scholarly journals Association between the lymph node ratio and hepatic tumor burden: importance for resectable colorectal liver metastases?

2018 ◽  
Vol 7 (3) ◽  
pp. 206-208
Author(s):  
Kristoffer Watten Brudvik ◽  
Kjetil Søreide
Author(s):  
Giovanni Li Destri ◽  
Giuseppe Privitera ◽  
Gaetano La Greca ◽  
Roberto Scilletta ◽  
Antonio Pesce ◽  
...  

Abstract Objective The authors seek to assess whether the LNR could predict the risk of metachronous liver metastases. Background data Using the goal of sampling 12 lymph nodes for a proper staging of colorectal cancer is often "uncommon" and the lymph node ratio (LNR) is what allows for a better prognosis selection of patients. Methods A homogeneous group of 280 patients, followed-up for at least 5 years, was evaluated. In order to highlight the groups with the highest risk of metachronous liver metastases, patients were divided into four quartiles groups in relation to the LNR. Results The number of lymph nodes sampled in group "stage I" was significantly lower. Even if statistical significance between the global LNR and the development of liver metastases has not been reached, the subdivision into quartiles has made it possible to highlight that in the more advanced ratio groups, a higher incidence of metachronous liver metastases (p <0.028) was registered and was a different distribution of patients with or without liver metastasis in function of quartiles (P =0.01). Conclusions The LNR has enabled us to prognosticate patients who are at greater risk of developing metachronous liver metastases. The lower lymph node sampling in the patients with less advanced staging (I) and in patients with node-negative cancer (I+II) who developed liver metastases, leads us to believe that some patients have been understaged. We believe that the LNR, especially in cases of adequate lymph node sampling, is a useful gauge to better sub-stratify "node-positive" patients.


2017 ◽  
Vol 6 (3) ◽  
pp. 154-161 ◽  
Author(s):  
Ali Ahmad ◽  
Jeffrey Reha ◽  
Abdul Saied ◽  
N. Joseph Espat ◽  
Ponnandai Somasundar ◽  
...  

2017 ◽  
Vol 77 (04) ◽  
pp. 396-405
Author(s):  
M Kranawetter ◽  
R Schwameis ◽  
S Polterauer ◽  
I Zapardiel

Breast Cancer ◽  
2021 ◽  
Author(s):  
Vincent Vinh-Hung ◽  
Hendrik Everaert ◽  
Olena Gorobets ◽  
Hilde Van Parijs ◽  
Guy Verfaillie ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Honghu Wang ◽  
Hao Qi ◽  
Xiaofang Liu ◽  
Ziming Gao ◽  
Iko Hidasa ◽  
...  

AbstractThe staging system of remnant gastric cancer (RGC) has not yet been established, with the current staging being based on the guidelines for primary gastric cancer. Often, surgeries for RGC fail to achieve the > 15 lymph nodes needed for TNM staging. Compared with the pN staging system, lymph node ratio (NR) may be more accurate for RGC staging and prognosis prediction. We retrospectively analyzed the data of 208 patients who underwent R0 gastrectomy with curative intent and who have ≤ 15 retrieved lymph nodes (RLNs) for RGC between 2000 and 2014. The patients were divided into four groups on the basis of the NR cutoffs: rN0: 0; rN1: > 0 and ≤ 1/6; rN2: > 1/6 and ≤ 1/2; and rN3: > 1/2. The 5-year overall survival (OS) rates for rN0, rN1, rN2, and rN3 were 84.3%, 64.7%, 31.5%, and 12.7%, respectively. Multivariable analyses revealed that tumor size (p = 0.005), lymphovascular invasion (p = 0.023), and NR (p < 0.001), but not pN stage (p = 0.682), were independent factors for OS. When the RLN count is ≤ 15, the NR is superior to pN as an important and independent prognostic index of RGC, thus predicting the prognosis of RGC patients more accurately.


Sign in / Sign up

Export Citation Format

Share Document