scholarly journals Phosphorylation and Fragmentation of the Cardiac Troponin T: Mechanisms, Role in Pathophysiology and Laboratory Diagnosis

2021 ◽  
Vol 11 (3) ◽  
pp. 250-259 ◽  
Author(s):  
Aleksey M. Chaulin
Keyword(s):  
Cardiac Troponin ◽  
Extracellular Enzymes ◽  
Troponin T ◽  
Cardiac Contractility ◽  
Laboratory Diagnosis ◽  
Cardiac Troponin T ◽  
Post Translational Modifications ◽  
Physiological Conditions ◽  
Acid Structure

Cardiac troponin T (cTnT), a protein essential for calcium-regulated, myofibrillar ATPase activity, is extremely sensitive to the action of a significant number of intra- and extracellular enzymes, the action of which causes post-translational modifications (PTMs) of amino acid structure and functioning cTnT. PTMs of cTnT may play important roles in the regulation of cardiac contractility. The vast majority of cTnT modifications involve the phosphorylation by a variety of Ser/Thr kinases, including PKC. At the same time, the activity of cTnT phosphorylation can change under physiological conditions and in some CVDs, including HF, AMI, and arrhythmias. Along with cTnT phosphorylation, cTnT fragmentation occurs, the activity of which can also change. This article discusses the mechanisms of cTnT phosphorylation and fragmentation, discusses the important role of these processes in the pathophysiology and laboratory diagnosis of some CVD, and notes promising directions for further research.

Reply: The complementary role of cardiac troponin I and cardiac troponin T

2020 ◽  
Vol 78 ◽  
pp. 42
Author(s):  
Sjur H. Tveit ◽  
Peder L. Myhre ◽  
Helge Røsjø ◽  
Torbjørn Omland
Keyword(s):  
Cardiac Troponin ◽  
Troponin I ◽  
Troponin T ◽  
Cardiac Troponin I ◽  
Cardiac Troponin T ◽  
Complementary Role

Kinetics of high-sensitivity cardiac troponin T or troponin I compared to creatine kinase in patients with revascularized acute myocardial infarction

2015 ◽  
Vol 53 (5) ◽  
Author(s):  
Kamila Solecki ◽  
Anne Marie Dupuy ◽  
Nils Kuster ◽  
Florence Leclercq ◽  
Richard Gervasoni ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Troponin T ◽  
High Sensitivity ◽  
Cardiac Troponin T ◽  
Significant Difference ◽  
Kinetics Of

AbstractCardiac biomarkers are the cornerstone of the biological definition of acute myocardial infarction (AMI). The key role of troponins in diagnosis of AMI is well established. Moreover, kinetics of troponin I (cTnI) and creatine kinase (CK) after AMI are correlated to the prognosis. New technical assessment like high-sensitivity cardiac troponin T (hs-cTnT) raises concerns because of its unclear kinetic following the peak. This study aims to compare kinetics of cTnI and hs-cTnT to CK in patients with large AMI successfully treated by percutaneous coronary intervention (PCI).We prospectively studied 62 patients with anterior AMI successfully reperfused with primary angioplasty. We evaluated two consecutive groups: the first one regularly assessed by both CK and cTnI methods and the second group by CK and hs-cTnT. Modeling of kinetics was realized using mixed effects with cubic splines.Kinetics of markers showed a peak at 7.9 h for CK, at 10.9 h (6.9–12.75) for cTnI and at 12 h for hs-cTnT. This peak was followed by a nearly log linear decrease for cTnI and CK by contrast to hs-cTnT which appeared with a biphasic shape curve marked by a second peak at 82 h. There was no significant difference between the decrease of cTnI and CK (p=0.63). CK fell by 79.5% (76.1–99.9) vs. cTnI by 86.8% (76.6–92.7). In the hs-cTnT group there was a significant difference in the decrease by 26.5% (9–42.9) when compared with CK that fell by 79.5% (64.3–90.7).Kinetic of hs-cTnT and not cTnI differs from CK. The role of hs-cTnT in prognosis has to be investigated.

scholarly journals A Pilot Study of Matrix Metalloproteinases on the Model of Daunorubicin-induced Cardiomyopathy in Rabbits

2007 ◽  
Vol 50 (2) ◽  
pp. 109-111 ◽  
Author(s):  
Anna Potáčová ◽  
Michaela Adamcová ◽  
Martin Štěrba ◽  
Olga Popelová ◽  
Tomáš Šimůnek ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Matrix Metalloproteinases ◽  
Cardiac Remodeling ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Myocardial Necrosis ◽  
Control Group ◽  
Cardiac Troponin T ◽  
Wet Weight

Matrix metalloproteinases (MMPs), activated by oxidative stress, play a key role during cardiac remodeling. In the present study we aimed to assess the role of MMPs in experimental cardiomyopathy induced by repeated 10-week administration of daunorubicin (3 mg/kg i.v.) to rabbits. In the daunorubicin group, the plasma cardiac troponin T levels (cTnT – a marker of myocardial necrosis) were significantly increased (p<0.05), commencing with the 8th administration compared with the controls. The amount of collagen (an estimate of fibrosis) was also significantly higher in the daunorubicin group (13.39 ± 0.97 mg/g wet weight) compared to the control group (10.03 ± 0.65 mg/g wet weight). In both groups, the LV MMP-activity was observed only in the gelatine substrate in the 70 kDa region (MMP-2), while no MMPs activities were detectable either in the casein or collagen containing zymograms. At the end of the experiment, the MMP- 2 activity was slightly up-regulated (by 16 %) compared with the controls.

Metaanalysis in clinical chemistry: validation of cardiac troponin T as a marker for ischemic heart diseases

1995 ◽  
Vol 41 (8) ◽  
pp. 1228-1233 ◽  
Author(s):  
A H Wu ◽  
P L Lane
Keyword(s):  
Cardiac Troponin ◽  
Troponin T ◽  
Clinical Chemistry ◽  
Heart Diseases ◽  
Ischemic Heart ◽  
Cardiac Troponin T ◽  
Unpublished Manuscript ◽  
Retrospective Diagnosis ◽  
Creatine Kinase Mb

Abstract Metaanalysis is a method that incorporates the pooling of previously published results to produce more statistically significant results. We used metaanalysis to examine the role of a new cardiac marker, cardiac troponin T (cTnT), in patients with ischemic heart disease. Metaanalysis of six articles and one abstract on cTnT showed that this marker was just as sensitive as creatine kinase MB isoenzyme (CK-MB) for the retrospective diagnosis of acute myocardial infarction (AMI) 12-48 h after onset but less specific. Most of these articles showed that cTnT was increased in non-AMI patients with unstable angina pectoris. In a metaanalysis of four papers, two abstracts, a letter, and an unpublished manuscript, we examined the prognostic role of cTnT in non-AMI cardiac patients. For an unfavorable endpoint defined as cardiac death, AMI, or the need for coronary artery revascularization, the results demonstrated that abnormal concentrations of cTnT were associated with a higher risk for a poor outcome than were normal concentrations of cTnT. We also compared cTnT with CK-MB for risk stratification. Metaanalysis will become an increasingly important tool for evaluating new tests as they become available.

scholarly journals The role of cardiac troponin t and other new biochemical markers in evaluation and risk stratification of patients with acute chest pain syndromes

1997 ◽  
Vol 20 (11) ◽  
pp. 934-942 ◽  
Author(s):  
B. Charles Solymoss ◽  
Martial G. Bourassa ◽  
Ewa Wesolowska ◽  
Ihor Dryda ◽  
Pierre Th$Earoux ◽  
...  
Keyword(s):  
Chest Pain ◽  
Risk Stratification ◽  
Cardiac Troponin ◽  
Biochemical Markers ◽  
Troponin T ◽  
Acute Chest Pain ◽  
Cardiac Troponin T ◽  
Pain Syndromes

scholarly journals Role of cardiac troponin T in predicting development of acute kidney injury following liver transplantation

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S788
Author(s):  
H. Kamei ◽  
N. Kurata ◽  
S. Ogiso ◽  
Y. Onishi ◽  
Y. Ogura
Keyword(s):  
Liver Transplantation ◽  
Acute Kidney Injury ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Kidney Injury ◽  
Cardiac Troponin T
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