scholarly journals Five Serum Trace Elements Associated with Risk of Cardia and Non-cardia Gastric Cancer in a Matched Case-control Study

2019 ◽  
Author(s):  
Yulan Lin ◽  
Chuancheng Wu ◽  
Wei Yan ◽  
Saixiong Guo ◽  
Baoying Liu
Keyword(s):  
Gastric Cancer ◽  
Trace Elements ◽  
Case Control Study ◽  
Case Control ◽  
Serum Selenium ◽  
Healthy Controls ◽  
Cardia Cancer ◽  
Copper Zinc ◽  
Serum Trace Elements ◽  
Control Study

Abstract Background: Serum trace elements have been some time suggested to influence the development of gastric cancer, but evidence is still lacking. Methods: In a case-control study from a high risk region of East China, all newly diagnosed patients with gastric cancer were compared with healthy controls 1:1 matched by sex, age (± 3 years) and place of residence during 2013- 2015. Results: A total of 299cases of gastric cancers, which included 122 cases of gastric cardia cancer (GCC) and 177 gastric non-cardia cancer (NCGC), and 299 healthy controls were included. Positive associations were found between serum copper and copper/zinc ratio and risk of overall gastric cancer (OR4th vs. 1st quartile: 2.42, 95% CI: 1.10-5.32 for copper, p for trend=0.003; OR4th vs. 1st quartile: 11.7, 95% CI: 3.83-35.6 for copper/zinc ratio, p for trend<0.0001), and for both GCC and NCGC subtypes. Serum selenium inversely associated with risk of NCGC (OR4th vs. 1st quartile: 0.18, 95% CI: 0.07-0.51, p for trend=0.0001), while molybdenum seem to reduce risk of GCC (OR4th vs. 1st quartile: 0.12, 95% CI: 0.03-0.47, p for trend<0.0001). Strong inverse associations were also detected between serum calcium and risk of all groups of gastric cancer (all p for trend<0.05). Although intermediate serum level of zinc and iron had lower risk of gastric cancer, no linear association was however found (all p for trend>0.05). Conclusions: The current study present evidences for positive associations between copper, copper/zinc ratio and gastric cancer, as well as for inverse associations between serum selenium, molybdenum and calcium and risk of gastric cancer.

scholarly journals Five Serum Trace Elements Associated with Risk of Cardia and Non-cardia Gastric Cancer in a Matched Case-control Study

2019 ◽  
Author(s):  
Yulan Lin ◽  
Chuancheng Wu ◽  
Wei Yan ◽  
Saixiong Guo ◽  
Baoying Liu
Keyword(s):  
Gastric Cancer ◽  
Trace Elements ◽  
Case Control Study ◽  
Case Control ◽  
Serum Selenium ◽  
Healthy Controls ◽  
Cardia Cancer ◽  
Copper Zinc ◽  
Serum Trace Elements ◽  
Control Study

Abstract Background : Serum trace elements have been some time suggested to influence the development of gastric cancer, but evidence is still lacking. Methods : In a case-control study from a high risk region of East China, all newly diagnosed patients with gastric cancer were compared with healthy controls 1:1 matched by sex, age (± 3 years) and place of residence during 2013- 2015. Results : A total of 299cases of gastric cancers, which included 122 cases of gastric cardia cancer (GCC) and 177 gastric non-cardia cancer (NCGC), and 299 healthy controls were included. Positive associations were found between serum copper and copper/zinc ratio and risk of overall gastric cancer (OR 4th vs. 1st quartile : 2.42, 95% CI: 1.10-5.32 for copper, p for trend=0.003; OR 4th vs. 1st quartile : 11.7, 95% CI: 3.83-35.6 for copper/zinc ratio, p for trend<0.0001), and for both GCC and NCGC subtypes. Serum selenium inversely associated with risk of NCGC (OR 4th vs. 1st quartile : 0.18, 95% CI: 0.07-0.51, p for trend=0.0001), while molybdenum seem to reduce risk of GCC (OR 4th vs. 1st quartile : 0.12, 95% CI: 0.03-0.47, p for trend<0.0001). Strong inverse associations were also detected between serum calcium and risk of all groups of gastric cancer (all p for trend<0.05). Although intermediate serum level of zinc and iron had lower risk of gastric cancer, no linear association was however found (all p for trend>0.05). Conclusions : The current study present evidences for positive associations between copper, copper/zinc ratio and gastric cancer, as well as for inverse associations between serum selenium, molybdenum and calcium and risk of gastric cancer.

Serum trace elements in childhood anemia: A prospective case control study

2016 ◽  
Vol 03 (04) ◽  
pp. 247-252
Author(s):  
Raman Venkataraman ◽  
Lalitha Janakiraman ◽  
Balasubramanian Meenakshi
Keyword(s):  
Trace Elements ◽  
Case Control Study ◽  
Case Control ◽  
Childhood Anemia ◽  
Serum Trace Elements ◽  
Control Study ◽  
Prospective Case Control Study

scholarly journals Serum trace elements in obese Egyptian children: a case–control study

2014 ◽  
Vol 40 (1) ◽  
Author(s):  
Seham FA Azab ◽  
Safaa H Saleh ◽  
Wafaa F Elsaeed ◽  
Mona A Elshafie ◽  
Laila M Sherief ◽  
...  
Keyword(s):  
Trace Elements ◽  
Case Control Study ◽  
Case Control ◽  
Egyptian Children ◽  
Serum Trace Elements ◽  
Control Study

scholarly journals Association Between Polymorphisms in Gastric Cancer Related Genes and Risk of Gastric Cancer: A Case-Control Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Yan Pu ◽  
Xu Wen ◽  
Zhangjun Jia ◽  
Yu Xie ◽  
Changxing Luan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Case Control Study ◽  
High Sensitivity ◽  
Case Control ◽  
Healthy Controls ◽  
Genotype Frequencies ◽  
Related Variant ◽  
Gastric Cancer Patients ◽  
Control Study

Gastric cancer has the second highest incidence among all the malignancies in China, just below lung cancer. Gastric cancer is likewise one of the main sources of cancer related passings. Gastric cancer therefore remains a huge threat to human health. The primary reason is absence of high sensitivity and specificity for early detection while the pathogenesis of GC is stayed muddled. During the last few decades, a lot of GC related genes have been identified. To find candidate GC related variant in these GC related genes, we conducted this case-control study. 29 tagSNPs located in 7 GC related genes were included. 228 gastric cancer patients and 299 healthy controls were enrolled. Significant differences were found between the genotype frequencies of EFNA1 rs4971066 polymorphism between gastric cancer patients and healthy controls. The result indicated that ephrin-A1 tagSNP rs4971066 GT/TT genotypes was significantly associated with reduced susceptibility of gastric cancer development.

scholarly journals A case–control study of microRNA polymorphisms in gastric cancer screening by SNP chip combined with time of flight mass spectrometry

2020 ◽  
Vol 14 (16) ◽  
pp. 1563-1572
Author(s):  
Chuancheng Wu ◽  
Renjie Han ◽  
Shuangfeng Yang ◽  
Yu Jiang ◽  
Zhixiong Shu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gastric Cancer ◽  
Cancer Screening ◽  
Case Control Study ◽  
Case Control ◽  
Matched Pairs ◽  
Healthy Controls ◽  
Flight Mass Spectrometry ◽  
Gastric Cancer Screening ◽  
Control Study

Aims: To explore new SNP sites of miRNAs associated with gastric cancer, thereby providing valuable biomarkers to diagnose and screen gastric cancer. Materials & methods: A 1:1 case–control study was carried out. Microarrays were used to screen the SNP loci of miRNAs in the genomes of matched pairs of patients, 96 with gastric cancer and 96 healthy controls. For validation, mass spectrometry was used to classify miRNA SNP loci in 622 pairs of subjects. Results: rs7143252 was linked to a higher occurrence of gastric cancer. Conclusion: These results suggest that rs7143252 could be used as a specific biomarker to diagnose and screen gastric cancer.

scholarly journals SAT0077 CARDIOVASCULAR RISK ASSESSMENT WITH CAROTID ULTRASONOGRAPHY IN ADDITION TO THE TRADITIONAL CARDIOVASCULAR RISK FACTORS IN RHEUMATOID ARTHRITIS PATIENTS: A CASE CONTROL STUDY

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 973-973
Author(s):  
R. Gonzalez Mazario ◽  
J. J. Fragio-Gil ◽  
P. Martinez Calabuig ◽  
E. Grau García ◽  
M. De la Rubia Navarro ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Disease Duration ◽  
Case Control Study ◽  
Case Control ◽  
Healthy Controls ◽  
Carotid Ultrasonography ◽  
Control Study

Background:Cardiovascular disease (CV) is the most frequent cause of death in rheumatoid arthritis (RA) patients. It is well known that RA acts as an independent cardiovascular risk factor.Objectives:To assess the CV risk in RA patients using carotid ultrasonography (US) additionally to the traditional CV risk factors.Methods:A prospective transversal case control study was performed, including adult RA patients who fulfilled ACR/EULAR 2010 criteria and healthy controls matched according to CV risk factors. Population over 75 years old, patients with established CV disease and/or chronic kidney failure (from III stage) were excluded. The US evaluator was blinded to the case/control condition and evaluated the presence of plaques and the intima-media thickness. Statistical analysis was performed with R (3.6.1 version) and included a multivariate variance analysis (MANOVA) and a negative binomial regression adjusted by confounding factors (age, sex and CV risk factors).Results:A total of 200 cases and 111 healthy controls were included in the study. Demographical, clinical and US data are exposed in table 1. Not any difference was detected in terms of CV risk factors between the cases and controls. In both groups a relationship between age, BMI and high blood pressure was detected (p<0.001).Table 1.Table 2.RA basal characteristicsDisease duration (years)16,98 (11,38)Erosions (X-Ray of hands/feet)163 (81,5%)Seropositive (RF/anti-CCP)146 (73%)Extra-articular symptoms44 (22%)Intersticial difusse lung disease10 (5%)Rheumatoid nodules14 (7%)Prednisone use103 (51,5%)Median dose of Prednisone last year (mg)2,34 (2,84)sDMARDsMethotrexate104 (52%)Leflunomide29 (14,5%)Hydroxycloroquine9 (4,5%)bDMARDs89 (44,5%) TNFi41 (20,5%) Abatacept15 (7,5%) IL6i22 (11%) RTX11 (5,5%)JAKi26 (13%) Baricitinib11 (5,5%) Tofacitinib15 (7,5%)DAS 28-ESR3,1 (2,3, 3,9)SDAI7,85 (4,04, 13,41)HAQ0,88 (0,22, 1,5)RF (U/mL)51 (15, 164,25)Anti-CCP (U/mL)173 (22, 340)Patients showed higher intima-media (both right and left) thickness compared to controls (p<0.006). Moreover it was also related to the disease duration and DAS28 score (p<0.001). A higher plaque account was noted in cases(p<0.004) and it was also related to the disease duration (p<0.001).Conclusion:RA implies a higher CV risk. Traditional CV risk factors explains only partially the global risk. These findings support that RA acts as an independent cardiovascular risk factor.Disclosure of Interests:None declared

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