Changes in growth-plate morphology associated with rejection of rat-limb allografts.

1992 ◽  
Vol 74 (9) ◽  
pp. 1375-1384 ◽  
Author(s):  
M Mohtai ◽  
T Hotokebuchi ◽  
K Arai ◽  
Y Sugioka
Keyword(s):  
Growth Plate ◽  
Plate Morphology

IL-1RI participates in normal growth plate development and bone modeling

2013 ◽  
Vol 305 (1) ◽  
pp. E15-E21 ◽  
Author(s):  
Stav Simsa-Maziel ◽  
Janna Zaretsky ◽  
Adi Reich ◽  
Yoav Koren ◽  
Ron Shahar ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Growth Plate ◽  
Knockout Mice ◽  
Bone Structure ◽  
Interleukin 1 ◽  
Normal Growth ◽  
Bone Modeling ◽  
Type I ◽  
Mineral Density ◽  
Plate Morphology

The proinflammatory cytokine interleukin-1 (IL-1) signals through IL-1 receptor type I (IL-1RI) and induces osteoclastogenesis and bone resorption mainly during pathological conditions. Little is known about the effect of excess or absence of IL-1 signaling on the physiological development of the growth plate and bone. In this study, we examine growth plate morphology, bone structure, and mechanical properties as well as osteoclast number in IL-1RI knockout mice to evaluate the role of IL-1RI in the normal development of the growth plate and bone. We show for the first time that IL-1RI knockout mice have narrower growth plates due to a smaller hypertrophic zone, suggesting a role for this cytokine in hypertrophic differentiation, together with higher proteoglycan content. The bones of theses mice exhibit higher trabecular and cortical mass, increased mineral density, and superior mechanical properties. In addition, IL-1RI knockout mice have significantly reduced osteoclast numbers in the chondro-osseous junction, trabecular bone, and cortical bone. These results suggest that IL-1RI is involved in normal growth plate development and ECM homeostasis and that it is significant in the physiological process of bone modeling.

scholarly journals Similar growth plate morphology in stapling and tension band plating hemiepiphysiodesis: A porcine experimental histomorphometric study

2012 ◽  
Vol 31 (4) ◽  
pp. 574-579 ◽  
Author(s):  
Martin Gottliebsen ◽  
Ole Rahbek ◽  
Hanne Damgaard Poulsen ◽  
Bjarne Møller-Madsen
Keyword(s):  
Growth Plate ◽  
Tension Band ◽  
Histomorphometric Study ◽  
Plate Morphology ◽  
Similar Growth

scholarly journals 165 COLLAGEN IX IS INDISPENSABLE FOR PROPER GROWTH PLATE MORPHOLOGY AND ORGANISATION

2007 ◽  
Vol 15 ◽  
pp. C99
Author(s):  
R. Dreier ◽  
A. Opolka ◽  
J. Grifka ◽  
P. Bruckner ◽  
S. Grässel
Keyword(s):  
Growth Plate ◽  
Plate Morphology ◽  
Collagen Ix

scholarly journals Short-term glucocorticoid treatment of piglets causes changes in growth plate morphology and angiogenesis

2003 ◽  
Vol 11 (12) ◽  
pp. 864-871 ◽  
Author(s):  
J.J Smink ◽  
I.M Buchholz ◽  
N Hamers ◽  
C.M van Tilburg ◽  
C Christis ◽  
...  
Keyword(s):  
Growth Plate ◽  
Short Term ◽  
Glucocorticoid Treatment ◽  
Plate Morphology

Effects of long-term use of the preferential COX-2 inhibitor meloxicam on growing pigs

2017 ◽  
Vol 181 (21) ◽  
pp. 564-564 ◽  
Author(s):  
Ben M C Gorissen ◽  
Joost J Uilenreef ◽  
Wilhelmina Bergmann ◽  
Ellen Meijer ◽  
Bert van Rietbergen ◽  
...  
Keyword(s):  
Side Effects ◽  
Trabecular Bone ◽  
Growth Plate ◽  
Bone Microarchitecture ◽  
Growing Pigs ◽  
Pathological Examination ◽  
Trabecular Bone Microarchitecture ◽  
Cox 2 ◽  
Plate Morphology

Meloxicam, a preferential COX-2 inhibitor, is a commonly used NSAID in pigs. Besides having potential side effects on the gastrointestinal tract, this type of drug might potentially affect osteogenesis and chondrogenesis, processes relevant to growing pigs. Therefore, the effects of long-term meloxicam treatment on growing pigs were studied. Twelve piglets (n=6 receiving daily meloxicam 0.4 mg/kg orally from 48 until 110 days of age; n=6 receiving only applesauce (vehicle control)) were subjected to visual and objective gait analysis by pressure plate measurements at several time points. Following euthanasia a complete postmortem examination was performed and samples of the talus and distal tibia, including the distal physis, were collected. Trabecular bone microarchitecture was analysed by microCT scanning, bone stiffness by compression testing and growth plate morphology using light microscopy. Animals were not lame and gait patterns did not differ between the groups. Pathological examination revealed no lesions compatible with known side effects of NSAIDs. Trabecular bone microarchitecture and growth plate morphology did not differ between the two groups. The findings of this in vivo study reduce concerns regarding the long-term use of meloxicam in young, growing piglets.

Evaluation of a Method for Biopsy of the Distal Radial Physeal Growth Plate in Neonatal Foals

1999 ◽  
Vol 12 (03) ◽  
pp. 128-133
Author(s):  
E. C. Firth ◽  
W. F. Hunt ◽  
S. G. Pearce
Keyword(s):  
Growth Plate ◽  
Postoperative Morbidity ◽  
Postmortem Examination ◽  
Unoperated Control ◽  
Biopsy Site ◽  
Left Limb ◽  
Plate Morphology ◽  
The Right ◽  
Thoroughbred Foals

SummaryA technique was devised for taking biopsies from the distal radial physeal growth plate in neonatal foals to study cartilage morphology. The biopsy taken from the right forelimb of 21 Thoroughbred foals, four to 10 days of age, was performed under inhalation anaesthesia, using a 9 mm diameter trephine on a multi speed drill. Due to their exercise not being adequately restricted postoperatively, five foals (24%) developed excessive incisional granulation tissue at the biopsy site. Nine foals (43%) developed some flexion of the carpus (over at the knee) and 15 (71%) developed outward rotation of the left limb. There was significantly greater carpal valgus in the left limb when compared with the right limb (p <0.005), a situation which was not present in six agematched, unoperated, control foals. Abnormalities in the congruency of the antebrachiocarpal joint were not detected grossly at postmortem at five months of age. However, there were localised gross and histological abnormalities of the distal radial physeal growth plate. Postoperative morbidity, significant changes to conformation, and the unknown long term consequences of the disruption to the biopsied physeal growth plate are likely to make this procedure inappropriate for clinical usage. However, the biopsy procedure was easy to perform, and provided a suitable sample for both histological and histomorphometric examination of the physeal growth plate cartilage. Therefore this technique provides a useful research method for study of growth plate morphology in neonates.A technique was developed for biopsy of the distal radial physeal growth plate in neonatal foals. Additionally, the effects on conformation, and on gross and histological abnormalities at five months of age, were reported. There were significant, mild conformational abnormalities, which self-corrected without intervention, and there were abnormalities detected at postmortem examination, but these abnormalities did not appear to affect the joint. The expected effects of this procedure are stated, and provided that these are accounted for, the technique is useful for harvesting and studying the physeal growth plate of neonates.

scholarly journals Relating the Chondrocyte Gene Network to Growth Plate Morphology: From Genes to Phenotype

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e34729 ◽  
Author(s):  
Johan Kerkhofs ◽  
Scott J. Roberts ◽  
Frank P. Luyten ◽  
Hans Van Oosterwyck ◽  
Liesbet Geris
Keyword(s):  
Growth Plate ◽  
Gene Network ◽  
Plate Morphology

Intrauterine Exposure to a Maternal Low Protein Diet Reduces Adult Bone Mass and Alters Growth Plate Morphology in Rats

2002 ◽  
Vol 71 (6) ◽  
pp. 493-498 ◽  
Author(s):  
G. Mehta ◽  
H.I. Roach ◽  
S. Langley-Evans ◽  
P. Taylor ◽  
I. Reading ◽  
...  
Keyword(s):  
Bone Mass ◽  
Growth Plate ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Intrauterine Exposure ◽  
Low Protein ◽  
Plate Morphology ◽  
Adult Bone

scholarly journals Temporal Analysis of Rat Growth Plates: Cessation of Growth with Age Despite Presence of a Physis

2003 ◽  
Vol 51 (3) ◽  
pp. 373-383 ◽  
Author(s):  
Helmtrud I. Roach ◽  
Gautam Mehta ◽  
Richard O.C. Oreffo ◽  
Nicholas M.P. Clarke ◽  
Cyrus Cooper
Keyword(s):  
Bone Formation ◽  
Growth Plate ◽  
Bone Growth ◽  
Temporal Analysis ◽  
Aged Rats ◽  
Growth Plate Chondrocytes ◽  
Growth Plates ◽  
Rat Growth ◽  
Old Rats ◽  
Plate Morphology

Despite the continued presence of growth plates in aged rats, longitudinal growth no longer occurs. The aims of this study were to understand the reasons for the cessation of growth. We studied the growth plates of femurs and tibiae in Wistar rats aged 62–80 weeks and compared these with the corresponding growth plates from rats aged 2–16 weeks. During skeletal growth, the heights of the plates, especially that of the hypertrophic zone, reflected the rate of bone growth. During the period of decelerating growth, it was the loss of large hydrated chondrocytes that contributed most to the overall decrease in the heights of the growth plates. In the old rats we identified four categories of growth plate morphology that were not present in the growth plates of younger rats: (a) formation of a bone band parallel to the metaphyseal edge of the growth plate, which effectively sealed that edge; (b) extensive areas of acellularity, which were resistant to resorption and/or remodeling; (c) extensive remodeling and bone formation within cellular regions of the growth plate; and (d) direct bone formation by former growth plate chondrocytes. These processes, together with a loss of synchrony across the plate, would prevent further longitudinal expansion of the growth plate despite continued sporadic proliferation of chondrocytes.

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