Measurement of CYP1A2 Phenotype Using Female Volunteer Plasma: A Focus on Caffeine and Paraxanthine as a Probe

2016 ◽  
Vol 8 (2) ◽  
Author(s):  
Saima Rehman ◽  
Shagufta Kamal ◽  
Shumaila Kiran ◽  
Ismat Bibi ◽  
Iqbal Hussain
Keyword(s):  
2016 ◽  
Vol 8 ◽  
pp. 34
Author(s):  
Saima Rehman ◽  

Caffeine neither causing didn't decrease the risk of cancer, yet it used just to note the activity of cytochrome P-4501A2 (CYP1A2) by converting into its metabolite i.e., paraxanthine. The purpose of the present study was to determine the caffeine and its metabolite phenotypes and their relation to cancer risk in healthy female volunteers of local population in Pakistan. The average value of metabolic ratio [(1,7-dimethylxanthine (17X) and Caffeine 1,3,7-trimethylxanthine (137X)] was found to be 1.182995 ± 0.21137. BMI (used to categorize into different groups, i.e., overweight, underweight etc.) of all volunteers were found to be 19.93Kg/m2. Retention time was 15 and 37 min for 1,7-dimethylxanthine (17DMX) and 1,3,7 trimethylxanthine (137TMX), respectively.


2001 ◽  
Vol 17 (3) ◽  
pp. 233-240 ◽  
Author(s):  
Ahmed M. Abdel-Khalek

Summary: The original Beck Depression Inventory (BDI-O) consists of 21 item groups. Each group contains four options (i. e., 84 overall statements). The proposed short BDI version contains only 21 statements denoting the highest degree of clinical depression, i. e., the last alternative in each item group. Items of the short version were introduced in two response forms: Likert (L) and Yes/No (Y/N) format. Two depression subscales derived from the Symptom Check List-90 and the Hopkins Symptom Check List were also used. A sample of 203 male and female volunteer Kuwaiti undergraduates was recruited. It was found that the BDI-O had relatively lesser skew and kurtosis. However, the M/SD ratio was well balanced in the BDI-L and not in the original and BDI-Y/N versions. Cronbach's α, correlations with four other scales, and loadings onto two separate factors of depression were high in both BDI-O and BDI-L - although they were higher in the BDI-L. It also had improved factorial structure. Nevertheless, the proposed short BDI-L version contains only one-fourth of the BDI-O without deleting any of its symptom indicators. Therefore, it was concluded that the short BDI-L version can make a good contribution to enhancing the BDI cost-effectiveness, especially in empirical research projects containing loaded test batteries.


1978 ◽  
Vol 47 (2) ◽  
pp. 443-449 ◽  
Author(s):  
Michael C. Rush ◽  
James S. Phillips ◽  
Paul E. Panek

To assess the potential bias introduced by subject recruitment procedures, differences in perceptual style, personality, and performance on an auditory selective attention task were investigated for a sample of 47 female, volunteer research participants. Half of the subjects ( N = 24) had been recruited as unpaid volunteers while the others ( N = 23) received $2.50 per hour for their participation. Stepwise discriminant analysis indicated that unpaid volunteers tended to be significantly more interpersonal in orientation, were more field-dependent, and committed fewer omission errors on a selective attention task than subjects who had volunteered for pay. The findings were discussed in terms of the problems associated with generalizing from one sample to other samples and to the criterion population as a function of experimental boundary conditions.


Author(s):  
Yi-Chun Liu ◽  
Li-Chen Yen ◽  
Fang-Yih Liaw ◽  
Ming-Han Lin ◽  
Shih-Hung Chiang ◽  
...  

Background: The theory of planned behaviour (TPB) explanation of smoking cessation intentions consists of gender differences. The purpose of this study is to adopt the extended TPB to discuss factors influencing the smoking cessation intentions of young adult volunteer soldiers and to further compare the respective factors for both genders. Methods: This is a cross-sectional study. Data were collected from 139 and 165 male and female volunteer soldiers who smoked, respectively. Research participants completed a self-administered questionnaire that comprised items pertaining to the participants’ demographic characteristics, smoking behaviours, smoking cessation experiences, social environments, and TPB variables. Results: Subjective norms (friends) are a positive key factor for young adult male (β = 0.033, p = 0.012) and female (β = 0.076, p < 0.001) volunteer soldiers’ smoking cessation intentions, and perceived behavioural control is a key factor for male young (β = 0.226, p = 0.040) adult volunteer soldiers’ smoking cessation intention. The extended TPB accounted for 27.9% and 53.2% of the variance in the intention to quit smoking in the male and female volunteer soldiers, respectively. Conclusions: We suggest that smoking cessation strategies can reinforce gender-specific intervention strategies to assist young adult volunteer soldiers in smoking cessation.


1860 ◽  
Vol s2-IX (218) ◽  
pp. 165-165
Author(s):  
Z.
Keyword(s):  

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