scholarly journals Overexpression of p75NTR in Testicular Germ Cell Tumors: a New Biomarker of Cancer Differentiation?

2021 ◽  
Author(s):  
Anna Perri ◽  
Vittoria Rago ◽  
Rocco Malivindi ◽  
Lorenza Maltese ◽  
Danilo Lofaro ◽  
...  
Keyword(s):  
Germ Cell ◽  
Human Cancer ◽  
Germ Cell Tumors ◽  
Receptor Protein ◽  
Specific Marker ◽  
Nuclear Staining ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Cancer Types

Several studies have demonstrated that the p75NTR low-affinity receptor of Nerve Growth Factor (NGF), is produced in abnormally large amounts in several human cancer types. However, the role of p75NTR varies substantially depending on cell context, so that a dual role of this receptor protein in tumor cell survival and invasion, as well as cell death, has been supported in recent studies. Herein we explored for the first time the expression of p75NTR in human specimens (nr=40) from testicular germ cell tumors (TGCTs), mostly seminomas. Nuclear overexpression of p75NTR was detected by immunohistochemistry in tumor tissue as compared to normal tissue, whereas neither NGF nor its high-affinity TrkA receptor was detected. An increased nuclear staining of phospho-JNK, belonging to the p75NTR signaling pathway, and its pro-apoptotic target gene, p53, was concomitantly observed. Interestingly, our analysis revealed that decreased expression frequency of p75NTR, p-JNK, and p53 was related to staging progression, thus suggesting that p75NTR may represent a specific marker of differentiation in TGCTs.

scholarly journals Overexpression of p75NTR in Human Seminoma: A New Biomarker?

Life ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 629
Author(s):  
Anna Perri ◽  
Vittoria Rago ◽  
Rocco Malivindi ◽  
Lorenza Maltese ◽  
Danilo Lofaro ◽  
...  
Keyword(s):  
Human Cancer ◽  
Germ Cell Tumors ◽  
Receptor Protein ◽  
Specific Marker ◽  
Nuclear Staining ◽  
Trka Receptor ◽  
Testicular Germ Cell ◽  
Cancer Types ◽  
First Time

Several studies have demonstrated that the p75NTR low-affinity receptor of Nerve Growth Factor (NGF), is produced in abnormally large amounts in several human cancer types. However, the role of p75NTR varies substantially depending on cell context, so that a dual role of this receptor protein in tumor cell survival and invasion, as well as cell death, has been supported in recent studies. Herein we explored for the first time the expression of p75NTR in human specimens (nr = 40) from testicular germ cell tumors (TGCTs), mostly seminomas. Nuclear overexpression of p75NTR was detected by immunohistochemistry in seminoma tissue as compared to normal tissue, whereas neither NGF nor its high-affinity TrkA receptor was detected. An increased nuclear staining of phospho-JNK, belonging to the p75NTR signaling pathway and its pro-apoptotic target gene, p53, was concomitantly observed. Interestingly, our analysis revealed that decreased expression frequency of p75NTR, p-JNK and p53 was related to staging progression, thus suggesting that p75NTR may represent a specific marker for seminoma and staging in TGCTs.

scholarly journals The Role of the Mouse Y Chromosome on Susceptibility to Testicular Germ Cell Tumors

2009 ◽  
Vol 69 (8) ◽  
pp. 3614-3618 ◽  
Author(s):  
Philip D. Anderson ◽  
Man-Yee Lam ◽  
Christophe Poirier ◽  
Colin E. Bishop ◽  
Joseph H. Nadeau
Keyword(s):  
Germ Cell ◽  
Y Chromosome ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell

scholarly journals Role of microRNAs in mammalian spermatogenesis and testicular germ cell tumors

Reproduction ◽  
2015 ◽  
Vol 149 (3) ◽  
pp. R127-R137 ◽  
Author(s):  
Li Wang ◽  
Chen Xu
Keyword(s):  
Germ Cell ◽  
Expression Profiles ◽  
Regulation Of Gene Expression ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Mirna Regulation ◽  
Testicular Germ Cell ◽  
Complex Process ◽  
Regulatory Functions

microRNAs (miRNAs) are a class of small endogenous RNAs, 19–25 nucleotides in size, which play a role in the regulation of gene expression at transcriptional and post-transcriptional levels. Spermatogenesis is a complex process through which spermatogonial stem cells (SSCs) proliferate and differentiate into mature spermatozoa. A large number of miRNAs are abundantly expressed in spermatogenic cells. Growing evidence supports the essential role of miRNA regulation in normal spermatogenesis and male fertility and cumulative research has shown that this form of regulation contributes to the etiology of testicular germ cell tumors (TGCTs). In this review, we addressed recent advancements of miRNA expression profiles in testis and focused on the regulatory functions of miRNA in the process of SSC renewal, spermatogonial mitosis, spermatocyte meiosis, spermiogenesis, and the occurrence of TGCTs.

The Role of Alkaline Phosphatase Isoenzymes as Tumor Markers for Testicular Germ Cell Tumors

1991 ◽  
Vol 146 (1) ◽  
pp. 57-60 ◽  
Author(s):  
K. Koshida ◽  
A. Nishino ◽  
H. Yamamoto ◽  
T. Uchibayashi ◽  
K. Naito ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Germ Cell ◽  
Tumor Markers ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Alkaline Phosphatase Isoenzymes

scholarly journals The role of microenvironment in testicular germ cell tumors

2010 ◽  
Vol 10 (6) ◽  
pp. 529-536 ◽  
Author(s):  
Alejandro Díez-Torre ◽  
Unai Silván ◽  
María Díaz-Núñez ◽  
Juan Arechaga
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell

scholarly journals Critical role of CCDC6 in the neoplastic growth of testicular germ cell tumors

BMC Cancer ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Stefania Staibano ◽  
Gennaro Ilardi ◽  
Vincenza Leone ◽  
Chiara Luise ◽  
Francesco Merolla ◽  
...  
Keyword(s):  
Germ Cell ◽  
Critical Role ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Neoplastic Growth

scholarly journals Testicular germ cell tumors: the changing role of the pathologist

2019 ◽  
Vol 7 (S6) ◽  
pp. S204-S204 ◽  
Author(s):  
Andrea Ronchi ◽  
Francesca Pagliuca ◽  
Renato Franco
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Changing Role

Testicular Cancer

2017 ◽  
Author(s):  
Katherine A. McGlynn ◽  
Ewa Rajpert-De Meyts ◽  
Andreas Stang
Keyword(s):  
Testicular Cancer ◽  
Germ Cell ◽  
Germ Cell Tumors ◽  
Developed Countries ◽  
Mortality Rates ◽  
Incidence Rates ◽  
European Ancestry ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Cancer Types

Testicular cancer is a rare cancer in the general population, but is the most common neoplasm among young men in many countries. It has one of the highest heritabilities of all cancer types. The vast majority of testicular cancers are germ cell tumors; thus the terms “testicular cancer” and “testicular germ cell tumors” (TGCTs) are often used interchangeably. Globally, the incidence of testicular cancer is highest among men of European ancestry and lowest among men of African and Asian ancestries. Incidence rates have been increasing in many countries since at least the mid-twentieth century. Mortality rates, however, have sharply declined in developed countries. While the reason for the decline in mortality rates is well known, reasons for the increase in incidence remain poorly understood. Accumulating evidence supports the hypothesis that most TGCTs are linked to disturbed development of the testes, beginning in utero, but fostered by postnatal events.

scholarly journals The decisive role of molecular pathology in presumed somatic metastases of type II testicular germ cell tumors: report of 2 cases

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Mariëtte E. G. Kranendonk ◽  
Wenzel M. Hackeng ◽  
G. Johan A. Offerhaus ◽  
Folkert H. M. Morsink ◽  
Geertruida N. Jonges ◽  
...  
Keyword(s):  
Germ Cell ◽  
Molecular Pathology ◽  
Germ Cell Tumors ◽  
Decisive Role ◽  
Type Ii ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell
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