Measurement and Prediction of Sound Exposure Levels by University Wind Bands

2010 ◽  
Vol 25 (1) ◽  
pp. 29-34 ◽  
Author(s):  
Kris Chesky
Keyword(s):  
Linear Regression Analysis ◽  
Critical Role ◽  
Significant Proportion ◽  
Sound Exposure ◽  
Sound Levels ◽  
Wind Bands ◽  
Exposure Levels ◽  
The Mean ◽  
Over Time

The purpose of this study was to determine sound exposure levels generated in two college wind bands. Dosimeter data from a large sample of ensemble-based instructional activities (n = 43) was collected over time and processed to assess associations with predictor variables that may be relevant to this context, including indicators of time spend at various intensity levels, maximum and peak sound levels, degree of variability of sound levels over time, and the percentage of time playing music. The mean dose per event for the entire sample was 109.5% and ranged from 53.8% to 166.9%. Results of linear regression analysis revealed that regressors accounted for a significant proportion of the variance in dose (F = 128.42, p < 0.000) and a statistically significant and very large (96% variance accounted for) contribution to the prediction of dose. Findings implicate the critical role of the instructor and teaching pedagogy.

AMPK blocks chromatin activation and consequent R-loop formation to protect genome stability following acute starvation

2021 ◽  
Author(s):  
Bing Sun ◽  
McLean Sherrin ◽  
Richard Roy
Keyword(s):  
Dna Damage ◽  
Genome Stability ◽  
Germ Line ◽  
Critical Role ◽  
Significant Proportion ◽  
Loop Formation ◽  
C Elegans ◽  
Chromatin Activation ◽  
Acute Starvation

Abstract During periods of starvation organisms must modify both gene expression and metabolic pathways to adjust to the energy stress. We previously reported that C. elegans that lack AMPK have transgenerational reproductive defects that result from abnormally elevated H3K4me3 levels in the germ line following recovery from acute starvation1. Here we show that H3K4me3 is dramatically increased at promoters, driving aberrant transcription elongation that results in the accumulation of R-loops in the starved AMPK mutants. DRIP-seq analysis demonstrated that a significant proportion of the genome was affected by R-loop formation with a dramatic expansion in the number of R-loops at numerous loci, most pronounced at the promoter-TSS regions of genes in the starved AMPK mutants. The R-loops are transmissible into subsequent generations, likely contributing to the transgenerational reproductive defects typical of these mutants following starvation. Strikingly, AMPK null germ lines show considerably more RAD-51 foci at sites of R-loop formation, potentially sequestering it from its critical role at meiotic breaks and/or at sites of induced DNA damage. Our study reveals a previously unforeseen role of AMPK in maintaining genome stability following starvation, where in its absence R-loops accumulate, resulting in reproductive compromise and DNA damage hypersensitivity.

Abstract 3851: Temporal Distribution of Stroke Volumes and Clinical-Diffusion Mismatch in Patients with Proximal Arterial Occlusions

Stroke ◽  
2012 ◽  
Vol 43 (suppl_1) ◽  
Author(s):  
Raul G Nogueira ◽  
David S Liebeskind ◽  
Leticia M Souza ◽  
Qing Hao ◽  
Karen Furie ◽  
...  
Keyword(s):  
Linear Regression ◽  
Infarct Volume ◽  
Linear Regression Analysis ◽  
Significant Proportion ◽  
Arterial Occlusion ◽  
Reperfusion Therapy ◽  
Poor Correlation ◽  
Lesion Volume ◽  
Collateral Flow ◽  
Over Time

Background and Purpose: Previous studies have demonstrated that the benefit of reperfusion therapy declines over time. The Clinical-Diffusion Mismatch (CDM) model has been suggested as surrogate for salvable tissue in acute ischemic stroke (AIS) patients. We sought to describe the temporal behavior profile of infarct volumes and CDM in patients suffering AIS due to proximal arterial occlusion (PAO). Methods: We performed a retrospective analysis of consecutive AIS patients admitted to two large academic institutions fulfilling the following criteria: (1) Baseline NIHSS ≥8; (2) PAO defined as MCA-M1, intracranial ICA, or tandem cervical + ICA/MCA-M1 occlusion on admission CTA/MRA; and (3) MRI-DWI performed ≤8 hours from time of stroke onset/last seen well (TSO). CDM was defined as baseline NIHSS ≥8 and DWI volume ≤25cc (as proposed by Davalos et al). Linear regression analysis was performed to define the changes on DWI lesion volume on presentation over time. The observed TSO to MRI were broken down into quartiles to look for any differences in the distribution of the baseline variables over time. Results: A total of 132 consecutive patients were identified (mean age, 66±16.8 years; 57% females; mean baseline NIHSS 17.5±5.3; occlusion site: MCA-M1, 64%; intracranial-ICA, 29%; tandem, 5%, mean TSO to DWI, 269.5±105.48 minutes). The mean DWI stroke volume on presentation was 46.7±54.8 cc (range, 0.19-436.1) and 63 (46.7%) patients had CDM. There was no significant changes in age, gender, baseline NIHSS, or occlusion site amongst the different time quartiles. Median infarct volume (cc) increased (quartile #1=8.5; #2=30.1; #3=38.5; #4=29.4) and the chances of having a CDM decreased (p<0.0001) across the different time quartiles. However, there was an overall poor correlation between DWI lesion volume on presentation and TSO to MRI (R-square=0.031, Figure ) and a significant proportion of the patients still had a CDM at later time epochs (#1=91.1%[20/22]; #2=47.8%[11/23]; #3=34.4%[21/61]; #4=42.3%[11/26]). Conclusions: Although infarct volume increases and the amount of penumbral tissue decreases over time, many patients with PAO will still have salvable penumbra at the later time epochs. This reflects individual differences in anatomic and physiological characteristics including the strength of collateral flow and highlights that selected patients may benefit from reperfusion therapy even at the later time windows. Figure : Relationship between Baseline DWI Volume (cc) and Time (minutes). Line is best fitted linear regression model.

scholarly journals Zinc deficiency may play a crucial role in dialysis-associated bacterial infections

2020 ◽  
Vol 11 (1) ◽  
pp. e9-e9
Author(s):  
Zahra Lotfi ◽  
Abbas Ali Zeraati ◽  
Elaheh Dashti ◽  
Tina Zeraati ◽  
Maryam Arghiany ◽  
...  
Keyword(s):  
Zinc Deficiency ◽  
Bacterial Infections ◽  
Critical Role ◽  
Serum Zinc ◽  
Zinc Level ◽  
Healthy Individuals ◽  
Mortality And Morbidity ◽  
Increased Risk ◽  
The Mean

Introduction: Systemic bacterial infections are a common cause of mortality and morbidity in hemodialysis patients. Zinc has a critical role in several immune system functions. Patients who have enough amounts of zinc are able to better face infections caused by various pathogens in comparison to those with zinc insufficiency Objective We sought to assess the role of zinc deficiency in dialysis-associated bacterial infections. Patients and Methods: Eighty-Three adult patients with end-stage renal disease (ESRD) on hemodialysis including 43 patients with bacterial infectious complications and 40 non-infected patients as well as 41 healthy individuals were enrolled. Clinical data, laboratory values including serum zinc level and imaging findings were collected. SPSS was utilized to analyze the data with a significance cutoff set at P < 0.05. Results: Out of 124 participants, 80 (64.51%) were males and 44 (35.49%) were females. The mean age of infected hemodialysis group, non-infected hemodialysis group, and healthy controls were 50.8 ± 16.25, 49.1 ± 18.1, and 56.3 ± 18.2 years, respectively. Catheter site infection (37.3%) and urinary tract infection (30.2%) were the most common infections. The mean serum zinc concentration was significantly lower in the infected patients, compared to non-infected patients and healthy individuals (P < 0.001). Conclusion: The ESRD patients on hemodialysis have lower serum zinc levels which are associated with increased risk of bacterial infection. The role of screening for zinc deficiency and use of supplemental zinc in these patients need to be studied.

scholarly journals A longitudinal survey of adult spine and peripheral nerve case entries during neurosurgery residency training

2018 ◽  
Vol 29 (4) ◽  
pp. 442-447 ◽  
Author(s):  
Nitin Agarwal ◽  
Michael D. White ◽  
D. Kojo Hamilton
Keyword(s):  
Peripheral Nerve ◽  
Residency Training ◽  
Spine Surgery ◽  
Linear Regression Analysis ◽  
Critical Role ◽  
Senior Resident ◽  
Case Volume ◽  
Minimum Requirements ◽  
The Mean ◽  
Adult Spine

OBJECTIVECurrently, there is a lack of research assessing residents’ operative experience and caseload variability. The current study utilizes data from the Accreditation Council for Graduate Medical Education (ACGME) case log system to analyze national trends in neurosurgical residents’ exposure to adult spinal procedures.METHODSProspectively populated ACGME resident case logs from 2013 to 2017 were retrospectively reviewed. The reported number of spinal procedures was compared to the ACGME minimum requirements for each surgical category pertaining to adult spine surgery. A linear regression analysis was conducted to identify changes in operative caseload by residents graduating during the study period, as well as a one-sample t-test using IBM SPSS software to compare the mean number of procedures in each surgical category to the ACGME required minimums.RESULTSA mean of 427.42 total spinal procedures were performed throughout residency training for each of the 877 residents graduating between 2013 and 2017. The mean number of procedures completed by graduating residents increased by 19.96 (r2 = 0.95) cases per year. The number of cases in every procedural subspecialty, besides peripheral nerve operations, significantly increased during this time. The two procedural categories with the largest changes were anterior and posterior cervical approaches for decompression/stabilization, which increased by 8.78% per year (r2 = 0.95) and 9.04% per year (r2 = 0.95), respectively. There was also a trend of increasing cases logged for lead resident surgeons and a decline in cases logged for senior resident surgeons. Residents’ mean caseloads during residency were found to be vastly greater than the ACGME required minimums: residents performed at least twice as many procedures as the required minimums in every surgical category.CONCLUSIONSGraduating neurosurgical residents reported increasing case volumes for adult spinal cases during this 5-year interval. An increase in logged cases for lead resident surgeons as opposed to senior resident surgeons indicates that residents were logging more cases in which they had a more critical role in the procedure. Moreover, the average resident was noted to perform more than twice the number of procedures required by the ACGME in every surgical category, indicating that neurosurgical residents are getting greater exposure to spine surgery than expected. Given the known correlation between case volume and improved surgical outcomes, this data demonstrates each graduating neurosurgical residency class experiences an augmented training in spine surgery.

Anesthesia Information Management Systems (AIMS)

2011 ◽  
pp. 465-481
Author(s):  
Loren Riskin ◽  
Christoph Egger-Halbeis ◽  
Daniel Riskin
Keyword(s):  
Operating Room ◽  
Information Management ◽  
Fundamental System ◽  
Critical Role ◽  
Management Systems ◽  
Healthcare Information ◽  
Operative Care ◽  
Information Management Systems ◽  
Over Time

This chapter discusses the critical role of anesthesia information management systems (AIMS) in clinical tracking and operating room information management. It begins by reviewing the history and implementation of such systems and examines their current abilities and utilities. The current known benefits of AIMS, as documented by peer-reviewed literature, are examined. Possible additional benefits, both future and current, and the potential role of AIMS in future healthcare information management are discussed. Though AIMS vary greatly between individual systems and will continue to evolve over time, this chapter aims to highlight fundamental system features. The goal of this chapter is to broaden understanding of AIMS and their clinical utility, as they have an essential part of modern operative care.

scholarly journals Role of Maritime Continent Land Convection on the Mean State and MJO Propagation

2020 ◽  
Vol 33 (5) ◽  
pp. 1659-1675 ◽  
Author(s):  
Min-Seop Ahn ◽  
Daehyun Kim ◽  
Yoo-Geun Ham ◽  
Sungsu Park
Keyword(s):  
Climate Model ◽  
Global Climate ◽  
Global Climate Model ◽  
Critical Role ◽  
Moisture Gradient ◽  
Moisture Distribution ◽  
Boreal Winter ◽  
Maritime Continent ◽  
The Mean

AbstractThe Maritime Continent (MC) region is known as a “barrier” in the life cycle of the Madden–Julian oscillation (MJO). During boreal winter, the MJO detours the equatorial MC land region southward and propagates through the oceanic region. Also, about half of the MJO events that initiate over the Indian Ocean cease around the MC. The mechanism through which the MC affects MJO propagation, however, has remained unanswered. The current study investigates the MJO–MC interaction with a particular focus on the role of MC land convection. Using a global climate model that simulates both mean climate and MJO realistically, we performed two sensitivity experiments in which updraft plume radius is set to its maximum and minimum value only in the MC land grid points, making convective top deeper and shallower, respectively. Our results show that MC land convection plays a key role in shaping the 3D climatological moisture distribution around the MC through its local and nonlocal effects. Shallower and weaker MC land convection results in a steepening of the vertical and meridional mean moisture gradient over the MC region. The opposite is the case when MC land convection becomes deeper and stronger. The MJO’s eastward propagation is enhanced (suppressed) with the steeper (lower) mean moisture gradient. The moist static energy (MSE) budget of the MJO reveals the vertical and meridional advection of the mean MSE by MJO wind anomalies as the key processes that are responsible for the changes in MJO propagation characteristics. Our results pinpoint the critical role of the background moisture gradient on MJO propagation.

scholarly journals Branching and competitive hierarchies in populations of Galium aparine

1998 ◽  
Vol 76 (1) ◽  
pp. 63-74
Author(s):  
Javier G Puntieri ◽  
Petr Pysek
Keyword(s):  
Height Growth ◽  
Low Density ◽  
Growth Limitation ◽  
Galium Aparine ◽  
Key Words Allometry ◽  
Annual Herb ◽  
The Mean ◽  
Competitive Hierarchies ◽  
Over Time

The role of branching on the development of size hierarchies was studied on experimental populations of the annual herb Galium aparine L. (Rubiaceae). All branches of plants growing at high and low density were severed as plants developed, and the growth of individual plants, the development of growth and size inequalities, and the mean change in the size ranking of plants over time were compared with those of populations of naturally branched plants. Size allometries were analysed for all treatments. The effect of the branch-severing treatment on growth and size inequalities was not significant for crowded populations. The position of individual plants in the ranking of weights in crowded conditions was less variable for populations of unbranched plants than for those of branched plants. Size and growth inequalities among branched plants were not significantly affected by population density. The hypothesis that branching increases the development of competitive hierarchies in G. aparine populations is not supported by the results. The role of height growth limitation in crowded conditions as a constraint to competitive hierarchy development is discussed. Key words: allometry, branching pattern, competitive hierarchy, Galium aparine, intraspecific competition.

scholarly journals Serum Neutrophil Gelatinase-Associated Lipocalin Levels In Early Detection Of Contrast-Induced Nephropathy

2016 ◽  
Vol 39 (3) ◽  
pp. 88 ◽  
Author(s):  
Murat Muratoglu ◽  
Cemil Kavalci ◽  
Elif Kilicli ◽  
Meliha Findik ◽  
Afşin Emre Kayipmaz ◽  
...  
Keyword(s):  
Early Detection ◽  
P Value ◽  
Ngal Level ◽  
Contrast Induced Nephropathy ◽  
Sodium Potassium ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
The Mean ◽  
Neutrophil Gelatinase ◽  
Over Time

Purpose: The purpose of this study was to investigate the role of serum neutrophil gelatinase-associated lipocalin (NGAL) levels in the early detection of contrast-induced nephropathy (CIN). Methods: This prospective study enrolled 74 patients undergoing abdominal tomography with contrast (1 November 2014 - 28 February 2015). Demographic properties (age and sex), symptoms and CT examination results were analysed. Sodium, potassium, urea, creatinine and NGAL levels were measured at 0th, 6th, and 72nd hours. P value < 0.05 was considered statistically significant. Results: CIN developed in 16.2% of the study patients. The mean age was significantly higher in the patients who developed CIN (p0.05). Urea levels did not differ significantly between the groups at 0th and 6th hours (p>0.05) but was significantly higher in the patients with CIN at 72nd hour (p0.05). Creatinine level was not significantly different between the groups (p>0.05) but increased significantly over time (p>0.05). There were no significant differences between the groups with respect to NGAL levels at 0th and 72nd hours (p>0.05) whereas the group with CIN had a significantly higher NGAL level at 6th hour (p

scholarly journals Job insecurity and performance over time: the critical role of job insecurity duration

2019 ◽  
Vol 25 (3) ◽  
pp. 325-336 ◽  
Author(s):  
Maike E. Debus ◽  
Dana Unger ◽  
Cornelius J. König
Keyword(s):  
Job Performance ◽  
Job Insecurity ◽  
Critical Role ◽  
Future Research ◽  
Appraisal Theory ◽  
Stress Reactions ◽  
Content Type ◽  
Dynamic Perspective ◽  
Over Time

Purpose Research on the relationship between job insecurity and job performance has thus far yielded inconclusive results. The purpose of this paper is to offer a more dynamic perspective on the effects of job insecurity on job performance. Design/methodology/approach Drawing from cognitive appraisal theory, research on critical life events, and stress reactions as well as more general theorizing around the role of time, this paper proposes that individuals’ job performance reactions to job insecurity will be dynamic over time. Findings Adopting a person-centered perspective, this paper suggests that there are seven subpopulations that differ in their intra-individual job performance change patterns over time. Research limitations/implications This paper presents potential predictors of subpopulation membership and presents an agenda for future research. Originality/value We contribute to the literature by introducing a dynamic perspective to the study of job performance in the context of job insecurity. Delineating a set of open questions that follow from the presented theoretical arguments, the authors also hope to stimulate future research in the context of job insecurity and job performance.

scholarly journals Long-Term Infliximab Treatment in Psoriasis Patients: A National Multicentre Retrospective Study

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Clémentine Carlet ◽  
Damien Bichard ◽  
Marie Aleth Richard ◽  
Emmanuel Mahé ◽  
Clémence Saillard ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Critical Role ◽  
Real Life ◽  
Solid Cancer ◽  
Infliximab Treatment ◽  
Efficacy And Safety ◽  
Drug Survival ◽  
The Mean

Background. Although infliximab (IFX) has been available since 2005, there are very little data on the long-term drug survival of infliximab in real-life. Objective. Our aim was to identify and describe psoriasis patients treated with IFX for longer than 6 years. Methods. Psoriasis patients treated with IFX for longer than 6 years were retrospectively included. Demographic and clinical data were collected in May 2018. Results. Between January 2005 and December 2012, 43 patients were maintained on IFX for 6 years or longer. IFX was introduced as a 4.5 line of systemic therapy. The mean duration of IFX treatment was 8.5 years (6–12). In May 2018, 30 patients (70%) were still maintained on IFX at 4–6 mg/kg every 8–10 weeks with an efficiency of about 100%. IFX was stopped in 13 patients (30%) mainly for loss of efficacy in 6 patients (46%). Three patients developed solid cancer including bladder cancer, lung cancer, and prostate cancer. Limitation. Retrospective study. Conclusion. We report the efficacy and safety of IFX maintained for up to 12 years in psoriasis patients. The long-term use of IFX was associated with a high BMI confirming the critical role of weight-based dosing for this drug.

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