La denudation tectonique de la zone ultradauphinoise et l'inversion du front brianconnais au sud-est du Pelvoux (Alpes occidentales); une dynamique miocene a actuelle

2001 ◽  
Vol 172 (1) ◽  
pp. 49-58 ◽  
Author(s):  
Pierre Tricart ◽  
Stephane Schwartz ◽  
Christian Sue ◽  
Gerard Poupeau ◽  
Jean-Marc Lardeaux

Abstract In the western Alps, to the southeast of the Pelvoux massif (Champsaur-Embrunais-Brianconnais-Queyras transect), the Brianconnais zone consists of the southern tip of the Zone Houillere and small nappes of Mesozoic sediments, emplaced during the Eocene in HP-LT metamorphic conditions. During the Oligocene this tectonic pile was thrusted onto a late Eocene to early Oligocene flexural basin, deformed in low grade metamorphic conditions and belonging to the Ultradauphine zone. This major thrust, called here CBF [Chevauchement Brianconnais Frontal: Tricart 1986] represents the boundary between the external and the internal zones of the western Alps. It contains thin tectonic lenses of Subbrianconnais origin, so that the Brianconnais Front and the Penninic Front almost merge. Late Alpine extension. - We have recently discovered that the CBF was subsequently reactivated as an extensional detachment. This major negative inversion is associated with widespread extension in the internal (Brianconnais and Piemont) zones, resulting in multiscale normal faulting. Current field work in the Queyras area shows that this brittle multitrend extension is a continuation of the ductile extension that accompanied the exhumation of blue-schist bearing metamorphic units. Along the same transect, the external (Ultradauphine) zone was not affected by late-Alpine extension. This is still the present situation: to the east of the aseismic Pelvoux massif, the CBF bounds the Brianconnais seismic arc, the activity of which may be the continuation of the late-Alpine extension. At the scale of the western Alpine arc, active extensional-transtensional tectonics dominate in the internal zones while compressional uplift affects the external zone. In this contrasted stress field, the thrust-fault zone between internal and external arcs plays a major role of decoupling that can be demonstrated in several sites between the area analysed here and the Central Alps, including along the Ecors profile. Contribution of thermochronology. - In this paper, we compare apatite fission track (FT) ages from both sides of the inverted CBF to the southeast of the Pelvoux massif. In the hangingwall of the CBF, two ages were obtained from magmatic intrusions within the Zone houillere, close to Briancon. They are compared to recently published ages from the Champsaur Sandstones unit in the footwall of the CBF, along the same transect.


2020 ◽  
Vol 109 (7) ◽  
pp. 2425-2446
Author(s):  
Gang Lu ◽  
Maria Giuditta Fellin ◽  
Wilfried Winkler ◽  
Meinert Rahn ◽  
Marcel Guillong ◽  
...  

Abstract The late Eocene-to-early Oligocene Taveyannaz Formation is a turbidite series deposited in the Northern Alpine Foreland Basin (close to the Alpine orogenic front). Double dating of zircons with the fission-track and the U–Pb methods is applied on samples from the Taveyannaz Formation to reconstruct the exhumation history of the Central-Western Alps and to understand the syn-collisional magmatism along the Periadriatic lineament. Three samples from this unit show similar detrital zircon fission-track age populations that center at: 33–40 Ma (20%); 69–92 Ma (30–40%); and 138–239 Ma (40–50%). The youngest population contains both syn-volcanic and basement grains. Combined with zircon U–Pb data, it suggests that the basement rocks of Apulian-affinity nappes (Margna Sesia, Austroalpine) were the major sources of detritus, together with the Ivrea Zone and recycled Prealpine flysch, that contributed debris to the Northern Alpine Foreland Basin. Furthermore, the rocks of the Sesia–Lanzo Zone or of equivalent units exposed at that time presumably provided the youngest basement zircon fission-track ages to the basin. The Biella volcanic suite was the source of volcanogenic zircons. Oligocene sediment pathways from source to sink crossed further crystalline basement units and sedimentary covers before entering the basin from the southeast. The lag times of the youngest basement age populations (volcanic zircons excluded) are about 11 Myr. This constrains average moderate-to-high exhumation rate of 0.5–0.6 km/Myr in the pro-side of the orogenic wedge of the Central Alps during the late Eocene to early Oligocene.



2021 ◽  
Author(s):  
Nick Thompson ◽  
Ulrich Salzmann ◽  
Adrián López Quirós ◽  
Carlota Escutia ◽  
Peter Bijl ◽  
...  

<p>The possible causes of the onset of Antarctic glaciation around the Eocene-Oligocene Transition (EOT), approximately 34 million years ago (~34Ma), are poorly understood. Uncertainties particularly remain over the role of the Drake Passage opening on the development of the Antarctic Circumpolar Current (ACC), and how this affected both marine and terrestrial environments. A major obstacle in understanding the role of the opening Drake Passage and ACC in Cenozoic climate changes has been the lack of continuous records spanning the EOT from the region. Here we present new palynomorph data from ODP Leg 113 Site 696 Hole B, recording changes in terrestrial environments and paleoclimate across the EOT. The sporomorph assemblage reveals the presence of Nothofagus-dominated forests with secondary Podocarpaceae and an understory of angiosperms and cryptogams growing across much of the Northern Antarctic Peninsula and South Orkney Microcontinent during the late Eocene (~37.60-34.95 Ma). Palaeoclimate reconstructions show that these forests grew under wet temperate conditions, with mean annual temperature and precipitation around 12°C and 1650mm, respectively. Today, similar temperate Nothofagus-dominated mixed-podocarp forests occur in the temperate Valdivian region of southern Chile. At the onset of the EOT, the palynomorph assemblage indicates an unusual expansion of gymnosperms and cryptogams, accompanied by a rapid increase in taxa diversity between ca. 34 and 32 Ma. Sporomorph based climate reconstructions do not provide evidence for an abrupt cooling at the EOT but reveal the onset of prolonged cooling phases throughout the early Oligocene. A contemporaneous increase in reworked Mesozoic sporomorphs at the EOT is likely to be linked to frequent glacial advances from the Antarctic Peninsula and South Orkney Microcontinent, although iceberg-rafted debris from Antarctica cannot be ruled out. We conclude that climate instability and glacial related disturbance at the onset of the EOT facilitated the suppression of Nothofagus and the expansion of a more diverse vegetation with many pioneer taxa that were able to quickly colonise during glacial retreat cycles.</p>



2018 ◽  
Vol 189 (3) ◽  
pp. 12 ◽  
Author(s):  
Sébastien Jourdan ◽  
Matthias Bernet ◽  
Elizabeth Hardwick ◽  
Jean-Louis Paquette ◽  
Pierre Tricart ◽  
...  

The clastic sedimentary formations of the Saint Antonin basin in the French Maritime Alps contain the record of the Early Oligocene erosional history of the Maures-Esterel massif, Sardinia and Corsica. Detrital apatite fission-track dating and zircon fission-track/U-Pb double dating of samples collected from the Saint Antonin basin confirm sediment provenance and allow obtaining first-order estimates of drainage basin maximum and long-term average exhumation rates. Whereas average exhumation rates were on the order of 0.1–0.2 km/Myr during the Early Oligocene, small parts of the Saint Antonin basin source areas may have experienced maximum exhumation rates on the order of 0.4–0.7 km/Myr. Although zircons and apatites with Early Oligocene fission-track cooling ages make up between 11–15% of the dated grains, a possible volcanic contribution is negligible, as only one single volcanic zircon grain was identified by fission-track/U-Pb double dating. Regional geodynamic processes with convergence in the Western Alps to the east and the end of the Pyreneo-Provençal compression phase by the early Oligocene controlled the differences in basin fill history and sediment provenance between the Saint Antonin basin and the largely contemporaneous Barrême basin in south-eastern France.



Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 469-P
Author(s):  
MILOS MRAZ ◽  
ANNA CINKAJZLOVA ◽  
ZDENA LACINOVÁ ◽  
JANA KLOUCKOVA ◽  
HELENA KRATOCHVILOVA ◽  
...  




Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3727
Author(s):  
Dafne Jacome Sanz ◽  
Juuli Raivola ◽  
Hanna Karvonen ◽  
Mariliina Arjama ◽  
Harlan Barker ◽  
...  

Background: Dysregulated lipid metabolism is emerging as a hallmark in several malignancies, including ovarian cancer (OC). Specifically, metastatic OC is highly dependent on lipid-rich omentum. We aimed to investigate the therapeutic value of targeting lipid metabolism in OC. For this purpose, we studied the role of PCSK9, a cholesterol-regulating enzyme, in OC cell survival and its downstream signaling. We also investigated the cytotoxic efficacy of a small library of metabolic (n = 11) and mTOR (n = 10) inhibitors using OC cell lines (n = 8) and ex vivo patient-derived cell cultures (PDCs, n = 5) to identify clinically suitable drug vulnerabilities. Targeting PCSK9 expression with siRNA or PCSK9 specific inhibitor (PF-06446846) impaired OC cell survival. In addition, overexpression of PCSK9 induced robust AKT phosphorylation along with increased expression of ERK1/2 and MEK1/2, suggesting a pro-survival role of PCSK9 in OC cells. Moreover, our drug testing revealed marked differences in cytotoxic responses to drugs targeting metabolic pathways of high-grade serous ovarian cancer (HGSOC) and low-grade serous ovarian cancer (LGSOC) PDCs. Our results show that targeting PCSK9 expression could impair OC cell survival, which warrants further investigation to address the dependency of this cancer on lipogenesis and omental metastasis. Moreover, the differences in metabolic gene expression and drug responses of OC PDCs indicate the existence of a metabolic heterogeneity within OC subtypes, which should be further explored for therapeutic improvements.



2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Claudia Bello-Alvarez ◽  
Ignacio Camacho-Arroyo

Abstract Background As in other types of cancers, sex is an essential factor in the origin and progression of glioblastomas. Research in the field of endocrinology and cancer suggests that gonadal steroid hormones play an important role in the progression and prevalence of glioblastomas. In the present review, we aim to discuss the actions and mechanism triggered by gonadal steroid hormones in glioblastomas. Main body Glioblastoma is the most common malignant primary brain tumor. According to the epidemiological data, glioblastomas are more frequent in men than in women in a 1.6/1 proportion both in children and adults. This evidence, and the knowledge about sex influence over the prevalence of countless diseases, suggest that male gonadal steroid hormones, such as testosterone, promote glioblastomas growth. In contrast, a protective role of female gonadal steroid hormones (estradiol and progesterone) against glioblastomas has been questioned. Several pieces of evidence demonstrate a variety of effects induced by female and male gonadal steroid hormones in glioblastomas. Several studies indicate that pregnancy, a physiological state with the highest progesterone and estradiol levels, accelerates the progression of low-grade astrocytomas to glioblastomas and increases the symptoms associated with these tumors. In vitro studies have demonstrated that progesterone has a dual role in glioblastoma cells: physiological concentrations promote cell proliferation, migration, and invasion while very high doses (out physiological range) reduce cell proliferation and increases cell death. Conclusion Gonadal steroid hormones can stimulate the progression of glioblastomas through the increase in proliferation, migration, and invasion. However, the effects mentioned above depend on the concentrations of these hormones and the receptor involved in hormone actions. Estradiol and progesterone can exert promoter or protective effects while the role of testosterone has been always associated to glioblastomas progression.



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