scholarly journals Dynamics of Morphological Changes in the Anterior Segment of the Rat Eye after Experimental Alkali Burn Depending on the Acetylator Phenotype

2015 ◽  
Vol 5 (4) ◽  
pp. 219-223
Author(s):  
Khalidjan Kamilov ◽  
◽  
Laylo Maksudova ◽  
◽  
Keyword(s):  
Morphological Changes ◽  
Anterior Segment ◽  
Acetylator Phenotype ◽  
Alkali Burn

scholarly journals Morphological changes in the trabecular meshwork and Schlemm’s canal after treatment with topical intraocular pressure-lowering agents

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ji-Hye Park ◽  
Hyun Woo Chung ◽  
Eun Gyu Yoon ◽  
Min Jung Ji ◽  
Chungkwon Yoo ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Trabecular Meshwork ◽  
Morphological Changes ◽  
Open Angle Glaucoma ◽  
Anterior Segment ◽  
Schlemm’S Canal ◽  
Schlemm's Canal ◽  
Before And After ◽  
Treatment Naïve ◽  
Aqueous Outflow

AbstractGlaucoma treatment is usually initiated with topical medication that lowers the intraocular pressure (IOP) by reducing the aqueous production, enhancing the aqueous outflow, or both. However, the effect of topical IOP-lowering medications on the microstructures of the aqueous outflow pathway are relatively unknown. In this retrospective, observational study, 56 treatment-naïve patients with primary open-angle glaucoma were enrolled. Images of the nasal and temporal corneoscleral limbus were obtained using anterior segment optical coherence tomography (AS-OCT). The conjunctival vessels and iris anatomy were used as landmarks to select the same limbal area scan, and the trabecular meshwork (TM) width, TM thickness, and Schlemm’s canal (SC) area were measured before and after using the IOP-lowering agents for 3 months. Among the 56 patients enrolled, 33 patients used prostaglandin (PG) analogues, and 23 patients used dorzolamide/timolol fixed combination (DTFC). After 3 months of DTFC usage, the TM width, TM thickness, and SC area did not show significant changes in either the nasal or temporal sectors. Conversely, after prostaglandin analog usage, the TM thickness significantly increased, and the SC area significantly decreased (all P < 0.01). These findings warrant a deeper investigation into their relationship to aqueous outflow through the conventional and unconventional outflow pathways after treatment with PG analogues.

scholarly journals A Study Based on CASIA2: What the Subtle Changes Has Taken Place in the Shape of the Crystalline Lens After Cycloplegia?

2021 ◽  
Author(s):  
Cheng Dai ◽  
Meng Liu ◽  
Xiaodong Lv ◽  
Binzhong Li
Keyword(s):  
Children And Adolescents ◽  
Crystal Morphology ◽  
Morphological Changes ◽  
Anterior Segment ◽  
Anterior Chamber Depth ◽  
Crystalline Lens ◽  
Equivalent Diameter ◽  
Swept Source ◽  
Before And After ◽  
The Relationship

Abstract Background: To evaluate the shape of the crystalline lens biometry and the diopter before and after cycloplegia using the CASIA2 swept-source (SS) optical coherence tomography (OCT) system on the anterior segment.Methods: This is a retrospective study. Children and adolescents (26 males and 29 females, aged 4–21 years) with simple ametropia were selected for optometry and CASIA2 imaging at 2 separate visits before and after cycloplegia. Diopter is derived from the spherical power (S) obtained by optometry. The Biometric parameters of the crystalline lens, including anterior chamber depth (ACD), anterior and posterior curvature of the lens (ACL and PCL), lens thickness (LTH), lens decentration(LD), lens tilt(LT), and the equivalent diameter of the lens (LED), were measured by CASIA2. The differences of these parameters before and after cycloplegia were compared, and the relationship between them was analyzed.Results: Fifty-five participants (106 eyes) were initially enrolled. The differences were statistically significant(P<0.05) in S (t=-7.026, P=0.000), ACD (t=-8.796, P=0.000), ACL (t=-13.263, P=0.000) and LTH（t=7.363, P=0.000）before and after cycloplegia. The change of PCL (t=1.557,P=0.122), LD (t=0.876, P=0.383), LT (t=0.440, P=0.661) and LED（t=-0.351, P=0.726） was not statistically significant (P>0.05). There was a significant (P<0.05) correlation between the change in S and ACL(r=0.466, P=0.000),LTH (r=-0.592, P=0.000),and LED (r=0.223, P=0.021) but not between the PCL(r=0.19, P=0.051), LD (r=-0.048, P=0.0628) and LT (r=-0.022, P=0.822). Furthermore, the change of ACD is closely related to the change of crystal morphology. However, in children and adolescents, we found that the change of crystal morphology will not have anything to do with age.Conclusion: The morphological changes of the lens before and after cycloplegia are mainly the ACL and LTH, but there is no difference in the PCL, LD, LT, and LED. In the adolescent population, the change of S is related to the change of ACL, LED and LTH. However, age gets nothing to do with the shape of the crystalline lens. For different refractive states (myopia, hyperopia, emmetropia), whether groups of different ages can reach the same conclusion needs further research.

scholarly journals Assessment of Anterior Segment Changes in Pseudophakic Eyes, Using Ultrasonic Biomicroscopic Imaging, after Pars Plana Vitrectomy with Silicone Oil or Gas Tamponade

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Erkan Ünsal ◽  
Kadir Eltutar ◽  
Belma Karini ◽  
Osman Kızılay
Keyword(s):  
Intraocular Pressure ◽  
Pars Plana Vitrectomy ◽  
Silicone Oil ◽  
Morphological Changes ◽  
Anterior Segment ◽  
Anterior Chamber Depth ◽  
Ciliary Process ◽  
Pars Plana ◽  
Group 2 ◽  
Group 1

Objective. To evaluate the morphological changes of the anterior segment using ultrasonic biomicroscopy (UBM) imaging in pseudophakic patients who underwent pars plana vitrectomy (PPV) with silicone oil or gas (C3F8) internal tamponade agent injection.Method. This prospective study included pseudophakic patients with planned PPV, divided into two groups according to internal tamponade agent: those in which silicone oil was used (n=27, Group 1) and those in which gas (C3F8) was used (n=24, Group 2). UBM measurements were performed in the supine position before and one week after surgery.Results. In patients of Group 1, postoperative trabecular meshwork-ciliary process distance (T-CPD) and iris-ciliary process distance (I-CPD), according to preoperative values, were found to be statistically significantly reduced, and postoperative mean value of scleral thickness (ST) and intraocular pressure (IOP), according to preoperative value, was found to be statistically significantly increased. In patients of Group 2, postoperative mean values of anterior chamber depth (ACD), ciliary body thickness (CBT), T-CPD, I-CPD, and IOP, according to preoperative values, were found to be statistically significantly reduced. Preoperatively, in Group 2 patients, according to Group 1 patients, TIA and IOP were found to be statistically significantly increased. Preoperative and postoperative IOP between the measured parameters with UBM showed no statistically significant correlation.Conclusions. Gases cause more morphological changes in the anterior segment structures. It is thought that complications such as increased intraocular pressure can be seen more frequently for this reason.

Morphological Changes in the Anterior Segment of the Abyssinian Cat Eye with Hereditary Rod-Cone Degeneration

2005 ◽  
Vol 30 (10) ◽  
pp. 855-862 ◽  
Author(s):  
Chr. Albrecht May ◽  
Elke Lütjen-Drecoll ◽  
Kristina Narfström
Keyword(s):  
Morphological Changes ◽  
Anterior Segment

scholarly journals Analysis of the Pathogenic Factors and Management of Dry Eye in Ocular Surface Disorders

2017 ◽  
Author(s):  
Marcella Nebbioso ◽  
Paola Del Regno ◽  
Magda Gharbiya ◽  
Marta Sacchetti ◽  
Rocco Plateroti ◽  
...  
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Morphological Changes ◽  
Anterior Segment ◽  
Tear Film ◽  
Female Gender ◽  
Good Health ◽  
Pathogenic Factors ◽  
Key Factor ◽  
Relevant Factors

The alteration of the delicate balance that regulates the secretion and distribution of the tear film determines the dry eye (DE) syndrome, because the tear film represents the interface between the eye and the environment. Despite having a multifactorial origin, the main risk factors for the emergence of the ocular disease are female gender and advanced age. Likewise, morphological changes in several glands and in chemical composition of their secretions such as proteins, mucins, lipidics, aqueous tears, and salinity, are highly relevant factors to maintain a condition of good health of the ocular anterior segment. Another key factor of recurrence and onset of the disease is the presence of local and/or systemic infiammation that reflex on the ocular surface. However, it is one of the most commonly encountered disease in clinical practice and many other causes related to daily life and to lengthen the average life will contribute to the beginning. This review will consider how and what disorders of the ocular surface are responsible for a widespread pathology so. In the end, the most appropriate and new therapies will be briefly exposed according to the specific pathology.

scholarly journals Chronological Observations of Iris Flocculi in a Japanese Family with Thoracic Aortic Aneurysm and Dissections

2019 ◽  
Vol 10 (3) ◽  
pp. 397-402 ◽  
Author(s):  
Yuka Mori ◽  
Noriyasu Hashida ◽  
Kazunobu Asao ◽  
Kazuichi Maruyama ◽  
Kohji Nishida
Keyword(s):  
Aortic Aneurysm ◽  
Thoracic Aortic Aneurysm ◽  
Morphological Changes ◽  
Anterior Segment ◽  
Slit Lamp ◽  
Epithelial Cyst ◽  
Causative Gene ◽  
Japanese Family ◽  
Pigment Epithelial ◽  
Iris Atrophy

Iris flocculi, a type of hereditary iris pigment epithelial cyst, have been reported in association with smooth muscle α-2 actin (ACTA2) gene as the causative gene of familial thoracic aortic aneurysm and dissections (FTAAD). The purpose of the report was to examine morphological changes in the shape of flocculi and iris features over time by comparing infants to adults with FTAAD combined with iris flocculi. A Japanese family with FTAAD and bilateral iris flocculi and the Arg149Cys gene mutation was included. A slit-lamp photograph and anterior segment optical coherence tomography (AS-OCT) were used to evaluate the structure and location of iris flocculi. AS-OCT was also used to measure the internal shape and iris thickness of the dilated pupil muscle. A morphological change in the cyst was confirmed to be existent in the youngest cases. Pigment discoloration and iris atrophy of the iris body were observed in all cases. Besides, a decrease in iris thickness was observed with AS-OCT measurement. Changes across generations in iris flocculi occurred in a Japanese family with TAAD. ACTA2 gene abnormalities may cause iris atrophy and decrease thickness in addition to iris flocculi in early life. The prognosis is poor when FTAAD is combined with iris flocculi, and prevention of cardiovascular disease is necessary based on earlier findings of its emergence.

Morphological Changes in the Rat Granulosa Cell Surface During Differentiation Induced by Estradiol and Gonadotropins

1977 ◽  
Vol 35 ◽  
pp. 484-485
Author(s):  
P. Bagavandoss ◽  
JoAnne S. Richards ◽  
A. Rees Midgley
Keyword(s):  
Cell Surface ◽  
Granulosa Cell ◽  
Morphological Changes ◽  
Follicular Development ◽  
Female Rats ◽  
Functional Changes ◽  
Group 4 ◽  
Group 3 ◽  
Group 5 ◽  
Group 2

During follicular development in the mammalian ovary, several functional changes occur in the granulosa cells in response to steroid hormones and gonadotropins (1,2). In particular, marked changes in the content of membrane-associated receptors for the gonadotropins have been observed (1).We report here scanning electron microscope observations of morphological changes that occur on the granulosa cell surface in response to the administration of estradiol, human follicle stimulating hormone (hFSH), and human chorionic gonadotropin (hCG).Immature female rats that were hypophysectcmized on day 24 of age were treated in the following manner. Group 1: control groups were injected once a day with 0.1 ml phosphate buffered saline (PBS) for 3 days; group 2: estradiol (1.5 mg/0.2 ml propylene glycol) once a day for 3 days; group 3: estradiol for 3 days followed by 2 days of hFSH (1 μg/0.1 ml) twice daily, group 4: same as in group 3; group 5: same as in group 3 with a final injection of hCG (5 IU/0.1 ml) on the fifth day.

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