scholarly journals Use of Phentolamine Mesylate in Implant Surgery. Analysis of Adverse Effects and Haemodynamic Changes

2021 ◽  
Author(s):  
Clara Vintanel-Moreno ◽  
José María Martínez-González ◽  
Natalia Martínez-Rodríguez ◽  
Cristina Meniz-García ◽  
Isabel Leco-Berrocal
Keyword(s):  
Adverse Effects ◽  
Dental Treatment ◽  
Control Group ◽  
Reversal Agent ◽  
Implant Surgery ◽  
Randomised Study ◽  
Haemodynamic Changes ◽  
Conservative Dentistry ◽  
Implant Treatment

The clinical application of Phentolamine Mesylate (PM) as an anaesthetic reversal agent has been documented in paediatric patients and in conservative dentistry, but no studies have been found in implant surgery. A prospective randomised study was conducted in 60 patients eligible for mandibular implant treatment, randomly divided between the Control Group (CG) and Experimental Group (EG), who were administered PM. Haemodynamic changes, adverse effects and patient satisfaction were assessed. No statistically significant differences in haemodynamic changes and postoperative pain were found between CG and EG (p<0.05), except for Systolic Blood Pressure (SBP) which increased slightly in EG, without posing a risk to the patient. There were no differences in the presence of adverse effects between the two groups, except in the CG which presented greater difficulty in chewing and biting (p<0.05) and the EG with greater pain in the injection area (p=0.043). 83.3% of the EG patients would request PM again for future dental treatment. The use of PM offers an alternative in implant surgery, without increasing the risks and increasing the patient's quality of life.

scholarly journals Use of Phentolamine Mesylate in Implant Surgery: Analysis of Adverse Effects and Haemodynamic Changes

2021 ◽  
Vol 10 (17) ◽  
pp. 3875
Author(s):  
Clara Vintanel-Moreno ◽  
José María Martínez-González ◽  
Natalia Martínez-Rodríguez ◽  
Cristina Meniz-García ◽  
Isabel Leco-Berrocal
Keyword(s):  
Adverse Effects ◽  
Dental Treatment ◽  
Paediatric Population ◽  
Control Group ◽  
Reversal Agent ◽  
Implant Surgery ◽  
Randomised Study ◽  
Haemodynamic Changes ◽  
Conservative Dentistry ◽  
Dental Implant Surgery

The clinical application of phentolamine mesylate (PM) as an anaesthetic reversal agent has been documented in the paediatric population and in conservative dentistry, but no studies have been conducted regarding dental implant surgery. A prospective randomised study was conducted on 60 patients eligible for mandibular implant treatment, randomly divided between a control group (CG) and an experimental group (EG), to whom PM was administered. Haemodynamic changes, adverse effects and patient satisfaction were assessed. No statistically significant differences in haemodynamic changes and postoperative pain were found between CG and EG (p < 0.05), except for systolic blood pressure (SBP), which increased slightly in EG, without posing a risk to patients. There were no differences in the occurrence of adverse effects between the two groups, except for greater difficulty in chewing and biting (p < 0.05) in CG and greater pain in the injection area (p = 0.043) in EG. Among EG patients, 83.3% reported that they would request PM again for future dental treatment. The use of PM offers an alternative to implant surgery, thereby increasing patients’ quality of life without increasing the risks.

scholarly journals Psychological characteristics of patients with missing teeth at initial contact and after orthopedic treatment

2014 ◽  
Vol 95 (1) ◽  
pp. 128-130
Author(s):  
V Yu Kruchinin
Keyword(s):  
Dental Treatment ◽  
Psychological Characteristics ◽  
Control Group ◽  
Initial Contact ◽  
Missing Teeth ◽  
Orthopedic Treatment ◽  
Dental Procedures ◽  
Psychoemotional State ◽  
Dental Diseases

Aim. To study the influence of dental diseases and results of their treatment on patient’s psychological profile. Methods. 40 patients with hard teeth tissues and dentition defects at the esthetic zone aged from 30 to 57 years were included in the study. Control group consisted of 25 people not requiring dental treatment. A new method of determining patient’s psychological subtype, offered by A. Anuashvili and based on computer analysis of the patient’s photographs, allowing totally avoid the subjectivity of a diagnosis. Results. Analysis of emotional stress level in patients before the dental procedures showed that it was significantly higher in males compared to females (73.6±0.86 vs 57.9±0.93% respectively, р 0,01). It was also found that 60% of all patients had unstable aspects of psychological subtype regardless of gender. In the control group, only minor changes of psychoemotional state between two examinations were registered, allowing to conclude that psychoemotional state without strong stimuli is quite stable. The use of the video-computed psychoanalysis method can help a dentist to assess the patient’s psychoemotional status when patient is seeking for dental aid, and to communicate better considering the patient’s psychological subtype, as well as to control psychoemotional state during and after the treatment. Conclusion. Missing teeth not only impair chewing, but also deteriorate patient’s psychoemotional state, leading to worse quality of life.

scholarly journals OPTIMIZATION OF METHOD OF MANUFACTURING OVERLAPING DENTURES SUPPORTED BY TEETH AND DENTAL IMPLANTS

2020 ◽  
Vol 16 (1) ◽  
pp. 157-162
Author(s):  
Valentina Tlustenko ◽  
Ivan Bayrikov ◽  
Mukatdes Sadykov ◽  
Sergey Komlev ◽  
Irina Bazhutova ◽  
...  
Keyword(s):  
Dental Implants ◽  
Dental Treatment ◽  
Control Group ◽  
Advanced Manufacturing ◽  
Orthopedic Treatment ◽  
Advanced Technologies ◽  
Functional Efficiency ◽  
Abutment Teeth

Subject. Currently, there are many methods for restoring the crown of the tooth using various stump pin designs, but they are not always effective when prosthetics are removable dentures. Therefore, overlapping prostheses using locking elements and dental implants are becoming increasingly popular in the clinic of orthopedic dentistry. Locking fasteners can reduce pressure on the mucous membrane, increase functional efficiency by transferring pressure to the abutment teeth, which positively affects the stabilization and retention of orthopedic structures. The goal is to improve the quality of orthopedic treatment of partial absence of teeth with the help of overlapping prostheses based on spherical attachments, dental and collapsible dental implants. Methodology. Orthopedic treatment was performed for 27 patients (12 men and 15 women) aged 59 to 74 years, who were divided into two groups: control (10 people) and main (17 people). For patients of the control group, dental treatment was carried out using partial removable laminar prostheses using generally accepted technologies, the main one using advanced technologies for the manufacture of removable dentures and collapsible dental implants. Results. The use of removable orthopedic constructions based on teeth and dental implants using an advanced manufacturing technology (RF Patents No. 2593349, 2708828, 2588488 for an invention) made it possible to carry out dental treatment of patients with partial absence of teeth. An assessment of the quality of hygiene of removable dentures. Conclusions. The effectiveness of prosthetics depends on the rational choice of the orthopedic design and the use of dental implants, as well as the correct assessment of the periodontal condition of the abutment teeth and the determination of contraindications for the manufacture of cast stump pin inlays with spherical locks.

Influence of osteopatic correction on the quality of life of patients with removable dental prosthesis

2018 ◽  
pp. 14-18
Author(s):  
I. G. Yushmanov ◽  
M. N. Kalimullin ◽  
I. T. Zaripov ◽  
M. V. Zlatkovskaya
Keyword(s):  
Quality Of Life ◽  
Dental Treatment ◽  
Dental Prosthesis ◽  
Control Group ◽  
Life Questionnaire ◽  
Orthopedic Treatment ◽  
Removable Dental Prosthesis ◽  
Osteopathic Treatment ◽  
Group Control Group

Introduction. The use of removable dental prosthesis often leads to the alteration of the function of the temporomandibular joint, which signifi cantly reduces patients' quality of life. Osteopathic correction can be considered as a method aimed to improve patients' quality of life after prosthetics.Goal of research - to study the effect of osteopathic correction on the quality of life of patients with removable prosthesis.Materials and methods. Two groups of patients took part in the study: The fi rst group consisted of 15 patients who underwent both orthopedic and osteopathic treatment. The second group (control group) received only removable dental prosthetics. Evaluation of the patients' quality of life was performed before the beginning of orthopedic treatment and after 3 months. Special quality of life questionnaire «Oral Health Impacts Profi le» (OHIP-14) was used.Results. As a result of combined osteopathic and dental treatment, the number and the severity of regional dysfunctions reduced, whereas the quality of life of patients signifi cantly improved.Conclusion. Osteopathic correction can be recommended as a method improving the quality of life of patients with removable dental prosthesis.

Does screening for adverse effects improve health outcomes in epilepsy?

Neurology ◽  
2020 ◽  
Vol 95 (3) ◽  
pp. e239-e246 ◽  
Author(s):  
Valentina Franco ◽  
Maria Paola Canevini ◽  
Giovambattista De Sarro ◽  
Cinzia Fattore ◽  
Guido Fedele ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Adverse Effects ◽  
Intervention Group ◽  
Final Visit ◽  
Control Group ◽  
Systematic Screening ◽  
Related Quality ◽  
High Adverse Event ◽  
Health Related

ObjectiveTo determine whether systematic screening for adverse effects of antiepileptic drugs (AEDs) reduces toxicity burden and improves health-related quality of life in patients with epilepsy.MethodsConsecutive patients with uncontrolled seizures aged ≥16 years and a high Adverse Event Profile (AEP) score were randomized to 2 groups and followed up for 18 months at 11 referral centers. AEP scores were made available to treating physicians at all visits in the intervention group, but not in the control group. Co–primary endpoints were changes in AEP scores and Quality of Life Inventory for Epilepsy-31 (QOLIE–31) scores.ResultsOf 809 enrolled patients able to complete the AEP questionnaire, 222 had AEP scores ≥45 and were randomized to the intervention (n = 111) or control group (n = 111). A total of 206 patients completed the 18-month follow-up. Compared with baseline, AEP scores decreased on average by 7.2% at 6 months, 12.1% at 12 months, and 13.8% at 18 months in the intervention group (p < 0.0001), and by 7.7% at 6 months, 9.2% at 12 months, and 12.0% at 18 months in controls (p < 0.0001). QOLIE-31 scores also improved from baseline to final visit, with a mean 20.7% increase in the intervention group and a mean 24.9% increase in the control group (p < 0.0001). However, there were no statistically significant differences in outcomes between groups for the 2 co–primary variables.ConclusionsContrary to findings from a previous study, systematic screening for adverse effects of AEDs using AEP scores did not lead to a reduced burden of toxicity over usual physician treatment.Italian Medicines Agency (AIFA) identifierFARM52K2WM_003.Clinicaltrials.gov identifierNCT03939507 (registered retrospectively in 2019; the study was conducted during the 2006–2009 period and registration of clinical trials was not a widely established practice when this study was initiated).Classification of evidenceThis study provides Class II evidence that the additional collection of formal questionnaires regarding adverse effects of AEDs does not reduce toxicity burden over usual physician treatment.

Multiple sclerosis and brief moderate exercise. A randomised study

2007 ◽  
Vol 13 (6) ◽  
pp. 776-782 ◽  
Author(s):  
O.H. Bjarnadottir ◽  
A.D. Konradsdottir ◽  
K. Reynisdottir ◽  
E. Olafsson
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Physical Fitness ◽  
Anaerobic Threshold ◽  
Peak Oxygen Consumption ◽  
Control Group ◽  
Randomised Study ◽  
Degree Of Disability ◽  
The Mean

This is a randomised control study, to determine the effect of aerobic and strength exercise on physical fitness and quality of life in patients with mild multiple sclerosis (MS). Sixteen outpatients with definitive MS, aged 18-50, with an Expanded Disability Status Scale (EDSS) <4, completed the study. Every patient was evaluated according to physical fitness with peak oxygen consumption (V'O2peak ), workload and anaerobic threshold; quality of life (SF-36); and degree of disability (EDSS). The patients were then randomised to an exercise group (EG) (n =6) or a control group (CG) (n = 10). The EG exercised three times a week for five weeks, and the CG did not change their habits regarding exercise. In the EG, the mean change in workload was 0.34 W/kg (95% confidence interval (CI): 0.09-0.58), the mean change in V'O2peak was 4.54 mL/kg per minute (95% CI: 1.65-7.44), and the mean change in anaerobic threshold was 0.32 L/min (95% CI: 0.08-0.57). There was a tendency towards improved quality of life, and no change was detected in the degree of disability. This study confirms that brief, moderate, aerobic exercise improves physical fitness in individuals with mild MS. No evidence was found for worsening of MS symptoms in association with exercises. Multiple Sclerosis 2007; 13: 776-782. http://msj.sagepub.com

scholarly journals Dental Treatment on Cephalea from Orofacial Origin

PRILOZI ◽  
2019 ◽  
Vol 40 (3) ◽  
pp. 109-115
Author(s):  
Genc Demjaha ◽  
Biljana Kapushevska ◽  
Ajla Çesko Zymber ◽  
Budima Pejkovska Shahpaska
Keyword(s):  
Dental Treatment ◽  
Pathological Condition ◽  
Control Group ◽  
Prosthetic Devices ◽  
Therapeutic Modalities ◽  
Stabilization Splint ◽  
New Methods ◽  
Study Results ◽  
Dental Origin

Abstract Introduction: Cephalea from orofacial origin is a diffuse, mild to moderate pain that appears as a bandage around the head. There are many different etiological causes of dental origin that contribute to the appearance of cephalea. Purpose: The purpose of our research is dental treatment of patients with traumatic occlusion, bruxism and loss of occlusal support, which have a pathological condition - cephalea from orofacial origin. Material and methods:For the purposes of this paper, 15 patients with cephalea from orofacial origin were analysed, diagnosed and treated. The control group consisted of 15 patients without etiological factors. A butterfly deprogrammer and a stabilization splint were made depending on the indication. Results and discussion: According to our patient study results, it appears to be a link between inadequately made prosthetic devices, bruxism and loss of occlusal support with cephalea. The therapy should help the patient urgently and continue to relieve the cephalea symptoms from orofacial origin. The results show an improvement in 86.7% of the examinees. Conclusion: The butterfly deprogrammer and stabilization splint are new methods that can contribute along with other therapeutic modalities in improving the quality of life in a patient with cephalea from orofacial origin.

scholarly journals ONE-PIECE DENTAL IMPLANT UNTUK REHABILITASI RUANG KANINUS YANG SEMPIT

2017 ◽  
Vol 4 (1) ◽  
pp. 61
Author(s):  
Fredy Mardiyantoro ◽  
Ariyati Retno Pratiwi
Keyword(s):  
Dental Implant ◽  
Tooth Loss ◽  
Dental Treatment ◽  
Implant Therapy ◽  
Successful Rehabilitation ◽  
Narrow Space ◽  
Space Case ◽  
Root Planning ◽  
Implant Treatment

Background: Tooth loss has serious functional, esthetic disabilities, and compromising the patients’ quality of life. Dental implant treatment has become increasingly common for the management tooth loss. Different clinical situations, such as narrow edentulous space, are often encountered in which modifications have to be considered in order to achieve successful rehabilitation. One piece dental implan provided a solution for rehabilitation of narrow edentulous space. The purpose of this paper is to report a rehabilitation management of narrow edentulous space. Case Management: A 22-year-old woman had an upper right canine #13 malposition so there was a narrow space between upper right lateral insisiv #12 and upper right first premolar #14. The spacing between upper right lateral insisivus #12 and upper right first premolar #14 was found to be about 5 mm. Radiograph was assessed for type of bone and for the presence of any pathology. A patient given an initial dental treatment such as scalling root planning and extraction of caninus #13. Following the clinical evaluation, the procedure and complication of implant therapy were explained and consent taken for proposed treatment. One piece dental implant site was anesthetized. Flaps on the buccal aspect were raised. One Piece dental implant inserted using dental implant kit. On completion of treatment, the patient’s esthetics and funcions improved. Conclusion: This study observed that one piece dental implants are suitable for rehabilitation of narrow edentulous space

scholarly journals The Outcome of Hydroxychloroquine in Patients Treated for COVID-19: Systematic Review and Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-16
Author(s):  
Teshale Ayele Mega ◽  
Temesgen Mulugeta Feyissa ◽  
Dula Dessalegn Bosho ◽  
Kabaye Kumela Goro ◽  
Getandale Zeleke Negera
Keyword(s):  
Systematic Review ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Adverse Effects ◽  
Disease Progression ◽  
Meta Analysis ◽  
Control Group ◽  
Qtc Prolongation ◽  
Absolute Increase

Background. The pandemic of coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in an unprecedented public health challenge worldwide. Despite urgent and extensive global efforts, the existing evidence is inconclusive regarding the medications used for the treatment of COVID-19. Purpose. To generate an up-to-date evidence for the clinical safety and efficacy of hydroxychloroquine (HCQ) with or without azithromycin (AZ) among patients treated for COVID-19. Data Source. PubMed, Cochrane CENTRAL, LITCOVID, Web of Science, SCOPUS, BioRxiv, Embase, MedRxiv, and Wiley online library were searched from 2019/12/30 to 2020/05/23. Study Selection. Three investigators assessed the quality of the studies. Data Extraction. Data about study characteristics, effect estimates, and the quality of the studies were extracted by two independent reviewers and cross-checked by the third reviewer. Data Synthesis. The data of 6,782 (HCQ group, 3623; HCQ + AZ group, 1,020; control group, 2139) participants were included. HCQ was compared with standard care for virologic efficacy, disease progression, mortality, and adverse effects. HCQ was also compared with HCQ + AZ for QTc prolongation, admission to the intensive care unit, and mortality. The study found HCQ did not alter the rate of virologic cure (OR = 0.78; 95% CI: 0.39–1.56) and the risk of mortality (OR = 1.26; 95% CI: 0.66–2.39). The pooled prevalence for mortality was 5.8% (95% CI: 0.9%–10.8%). Moreover, HCQ did not impact disease progression (OR = 0.9; 95% CI: 0.36–2.29) but resulted in a higher risk of adverse effects (OR = 2.35; 95% CI: 1.15–4.8). HCQ was also compared against HCQ + AZ, and no difference was observed in QTc prolongation above 500 ms (OR = 1.11; 95% CI: 0.54–2.28), admission to the intensive care unit (OR = 0.92; 95% CI: 0.52–1.63), and mortality (OR = 0.88; 95% CI: 0.55–1.43). However, in the analysis of single-arm studies, about 11.2% (95% CI: 7.0%–15.5%) of patients have developed an absolute increase of QTc greater than 500 ms, and 4.1% (95% CI: 1.1%–7.1%) of patients discontinued their medication. Conclusion. This meta-analysis and systematic review, which included a limited number of poorly designed studies of patients with COVID-19, revealed HCQ is intolerable, unsafe, and not efficacious. Similarly, HCQ + AZ combination was not different from HCQ alone in curbing mortality and ICU admission.

scholarly journals Effects of ketamine hydrochloride (preservative free) and fentanyl citrate added to low dose hyperbaric bupivacaine for sub-arachnoid block in lower uterine caesarian section – a comperative study

2014 ◽  
Vol 24 (2) ◽  
pp. 53-59
Author(s):  
SM Rafiqul Islam ◽  
Hasina Begum ◽  
Md Mustafa Kamal ◽  
Md Shah Alam Bhuiyan ◽  
UH Shahera Khatun
Keyword(s):  
Low Dose ◽  
Sensory Block ◽  
Caesarian Section ◽  
Control Group ◽  
Base Line ◽  
Hyperbaric Bupivacaine ◽  
Significant Difference ◽  
Ketamine Hydrochloride ◽  
Haemodynamic Changes

Background Caesarian section is one of the most common operations Now a days for delivery of baby sub-arachnoid block is the better choice. World wide Commonly used bupivacaine with fentanile. Objective The present study was designed to observe the effects of intrathecal ketamine hydrochloride with bupivacaine+complne bupivacaine with fentanyl to observe quality of block eioth duration block during caesarian section. Methods Ninety ASA 1 parturients scheduled for elective caesarian section were randomly selected. There are thirty patients in each group. The base line haemodynamic parameters, heart rate, blood pressure respiratory rate SpO2 and indication of operation were recorded The control group BN (n = 30) received 1.75 ml of 0.5% hyperbaric bupivacaine plus 0.5 ml normal saline intrathecally. While the study group, fentanyl group BF (n = 30) received 1.75 ml of 0.5% hyperbaric bupivacaine plus 0.5 ml (25 mg) injection fentanyl, BK received 1.75 ml of 0.75% hyperbaric bupivacaine plus 0.5 ml (25 mg) of ketamine hydrochloride. Results Duration and quality of sensory and motor block, post-operative analgesia, haemodynamic changes and sedation levels were assessed. There was no significant difference in duration of motor blockade in three groups. Quality of analgesia, sensory block was significant (P<0.05) in BK and BF group than BN group. The quality of block was excellent throughout the surgical procedure in 80% BK group 60% in BF group and 53.3% in control (BN) group. Incidence of hypotension was less in group BF (26.6%) and BK (20%) than group BN (40%). Ketamine had an upper level of sensory block than fentanyl. Conclusion Injection ketamine 25 mg can be used as an adjunct to low dose spinal bupivacaine during caesarian. DOI: http://dx.doi.org/10.3329/jbsa.v24i2.19802 Journal of Bangladesh Society of Anaesthesiologists 2011; 24(2): 53-59

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