scholarly journals Generation of Biocompatible Titanium Alloy Surfaces Including Calcium and Phosphorus Elements by Laser-Induced Mist Spraying Wet Treatment

2020 ◽  
Vol 14 (4) ◽  
pp. 575-581
Author(s):  
Atsushi Ezura ◽  
Kazutoshi Katahira ◽  
Jun Komotori ◽  
◽  
◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Laser Irradiation ◽  
Hard Tissue ◽  
Complicated Shape ◽  
Osteoblast Cells ◽  
Cell Compatibility ◽  
P Elements ◽  
Test Pieces ◽  
Modified Surface ◽  
Contact Part

Titanium alloys are widely used for the hard tissue substitute implants. However, it is necessary to improve interfacial biocompatibility to reduce adhesion period. For improvement of biocompatibility of Ti-6Al-4V ELI alloys, texture and chemical composition on contact part with biological tissue play very important roles. In this research, micro texture was generated on the Ti-6Al-4V ELI alloy surfaces utilizing laser irradiation, in order to improve biocompatibility. The biocompatibility was evaluated by osteoblast cell culture assays. The results indicated the surface having micro texture improve biocompatibility as compared with untreated surface. This was considered in order the fact that the formed modified surface had hydrophilicity, thereby improving the cell compatibility, and the cell adhesion due to the complicated shape. In addition, mist of glycerophosphoric acid calcium aqueous solution was applied on the laser irradiated area. As result, micro texture including Ca and P elements was generated on the Ti-6Al-4V ELI alloy surfaces. When laser was irradiated, glycerophosphoric acid calcium aqueous solution was applied as mist flowed on the test pieces as droplet. The velocity of droplet fluid was relatively fast, so that laser irradiation was unhindered access to the surface of test pieces and the treatment was stable. In order to estimate biocompatibility, culture assays using osteoblast cells were conducted on the treated surface having micro texture including Ca and P elements. As results, it was clearly that biocompatibility of the specimen treated by laser with glycerophosphoric acid calcium aqueous solution mist more improved than either untreated specimen or treated specimen soaked in glycerophosphoric acid calcium aqueous solution.

Generation of Micro Texture Including Calcium and Phosphorus Elements on Titanium Alloy for Improvement of Biocompatibility With Laser Induced Mist Surface Treatment

2020 ◽  
Author(s):  
Atsushi Ezura ◽  
Kazutoshi Katahira ◽  
Jun Komotori
Keyword(s):  
Aqueous Solution ◽  
Titanium Alloy ◽  
Titanium Alloys ◽  
P Element ◽  
Hard Tissue ◽  
Osteoblast Cells ◽  
P Elements ◽  
Test Pieces ◽  
Calcium And Phosphorus ◽  
Contact Part

Abstract Titanium alloys are widely used for the hard tissue substitute implants. However, it is necessary to improve interfacial biocompatibility for reduce adhesion period. For improvement of biocompatibility of titanium alloys, texture and chemical composition on contact part with biological tissue play very important roles. In this research, mist of glycerophosphoric acid calcium aqueous solution was applied on the laser irradiated area. As result, micro texture including Ca and P elements was generated on the Ti-6Al-4V-ELI alloys surfaces. When laser was irradiated, glycerophosphoric acid calcium aqueous solution applied as mist flowed on the test pieces as droplet. The velocity of droplet fluid was relatively fast, so that laser irradiation was unhindered access to the surface of specimens and the treatment was stable. In order to estimate biocompatibility of treated surfaces having micro texture with Ca and P element, culture assays using osteoblast cells were conducted. As result, it was clearly that biocompatibility of the specimen treated by laser with glycerophosphoric acid calcium aqueous solution mist more improved than treated specimen soaked in glycerophosphoric acid calcium aqueous solution.

Size reduction of gold particles in aqueous solution by pulsed laser irradiation

1998 ◽  
Vol 72 (7) ◽  
pp. 789-791 ◽  
Author(s):  
Hideaki Kurita ◽  
Akinori Takami ◽  
Seiichiro Koda
Keyword(s):  
Aqueous Solution ◽  
Laser Irradiation ◽  
Pulsed Laser ◽  
Size Reduction ◽  
Gold Particles ◽  
Pulsed Laser Irradiation

Synthesis of CdS-Capped CdSe Nanocrystals without any Poisonous Materials

2014 ◽  
Vol 981 ◽  
pp. 806-809
Author(s):  
Wu Lei Zhou ◽  
Tuo Cai ◽  
Yun Chen ◽  
Xuan Lin Chen ◽  
Yu Qiu Qu ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Quantum Yield ◽  
Aqueous Medium ◽  
Laser Irradiation ◽  
Absorption Spectroscopy ◽  
Photoluminescence Spectroscopy ◽  
Luminescence Quantum Yield ◽  
Cdse Nanocrystals ◽  
Core Shell ◽  
Photo Stability

CdS-capped CdSe nanocrystals (NCs) which show high luminescence quantum yield are synthesized without any Poisonous Materials in aqueous solution. The synthesis in an aqueous medium without any poisonous materials is attached importance to. The absorption spectroscopy and photoluminescence spectroscopy are employed to analyze the NCs. It takes 78s that the intensity decreases to the half for bare CdSe NCs, but 442s for CdSe/CdS core/shell NCs. The photo stability of CdSe NCs under 325nm laser irradiation is enhanced greatly after CdS overcoating.

Strontium-Loaded Nanotubes of Ti–24Nb–4Zr–8Sn Alloys for Biomedical Implantation

2021 ◽  
Vol 17 (9) ◽  
pp. 1812-1823
Author(s):  
Fei Liu ◽  
Xinyu Wang ◽  
Shujun Li ◽  
Yiheng Liao ◽  
Xinxin Zhan ◽  
...  
Keyword(s):  
Early Stage ◽  
Contact Rate ◽  
Hard Tissue ◽  
Tissue Slices ◽  
Bone Implant ◽  
P Elements ◽  
Low Elastic Modulus ◽  
Bone Implant Contact

Ti–24Nb–4Zr–8Sn (Ti2448) alloys, with a relatively low elastic modulus and unique mechanical properties, are desirable materials for oral implantation. In the current study, a multifaceted strontium-incorporating nanotube coating was fabricated on a Ti2448 alloy (Ti2-NTSr) through anodization and hydrothermal procedures. In vitro, the Ti2-NTSr specimens demonstrated better osteogenic properties and more favorable osteoimmunomodulatory abilities. Moreover, macrophages on Ti2-NTSr specimens could improve the recruitment and osteogenic differentiation of osteoblasts. In vivo, dense clots with highly branched, thin fibrins and small pores existed on the Ti2-NTSr implant in the early stage after surgery. Analysis of the deposition of Ca and P elements, hard tissue slices and the bone-implant contact rate (BIC%) of the Ti2-NTSr implants also showed superior osseointegration. Taken together, these results demonstrate that the Ti2-NTSr coating may maximize the clinical outcomes of Ti2448 alloys for implantation applications.

Hydrothermal Modification of Products Fabricated by Electron Beam Melting

2012 ◽  
Vol 529-530 ◽  
pp. 580-583
Author(s):  
Hidetsugu Fukuda ◽  
Masato Ueda ◽  
Masahiko Ikeda ◽  
Takayoshi Nakano
Keyword(s):  
Aqueous Solution ◽  
Electron Beam ◽  
Hydrothermal Treatment ◽  
Electron Beam Melting ◽  
Three Dimensional ◽  
Free Form ◽  
Hard Tissue ◽  
Hydrothermal Modification ◽  
Ceramic Films ◽  
Surface Modification Techniques

Electron beam melting (EBM) method is one of the free-form fabrication techniques that enable near-net-shape manufacturing of complex three-dimensional, porous, and graded products, and is expected to facilitate the development of new methods for manufacturing biomaterials that could be used for hard-tissue substitutes. Titanium and its alloys have been used widely as biomaterials for hard-tissue substitutes because of their excellent mechanical properties and biocompatibility. However, the osteointegration of these materials is less than that of bioactive ceramics. Therefore, various surface-modification techniques have been developed to improve the osteointegration. The simplest way is to synthesize bioactive ceramic films on the surface of titanium or its alloys. The purpose of the present work was to synthesize a bioactive TiO2 film on Ti-6Al-4V (hereafter, abbreviated as Ti-64) substrates fabricated from powders using the EBM method and treated by a combination of chemical and hydrothermal treatment. Ti-64 plates fabricated by the EBM method were chemically treated with a H2O2/HNO3 aqueous solution under appropriate conditions. The plates were then hydrothermally treated with a NH3 aqueous solution. TiO2-gel films were produced by chemical treatment with a H2O2/HNO3 aqueous solution on the surface of a Ti-64 substrate. Anatase-type TiO2 films with high crystallinity were synthesized by the hydrothermal treatment of the TiO2-gel films.

scholarly journals Plasma-assisted multiscale topographic scaffolds for soft and hard tissue regeneration

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Woochan Kim ◽  
Yonghyun Gwon ◽  
Yang-Kyung Kim ◽  
Sunho Park ◽  
Sung-Ju Kang ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Hierarchical Structures ◽  
Plasma Modification ◽  
Hard Tissue ◽  
Calvarial Bone ◽  
Precise Control ◽  
Gas Plasma ◽  
Modified Surface ◽  
Capillary Force Lithography

AbstractThe design of transplantable scaffolds for tissue regeneration requires gaining precise control of topographical properties. Here, we propose a methodology to fabricate hierarchical multiscale scaffolds with controlled hydrophilic and hydrophobic properties by employing capillary force lithography in combination with plasma modification. Using our method, we fabricated biodegradable biomaterial (i.e., polycaprolactone (PCL))-based nitrogen gas (N-FN) and oxygen gas plasma-assisted flexible multiscale nanotopographic (O-FMN) patches with natural extracellular matrix-like hierarchical structures along with flexible and controlled hydrophilic properties. In response to multiscale nanotopographic and chemically modified surface cues, the proliferation and osteogenic mineralization of cells were significantly promoted. Furthermore, the O-FMN patch enhanced regeneration of the mineralized fibrocartilage tissue of the tendon–bone interface and the calvarial bone tissue in vivo in rat models. Overall, the PCL-based O-FMN patches could accelerate soft- and hard-tissue regeneration. Thus, our proposed methodology was confirmed as an efficient approach for the design and manipulation of scaffolds having a multiscale topography with controlled hydrophilic property.

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