scholarly journals Silver diamine fluoride (SDF) used in childhood caries management has potent antifungal activity against oral Candida species

2019 ◽  
Author(s):  
Kausar Sadia Fakhruddin ◽  
Lakshman Samaranayake ◽  
Hiroshi Egusa ◽  
Hien Chi Ngo ◽  
Venkatachalam Thenmozhi ◽  
...  
Keyword(s):  
Candida Species ◽  
Fungal Species ◽  
Silver Diamine Fluoride ◽  
Caries Management ◽  
Bacteria And Fungi ◽  
Oral Candida ◽  
Time Kill ◽  
First Time ◽  
Caries Lesions ◽  
Childhood Caries

Abstract Background The microbiome of Severe-Early Childhood Caries (S-ECC), is characterized by an ecosystem comprising bacterial and fungal species, with a predominance of Candida species. Hence, an anti-cariogen effective against both bacteria and fungi would be valuable in the management of S-ECC.Methods Here we evaluate the antifungal effect of silver diamine fluoride (SDF) against 35-clinical yeast isolates (Ten-each of C. albicans , C. krusei, C. tropicalis and five C. glabrata strains) from dentinal caries-lesions from S-ECC.Results Disc-diffusion and time-kill assays as well as MIC 50 and MIC 90 evaluations against therapeutic concentrations confirmed the broad-spectrum anti-candidal potency of SDF. Ultrastructural images revealed morphologic aberrations of yeast-cell walls on exposure to SDF. All C. krusei and C. glabrata isolates were significantly more sensitive to SDF, relative to the standard antifungal fluconazole.Conclusions Our data, for the first time, elucidate the antifungal potency of SDF, in addition to its known antibacterial activity, in the management of S-ECC.

scholarly journals Silver diamine fluoride (SDF) used in childhood caries management has potent antifungal activity against oral Candida species

2020 ◽  
Author(s):  
Kausar Sadia Fakhruddin ◽  
Hiroshi Egusa ◽  
Hien Chi Ngo ◽  
Chamila Panduwawala ◽  
Siripen Pesee ◽  
...  
Keyword(s):  
Candida Species ◽  
Fungal Species ◽  
Silver Diamine Fluoride ◽  
Low Concentrations ◽  
Caries Management ◽  
Bacteria And Fungi ◽  
Oral Candida ◽  
Time Kill ◽  
First Time ◽  
Childhood Caries

Abstract Background: The microbiome of Severe-Early Childhood Caries (S-ECC), is characterized by an ecosystem comprising bacterial and fungal species, with a predominance of Candida species. Hence, an anti-cariogen effective against both bacteria and fungi would be valuable in the management of S-ECC. Here we evaluate the antifungal effect of silver diamine fluoride (SDF) against 35-clinical yeast isolates (Ten-each of C. albicans , C. krusei, C. tropicalis and five C. glabrata strains) from dentinal caries-lesions from S-ECC. Results: Disc-diffusion and time-kill assays as well as MIC 50 and MIC 90 evaluations against therapeutic concentrations confirmed the broad-spectrum anti-candidal potency of SDF. Ultrastructural images revealed morphologic aberrations of yeast-cell walls on exposure to SDF. All C. krusei and C. glabrata isolates were significantly more sensitive to SDF, relative to the standard antifungal fluconazole. Further, SDF appears to effectively abrogate filamentation of C. albicans even at very low concentrations. Conclusions: Our data, for the first time, elucidate the anti-candidal potency of SDF, in addition to its known antibacterial activity, in the management of S-ECC.

scholarly journals Silver diamine fluoride (SDF) used in childhood caries management has potent antifungal activity against oral Candida species

2020 ◽  
Author(s):  
Kausar Sadia Fakhruddin ◽  
Lakshman Samaranayake ◽  
Hiroshi Egusa ◽  
Hien Chi Ngo ◽  
Venkatachalam Thenmozhi ◽  
...  
Keyword(s):  
Candida Species ◽  
Fungal Species ◽  
Silver Diamine Fluoride ◽  
Low Concentrations ◽  
Caries Management ◽  
Bacteria And Fungi ◽  
Oral Candida ◽  
Time Kill ◽  
First Time ◽  
Childhood Caries

Abstract Background: The microbiome of Severe-Early Childhood Caries (S-ECC), is characterized by an ecosystem comprising bacterial and fungal species, with a predominance of Candida species. Hence, an anti-cariogen effective against both bacteria and fungi would be valuable in the management of S-ECC. Methods : Here we evaluate the antifungal effect of silver diamine fluoride (SDF) against 35-clinical yeast isolates (Ten-each of C. albicans , C. krusei, C. tropicalis and five C. glabrata strains) from dentinal caries-lesions from S-ECC. Results: Disc-diffusion and time-kill assays as well as MIC 50 and MIC 90 evaluations against therapeutic concentrations confirmed the broad-spectrum anti-candidal potency of SDF. Ultrastructural images revealed morphologic aberrations of yeast-cell walls on exposure to SDF. All C. krusei and C. glabrata isolates were significantly more sensitive to SDF, relative to the standard antifungal fluconazole. Further, SDF appears to effectively abrogate filamentation of C . albicans even at very low concentrations. Conclusions: Our data, for the first time, elucidate the antifungal potency of SDF, in addition to its known antibacterial activity, in the management of S-ECC.

scholarly journals Silver diamine fluoride (SDF) used in childhood caries management has potent antifungal activity against oral Candida species

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Kausar Sadia Fakhruddin ◽  
Hiroshi Egusa ◽  
Hien Chi Ngo ◽  
Chamila Panduwawala ◽  
Siripen Pesee ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Candida Species ◽  
Silver Diamine Fluoride ◽  
Caries Management ◽  
Oral Candida ◽  
Childhood Caries

Parents’ Views on Silver Diamine Fluoride to Manage Early Childhood Caries

2020 ◽  
pp. 238008442093069
Author(s):  
G. Kyoon-Achan ◽  
R.J. Schroth ◽  
H. Martin ◽  
M. Bertone ◽  
B.A. Mittermuller ◽  
...  
Keyword(s):  
Early Childhood ◽  
Informed Consent ◽  
Qualitative Study ◽  
Early Childhood Caries ◽  
Study Data ◽  
Silver Diamine Fluoride ◽  
Anterior Teeth ◽  
Caries Management ◽  
Caries Lesions ◽  
Childhood Caries

Background: The use of silver diamine fluoride (SDF) as a nonsurgical caries management product is growing. Evidence suggests that SDF is very successful in arresting caries. However, a common concern with SDF treatment is the unaesthetic black staining. The purpose of this qualitative study was to determine parents’ views following their children’s treatment with SDF to manage severe early childhood caries (ECC). Method: Parents were interviewed as part of a mixed-method study of SDF to arrest severe ECC. Children with caries lesions in primary teeth were treated with 2 applications of 38% SDF, followed by fluoride varnish. Semistructured in-person and phone interviews were conducted with 19 parents of children in the study. Data were transcribed verbatim and manually coded and uploaded to NVivo 12 for further coding analysis. Results: None of the parents had previously heard about SDF, and they learned about it from the study dentist. Although parents trusted the dentist’s information on SDF, they welcomed additional evidence, especially relating to product safety and effectiveness. Some parents were minimally concerned with the black staining caused by SDF treatment. It was more important that SDF arrested caries progression, minimized pain and sensitivity, and prevented dental infection. However, some parents expressed concerns related to the unaesthetic black staining. Interestingly, many parents indicated that their children were not overly concerned with the black staining. A majority of parents said that they would recommend the treatment to others. Conclusion: This is the first qualitative study involving parents of children who were treated with SDF. Most parents were accepting of SDF as a nonsurgical treatment to arrest caries and minimize dentinal sensitivity secondary to caries, although some expressed concern about the black staining in anterior teeth. It is important to adequately inform parents of the negative aesthetic consequences and obtain informed consent before treatment. Knowledge Transfer Statement: This qualitative study revealed that many parents of children with severe ECC are accepting of SDF as a nonrestorative caries management option, despite the black staining of caries lesions. Dental professionals need to be aware of these parental concerns and obtain written informed consent prior to treatment. Parents also requested more information and resources on SDF on its benefits, effectiveness, and any associated risks.

scholarly journals Ozonized Gel Against Four Candida Species: A Pilot Study and Clinical Perspectives

Materials ◽  
2020 ◽  
Vol 13 (7) ◽  
pp. 1731 ◽  
Author(s):  
Vincenzina Monzillo ◽  
Fabiola Lallitto ◽  
Alba Russo ◽  
Claudio Poggio ◽  
Andrea Scribante ◽  
...  
Keyword(s):  
Candida Species ◽  
Inhibition Zone ◽  
Antifungal Drugs ◽  
Diffusion Method ◽  
Beneficial Effects ◽  
Growth Inhibition Zone ◽  
Wide Range ◽  
Fungicide Activity ◽  
Bacteria And Fungi ◽  
Oral Candida

Ozone therapy can display a wide range of clinical beneficial effects, including antimicrobial, immune-stimulant, analgesic, anti-hypoxic actions. However, there is still a paucity of data regarding the ozone fungicide activity. Oral Candida is the most common fungal infection in the mouth among denture wearers and people with weakened immune systems. In the case of generalized candidiasis or immunocompromised patients, systemic therapy is needed, while localized infections are treated with topic medications. However, many Candida strains are resistant to antifungal drugs. The aim of this preliminary analysis is to evaluate the antimycotic efficacy of a new ozonided oil (GeliO3), as a possible terapeutic alternative in local treatments of these infections, compared to chlorhexidine digluconate (Plak gel®). Chlorhexidine is a chemical synthesis disinfectant with a broad-spectrum antiseptic action, active against bacteria and fungi. Antimycotic activity was tested against the following four Candida species: C. albicans, C. parapsilosis, C. glabrata, C. tropicalis, through an agar diffusion method. No significant differences were found between the growth inhibition zone diameters of the ozonized gel and chlorhexidine. The results indicated that the ozonized gel may help to combat Candida infections. Moreover, useful applications could be used to counteract Candida colonization of endosseous implants.

scholarly journals Applications of Silver Diamine Fluoride in Dentistry

2021 ◽  
pp. 163-170
Author(s):  
Sayali Deshpande ◽  
Amit Reche ◽  
Priyanka Paul Madhu ◽  
Kumar Gaurav Chhabra ◽  
Sunaina Mutyalwar
Keyword(s):  
United States ◽  
Early Childhood ◽  
Early Childhood Caries ◽  
Dental Treatment ◽  
Silver Ions ◽  
The United States ◽  
Control Agent ◽  
Silver Diamine Fluoride ◽  
Patient Cooperation ◽  
Childhood Caries

Various studies published in the literature around the world indicate a significant prevalence of early childhood caries (ECC). Treatment of early childhood caries (ECC) using silver diamine fluoride (SDF) has become a viable alternative, particularly for young and anxious children, because traditional restorative treatments is unlikely to combat this prevalent condition. Arrested caries is identified by the hardening of teeth and it changes its color from dark brown to black. More restorative treatments can be performed if necessary. Traditional ECC restorative treatments are not always inexpensive or feasible, as they involve patient cooperation to achieve a satisfactory result. Japan was the first country to promote silver diamine fluoride in 1960. SDF has been used to prevent the spread of caries in various Asian nations, including Japan and China. It was enacted as a fluoride to treat sensitive teeth in the United States by Food and Drug Administration ( FDA). For young children or individuals with specific needs, it is painless and simple to use .The fluoride in SDF stimulates remineralization while the silver ions act as an antimicrobial agent when applied to carious lesions and stop cariogenic biofilms from growing. SDF also prevents future degradation of the dentin's collagen. With a 38 percent use rate, SDF has been utilized in a number of nations. According to a review, SDF is a harmless, economical caries control agent with a wide utilisation in dentistry, and it may meet the WHO Millennium Development Goal (MDG) as well as the United States Institute of Medicine's criteria. The applications of SDF in dental treatment are discussed in this article.

scholarly journals Didymocyrtis epiphyscia, Lichenochora weillii, and Lichenoconium xanthoriae newly recorded from Turkey

Mycotaxon ◽  
2021 ◽  
Vol 136 (2) ◽  
pp. 523-528
Author(s):  
Mustafa Kocakaya
Keyword(s):  
Fungal Species ◽  
First Time

Three lichenicolous fungal species, Didymocyrtis epiphyscia, Lichenochora weillii, and Lichenoconium xanthoriae, are reported for the first time from Turkey. Comments on the taxonomy, ecology, and hosts and photographic illustrations are provided for each species.

scholarly journals The Effect of Psychoactive Substances (Drugs) on the Presence and Frequency of Oral Candida Species and Candida Dubliniensis

2013 ◽  
Vol 25 (4) ◽  
pp. 223 ◽  
Author(s):  
Sanja Hadzic ◽  
Amira Dedic ◽  
Mirjana GojkovVukelic ◽  
Nermana MehicBasara ◽  
Mirsada Hukic ◽  
...  
Keyword(s):  
Candida Species ◽  
Candida Dubliniensis ◽  
Psychoactive Substances ◽  
Oral Candida

scholarly journals Penatalaksanaan early childhood caries Management of early childhood caries

2011 ◽  
Vol 10 (3) ◽  
pp. 179
Author(s):  
Fajriani Fajriani ◽  
Hendrastuty Handayani
Keyword(s):  
Early Childhood ◽  
Early Childhood Caries ◽  
Dental Hygiene ◽  
Treatment Plan ◽  
High Rate ◽  
Tooth Decay ◽  
Inappropriate Use ◽  
Caries Management ◽  
Dental Diseases ◽  
Childhood Caries

Early childhood caries (ECC), also known as milk bottle caries is a syndrome of severe tooth decay, occurs ininfants and children, is an infectious disease that develops rapidly and lead to health problems in children. Thissyndrome can be caused by inappropriate use of bottles. Most cases of untreated ECC to children aged 20 months.At this stage many children need serious treatment, because this will result in trauma to both the children andparents. The most common treatment ECC and other dental diseases have been included in each treatment ofdisease. Efforts to educate families about dental hygiene and practice start a diet, the high rate of recurrence of anyevidence of disease ranging from tooth decay to the failure of the treatment plan resulted in the need for specialattention to this disease. This paper is expected to be a good input for a dentist in the treatment of ECC

scholarly journals The Distribution of Oral Candida Species in Patient with Prosthetic Appliance

2014 ◽  
Vol 14 (4) ◽  
pp. 477-487 ◽  
Author(s):  
Seung Hwa Son ◽  
Su Min Baek ◽  
Young Min Park
Keyword(s):  
Candida Species ◽  
Oral Candida
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