scholarly journals Molecular imaging modalities using nanoprobes for cancer diagnosis

Author(s):  
Daryoush Shahbazi-Gahrouei ◽  
Pegah Moradi Khaniabadi ◽  
Bita Moradi khaniabadi ◽  
Saghar Shahbazi-Gahrouei ◽  
Mona Fazel

Molecular imaging modalities are used for different type of cancers detection and diagnosis. In recent few years, there has been an increased focus on developing novel nanoparticles as new imaging contrast agents for early detection of cancer. The aim of this review article is to summarize molecular imaging technologies accompanying with using nanoparticles to improve potential imaging for cancer detection and hence valuable therapy in the future. Nanoprobes are rapidly becoming potentially transformative tools on cancer diagnostics for a wide range of imaging modalities such as CT, MRI, SPECT, PET, Ultrasound and Optical imaging. The study results seen in the recent literature are provided and discussed the diagnostic performance of imaging modalities for cancer diagnosis and their future directions. With knowledge of the correlation between the application of nanoparticles and molecular imaging modalities and with the development of targeted contrast agents or nanoprobes, they may provide better cancer diagnosis in the future.

2005 ◽  
Vol 2 (3) ◽  
pp. 133-144 ◽  
Author(s):  
Paul J Cassidy ◽  
George K Radda

Molecular imaging is an emerging technology at the life science/physical science interface which is set to revolutionize our understanding and treatment of disease. The tools of molecular imaging are the imaging modalities and their corresponding contrast agents. These facilitate interaction with a biological target at a molecular level in a number of ways. The diverse nature of molecular imaging requires knowledge from both the life and physical sciences for its successful development and implementation. The aim of this review is to introduce the subject of molecular imaging from both life science and physical science perspectives. However, we will restrict our coverage to the prominent in vivo molecular imaging modalities of magnetic resonance imaging, optical imaging and nuclear imaging. The physical basis of these imaging modalities, the use of contrast agents and the imaging parameters of sensitivity, temporal resolution and spatial resolution are described. Then, the specificity of contrast agents for targeting and sensing molecular events, and some applications of molecular imaging in biology and medicine are given. Finally, the diverse nature of molecular imaging and its reliance on interdisciplinary collaboration is discussed.


2005 ◽  
Author(s):  
Ελένη Γρίβα

Teachers are being seen as the ultimate key to educational change and school management. Proposals made at the macro-level of educational policy depend for the effectiveness on the interpretation by teachers at the micro-level of pedagogic practice and on their abilities to understand and carry out these proposals. Furthermore, there are indications of a strong demand for qualified professionals to staff classrooms well in the future. Thus, it is reasonable to argue that the need for an effective provision to initiate, develop and sustain teachers through an appropriate process of education consequently should be among the highest priorities of educational policy. The motivation for the study stems from: a) the fact that the establishment of English language teaching in Primary Education has raised new teaching needs and teachers are required to respond to a wide range of demands. However, they have not received the adequate pre-service education and in-service training to meet the pedagogical and teaching demands in the Primary Education context, b) the absence of empirical researches dealing with the specific issue in Greece. The present study, which is limited to Greek primary EFL teachers, represents a descriptive research study in its method and is policy-oriented in its purpose. We tried to identify teachers’ INSET needs, to investigate the nature of the discrepancy between the provision of in-service training and the needs and wants of the targets, to pursue the investigation until we came up with an alternative INSET model framework. The objectives were the following: a) to reveal and shed light on the current INSET provision for EFL teachers in Greece, b) to identify the EFL teachers’ and advisors’ viewpoints concerning INSET organizing and planning, c) to identify the future EFL teachers’ INSET needs as perceived by the teachers themselves and the EFL advisors, d) to suggest a framework of a model for INSET based on the target needs of the EFL teachers, the current status of INSET provision for the EFL teachers and the related literature. More precisely, chapters one, two, three, four, five and six aim to provide a theoretical basis for this study, which, together with the field of study results, will help in the formulation of some new plans. The first chapter concentrates on definition of INSET, the purpose and importance of INSET, the effectiveness of INSET. The second and third chapters review the literature related to the theories and practices of INSET in order to highlight characteristics of effective INSET at the level of teacher behaviour change and improvement of teaching skills. The fourth chapter gives background information concerning the teaching of English language in Greek Primary schools. The fifth chapter describes the state teachers INSET in Greece with specific reference to the education and training of teachers of English as a foreign language and their academic profile. It provides a brief analysis of the policy of teacher preparation in order to highlight the strengths and weaknesses of the present system. The sixth chapter sets out models and forms of INSET. It concerns the content of the INSET programmes and it explores - explains the activities and procedures through which the content of INSET can be transmitted. The seventh chapter identifies and states the problem and presents the significance and objectives of the study. It outlines the type of research and the area of investigation, explains and justifies the methods and the instruments (questionnaires and interviews) of data collection and describes and defines the population and sample. It rationalizes the procedures used in collecting the data and explains the techniques used to analyze and interpret the findings of the study. In the eighth chapter, we present the results of the study, which clarify the nature of the discrepancy between the provision of INSET and the needs and wants of the targets. The findings of the study, which point to an absence of any significant difference in the perceptions of the two groups-teachers and advisors-, indicate the need for a new policy and plans to be established, commencing with the recommended ways of assessing teachers’ INSET needs, and extending to evaluation and feedback into the INSET system. In the ninth chapter INSET recommendations for an improved model for EFL teachers are set out in terms of a discussion of findings. The findings of the present study revealed that there was a gap between the current INSET provided by the ministry of Education and the perceived needs. An interim framework of INSET model, called the Participatory-Collaborative INSET model was designed to fill in the gap.


RSC Advances ◽  
2016 ◽  
Vol 6 (29) ◽  
pp. 24104-24110 ◽  
Author(s):  
Wei Lu ◽  
Ning Wang ◽  
YanYan Chu ◽  
Linzhu Zhou ◽  
Maolan Li ◽  
...  

CLIC1 antibody-conjugated nano-scale contrast agents exhibit a fast and sensitive detection of gallbladder tumors and may be used in the future as powerful targeted molecular imaging probes for gallbladder cancer diagnosis.


2009 ◽  
Vol 20 (4) ◽  
pp. 247-259 ◽  
Author(s):  
Marcus R. Makowski ◽  
Andrea J. Wiethoff ◽  
Christian H.P. Jansen ◽  
René M. Botnar

2006 ◽  
Vol 24 (20) ◽  
pp. 3299-3308 ◽  
Author(s):  
Mostafa Atri

Molecular imaging represents tissue-specific imaging and quantification of physiologic (functional) and molecular events in tumors utilizing new noninvasive imaging modalities, radioligands, and contrast agents. It combines anatomic, physiologic, and metabolic information in a single imaging session. Molecular imaging relies on the ability to target genes and proteins that are linked directly or indirectly to human disease. New imaging biomarkers are being developed. In addition, functional and molecular imaging can potentially replace anatomic longitudinal studies by assessing treatment response earlier. Vascular targeting agents can be evaluated by imaging of tumor angiogenesis using magnetic resonance imaging (MRI), computed tomography and ultrasound, and positron emission tomography (PET). Targeted contrast agents can accomplish site-directed imaging or therapy by a variety of active and passive mechanisms. Furthermore, there is the possibility of combining different modalities such as ultrasonic imaging and MRI or MRI and PET to increase the flexibility unachievable with either modality alone. However, there is a need to standardize these techniques so that longitudinal evaluation of tumor response to treatment is feasible.


Nanoscale ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 799-819 ◽  
Author(s):  
Xiangjun Han ◽  
Ke Xu ◽  
Olena Taratula ◽  
Khashayar Farsad

An urgent need for early detection and diagnosis of diseases continuously pushes the advancements of imaging modalities and contrast agents. Nanoparticles as imaging contrast agents demonstrate more advantages and have promise to greatly benefit clinical practice.


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