scholarly journals Use of a Method for Contour Analysis of Radiation Images of Malignant Breast Tumors on the Basis of Retrospective Material

2019 ◽  
Vol 100 (5) ◽  
pp. 254-262
Author(s):  
M. K. Mikhailov ◽  
E. A. Romanycheva ◽  
V. V. Sevast’yanov ◽  
Ya. A. Furman
Keyword(s):  
Visual Analysis ◽  
Malignant Tumors ◽  
Clinical Findings ◽  
Contour Analysis ◽  
Old Patients ◽  
X Ray ◽  
Mammographic Images ◽  
Oblique Projections ◽  
Malignant Breast ◽  
Mammographic Examination

Objective. To enhance the reliability of visual analysis of X-ray mammograms, by applying the mathematical models of neoplasms and a method for their processing based on the mathematical apparatus of contour analysis.Material and methods. Two data sets were generated from X-ray mammograms obtained from 38–82 year old patients at routine examinations in the Republican Oncology Dispensary. The first set contained 100 packages of X-ray mammographic images that failed to reveal abnormal malignant changes. The second set was represented by 168 packages of X-ray mammographic images showing morphologically verified breast cancer. All the packages of mammographic images are presented in the standard direct craniocaudal and mediolateral oblique projections. The images were obtained using an analog mammograph. Digital copies of images having a resolution of 600 dpi were obtained for subsequent computer processing. The latter of digital mammographic images involved segmentation of space-occupying lesions, determination of the linearity factor of their outlines, and differential diagnosis of space-occupying lesions based on the calculated value of the linearity factor of their outlines.Results. An algorithm was elaborated for identifying the outlines of space-occupying lesions on X-ray mammographic images. The sequence of complex-valued vectors approximating its curve was used as a mathematical model of the outline. The concept on the outline linearity factor, which quantitatively characterizes its shape, was introduced. A method was developed for the objective classification of malignant and benign space-occupying lesions based on the value of the introduced linearity factor. The outlines of benign space-occupying lesions in the breast were ascertained to be characterized by the higher linearity factor (in the region of 0.3–0.4) (BI-RADS category 2), while the outlines of malignant tumors had a much lower value of this factor (in the order of 0.05–0.1) (BI-RADS categories 4–5). The main quantitative measures (sensitivity, specificity, and accuracy) of the informative value of the proposed method were determined. The latter was shown to have a higher specificity than the traditional visual analysis carried out by a radiologist. This allows the proposed method to be used as an additional procedure in the visual analysis of mammograms to enhance the reliability of clinical findings.Conclusion. The practical value of the method is in quantitatively evaluating the shapes of malignant breast neoplasms, in reducing the performance of a mammographic examination, and in increasing its objectivity. The proposed method makes it possible to reduce the time of analyzing X-ray mammograms and to enhance the reliability of clinical findings.

scholarly journals PERSPECTIVE METHODS FOR CONTOUR ANALYSIS OF RADIOGRAPHIC IMAGES OF MALIGNANTBREAST TUMORS

2018 ◽  
pp. 40-45
Author(s):  
M. K. Mikhailov ◽  
E. A. Romanycheva ◽  
V. V. Sevastyanov ◽  
Ya. A. Furman
Keyword(s):  
Visual Analysis ◽  
Malignant Tumors ◽  
Diagnostic Methods ◽  
Benign Tumors ◽  
Tumor Type ◽  
Contour Analysis ◽  
Radiographic Images ◽  
X Ray ◽  
Relevant Task ◽  
Malignant Breast

X-ray mammography is considered one of the primary diagnostic methods for malignant breast tumors. Since the conclusion is mainly based on the visual analysis of analog or digital X-ray images of the breast, the objectivity of the method is highly dependent on the professional experience of the radiologist. Therefore, the automation of the process of analyzing X-ray mammograms is a relevant task. The present study aims to develop a method for the automatic classification of the types of tumors on x-ray mammograms. To this end, the boundaries of breast tissue densities were described analytically using the mathematical apparatus of contour analysis. It has been found that malignant tumors are characterized by rough contours, which enables the determination of the tumor type by calculating the straightness coefficient of its contour. The straightness coefficient values for malignant and benign tumors have been found. Based on a representative sample from the patients with a previously known diagnosis, consistent classification results have been obtained which is an indication of the feasibility of the proposed method.

scholarly journals Contour analysis of mammographic images in benign and malignant breast diseases

2015 ◽  
Vol 96 (3) ◽  
pp. 322-325 ◽  
Author(s):  
D V Pasynkov ◽  
I V Klyushkin ◽  
O V Busygina
Keyword(s):  
Breast Imaging ◽  
Diagnostic Value ◽  
Breast Diseases ◽  
Contour Analysis ◽  
Focal Lesions ◽  
Mammographic Images ◽  
Estimated Parameters ◽  
Imaging Results ◽  
Significant Difference ◽  
Malignant Breast

Aim. Development and evaluation of the diagnostic value of techniques for quantitative analysis of masses on mammographic images satisfying the requirements of categories 2-4 in BIRADS (Breast Imaging Reporting And Data System - the system for classification and description of breast imaging results of the American College of Radiology).Methods. Images of 375 focal lesions revealed on mammography (211 malignant and 164 benign, all were verified morphologically), satisfying the criteria 2-4 according to BIRADS classification, were analyzed. Mathematical processing was performed using the MammCheck 1.15 software package developed by authors, which uploads the obtained images. Contour, segments of area, peripheral outlines, homogeneity and inner outlines indexes were calculated.Results.The statistical analysis of foci at standard mammography images of BIRADS 2-4 categories revealed no statistically significant difference in all four estimated parameters. When using tomosynthesis images, statistically significant difference was discovered in the outline index in the groups of benign and malignant foci (mean ± standard deviation: 1.73±1.11 vs. 3.11±2.02, respectively, pConclusion. Outline analysis of mammograms, including those obtained using tomosynthesis, does not provide the necessary level of specificity for the differential diagnosis of benign and malignant microcalcifications and clusters.

A Retrieval System for a Library of Pathology Reports, Slides and Kodachromes

1972 ◽  
Vol 11 (03) ◽  
pp. 152-162 ◽  
Author(s):  
P. GAYNON ◽  
R. L. WONG
Keyword(s):  
Medical Records ◽  
Operative Procedure ◽  
Clinical Findings ◽  
Free Text ◽  
X Ray ◽  
Inverted File ◽  
Natural Language Parsing ◽  
On Line ◽  
Pathology Reports ◽  
Frequency Counts

With the objective of providing easier access to pathology specimens, slides and kodachromes with linkage to x-ray and the remainder of the patient’s medical records, an automated natural language parsing routine, based on dictionary look-up, was written for Surgical Pathology document-pairs, each consisting of a Request for Examination (authored by clinicians) and its corresponding report (authored by pathologists). These documents were input to the system in free-text English without manual editing or coding.Two types of indices were prepared. The first was an »inverted« file, available for on-line retrieval, for display of the content of the document-pairs, frequency counts of cases or listing of cases in table format. Retrievable items are patient’s and specimen’s identification data, date of operation, name of clinician and pathologist, etc. The English content of the operative procedure, clinical findings and pathologic diagnoses can be retrieved through logical combination of key words. The second type of index was a catalog. Three catalog files — »operation«, »clinical«, and »pathology« — were prepared by alphabetization of lines formed by the rotation of phrases, headed by keywords. These keywords were automatically selected and standardized by the parsing routine and the phrases were extracted from each sentence of each input document. Over 2,500 document-pairs have been entered and are currently being utilized for purpose of medical education.

HISTOLOGICAL DIAGNOSTICS OF MAMMARY GLAND NEOPLASMS IN CATS

2020 ◽  
Keyword(s):  
Mammary Gland ◽  
Malignant Tumors ◽  
Breast Tumors ◽  
Domestic Animals ◽  
Breast Diseases ◽  
Microscopic Studies ◽  
Malignant Breast ◽  
Poorly Differentiated ◽  
Breast Adenocarcinomas

Mammary gland neoplasms in cats are at the top of the list of the most common nosological diseases among domestic animals; more than half of the tumors appear as malignant. Veterinary practitioners have many questions about the prevalence of breast tumors in cats, depending on age, breed and seasons of the year. The article presents the results of diseases prevalence of benign and malignant breast tumors in cats kept in the conditions of Bishkek. The characteristic of macroscopic and microscopic studies of benign and malignant breast tumors in cats at different periods of life and depending on the breed is also described. Studies were conducted in the period from March 2018 to March 2019. Morphological methods were used in the study of breast tumors. As a result of our research, we established the morphological forms of benign and malignant breast tumors in cats. Among benign neoplastic breast diseases in cats, breast lipoma was observed. Also among the malignant tumors of the breast met highly differentiated, moderately differentiated and poorly differentiated breast adenocarcinomas malnutrition and necrosis as well as the rare phylloid (leaf-shaped) fibroadenoma of the mammary gland which makes up only 0.3-0.5 % of all breast tumors.

Outcomes of full-term infants with bilious vomiting: observational study of a retrieved cohort

2014 ◽  
Vol 100 (1) ◽  
pp. 14-17 ◽  
Author(s):  
Syed Mohinuddin ◽  
Pankaj Sakhuja ◽  
Benjie Bermundo ◽  
Nandiran Ratnavel ◽  
Stephen Kempley ◽  
...  
Keyword(s):  
Posterior Probability ◽  
Abdominal Distension ◽  
Clinical Findings ◽  
Likelihood Ratios ◽  
Term Infants ◽  
X Ray ◽  
Bilious Vomiting ◽  
Term Newborns ◽  
Time Critical ◽  
Surgical Condition

Bilious vomiting in a neonate may be a sign of intestinal obstruction often resulting in transfer requests to surgical centres. The aim of this study was to assess the use of clinical findings at referral in predicting outcomes and to determine how often such patients have a time-critical surgical condition (eg, volvulus, where a delay in treatment is likely to compromise gut viability).Methods4-year data and outcomes of all term newborns aged ≤7 days with bilious vomiting transferred by a regional transfer service were analysed. Specificity, sensitivity, likelihood ratios, correlations, prior and posterior probability of clinical findings in predicting newborns with surgical diagnosis were calculated.ResultsOf 163 neonates with bilious vomiting, 75 (46%) had a surgical diagnosis and 23 (14.1%) had a time-critical surgical condition. The diagnosis of a surgical condition in neonates with bilious vomiting was significantly associated with abdominal distension (χ2=5.17, p=0.023), abdominal tenderness (χ2=5.90, p=0.015) and abnormal abdominal X-ray findings (χ2=5.68, p=0.017) but not with palpation findings of a soft as compared with a tense abdomen (χ2=3.21, p=0.073). Abnormal abdominal X-ray, abdominal distension and tenderness had 97%, 74% and 62% sensitivity, respectively, with regard to association with an underlying surgical diagnosis. Normal abdominal X-ray reduced the posterior probability of surgical diagnosis from 50% to 16%. Overall, clinical findings at referral did not differentiate between infants with or without surgical or time-critical condition.ConclusionsWe recommend that term neonates with bilious vomiting referred for transfer are prioritised as time critical.

Clinical manifestations of aqueductal stenosis in adults

1975 ◽  
Vol 43 (5) ◽  
pp. 546-552 ◽  
Author(s):  
John R. Little ◽  
O. Wayne Houser ◽  
Collin S. MacCarty
Keyword(s):  
Clinical Manifestations ◽  
Aqueductal Stenosis ◽  
Anterior Wall ◽  
Clinical Findings ◽  
Increased Intracranial Pressure ◽  
Shunt Insertion ◽  
Duration Of Symptoms ◽  
Content Type ◽  
X Ray ◽  
Angiographic Findings

✓ The authors review 17 cases of aqueductal stenosis in adults and describe five modes of clinical presentation. The average duration of symptoms was 6 years. Dementia was infrequent. Skull x-ray films frequently demonstrated some degree of cranial enlargement and signs of chronic increased intracranial pressure. Characteristic alterations of the sella included elongation of the anterior wall and flattening, erosion, and anterior displacement of the dorsum. Aqueductal configurations as defined by ventriculography and pneumoencephalography in all cases, and the angiographic findings in seven cases are described. Most of the patients improved substantially after shunt insertion. The clinical findings suggested that aqueductal narrowing and associated hydrocephalus had been present in most of these patients since early life.

The Role of Clinical “Experience” in Diagnostic Performance

1998 ◽  
Vol 18 (2) ◽  
pp. 163-167 ◽  
Author(s):  
Angelo Fasoli ◽  
Silvia Lucchelli ◽  
Renato Fasoli
Keyword(s):  
Pulmonary Embolism ◽  
Multiple Regression ◽  
Clinical Experience ◽  
Diagnostic Performance ◽  
Roc Curves ◽  
Clinical Findings ◽  
X Ray ◽  
Biochemical Studies ◽  
Recorded Data

Twenty-one physicians examined records of 43 patients who had attended the hospital because of chest pain. Of these patients, 20 had had coronary heart disease (CHD), 15 had had nonspecific pain, and eight had had pulmonary embolism. The physicians indicated the probability of CHD in each case on the basis of 18 clinical findings, not including ECG, x-ray, or biochemical studies. The trial was repeated five years later, using the same records, by 16 of the same physicians. Diagnostic accuracy was evaluated by ROC curves, and the weight ascribed to each cue was inferred by multiple regression with estimated probability of CHD as the dependent variable. No significant change of areas under the ROC curves with increasing length of clinical experience was observed. Multiple regression was significant in 30 of 37 analyses. The distributions of most physicians' estimates of probabilities had similar shapes five years apart. It is concluded that “experience” does not have a clear role in diagnostic performance based on recorded data and that personal calibration and preferences in estimating probabilities often persist for years.

Retrospective Review of Clinical and Chest X-Ray Findings in Children Admitted to a Community Hospital for Respiratory Syncytial Virus Infection

2018 ◽  
Vol 57 (14) ◽  
pp. 1686-1692 ◽  
Author(s):  
Denver Niles ◽  
Brett Larsen ◽  
Arvind Balaji ◽  
Dana Delaney ◽  
Elizabeth Campos ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Pediatric Intensive Care ◽  
Clinical Findings ◽  
X Rays ◽  
Radiological Findings ◽  
X Ray ◽  
Severe Group ◽  
Rsv Infection ◽  
Chest X Ray ◽  
Syncytial Virus

Introduction. We performed a retrospective study to evaluate demographics, clinical course, outcome, and radiological findings of children with respiratory syncytial virus (RSV) infection. Methods. Four hundred patients admitted between October 2013 and May 2016 were enrolled. Clinical and radiographic trends were evaluated for association with severity of RSV presentation. Severity was defined as hospitalization >2 days, pediatric intensive care unit admission, or need for mechanical ventilation. Results. Common clinical findings included fever (78.5%), coughing (97%), rhinorrhea/congestion (93%), and hypoxia (44.8%). Hypoxia was seen in 64.7% of the severe group compared with 32.0% in the nonsevere group ( P < .001). Airspace opacification was seen in 49.2% of chest X-rays of the severe group compared with 26.4% in the nonsevere group ( P < .001). Conclusion. Higher incidence of hypoxia or airspace opacification on chest X-ray may be predictors of poorer outcomes for patients with RSV infection.

Comparison of peritumoral stromal tissue stiffness obtained by shear wave elastography between benign and malignant breast lesions

2018 ◽  
Vol 59 (10) ◽  
pp. 1168-1175 ◽  
Author(s):  
Hye Sun Park ◽  
Hee Jung Shin ◽  
Ki Chang Shin ◽  
Joo Hee Cha ◽  
Eun Young Chae ◽  
...  
Keyword(s):  
Shear Wave ◽  
Malignant Tumors ◽  
Shear Wave Elastography ◽  
Breast Cancers ◽  
Tissue Stiffness ◽  
Linear Arrangement ◽  
Luminal B ◽  
Tumor Subtypes ◽  
Stromal Tissue ◽  
Malignant Breast

Background Aggressive breast cancers produce abnormal peritumoral stiff areas, which can differ between benign and malignant lesions and between different subtypes of breast cancer. Purpose To compare the tissue stiffness of the inner tumor, tumor border, and peritumoral stroma (PS) between benign and malignant breast masses by shear wave elastography (SWE). Material and Methods We enrolled 133 consecutive patients who underwent preoperative SWE. Using OsiriX commercial software, we generated multiple 2-mm regions of interest (ROIs) in a linear arrangement on the inner tumor, tumor border, and PS. We obtained the mean elasticity value (Emean) of each ROI, and compared the Emean between benign and malignant tumors. Odds ratios (ORs) for prediction of malignancy were calculated. Subgroup analyses were performed among tumor subtypes. Results There were 85 malignant and 48 benign masses. The Emean of the tumor border and PS were significantly different between benign and malignant masses ( P < 0.05 for all). ORs for malignancy were 1.06, 1.08, 1.05, and 1.04 for stiffness of the tumor border, proximal PS, middle PS, and distal PS, respectively ( P < 0.05 for all). Malignant masses with a stiff rim were significantly larger than malignant masses without a stiff rim, and were more commonly associated with the luminal B and triple negative subtypes. Conclusion Stiffness of the tumor border and PS obtained by SWE were significantly different between benign and malignant masses. Malignant masses with a stiff rim were larger in size and associated with more aggressive pathologic subtypes.

Influence of Surface Relaxation and Multi-Dislocation Strain Field Interactions on X-ray Topographic Images of Dislocations in Semiconductor Materials

1992 ◽  
Vol 262 ◽  
Author(s):  
Jun Wu ◽  
Thomas Fannin ◽  
Michael Dudley ◽  
Vijay Shastry ◽  
Peter Anderson
Keyword(s):  
Local Stress ◽  
Surface Relaxation ◽  
Contour Analysis ◽  
Displacement Fields ◽  
X Ray ◽  
Relaxation Effects ◽  
Slip Bands ◽  
Sensitive Function ◽  
Local Slip ◽  
Surface Intersections

ABSTRACTAnalysis of the white beam synchrotron x-ray topographic contrast behavior of screw dislocations comprising slip bands in silicon, observed under low absorption conditions, is presented. For both individual and groups of dislocations, observed “Direct Image” contrast at the surface intersections of dislocation lines, on reflections for which g·b=0, could be accounted for using equi-misorientation contour analysis using displacement fields which take surface relaxation effects into account. This contrast is shown to be a sensitive function of the local stress environment. In addition, diffuse area contrast observed within and in the vicinity of slip bands on such reflections is also observed to be very sensitive to long range strain fields associated with adjacent slip bands and other defects in the local slip band environment.

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