scholarly journals The Complicated Body in Motion: Rediscovering the Mechanical Stimulations in Cell Models of Human Disease

2019 ◽  
Author(s):  
Tzyy-Yue Wong ◽  
Yu-Kai Tseng ◽  
Tung-Chen Yeh ◽  
Rong-Chang Jhong ◽  
Yue-Fang Wang ◽  
...  
Keyword(s):  
Mechanical Stimulation ◽  
Intracellular Signaling ◽  
The Body ◽  
Signaling Cascade ◽  
Physical Injury ◽  
Cell Models ◽  
Physical Stimulation ◽  
Intracellular Signaling Cascade ◽  
The Mind

Thought runs through the mind like blood runs through our body to keep us alive. Like the mind, the body does not stay inert and is in constant motion. Not a single cell in our body is left inert unless cell is under stress or dying. These scenarios are reflected upon when a person is sick, the person lies in bed with less movement; however, is active when the person is healthy. The topic of mechanical stimulation has emerged due to the increasing understanding of the physical stimulations we face each day. Further understanding of the mechanically-regulated mechanism can help us explore the pathological events in a disease. Here, we reviewed the role of sensory proteins in pathological events that are observed in cardiomyopathy, cancer, respiratory, renal, obesity, genetics, physical injury and bacterial infection. Taken together, sensory proteins are mechanically-activated which assist reception of external physical stimulation and convert into biochemical to trigger intracellular signaling cascade.

The Pleiotropic Intricacies of Hedgehog Signaling: From Craniofacial Patterning to Carcinogenesis

FACE ◽  
2021 ◽  
pp. 273250162110243
Author(s):  
Mikhail Pakvasa ◽  
Andrew B. Tucker ◽  
Timothy Shen ◽  
Tong-Chuan He ◽  
Russell R. Reid
Keyword(s):  
Intracellular Signaling ◽  
Limb Development ◽  
Hedgehog Signaling ◽  
Target Genes ◽  
Craniofacial Development ◽  
Signaling Cascade ◽  
Signaling Mechanisms ◽  
Intracellular Signaling Cascade ◽  
And Function

Hedgehog signaling was discovered more than 40 years ago in experiments demonstrating that it is a fundamental mediator of limb development. Since that time, it has been shown to be important in development, homeostasis, and disease. The hedgehog pathway proceeds through a pathway highly conserved throughout animals beginning with the extracellular diffusion of hedgehog ligands, proceeding through an intracellular signaling cascade, and ending with the activation of specific target genes. A vast amount of research has been done elucidating hedgehog signaling mechanisms and regulation. This research has found a complex system of genetics and signaling that helps determine how organisms develop and function. This review provides an overview of what is known about hedgehog genetics and signaling, followed by an in-depth discussion of the role of hedgehog signaling in craniofacial development and carcinogenesis.

Hypothetical Role of Growth Factors to Reduce Intervertebral Disc Degeneration Significantly through Trained Biological Transformations

2020 ◽  
Vol 26 ◽  
Author(s):  
Cristian Muresanu ◽  
Siva G. Somasundaram ◽  
Sergey V. Vissarionov ◽  
Liliya V. Gavryushova ◽  
Vladimir N. Nikolenko ◽  
...  
Keyword(s):  
Growth Factors ◽  
Blood Circulation ◽  
Seminal Fluid ◽  
Prostate Gland ◽  
The Body ◽  
Personal Experiences ◽  
Biological Transformation ◽  
The Mind

Background: From the evidence of failed injection-based growth factor therapies, it has been proposed that a naturally triggered uninterrupted blood circulation of the growth factors would be superior. Objective: We seek to stimulate discussions and more research about the possibility of using the already available growth factors found in the prostate gland and endometrium by starting a novel educable physiology, known as biological transformations controlled by the mind. Methods: We summarized the stretch-gated ion channel mechanism of the cell membrane, and offer several practical methods that can be applied by anyone, in order to stimulate and enhance the blood circulation of the growth factors from the seminal fluid to sites throughout the body. This details the practical application of our earlier published studies about biological transformations. Results: A previously reported single-patient case study has been extended, adding more from his personal experiences continually improving this novel physiological training and extending the ideas from our earlier findings in detail. Conclusion: The biological transformation findings demonstrate the need additional research to establish the benefits of these natural therapies to repair and rejuvenate tissues affected by various chronic diseases or aging processes.

scholarly journals Calcium Regulates HCC Proliferation as well as EGFR Recycling/Degradation and Could Be a New Therapeutic Target in HCC

Cancers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1588 ◽  
Author(s):  
Teresa Maria Elisa Modica ◽  
Francesco Dituri ◽  
Serena Mancarella ◽  
Claudio Pisano ◽  
Isabel Fabregat ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Therapeutic Target ◽  
Intracellular Signaling ◽  
Growth Factor Receptor ◽  
The Body ◽  
Biochemical Processes ◽  
Epidermal Growth ◽  
Abundant Element

Calcium is the most abundant element in the human body. Its role is essential in physiological and biochemical processes such as signal transduction from outside to inside the cell between the cells of an organ, as well as the release of neurotransmitters from neurons, muscle contraction, fertilization, bone building, and blood clotting. As a result, intra- and extracellular calcium levels are tightly regulated by the body. The liver is the most specialized organ of the body, as its functions, carried out by hepatocytes, are strongly governed by calcium ions. In this work, we analyze the role of calcium in human hepatoma (HCC) cell lines harboring a wild type form of the Epidermal Growth Factor Receptor (EGFR), particularly its role in proliferation and in EGFR downmodulation. Our results highlight that calcium is involved in the proliferative capability of HCC cells, as its subtraction is responsible for EGFR degradation by proteasome machinery and, as a consequence, for EGFR intracellular signaling downregulation. However, calcium-regulated EGFR signaling is cell line-dependent. In cells responding weakly to the epidermal growth factor (EGF), calcium seems to have an opposite effect on EGFR internalization/degradation mechanisms. These results suggest that besides EGFR, calcium could be a new therapeutic target in HCC.

scholarly journals Curating the Fieldwork Playlist

2019 ◽  
Vol 43 (2) ◽  
pp. 58-66
Author(s):  
Kieran Fenby-Hulse
Keyword(s):  
Digital Technologies ◽  
The Body ◽  
Research Practice ◽  
History Of ◽  
The Mind ◽  
The Relationship ◽  
The Voice

In this essay, I consider the music that has been chosen as part of the previous essays in this collection. I attempt to understand what this assemblage of musical tracks, this anthropology playlist, might tell us about fieldwork as a research practice. The chapter examines this history of the digital playlist before going on to analyse the varied musical contributions from curatorial, musicological, and anthropological perspetives. I argue that the playlist asks us to reflect on the field of anthropology and to consider the role of the voice, the body, the mind with anthropology, as well as the role digital technologies, ethics, and the relationship between indviduals and the community.

scholarly journals Possible regulation of genes associated with intracellular signaling cascade in rat liver regeneration

2009 ◽  
Vol 44 (4) ◽  
pp. 462-470 ◽  
Author(s):  
Cun-Shuan Xu ◽  
Heng-Yi Shao ◽  
Shuai-Shuai Liu ◽  
Bo Qin ◽  
Xiu-Feng Sun ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Rat Liver ◽  
Intracellular Signaling ◽  
Signaling Cascade ◽  
Rat Liver Regeneration ◽  
Intracellular Signaling Cascade

scholarly journals Mental health and politics since the eurozone crisis: The role of mental health professionals

2019 ◽  
Vol 62 ◽  
pp. 28-29 ◽  
Author(s):  
Isabel M. Perera
Keyword(s):  
Mental Health ◽  
Economic Crisis ◽  
Mental Health Professionals ◽  
Health Professionals ◽  
The Body ◽  
Generalized Anxiety ◽  
Eurozone Crisis ◽  
The Mind

Abstract Some of the most immediate health effects of the 2008 economic crisis concerned the mind, not the body. Rates of generalized anxiety, chronic depression, and even suicide spiked in many European societies. This viewpoint highlights the role of mental health professionals in responding to this emergency, and argues that their sustained mobilization is necessary to its long-term resolution.

scholarly journals “One’s Own Body of Pure Channels and Elements”: The Teaching and Practice of Tibetan Yoga at Namdroling

Religions ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 404
Author(s):  
Naomi Worth
Keyword(s):  
South India ◽  
The Body ◽  
Yoga Practice ◽  
Tibetan Buddhist ◽  
Religious Doctrine ◽  
Buddhist Doctrine ◽  
The Mind ◽  
The Buddha ◽  
The Relationship

The Tibetan yoga practice known as “winds, channels, and inner heat” (rtsa rlung gtum mo) is physically challenging, and yet is intentionally designed to transform the mind. This chapter explores the relationship between Buddhist doctrine and this physical practice aimed at enlightenment through the teachings of a contemporary yoga master at Namdroling Tibetan Buddhist Monastery and Nunnery in Bylakuppe, Karnataka, South India. This ethnographic profile exemplifies the role of a modern Tibetan lama who teaches a postural yoga practice and interprets the text and techniques for practitioners. While many modern postural yoga systems are divorced from religious doctrine, Tibetan Buddhist yoga is not. This essay highlights three key areas of Buddhist doctrine support the practice of Sky Dharma (gNam chos) yoga at Namdroling: (1) The history and legacy that accompany the practice, which identify the deity of Tibetan yoga as a wrathful form of Avalokiteśvara, the Buddha of compassion; (2) The role of deity yoga in the practice of Tibetan yoga, where the practitioner arises as the deity during yoga practice, an all-consuming inner contemplation; and (3) The framing of Tibetan yoga within the wider philosophy of karma theory and its relationship to Buddhist cosmology. Practitioners of Tibetan yoga endeavor to burn up karmic seeds that fuel the cycle of rebirth in the six realms of saṃsāra. In Tibetan yoga, the body acts in service of the text, the philosophy, and the mind to increasingly link the logic of texts to experience in meaningful ways.

scholarly journals Public misconceptions about dyslexia: The role of intuitive psychology

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0259019
Author(s):  
Iris Berent ◽  
Melanie Platt
Keyword(s):  
Public Attitudes ◽  
Psychological Disorders ◽  
Scientific Understanding ◽  
The Body ◽  
Causal Role ◽  
Phonological Decoding ◽  
Brain Scan ◽  
People’S Attitudes ◽  
The Mind

Despite advances in its scientific understanding, dyslexia is still associated with rampant public misconceptions. Here, we trace these misconceptions to the interaction between two intuitive psychological principles: Dualism and Essentialism. We hypothesize that people essentialize dyslexia symptoms that they anchor in the body. Experiment 1 shows that, when dyslexia is associated with visual confusions (b/d reversals)—symptoms that are naturally viewed as embodied (in the eyes), laypeople consider dyslexia as more severe, immutable, biological, and heritable, compared to when dyslexia is linked to difficulties with phonological decoding (a symptom seen as less strongly embodied). Experiments 2–3 show that the embodiment of symptoms plays a causal role in promoting essentialist thinking. Experiment 2 shows that, when participants are provided evidence that the symptoms of dyslexia are embodied (i.e., they “show up” in a brain scan), people are more likely to consider dyslexia as heritable compared to when the same symptoms are diagnosed behaviorally (without any explicit evidence for the body). Finally, Experiment 3 shows that reasoning about the severity of dyslexia symptoms can be modulated by manipulating people’s attitudes about the mind/body links, generally. These results show how public attitudes towards psychological disorders arise from the very principles that make the mind tick.

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