scholarly journals The Relationship between Serum Levels of Vitamin C, Uric Acid and Antioxidant status with Coronary Artery Disease: a Case-Control Study

2020 ◽  
Author(s):  
Aida Torkzaban ◽  
Seyed Amir Mansour Alavi Naeini ◽  
Akbar Hassanzadeh ◽  
Mehrdad Namdari
Keyword(s):  
Uric Acid ◽  
Vitamin C ◽  
Antioxidant Status ◽  
Case Control Study ◽  
Demographic Data ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Case Control ◽  
Significant Difference ◽  
Control Study

Abstract Background: Coronary Heart Disease (CHD) is among the main causes of death in adults. Increase of oxidative stress and defects in antioxidant defense play a major role in endothelium performance and are an effective factor in progress of atherosclerosis. The aim of this study is to measure the serum level of UA and vitamin C as well as the antioxidant status of CHD patients to evaluate their relationship and compare them with the healthy individual.Materials and methods: The present case-control study was performed on 44 cases and 44 controls. Demographic data and anthropometric indices were measured. Food frequency questionnaire (FFQ) and international physical activity questionnaire were also completed. After 12 hours of fasting, 10 ml blood was sampled from the participants. Uric acid (UA), vitamin C, TAC and MDA were also measured. The data were finally analyzed by SPSS Ver 22 software.Results: A significant difference was observed between the two groups in terms of uric acid (P<0.001) and vitamin C (P<0.03). However, mean MDA and TAC showed no significant difference between the two groups. The two groups’ difference in terms of vitamin A, E and beta carotene, zinc and selenium intake was not significant. A significant difference was however detected between the two groups in terms of vitamin C intake (P<0.047). A significant relationship was also observed between the systolic blood pressure and CHD (P<0.028).Conclusion: Our results suggest that increasing of serum uric acid and a decrease in serum vitamin C level can be considered as risk factors for CHD patients. Due to the lack of significant correlation between TAC and CHD in this study, it seems that different results will be obtained with increasing sample size.

scholarly journals The Relationship between Serum Levels of Vitamin C, Uric Acid and Antioxidant Condition with Coronary Artery Diseases: a Case-Control Study

2019 ◽  
Author(s):  
Aida Torkzaban ◽  
Seyed Amir Mansour Alavi Naeini ◽  
Akbar Hassanzadeh ◽  
Mehrdad Namdari
Keyword(s):  
Uric Acid ◽  
Vitamin C ◽  
Case Control Study ◽  
Demographic Data ◽  
Systolic Pressure ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Significant Difference ◽  
Control Study

Abstract Background Coronary hearth diseases are among the main causes of death in adults. Increase of oxidative stress and defects in antioxidant defense play a major role in endothelium performance and are an effective factor in progress of atherosclerosis. Some studies have also reported different malondialdehyde and total antioxidant capacity among the atherosclerosis patients.Methods In this case-control study, 44 atherosclerosis patients referring to Shahid Madani treatment-education center were considered as the case group; while 44 healthy peoples were placed in the control group. Demographic data and anthropometric indices were measured. Food frequency questionnaire and international physical activity questionnaires were also completed. After 12 hours of fasting, 10 ml blood was sampled from the participants. Uric acid, vitamin C, TAC and MDA were also measured. The data were finally analyzed by SPSS Ver 22 software.Results A significant difference was observed between the two groups in terms of uric acid (P<0.001) and vitamin C (P<0.03). However, mean MDA and TAC showed no significant difference between the two groups. The two groups’ difference in terms of vitamin A, E and beta carotene, zinc and selenium intake was not significant. A significant difference was however detected between the two groups in terms of vitamin C (P<0.047). A significant relationship was also observed between the systolic pressure and CHD (P<0.028).Conclusion Results of this study indicated that the uric acid and vitamin C levels of atherosclerosis patients had significant increase and decrease in comparison with the healthy subjects, respectively. Mean TAC and antioxidant levels of their diets (except for vitamin C) showed no significant difference. Systolic blood pressure of the patients was significantly higher than the controls.

scholarly journals Assessment of peripheral biomarkers potentially involved in episodic and chronic migraine: a case-control study with a focus on NGF, BDNF, VEGF, and PGE2

2022 ◽  
Vol 23 (1) ◽  
Author(s):  
Mohammad Mozafarihashjin ◽  
Mansoureh Togha ◽  
Zeinab Ghorbani ◽  
Abolfazl Farbod ◽  
Pegah Rafiee ◽  
...  
Keyword(s):  
Growth Factor ◽  
Chronic Migraine ◽  
Case Control Study ◽  
Demographic Data ◽  
Serum Levels ◽  
Episodic Migraine ◽  
Case Control ◽  
Blood Levels ◽  
Headache Frequency ◽  
Control Study

Abstract Background Several inflammatory and vascular molecules, and neurotrophins have been suggested to have a possible role in the development of migraine. However, pathophysiological events leading to migraine onset and transformation of episodic migraine (EM) to chronic migraine (CM) are not fully understood. Thus, we aimed to assess peripheral levels of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), and prostaglandin E2 (PGE2) in EM and CM patients, and controls. Methods From September 2017 to June 2020, 89 subjects were enrolled in a case-control study; 23 and 36 EM and CM patients, respectively, and 30 age and sex-matched controls. Demographic data and medical history were obtained from all patients. Headache characteristics were recorded at baseline visit and ensuing 30 days for persons with migraine disease. Serum levels of NGF, BDNF, VEGF, and PGE2 were measured once for controls and EM and CM patients, and adjusted for age, sex, and body mass index. Results Serum levels of NGF were significantly lower in EM patients compared to controls and CM patients (P-value=0.003 and 0.042, respectively). Serum levels of BDNF were significantly lower in EM and CM patients as opposed to controls (P-value<0.001), but comparable between EM and CM patients (P-value=0.715). Peripheral blood levels of VEGF were significantly higher in EM and CM patients as opposed to controls (P-value<0.001), but not different between EM and CM patients (P-value=0.859). Serum levels of PGE2 were significantly lower in EM patients compared to controls (P-value=0.011), however similar between EM and CM patients (P-value=0.086). In migraine patients, serum levels of NGF and PGE2 positively correlated with headache frequency (NGF: ρ = 0.476 and P-value<0.001; PGE2: ρ = 0.286 and P-value=0.028), while corresponding levels of BDNF and VEGF did not correlate with headache frequency (BDNF: ρ = 0.037 and P-value=0.778; VEGF: ρ= -0.025 and P-value=0.850). Conclusions Our findings suggest that NGF, BDNF, PGE2, and VEGF may play a significant role in migraine pathogenesis and/or chronification, and therefore might bear potential value for novel targeted abortive and prophylactic migraine therapy. Further prospective cohort studies with larger sample sizes can more robustly evaluate the implications of these findings.

scholarly journals COMPARISON OF SERUM LEVELS OF VITAMIN A, VITAMIN D AND ZINC IN ACUTE LOWER RESPIRATORY TRACT INFECTIONS IN CHILDREN

2020 ◽  
pp. 1-4
Author(s):  
Anil Sharma ◽  
Shalini Dash
Keyword(s):  
Vitamin D ◽  
Vitamin A ◽  
Case Control Study ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Case Control ◽  
Indian Children ◽  
Serum Vitamin D ◽  
Tract Infections ◽  
Control Study

Aim: Acute lower respiratory infections (ALRIs) are global problem, and there are large differences in mortality rates between developed and developing countries. Deficiency of micronutrients may increase the risk of ALRI. A case-control study was conducted to assess the associations between vitamin A, vitamin D, zinc and ALRI in eastern part of Indian children. Methods: Children aged 1 – 60 months hospitalizes with ALRI (cases, N = 51) were matched to controls on age, sex and socio-economic status (N = 31). The mean Serum levels of Vitamin A, Vitamin D (25-hydroxy vitamin D) and Zinc in cases and controls was compared using student's paired t-test and compared the severity of pneumonia with these levels. Results: Mean (SD) level of serum vitamin A, vitamin D and zinc in the cases were 17.08 (±10.53) ìg/dl; 13.91 (±2.99) ng/ml and 61.51 (±13.84) ìg/dl, respectively. The serum vitamin A, vitamin D and zinc levels were significantly lower in cases of ALRI as compared to controls (p<0.001). In our study serum vitamin D level was significantly associated with severity of ALRIs (p=0.042), and mean level of serum vitamin A was significantly low in case of severe pneumonia as compared to pneumonia (p=0.011). Conclusion: Vitamin A, vitamin D and zinc status was associated with childhood ALRI in matched case-control study in eastern part of India. Randomized trials may establish whether interventions to improve theses micronutrients status can reduce the burden of ALRI in children.

scholarly journals The Role of Possible Factors Affecting the Risk of Getting Infected by COVID-19 in Emergency Medical Technicians: A Case-Control Study

2020 ◽  
Author(s):  
Mostafa Sadeghi ◽  
Peyman Saberian ◽  
Parisa Hasani-Sharamin ◽  
Fatemeh Dadashi ◽  
Sepideh Babaniamansour ◽  
...  
Keyword(s):  
Case Control Study ◽  
Demographic Data ◽  
Case Control ◽  
Emergency Medical Technicians ◽  
Control Group ◽  
Case Group ◽  
Factors Affecting ◽  
Emergency Medical ◽  
Significant Difference ◽  
Control Study

Abstract Background: Emergency medical technicians (EMTs) are at the highest risk of coronavirus disease-19 (COVID-19). Adequate access and knowledge about donning and doffing of personal protective equipment (PPE) can decrease the risk of transmission. The aim of this study was to assess the possible factors associated with increasing risk of COVID-19 among EMTs.Methods: This study was a case-control study conducted in Tehran, Iran during 18th February to 20th April 2020. Case group was consisted of confirmed COVID-19 EMTs based on the results of reverse transcriptase polymerase chain reaction and/or lung computed tomography scan. Healthy EMTs were randomly selected as control group. Patients were asked to fill out a checklist including demographic data, data related to the work situation (such as number of missions and type of mask and cloth) and PPE precautions.Results: Sixty-eight patients and 148 healthy persons took part in this study as case and control group, respectively. Having two EMTs involved directly in taking care of patients (p < 0.001) and working with a confirmed case teammate (p < 0.001), considering the precautions such as seal check after wearing the mask (p=0.015), covering the hair with a medical hat (p<0.001), not using personal items despite protective clothing (p<0.001), and avoiding contact with the outer surface of clothing while removing (p<0.001) had significant difference in two groups.Conclusion: We found that the type of used face masks (the surgical mask) and the type of used cloths (using NW (disposable, one-piece, non-waterproof protective cloth)) are correlated with the higher risk of COVID-19 in EMTs.

Vitamin C, Vitamin B12, Folate and the Risk of Osteoporotic Fractures. A Case-Control Study

2007 ◽  
Vol 77 (6) ◽  
pp. 359-368 ◽  
Author(s):  
Martínez-Ramírez ◽  
Palma Pérez ◽  
Delgado-Martínez ◽  
Martínez-González ◽  
De la Fuente Arrillaga ◽  
...  
Keyword(s):  
Folic Acid ◽  
Vitamin C ◽  
Fracture Risk ◽  
Case Control Study ◽  
Serum Vitamin ◽  
Osteoporotic Fractures ◽  
Case Control ◽  
Vitamin B ◽  
Erythrocyte Folate ◽  
Control Study

Water-soluble vitamins influence the development of an adequate structure of bone tissue, but there is scant information relating them with osteoporotic fractures. We analyze whether serum vitamin C, vitamin B12, and erythrocyte folate, or dietary intake of vitamin C and folate, are related with osteoporotic fractures in the elderly. A hospital-based case-control study was carried out at the Hospital of Jaén (167 cases, 167 controls), Spain. Cases were defined as patients aged 65 or more years with a low-energy fracture. Controls were people without fracture, matched for age and sex with cases. Diet was assessed by a semi-quantitative food frequency questionnaire. Serum vitamin C was measured using high-performance liquid chromatography (HPLC). Folic acid and vitamin B12 were measured using procedures of competitive or immunometric immunoassay. Multivariable analyses were also fitted to adjust for confounding using analysis of covariance (for the comparison of adjusted means) and conditional logistic regression (for estimating adjusted odds ratios). A statistically significant difference between cases and controls for vitamin C blood levels was found, being higher for controls (p = 0.01). Analysis of the association between serum vitamin C and fracture risk showed a linear trend (p = 0.03) with a significantly reduced risk for the upper quartile (OR = 0.31; 95% CI 0.11–0.87). The intake of vitamin C, folic acid, and B12 was not related to fracture risk, nor was there any association with erythrocyte folate or serum vitamin B12. In conclusion, serum vitamin C levels were lower in cases with osteoporotic fractures than in controls.

scholarly journals Assessment of Serum Vitamin D Levels in Patients with Vitiligo in Jordan: A Case-Control Study

2019 ◽  
Vol 2019 ◽  
pp. 1-4 ◽  
Author(s):  
Diala M. Alshiyab ◽  
Firas A. Al-qarqaz ◽  
Leen H. Heis ◽  
Jihan M. Muhaidat ◽  
Wlla S. Eddin ◽  
...  
Keyword(s):  
Vitamin D ◽  
Case Control Study ◽  
Skin Diseases ◽  
Serum Vitamin ◽  
Case Control ◽  
Vitamin D Receptors ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Control Study

Background. Low vitamin D serum levels have been associated with many autoimmune disorders and several other skin diseases. Vitiligo is an autoimmune disease characterized by destruction of melanocytes by immune mechanisms. Melanocytes express vitamin D receptors, and their function can be affected by vitamin D status. Objectives. The main objective of this study is to compare vitamin D levels in patients with vitiligo vs normal population and whether vitamin D deficiency is associated with vitiligo. Methods. A case-control study was conducted. 100 vitiligo patients and 100 as controls were included in this study. Serum vitamin D level was measured for both vitiligo patients and controls, results were compared, and statistical analysis was done to compare the results. Results. The median age of vitiligo cases was 23 years (ranges, 2–80). 58% of vitiligo patients were females. The median vitamin D level was not significantly different between the two groups (vitiligo = 14.1 (IQR 9.9–20.4) vs control = 16.5 (IQR 10.3–25.3) (P=0.28)). Most vitiligo cases and controls were found to have low levels of vitamin D (either insufficient 20–30 ng/mL or low <20 ng/mL). Conclusions. There was no significant difference in vitamin D levels in vitiligo patients compared to controls. However, vitamin D levels were generally low in both groups.

scholarly journals Predictive Value of Serum Vitamin D3 Level for Forearm Fractures among Children in a Tropical Country: A Case Control Study

2021 ◽  
Author(s):  
Musiliu A Oladosu ◽  
Oluwadare Esan ◽  
Lawrence M Oginni ◽  
Olayinka O Adegbehingbe ◽  
Tewogbade Adeoye Adedeji
Keyword(s):  
Vitamin D3 ◽  
Case Control Study ◽  
Demographic Data ◽  
Forearm Fracture ◽  
Serum Vitamin ◽  
Case Control ◽  
Forearm Fractures ◽  
Fractures In Children ◽  
Low Middle Income Countries ◽  
Control Study

Introduction: Orthopaedic emergency department commonly receives paediatric fractures, of which forearm fractures constitute a larger proportion with the burden greatest in low-middle income countries. Studies done in the temperate region found an association between forearm fractures in children and low serum vitamin D3. Some studies in our environment have shown low levels of 25-hydroxy vitamin D3 {25(OH)D} in normal Nigerian children, but the association with forearm fractures has not been studied. Aim: To determine if serum vitamin D3 level can predict the occurrence of forearm fractures in children. Materials and Methods: This was a case control study conducted over a year from January 2018 to December 2018 at a tertiary health facility in South-West Nigeria among paediatric patients. Thirty children with forearm fractures and thirty children with no forearm fractures were recruited for the study. Socio-demographic data, mechanisms of fracture, anthropometric measurements and serum 25(OH)D levels were determined. Univariate and multivariate analyses were done for the variables concerning the presence or absence of forearm fractures (dependent variable is the presence or absence of forearm fractures; independent variables include the age, sex, mechanism of injury, outdoor playing time, serum vitamin D3 level). Results: The mean serum 25(OH)D levels in the study group were significantly lower than the controls; (60.751±15.041 ng/mL and 95.506±19.489 ng/mL, respectively). There was a statistically significant relationship between the serum level of 25(OH)D and the presence of forearm fracture in children (p=0.002 and OR of 0.838). Conclusion: Children with forearm fracture have relatively lower serum vitamin D3 compared with age matched ones without fracture and they have correspondingly increased odd risks of sustaining forearm fracture.

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