patients per day. Adult patients with suspected sepsis presenting to our ED were included in the study, between January 2019 and December 2020. The study was divided into three phases; preintervention phase (100 patients), intervention phase (100 patients) and postintervention phase (93 patients). DTAT and blood cultures prior to antibiotic administration was recorded for all patients. Blood culture yield and 24-hour in-hospital mortality were also recorded using standard data templates. Change ideas planned by the Sepsis QI Team were implemented after conducting plan-do-study-act cycles.ResultsThe median DTAT reduced from 155 min in preintervention phase to 78 min in postintervention phase. Drawing of blood cultures prior to antibiotic administration improved by 67%. Application of novel screening tool at triage was found to be an independent predictor of reduced DTAT.ConclusionOur QI project identified the existing lacunae in implementation of the sepsis bundle which were dealt with in a stepwise manner. The sepsis screening tool and on-site training improved care of patients with sepsis. A similar approach can be used to deal with complex quality issues in other high-volume low-resource settings.


Sign in / Sign up

Export Citation Format

Share Document