scholarly journals Spleen, as an Optimal Site for Islet Transplantation

2018 ◽  
Author(s):  
Naoaki Sakata ◽  
Gumpei Yoshimatsu ◽  
Shohta Kodama
Keyword(s):  
Islet Transplantation ◽  
Islet Cells ◽  
Clinical Success ◽  
Splenic Infarction ◽  
Severe Diabetes ◽  
Clinical Islet Transplantation ◽  
Long Time ◽  
Transplantation Site ◽  
Optimal Site ◽  
Selection Of

Islet transplantation is a cellular replacement therapy to treat severe diabetes mellitus, but its clinical outcome is unsatisfactory at present. One factor in clinical success of this therapy is selection of the most appropriate transplantation site. In this review, we review evidence showing the advantages of the spleen as a transplantation site for islets. The spleen has been studied for a long time as a candidate site for islet transplantation. Its advantages include physiological insulin drainage and regulation of immunity. Recently it has also been shown that the spleen contributes to the regeneration of transplanted islets and that splenic stem cells have the potential to differentiate into islet cells. The spleen also has some disadvantages associated with the transplantation procedure itself (bleeding, thrombosis and splenic infarction). The efficacy of transplantation is not as high as that obtained with intraportal transplantation, which is the current representative method of clinical islet transplantation. Safer and more effective methods of islet transplantation need to be established before the spleen can be effectively used in the clinic to support the engraftment of multiple transplanted islets.

scholarly journals Spleen, as an Optimal Site for Islet Transplantation and a Source of Mesenchymal Stem Cells

2018 ◽  
Author(s):  
Naoaki Sakata ◽  
Gumpei Yoshimatsu ◽  
Shohta Kodama
Keyword(s):  
Diabetes Mellitus ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Islet Transplantation ◽  
Clinical Success ◽  
Severe Diabetes ◽  
Clinical Islet Transplantation ◽  
Long Time ◽  
Optimal Site

In this review, we show the unique potential of spleen as an optimal site for islet transplantation and a source of mesenchymal stem cells. Islet transplantation is a cellular replacement therapy to treat severe diabetes mellitus, but its clinical outcome is unsatisfactory at present. One factor in clinical success of this therapy is selection of the most appropriate transplantation site. The spleen has been studied for a long time as a candidate site for islet transplantation. Its advantages include physiological insulin drainage and regulation of immunity. Recently it has also been shown that the spleen contributes to the regeneration of transplanted islets. The efficacy of transplantation is not as high as that obtained with intraportal transplantation, which is the current representative method of clinical islet transplantation. Safer and more effective methods of islet transplantation need to be established before the spleen can be effectively used in the clinic. Spleen also has an interesting aspect as a mesenchymal stem cell reservoir. The splenic mesenchymal stem cells contribute to tissue repair in damaged tissue, and thus, the infusion can be a promising therapy for autoimmune diseases, including type 1 diabetes mellitus and Sjogren’s syndrome.

scholarly journals White Adipose Tissue as a Site for Islet Transplantation

2020 ◽  
Vol 1 (2) ◽  
pp. 55-70
Author(s):  
Naoaki Sakata ◽  
Gumpei Yoshimatsu ◽  
Shohta Kodama
Keyword(s):  
Adipose Tissue ◽  
Islet Transplantation ◽  
White Adipose Tissue ◽  
Severe Diabetes ◽  
Clinical Islet Transplantation ◽  
Translational Studies ◽  
Large Animals ◽  
A Site ◽  
Transplant Site ◽  
Shed Light

Although islet transplantation is recognized as a useful cellular replacement therapy for severe diabetes, surgeons face difficulties in islet engraftment. The transplant site is a pivotal factor that influences the engraftment. Although the liver is the current representative site for clinical islet transplantation, it is not the best site because of limitations in immunity, inflammation, and hypoxia. White adipose tissue, including omentum, is recognized as a useful candidate site for islet transplantation. Its effectiveness has been evaluated in not only various basic and translational studies using small and large animals but also in some recent clinical trials. In this review, we attempt to shed light on the characteristics and usefulness of white adipose tissue as a transplant site for islets.

White Adipose Tissue as a Site for Islet Transplantation

2020 ◽  
Vol 1 (1) ◽  
pp. 55-71
Author(s):  
Naoaki Sakata ◽  
Gumpei Yoshimatsu ◽  
Shohta Kodama
Keyword(s):  
Adipose Tissue ◽  
Islet Transplantation ◽  
White Adipose Tissue ◽  
Severe Diabetes ◽  
Clinical Islet Transplantation ◽  
Translational Studies ◽  
Large Animals ◽  
A Site ◽  
Transplant Site ◽  
Shed Light

Although islet transplantation is recognized as a useful cellular replacement therapy for severe diabetes, surgeons face difficulties in islet engraftment. The transplant site is a pivotal factor that influences the engraftment. Although the liver is the current representative site for clinical islet transplantation, it is not the best site because of limitations in immunity, inflammation, and hypoxia. White adipose tissue, including omentum, is recognized as a useful candidate site for islet transplantation. Its effectiveness has been evaluated in not only various basic and translational studies using small and large animals but also in some recent clinical trials. In this review, we attempt to shed light on the characteristics and usefulness of white adipose tissue as a transplant site for islets.

360-OR: BETA-2 Score Is Highly Correlated with Acute Insulin Response to Intravenous Glucose: An Analysis of the Clinical Islet Transplantation Consortium Trials

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 360-OR
Author(s):  
PETER A. SENIOR ◽  
MICHAEL R. RICKELS ◽  
THOMAS EGGERMAN ◽  
LEVENT BAYMAN ◽  
JULIE QIDWAI ◽  
...  
Keyword(s):  
Islet Transplantation ◽  
Insulin Response ◽  
Acute Insulin Response ◽  
Intravenous Glucose ◽  
Clinical Islet Transplantation ◽  
Beta 2 ◽  
Highly Correlated

SISTEM PENDUKUNG KEPUTUSAN PEMILIHAN KEPALA CABANG TERBAIK BANK SUMUT DENGAN MENERAPKAN METODE VIKOR

2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Betrik J Hutapea ◽  
Mesran Mesran ◽  
Siti Nurhabibah
Keyword(s):  
Decision Support ◽  
Decision Support System ◽  
Support System ◽  
Development Bank ◽  
Vikor Method ◽  
The North ◽  
Long Time ◽  
North Sumatra ◽  
Regional Development Bank ◽  
Selection Of

SUMUT Bank is one of the Banks in Indonesia with the name of the company PT. Regional Development Bank of North Sumatra. The North Sumatra Bank has branches in each region in North Sumatra both in the district and in the sub-district, and each of these branches is led by a branch leader or branch head. The head of this branch is responsible for the reversal of the Bank being led. The best and most accomplished branch heads deserve more and more awards. The selection of the best branch heads is selected transparently and structured in the hope that it can be a motivation for all branch heads to be able to further improve the quality and service of the Bank they lead. Making the best branch head selection done manually will take a long time and tends to be less transparent and structured. One solution so that the implementation of the selection can be carried out easily and quickly, it requires a Decision Support System that can provide consistency of assessment. In this study the method used is the VIKOR method (Visekriterijumsko Kompromisno Rangiranje). This method makes cracking on alternatives based on criteria that have been determined with an ideal compromise solution or the best solution, so that this system can later be beneficial for the SUMUT Bank to get the title in determining the best branch head.Keywords: Decision Support System, North Sumatra Bank, Branch Head, Vikor

scholarly journals Internet page content analysis of north European Sea ports

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Olli-Pekka Hilmola ◽  
Andres Tolli ◽  
Ain Kiisler
Keyword(s):  
Content Analysis ◽  
Environmental Issues ◽  
Basic Design ◽  
Time Period ◽  
Long Time ◽  
Sea Ports ◽  
Selection Of

Abstract This study analyses 98 Internet pages of sea ports located in Sweden, Finland and Estonia during years 2017–2019. Aim of the study is to find, how website basic design is completed (colours and languages), how slogans, environmental issues, statistics and hinterland transports are reported. Based on the analysis, it appears as rather common that sea ports follow conservative selection of colours in their websites, where blue and white are clearly most popular. Typically, English and Swedish are as the most common used language, followed by Finnish, Russian and Estonian. In some rare cases, websites are offered in Chinese or German. Larger sea ports do have clear “slogans”, where smaller ones are just having lengthy justification for their existence. Environmental issues are increasing concern among sea ports, and these are mostly mentioned in details within Swedish actors. Providing statistics varies among companies, and in some sea ports these are provided from very long time period, where in others from just previous years or then only from last year (or even at all). It is common for companies to report that they have sustainable hinterland access, railway available.

Suitability of Natural Geomedia for Radwaste Storage

1982 ◽  
Vol 15 ◽  
Author(s):  
W. S. Fyfe
Keyword(s):  
Rock Properties ◽  
Fracture Flow ◽  
Time Prediction ◽  
Sedimentary Sequences ◽  
Rock Types ◽  
Direct Observations ◽  
Long Time ◽  
Mining Disturbance ◽  
Selection Of

ABSTRACTSelection of the best rock types for radwaste disposal will depend on their having minimal permeability, maximal flow dispersion, minimal chance of forming new wide aperture fractures, maximal ion retention, and minimal thermal and mining disturbance. While no rock is perfect, thinly bedded complex sedimentary sequences may have good properties, either as repository rocks, or as cover to a repository.Long time prediction of such favorable properties of a rock at a given site may be best modelled from studies of in situ rock properties. Fracture flow, dispersion history, and geological stability can be derived from direct observations of rocks themselves, and can provide the parameters needed for convincing demonstration of repository security for appropriate times.

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