scholarly journals Acute kidney injury in Plasmodium vivax malaria hospitalized patients in Manaus, Brazilian Amazon: are we underestimating the real burden?

2019 ◽  
Author(s):  
Thalie Santos ◽  
Jose Diego Brito-Sousa ◽  
Fernando Val ◽  
Jacqueline Sachett ◽  
Miguel MD Mo ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Vivax Malaria ◽  
Kidney Injury ◽  
Plasmodium Falciparum Malaria ◽  
Brazilian Amazon ◽  
Acute Kidney Injury Network ◽  
Hospitalized Patients ◽  
World Health ◽  
Who Criteria ◽  
The Real

Abstract Background Acute kidney injury (AKI) is a common complication of Plasmodium falciparum malaria and can also occur secondary to P. malariae infections. Its association with P. vivax malaria is not well estimated neither understood.Methods Retrospective assessment of medical records was conducted among P. vivax malaria hospitalized patients in a reference hospital of Manaus, Brazilian Amazon, from 2009 to 2017. AKI was classified according to Acute Kidney Injury Network (AKIN) criteria and through the World Health Organization (WHO) criteria for severe malaria. Patients diagnosed with primaquine-induced hemolysis due to confirmed glucose 6-phosphate dehydrogenase deficiency (G6PDd) and chronic renal failure were excluded. Prevalence of AKI and factors associated to this complication were assessed.Results Out of 28,095 P. vivax malaria diagnoses during the study period in the reference center, 638 cases (2.3%) required hospitalization; with 433 (67.8%) of those patients having at least one creatinine measure. Twenty-two patients (5.1%) were diagnosed with AKI as per WHO criteria; 241 patients presented more than two creatinine measures, of which 117 (49.2%) patients had AKI per AKIN criteria. These were stratified in stage I (n=88; 75.2%), stage II (n=6; 5.1%), and stage III (n=23; 19.6%). Major risk factor for AKI was older age. Renal replacement therapy (dialysis) was necessary in 6 cases (1.4%).Conclusions AKI secondary to vivax malaria was not unfrequent amongst hospitalized patients and may be a potentially severe complication. WHO diagnostic criteria for malaria AKI was shown to underestimate the real burden of AKI. Renal impairment should be closely monitored especially in older patients.

Evaluation of the Acute Kidney Injury Network criteria in hospitalized patients with cirrhosis and ascites

2013 ◽  
Vol 59 (3) ◽  
pp. 482-489 ◽  
Author(s):  
Salvatore Piano ◽  
Silvia Rosi ◽  
Giulio Maresio ◽  
Silvano Fasolato ◽  
Marta Cavallin ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Acute Kidney Injury Network ◽  
Hospitalized Patients

scholarly journals Acute kidney injury in hospitalized patients with COVID-19 (retrospective study)

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Haitham A. Azeem ◽  
Hytham Abdallah ◽  
Mohamad M. Abdelnaser
Keyword(s):  
Acute Kidney Injury ◽  
Retrospective Study ◽  
Serum Creatinine ◽  
Kidney Injury ◽  
Multiple Organ ◽  
Hospitalized Patients ◽  
World Health ◽  
Incidence And Mortality ◽  
Novel Coronavirus ◽  
Health Organization

Abstract Background The World Health Organization (WHO) has named the virus as 2019 novel coronavirus on January 12, 2020, and has declared a public health emergency globally on January 30, 2020. The epidemic started in Wuhan, China, in December of 2019 and quickly spread to over 200 countries. COVID-19 can cause multiple organ injuries (e.g., kidney, heart, blood, and nervous system). Among them, acute kidney injury (AKI) is a critical complication due to its high incidence and mortality rate. So, it is essential to evaluate AKI in COVID-19 patients during this pandemic state. The aim of this work is to detect the occurrence of AKI in hospitalized COVID-19 patients. So, a retrospective study was conducted on hospitalized adult patients > 18 years old with confirmed SARS-CoV-2 infection admitted to the Abo Teeg Hospital at Assiut City, Egypt, from May 1, 2020, to July 1, 2020. All data were collected from medical records, patients’ follow-up, and charts. Data were verified, coded by the researcher, and analyzed using IBM-SPSS 21.0. Results Eighty-six COVID-19 patients were admitted to Abo Teeg Hospital in Assiut City, Egypt, between May and July 2020. Thirty-eight patients (33%) were of the male gender. Mean age was 58.07 ± 17.9, and 61 patients developed AKI. 32.8% of the AKI group were a stage I severity (increase in serum creatinine by 0.3 mg/dl within 48 h), 21.3% of them presented by stage II (2–2.9 times increase in serum creatinine), and 45.9% were in stage III (3 times or more increase in serum creatinine). The overall hospital mortality for the patients admitted to ICU with AKI was 6.7% (11/61), compared to 1% (4/25) in those without AKI. Conclusion Hospitalized patients with COVID-19 had a higher risk of AKI, and we recommended that those patients should be evaluated after discharge for the development of CKD.

Low sodium to potassium ratio in spot urine sample is associated with progression to acute kidney injury and mortality in hospitalized patients with cirrhosis

2021 ◽  
Author(s):  
Elayne Cristina Morais Rateke ◽  
Camila Matiollo ◽  
Emerita Quintina de Andrade Moura ◽  
Michelle Andrigueti ◽  
Claudia Maccali ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Urine Sample ◽  
Kidney Injury ◽  
Hospitalized Patients ◽  
Spot Urine ◽  
Low Sodium ◽  
Spot Urine Sample

scholarly journals Urine YKL-40 is associated with progressive acute kidney injury or death in hospitalized patients

2014 ◽  
Vol 15 (1) ◽  
Author(s):  
Isaac E Hall ◽  
Edward P Stern ◽  
Lloyd G Cantley ◽  
Jack A Elias ◽  
Chirag R Parikh
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Hospitalized Patients

scholarly journals Morbid Obesity Is Associated With Mortality And Acute Kidney Injury In Hospitalized Patients With Covid-19

2021 ◽  
Author(s):  
Martín-del-Campo Fabiola ◽  
Ruvalcaba-Contreras Neri ◽  
Velázquez-Vidaurri Alma L ◽  
Cueto-Manzano Alfonso M ◽  
Rojas-Campos Enrique ◽  
...  
Keyword(s):  
Morbid Obesity ◽  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Hospitalized Patients

Elevated Levels of Urinary Biomarkers TIMP-2 and IGFBP-7 Predict Acute Kidney Injury in Neonates after Congenital Heart Surgery

2021 ◽  
Author(s):  
Michelle Ramírez ◽  
Sujata Chakravarti ◽  
Jaclyn McKinstry ◽  
Yasir Al-qaqaa ◽  
Raj Sahulee ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Congenital Heart ◽  
Heart Surgery ◽  
Kidney Injury ◽  
Acute Kidney Injury Network ◽  
Congenital Heart Surgery ◽  
Adverse Outcomes ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Stress Injury ◽  
Stage 1

Abstract Objectives: This article investigated the utility of urine biomarkers tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding protein-7 (IGFBP-7) in identifying acute kidney injury (AKI) in neonates after congenital heart surgery (CHS). TIMP-2 and IGFBP-7 are cell cycle arrest proteins detected in urine during periods of kidney stress/injury. Methods: We conducted a single-center, prospective study between September 2017 and May 2019 with neonates undergoing CHS requiring cardiopulmonary bypass (CPB). Urine samples were analyzed using NephroCheck prior to surgery and 6, 12, 24, and 96 hours post-CPB. All patients were evaluated using the Acute Kidney Injury Network (AKIN) criteria. Wilcoxon rank sum tests were used to compare the medians of the [TIMP-2*IGFBP-7] values in the AKIN negative and positive groups at each time point. Receiver operating characteristic curves were used to measure how well the [TIMP-2*IGFBP-7] values predict AKIN status. Results: Thirty-six patients were included. No patients met the AKIN criteria for AKI preoperatively. Postoperatively, 19 patients (53%) met the AKIN criteria for AKI diagnosis: 13 (36%) stage 1, 5 (14%) stage 2, and 1 (3%) stage 3. None required renal replacement therapy. At the 24-hour time points, patients who met the AKIN criteria for AKI had a statistically significantly higher [TIMP-2*IGFBP7] values than the patients without AKI (1.1 vs. 0.27 [ng/mL]2/1,000) at 24 hours (adj-p = 0.0019). Conclusion: AKI is a serious complication associated with adverse outcomes in patients undergoing cardiac surgery. [TIMP-2*IGFBP-7] urinary level 24 hours after CPB is a good predictor of AKI in this population.

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