Exploring the influence of advanced maternal age on adverse perinatal outcome in Southern Anhui province, China

Abstract Background : Elderly parturient women may face many pregnancy risks, which have serious consequences for perinatal and maternal. The objective of this study is to explore the association between advanced maternal age and adverse perinatal outcomes. Methods : In this study, we used retrospective study to randomly selected 977 puerpera ( aged 35 years and older) as the research group and 977 puerpera (aged 20 to 34 years older) as the control group from Yijishan Hospital for the years 2017-2018. Univariate analysis was used to test the association between gestational age and adverse perinatal outcomes. Multiple logistic regression analysis was performed to examine the factors associated with adverse perinatal outcome. A nomogram was conducted to explore the risk probability between risk factors and adverse perinatal outcome. Results : the AMA group (23.2%)exhibited a higher incidence of adverse perinatal outcome than the Non-AMA group(17.8%). Multiple logistic regression analysis showed among those who experienced multiple pregnancy, premature, hypertension, diabetes were more likely to induce adverse perinatal outcome. In this study, the risk of adverse perinatal outcome occurred in women aged 35 to 45 years with multiple pregnancy and preterm birth all was 42%-48%. The risk of adverse perinatal outcome in women aged 35 to 45 years with other variables respectively were 18%-19% (diabetes), 16%-18% (hypertension).The risk of adverse perinatal outcomes among women with AMA combined with these variables were higher than the counterpart. Conclusions : AMA is the risk factor for adverse perinatal outcome among pregnancy women and the probability that these risk factors combined with age produced poor perinatal outcome were also found. Active intervention measures focusing on the complications and treatment in AMA should be taken to ensure the health of mother and baby.

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Advanced maternal age and risk of adverse perinatal outcome among women with congenital heart disease: A nationwide register‐based cohort study

Paediatric and Perinatal Epidemiology ◽

10.1111/ppe.12672 ◽

2020 ◽

Vol 34 (6) ◽

pp. 637-644

Author(s):

Stine Kloster ◽

Anne‐Marie Nybo Andersen ◽

Søren Paaske Johnsen ◽

Dorte Guldbrand Nielsen ◽

Annette Kjær Ersbøll ◽

...

Keyword(s):

Congenital Heart Disease ◽

Cohort Study ◽

Heart Disease ◽

Perinatal Outcome ◽

Maternal Age ◽

Congenital Heart ◽

Advanced Maternal Age ◽

Adverse Perinatal Outcome

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STUDY ON THE EFFECT OF ADVANCED MATERNAL AGE AT OBSTETRIC AND PERINATAL LEVEL

10.36106/ijsr/0602247 ◽

2021 ◽

pp. 60-62

Author(s):

Juliya John ◽

Aswath Kumar ◽

Saley Daniel

Keyword(s):

Caesarean Section ◽

Pregnancy Outcomes ◽

Maternal Age ◽

Gestational Hypertension ◽

Preterm Labour ◽

Perinatal Outcomes ◽

Advanced Maternal Age ◽

Control Group ◽

Study Group ◽

Adverse Perinatal Outcomes

INTRODUCTION: Advanced maternal age is commonly considered to be 35 years or older. The association between adverse perinatal outcomes and advanced maternal age has been a matter of controversy in several studies. While some researchers have noted an increased rate of adverse pregnancy outcomes in women older than 35 years, others have failed to nd any association between advanced maternal age and adverse perinatal outcomes. This discordance in conclusions could be attributed to the heterogeneity of study populations, differences in the denition of pregnancy outcomes, and failure to adjust for potential confounders. Therefore, we aimed to investigate the impact of advanced maternal age on obstetric and perinatal outcomes in this study. MATERIALS AND METHODS: The study was carried out among the patients who presented to the labour ward. This is a prospective observational study. The demographic data of these women, gestational age at time of delivery and complication during pregnancy are noted. They will be followed up till discharge and mode of delivery, perinatal outcome and any intrapartum and postpartum complications will be recorded in the research proforma. Sample Size: 252. RESULTS: Though there were higher incidence of Gestational hypertension, PROM, Preterm labour, placenta previa, Malpresentation, Multiple Pregnancy, FGR and treatment taken for infertility among the study group when compared to control group, their statistical signicance could not be established. There was also higher incidence of caesarean section (50.8%) and Operative vaginal delivery (2.6%) in the study group. There was no statistically signicant weight difference among the babies born to mothers in case and control group. CONCLUSION: Pregnant women of Advanced Maternal Age is thought about with great concern among the doctors as well as patients. In this study, there is an increased incidence of antenatal complications like Gestational Diabetes Mellitus, Gestational Hypertension, Caesarean Section and Preterm labour in women aged more than 35 years compared to the women of age 20 to 35 years.

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Advanced Maternal Age and Adverse Perinatal Outcomes – One Decade Analysis

MIDDLE BLACK SEA JOURNAL OF HEALTH SCIENCE ◽

10.19127/mbsjohs.542026 ◽

2019 ◽

Author(s):

Seda Keskin

Keyword(s):

Maternal Age ◽

Perinatal Outcomes ◽

Advanced Maternal Age ◽

Adverse Perinatal Outcomes

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Effect of pregnancy induced hypertension on adverse perinatal outcomes in Tigray regional state, Ethiopia: a prospective cohort study

10.21203/rs.2.14708/v4 ◽

2019 ◽

Author(s):

Abadi Kidanemariam Berhe ◽

Abiodun O. ILESANMI ◽

Christopher O. AIMAKHU ◽

Afework Mulugeta

Keyword(s):

Perinatal Outcome ◽

Neonatal Intensive Care ◽

Perinatal Death ◽

Birth Asphyxia ◽

Perinatal Outcomes ◽

Pregnancy Induced Hypertension ◽

Adverse Perinatal Outcome ◽

Regional State ◽

Induced Hypertension ◽

Adverse Perinatal Outcomes

Abstract Background: The prevalence of pregnancy-induced hypertension in Ethiopia ranges from 2.2 to 18.3%. However, so far little is known about the adverse perinatal outcomes of pregnancy-induced hypertension in Tigray regional state, Ethiopia. Therefore, the objective of this study was to assess the effect of pregnancy-induced hypertension on adverse perinatal outcomes in Tigray Regional State, Ethiopia. Methods: a prospective cohort study was conducted on a total sample of 782 pregnant women attending antenatal care in hospitals of Tigray regional state, Ethiopia. Pregnant mothers diagnosed with PIH during the data collection period in the selected hospitals were included as exposed group and normotensive women were also enrolled as a control group. Women diagnosed with pregnancy-induced hypertension between 28 and 35 weeks of gestation were enrolled for follow up to this study. Data were collected using an interviewer-administered questionnaire and review of their medical records from February 2018, to February 2019. The adverse perinatal outcome event includes low birth weight, birth asphyxia, small for gestational age, preterm delivery, admission to neonatal intensive care unit and perinatal death. A modified Poisson regression model with robust standard errors was used to analyze relative risk. Results: In this study, the overall incidence of adverse perinatal outcome was higher among women with pregnancy-induced hypertension than normotensive women (66.4% vs 22.2%). After adjusted for confounders women with pregnancy-induced hypertension were born babies with a higher risk of low birth weight (adjusted RR(95%CI)= 5.1(3.4,7.8)), birth asphyxia (aRR=2.6(1.9,3.8)), small for gestational age (aRR=3.3(2.3,4.6)), preterm delivery (aRR=5.2(3.4,7.9)), stillbirth (aRR=3.46(1.40,8.54)), admission to neonatal intensive care unit (aRR=5.1(3.1,8.4)) and perinatal death (aRR=3.6(1.8,7.4)) compared to normotensive pregnant women. Conclusions: Higher incidences of adverse perinatal outcomes occurred among women pregnancy-induced hypertension in Tigray regional state, Ethiopia. Hence health care providers should strengthen prevention, early diagnosis and prompt management of pregnancy-induced hypertension to reduce adverse perinatal outcomes of pregnancy-induced hypertension. Keywords : Adverse perinatal outcomes, pregnancy-induced hypertension, Tigray, Ethiopia

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Adverse perinatal outcomes at advanced maternal age: An experience from a large Indian cohort

International Journal of Clinical Obstetrics and Gynaecology ◽

10.33545/gynae.2020.v4.i1e.478 ◽

2020 ◽

Vol 4 (1) ◽

pp. 292-297

Author(s):

Sanghamitra Panda ◽

Mohammed Ismail Khan ◽

Mohamed Ashiq Shazahan ◽

Fardeen .

Keyword(s):

Maternal Age ◽

Perinatal Outcomes ◽

Advanced Maternal Age ◽

Adverse Perinatal Outcomes

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Adverse perinatal outcomes and its associated factors among adult and advanced maternal age pregnancy in Northwest Ethiopia

Scientific Reports ◽

10.1038/s41598-021-93613-x ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Temesgen Getaneh ◽

Azezu Asres ◽

Toyiba Hiyaru ◽

Selamawit Lake

Keyword(s):

Birth Interval ◽

Maternal Age ◽

Associated Factors ◽

Perinatal Outcomes ◽

Advanced Maternal Age ◽

Northwest Ethiopia ◽

Public Hospitals ◽

Inconsistent Result ◽

Short Birth Interval ◽

Adverse Perinatal Outcomes

AbstractEven though reduction of neonatal mortality is needed to achieve Sustainable Development Goals 2030, advanced maternal age is still an independent and a substantial risk factor for different adverse perinatal outcomes, in turn causes neonatal morbidity and mortality. In Ethiopia, research has validated that advanced maternal age is a significant factor in adverse perinatal outcomes, but researches which addressed or estimated its adverse perinatal outcomes are limited, reported inconsistent result and specifically no study was done in the study area. Therefore, this study was aimed to compare adverse perinatal outcomes and its associated factors among women with adult and advanced maternal age pregnancy in Northwest Ethiopia. Comparative cross-sectional study was conducted in Awi Zone, public hospitals, Northwest Ethiopia. Systematic random sampling was employed to select 348 adult and 176 advanced aged pregnant women. Structured questionnaire were used to collect the data. The collected data were analyzed using Statistical Package for the Social Sciences version 25. Binary and multivariate logistic regressions were fitted to assess the association between adverse perinatal outcomes and explanatory variables. P-value less than 0.05 was used to declare statistical significance. Significant percentage of advanced aged women (29.1%) had adverse perinatal outcomes compared to (14.5%) adult aged women. Similarly, proportion low birth weight, preterm birth and low Apgar score were significantly higher among advanced maternal age. The odds of composite adverse perinatal outcomes were higher among advanced maternal age women when compared to adult aged women (AOR 2.01, 95% CI 1.06, 3.79). No formal education (AOR 2.75, 95% CI 1.27, 5.95), short birth interval (AOR 2.25, 95% CI 1.07, 4.73) and complications during pregnancy (AOR 2.12, 95% CI 1.10, 4.10) were also factors significantly associated with adverse perinatal outcomes. Being advanced maternal age is at higher risk for adverse perinatal outcomes compared to adult aged women. Maternal illiteracy, short birth interval and complications during pregnancy were also significantly associated with adverse perinatal outcomes. Access of equal education, provision of family planning and perinatal care (including early detection and management of complication) is recommended.

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Advanced Maternal Age and Adverse Perinatal Outcome

Obstetrics and Gynecology ◽

10.1097/01.aog.0000140682.63746.be ◽

2004 ◽

Vol 104 (4) ◽

pp. 727-733 ◽

Cited By ~ 366

Author(s):

Bo Jacobsson ◽

Lars Ladfors ◽

Ian Milsom

Keyword(s):

Perinatal Outcome ◽

Maternal Age ◽

Advanced Maternal Age ◽

Adverse Perinatal Outcome

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Association between maternal age and adverse perinatal outcomes in Arba Minch zuria, and Gacho Baba district, southern Ethiopia: a prospective cohort study

BMC Pregnancy and Childbirth ◽

10.1186/s12884-020-03285-0 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Abera Mersha ◽

Gistane Ayele ◽

Tilahun Worku ◽

Zerihun Zerdo ◽

Shitaye Shibiru ◽

...

Keyword(s):

Cohort Study ◽

Neonatal Mortality ◽

Prospective Cohort ◽

Maternal Age ◽

Perinatal Outcomes ◽

Advanced Maternal Age ◽

Southern Ethiopia ◽

Age Group ◽

Delayed Childbearing ◽

Adverse Perinatal Outcomes

Abstract Background Globally, delayed childbearing to the advanced age is a growing option. It is an emerging public health issue in developing countries. Currently, adverse perinatal outcomes significantly increased. A few studies showed the effect of advanced maternal age on adverse perinatal outcomes. However, most used secondary data or chart reviews, and this increases the risk of biases. Besides, there are limited studies in-country Ethiopia as advanced maternal age steadily increased. Therefore, this study aimed to assess the status of advanced maternal age and its effect on perinatal outcomes in the study setting. Methods A community-based prospective cohort study was conducted among 709 study participants from October 15, 2018, to September 30, 2019, in Arba Minch zuria, and Gacho Baba district, southern Ethiopia. The data were collected by a pretested interviewer-administered structured Open Data Kit survey tool and analyzed by SPSS version 25. The log-linear regression model was used to compare perinatal outcomes among women aged 20–34 years and ≥ 35 years. The log-likelihood ratio tested for the goodness of fit. In this study, P-value < 0.05 was considered to declare a result as a statistically significant association. Results In this study, 209(29.5%) of the women were age group ≥35 years old, and 500(70.5%) were age group from20–34 years old. Stillbirth (β = 0.29, 95%CI: 0.05, 0.52), and neonatal mortality (β = 0.11, 95%CI: 0.01, 0.21) were significantly associated with the advanced maternal age. Conclusions Perinatal outcomes such as stillbirth and neonatal mortality were independently associated with advanced maternal age after controlling for possible cofounders. Therefore, different strategies should design for the women who planned to bear child, and information should provide for women who are advanced age or delayed childbearing to alert them.

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Amniotic-Umbilical-to-Cerebral Ratio – A Novel Ratio Combining Doppler Parameters and Amniotic Fluid Volume to Predict Adverse Perinatal Outcome in SGA Fetuses At Term

Ultraschall in der Medizin - European Journal of Ultrasound ◽

10.1055/a-1205-0161 ◽

2020 ◽

Author(s):

Florian Matthias Stumpfe ◽

Florian Faschingbauer ◽

Sven Kehl ◽

Jutta Pretscher ◽

Julius Emons ◽

...

Keyword(s):

Perinatal Outcome ◽

Neonatal Intensive Care ◽

Predictive Accuracy ◽

Area Under The Curve ◽

Perinatal Outcomes ◽

Fetal Distress ◽

Adverse Perinatal Outcome ◽

Adverse Perinatal Outcomes ◽

Nicu Admission ◽

Singleton Pregnancies

Abstract Purpose Introduction of a novel ratio – the amniotic-umbilical-to-cerebral ratio (AUCR) – to predict adverse perinatal outcome in SGA fetuses at term and comparison of its predictive accuracy with established parameters. Materials and Methods This retrospective cohort study included 165 singleton pregnancies with SGA fetuses (birth weight < 10th percentile) at term. Cases with planned vaginal delivery and documented pulsatility indices (PI) of the umbilical artery (UA), middle cerebral artery (MCA), and single deepest pocket (SDP) were included. CPR was calculated as the ratio between MCA PI and UA PI, UCR as the ratio between UA PI and MCA PI. AUCR was defined as follows: SDP/(UA PI/MCA PI). Adverse perinatal outcomes were defined as operative intervention (OI), OI due to fetal distress, admission to the neonatal intensive care unit (NICU), and composite adverse perinatal outcome (CAPO). Associations between Doppler parameters and these outcomes were estimated using regression analyses. Results OI was statistically significantly associated with UCR, SDP, and AUCR, whereas no association was observed for UA PI, MCA PI, and CPR. Fetuses requiring OI due to fetal distress revealed a significantly higher UA PI and UCR as well as a lower MCA PI, CPR, and AUCR. With regard to NICU admission and CAPO, a significantly higher UA PI and lower CPR were found. Furthermore, a significant association was shown for SDP, UCR, and AUCR. AUCR achieved the best area under the curve for all outcome parameters. Conclusion AUCR leads to an improvement in the prediction of unfavorable outcome in SGA fetuses at term. Furthermore, results of our study show that UCR might be superior to CPR.

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